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Zanaflex (Tizanidine)
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Zanaflex

Zanaflex is a medication that is used to treat muscle spasticity due to spinal cord injury or multiple sclerosis. Effectiveness appears similar to baclofen or diazepam. It is taken by mouth.

Other names for this medication:
Tizanidine

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Also known as: Tizanidine

Description

Generic Zanaflex is an agonist at (alpha) 2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, Generic Zanaflex has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of Generic Zanaflex are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons. The imidazoline chemical structure of Generic Zanaflex is related to that of the anti-hypertensive drug clonidine and other (alpha) 2 -adrenergic agonists. Pharmacological studies in animals show similarities between the two compounds, but Generic Zanaflex was found to have one-tenth to one-fiftieth (1/50) of the potency of clonidine in lowering blood pressure. Zanaflex is also known as Tizanidine, Sirdalud. Generic name of Generic Zanaflex is Tizanidine-Oral. Brand name of Generic Zanaflex is Zanaflex.

Dosage

Usual Adult Dose for Muscle Spasm:

-Initial dose: 2 mg orally every 6 to 8 hours as needed -The dose of Zanaflex can be increased by your doctor if needed -The medication effects peak in about 1 to 2 hours and last for 3 to 6 hours -Do not take more than 16mg of Zanaflex at one time. Do not take more than 36mg in 24 hours.

Comments: -The capsules and tablets are absorbed differently by the body. Do not switch from one to the other without talking to your doctor. -Zanaflex should be taken with food every time or without food every time. Do not switch back and forth.

Detailed Zanaflex dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include weakness, drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, or fainting.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Tizanidine dosage information

Side effects

The most common side effects associated with Zanaflex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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We found that radiation caused hippocampus excitotoxicity, resulting from overactivation of the N-methyl-D-aspartate receptor (NMDAR) and always accompanied by subsequent elevation of the intracellular calcium level and activation of calcineurin (CaN). Biodegradation of polychlorinated biphenyls by rhizobia: a novel finding. Evidence of MV production accumulated in recent years among bacterial species involved in fermentation processes. Ventricular assist systems: experience in Japan with Toyobo pump and Zeon pump. In contrast, the G306E mutation, which inactivates the phosphotyrosine binding domain of Cbl, blocks NFAT/AP1 activation by 70Z Cbl. Comparison of the relation between the calcium score and plaque characteristics in patients with acute coronary syndrome versus patients with stable coronary artery disease, assessed by computed tomography angiography and virtual histology intravascular ultrasound. Entrepreneurship in surgical education and research using animal experiments: a reconstructed barn as a private center for experimental surgery. The time spent in open arms and at the intersection was unaffected. This study tested the hypothesis that oxidative stress-responsive mediators can influence joint inflammation of patients with RCT.

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High-level expression of the tick-borne encephalitis virus NS1 protein by using an adenovirus-based vector: protection elicited in a murine model. The tissue specific elevation in synthesis of the 90 kDa heat shock protein precedes the onset of disease in lupus prone MRL/lpr mice. Since BHRF1 efficiently suppresses apoptosis induced by anti-cancer agents, its expression may have important implications for the chemotherapy of EBV-induced malignancies. A critical assessment of hemodynamic depression during laparoscopy is a demand. Dermatomycoses: a brief history of therapy and initial results with clotrimazole.

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