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Vasotec

Vasotec is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease, and heart failure. For heart failure, it is generally used with a diuretic, such as furosemide. It is given by mouth or by injection into a vein.

Other names for this medication:
Acepril, Alicante, Anapril, Antiprex, Auspril, Bidinatec, Bitensil, Cetampril, Convertase, Dilvas, Dinid, Ednyt, Ekaril, Enadigal, Enadura, Enafril, Enalafel, Enalagamma, Enalapril, Enalaprilmaleat, Enalart, Enalich, Enaprel, Enapren, Enaprotec, Enaril, Ephicord, Fibrosan, Herten, Iecatec, Imotoran, Innovace, Kalpiren, Konveril, Linatil, Lotrial, Lowtril, Nalabest, Pharmapress, Pharpril, Presopril, Presuren, Renacardon, Renipril, Renistad, Reniten, Sulocten, Tencas, Tensazol, Zacool

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Also known as: Enalapril

Description

Enalaprilat injection is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Enalaprilat works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax. This lowers blood pressure and increases the supply of blood and oxygen to the heart .

This medicine is available only with your doctor's prescription .

Dosage

Usual Adult Dose for Hypertension:

Initial dose: 5 mg orally once a day Maintenance dose: 10 to 40 mg orally per day as a single dose or in 2 divided doses Maximum dose: 40 mg orally daily as a single dose or in 2 divided doses In combination with diuretics: Initial dose: 2.5 mg orally once a day If feasible, the diuretic should be discontinued 2 to 3 days prior to initiation of therapy with enalapril. If required, diuretic therapy may be gradually resumed.

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 2.5 mg orally once a day Maintenance dose: 2.5 to 20 mg daily in 2 divided doses Maximum dose: 40 mg orally per day in 2 divided doses Comments: -Treatment is usually combined with diuretics and digitalis. -Doses should be titrated upward, as tolerated, over a period of a few days or weeks.

Usual Adult Dose for Left Ventricular Dysfunction:

Initial dose: 2.5 mg orally twice a day Maintenance dose: 20 mg orally per day in 2 divided doses Comments: -After the initial dose, the patient should be observed for at least 2 hours and until blood pressure has stabilized for at least an additional hour. -If possible, the dose of any concomitant diuretic should be reduced which may diminish the likelihood of hypotension.

Usual Pediatric Dose for Hypertension:

Children 1 month to 17 years: Initial dose: 0.08 mg/kg/day (up to 5 mg) in 1 to 2 divided doses. Adjust dosage based on patient response. Maximum dose: Doses greater than 0.58 mg/kg (40 mg) have not been evaluated in pediatric patients. Comment: -Not recommended in neonates and in pediatric patients with glomerular filtration rate less than 30 mL/min, as no data are available.

Detailed Vasotec dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Vasotec are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Enalapril can decrease sweating and you may be more prone to heat stroke.

Drinking alcohol can further lower your blood pressure and may increase certain side effects of enalapril.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

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We demonstrate that the PTP1B orthologue PTP61F dephosphorylates the Drosophila IR in S2 cells in vitro and attenuates IR-induced eye overgrowth in vivo. SC DNA is homologous to LINE family and in contrast to genomic DNA is enriched with alternative (GT/CA)n sequences and palindromes. Effectiveness of implementing a trauma triage system on outcome: a prospective evaluation. Although the new pathogenetic theories for auto-immune diseases, and especially coeliac disease, are of considerable interest, experimental confirmation is eagerly awaited. Preventing suicide among returning combat veterans: a moral imperative.

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Cyclic AMP prevents activation of a swelling-induced chloride-sensitive conductance in chick heart cells. Acute myelogenous leukemia: current treatment and future directions. Treatment with GalN and LPS alone or in combination led to equivalent increases in hepatic and splenic TNF-alpha gene expression. It provides a good alternative beyond conventional thyroidectomy, especially for those previously excluded from minimally invasive techniques. Signature inversion and change in triaxiality in 159Tm and 159Er. A retrospective review of patients suffering from male breast cancer was carried out at the Shands Teaching Hospital of the University of Florida. Venous collapse and the respiratory variability in systemic venous return.

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Our knowledge of its prognosis derives primarily from case series, which are subject to possible selection bias and other limitations. We studied the frequencies of red cell enzyme types, AcP, PGM1 and EsD in 213 patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), rheumatic heart disease (RHD), scleroderma (Scl) and psoriatic arthropathy (PsA). Effect of pH on the denitrifying enzyme activity in pasture soils in relation to the intrinsic differences in denitrifier communities. Immunostaining was present in pachytene spermatocytes, round spermatids, elongated spermatids, flagella of late spermatids, and sperm in the epididymal region. If the liver was perfused in a retrograde fashion, i.e., from the vena cava to the portal vein, phorbol myristate acetate or PGE2 exerted only minor effects. The tissue inhibitor of metalloproteinases-1 (TIMP-1) is an moduretic drug class inhibitor of the extracellular matrix-degrading metalloproteinases. Israel is situated in a complex geo-climatic region with contrasting geographic and weather patterns, including both dark and bright surfaces within a relatively small area.

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Shimming protocols (iterative, first-order, and second-order) and perfluorocarbon (PFC) pads were evaluated using water peak linewidth measurements obtained from single-voxel magnetic resonance spectroscopy (MRS) on a head and neck phantom. Key areas of organs and structures during reorientation were illustrated using dwell time normalized visual maps. Can child care workers contribute to the early detection of autism spectrum disorders?. About the clinical performance of the Sysmex XE-500 for automated cerebrospinal fluid cell counts. This review summarizes recent literature on the structure, and on the angiogenic, contractile, proliferative, and secretory activities mediated by the prostatic stroma and its agents. Multi Groups Cooperation based Symbiotic Evolution for TSK-type Neuro-Fuzzy Systems Design. The direct involvement of water in the retinal binding site remeron medication class was demonstrated by measuring the rhodopsin-bathorhodopsin FTIR difference spectra of rhodopsin hydrated with H2O and H2(18)O. Covalent inhibitors possess numerous advantages, including increased biochemical efficacy, longer duration of action, the high potential for improved therapeutic index due to lower effective dose, and the potential to inhibit certain drug resistance mechanisms. In this paper, a 4-stage framework (Development, Testing, Institutionalization, and Evaluation) is presented.

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