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Simpli (Azithromycin)

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Simpli is created by pharmacy specialists to struggle against dangerous infections (STD, pneumonia, bronchitis, lungs, throat or ears infections, skin infections, MAC). Target of Generic Simpli is to control, ward off and terminate bacteria.

Other names for this medication:
Azadose, Azifast, Azimac, Azimakrol, Azimit, Azinix, Aziphar, Azirox, Aziwok, Azromax, Aztrin, Azycyna, Clearsing, Doromax, Ezith, Macromax, Magnabiotic, Momicine, Neozith, Nifostin, Novatrex, Oranex, Tanezox, Tridosil, Vectocilina, Zimax, Zitrocin

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Also known as: Azithromycin


Simpli is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases. In children, it is used to treat middle ear infection, pneumonia, tonsillitis, and strep throat.

Simpli, a semisynthetic antibiotic belonging to the macrolide subgroup of azalides, is used to treat STDs due to chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex (MAC) in patients with advanced HIV disease. Similar in structure to erythromycin. azithromycin reaches higher intracellular concentrations than erythromycin, increasing its efficacy and duration of action.

Bioavailability is 37% following oral administration. Absorption is not affected by food. Azithromycin is extensively distributed in tissues with tissue concentrations reaching up to 50 times greater than plasma concentrations. Drug becomes concentrated within macrophages and polymorphonucleocytes giving it good activity against Chlamydia trachomatis.


Use Simpli as directed by your doctor.

Take Simpli by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Do not take an antacid that has aluminum or magnesium in it within 1 hour before or 2 hours after you take Simpli.

Simpli works best if it is taken at the same time each day.

To clear up your infection completely, use Simpli for the full course of treatment. Keep using it even if you feel better in a few days.

Ask your health care provider any questions you may have about how to use Simpli.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets. Do not store the liquid longer than 10 days.

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The most common side effects associated with Simpli are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Ketolide allergy. History of cholestatic jaundice/hepatic dysfunction associated with prior use.

Pneumonia: oral treatment is for mild, community-acquired cases suitable for outpatient therapy only. Discontinue if signs/symptoms of hepatitis occur. Known QT prolongation, proarrhythmic conditions, clinically significant bradycardia: avoid. Allergic symptoms may recur after initial successful symptomatic treatment. Myasthenia gravis. Hepatic or renal impairment. Elderly. Pregnancy (Cat.B). Nursing mothers.

Avoid concomitant aluminum- or magnesium-containing antacids. Monitor with digoxin, phenytoin, warfarin. Monitor for azithromycin toxicity (eg, liver dysfunction, ototoxicity) with nelfinavir. Concomitant Class 1A (eg, quinidine, procainamide), or Class III (eg, dofetilide, amiodarone, sotalol) antiarrhythmics, or others known to prolong the QT interval: avoid.

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