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Provigil (Modafinil)
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Provigil

Provigil is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Anafranil, Coreg, Lamisil, Dilantin, Arcoxia, Myambutol

Also known as: Modafinil

Description

{name} (modafinil) is a medication that promotes wakefulness. It is thought to work by altering the natural chemicals (neurotransmitters) in the brain.

{name} is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder.

Dosage

Usual Adult Dose for Narcolepsy:

200 mg orally daily in the morning

Usual Adult Dose for Obstructive Sleep Apnea/Hypopnea Syndrome:

200 mg orally daily in the morning

Usual Adult Dose for Shift Work Sleep Disorder:

200 mg orally daily one hour prior to the start of the work shift

Usual Pediatric Dose for Attention Deficit Disorder:

Not FDA approved. Reports of serious dermatologic adverse effects and psychiatric events has resulted in the FDA's Pediatric Advisory Committee unanimously recommending that a specific warning against the use of modafinil in children be added to the manufacturer's labeling; use only if first- and second-line treatments have failed and the benefits outweigh the risks. Children less than 30 kg: 200-340 mg once daily Children more than 30 kg: 300-425 mg Randomized, double-blind, placebo-controlled pediatric studies have utilized an 85 mg film-coated tablet (currently not commercially available) to provide these dosages. All studies utilized a titration method but varied the length of titration (3 weeks vs 7-9 days); clinical improvement was noted earlier in the shorter titration period.

Detailed Provigil dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Provigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Provigil if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil (Nuvigil).

To make sure Provigil is safe for you, tell your doctor if you have:

angina (chest pain); cirrhosis or other liver problem; kidney disease; high blood pressure, heart disease, or history of heart attack; a history of mental illness or psychosis; or history of alcoholism or drug addiction.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Provigil can make certain birth control less effective. Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment. Talk with your doctor about the best methods of birth control to use while taking Provigil.

It is not known whether modafinil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Provigil is not approved for use by anyone younger than 17 years old.

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Rapid purification of recombinant human tumor necrosis factor beta. Salivary gland infiltrates (sialitis) were also delayed in animals injected with both CD 4 and CD 8 antibodies though the degree of protection was less pronounced than that seen for insulitis. Inflammation (high serum CRP) and malnutrition (low serum albumin) in patients on haemodialysis are significantly associated with carotid atherosclerosis. Central odontogenic fibroma: new findings and report of a multicentric collaborative study. Pathological changes of the internal organs in injuries to earthquake victims. Hematocrit changes, status of iron stores, incidence of peritonitis, and dosage of Erythropoietin.

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At 1 year follow-up, physiological and psychological benefits remained significantly improved from baseline. Effective mass anisotropy of HgBa2Ca3Cu4O10 measured on a microcrystal by means of miniaturized torque magnetometry. Effects of the pyrethroid insecticide, deltamethrin, on respiratory modulated hypoglossal motoneurons in a brain stem slice from newborn mice. The amino acid sequence of human AT1 receptor deduced from its base sequence has 359 amino acids and showed a high degree of sequence identity to bovine and rat AT1 receptor sequences. Importance of using two-dimensional echocardiography in familial supravalvular aortic stenosis. A simple method to obtain long-term access to the biliary tree in dogs and pigs is presented. Simulation of vascular surfaces: differential saturation with glycosaminoglycans and their quantitative analysis. A new en bloc stain for cell membranes: tannic methylamine tungstate. Temporal variation of titers of serologic reactions in the chronic phase of Chagas disease and its possible clinical correlation. Serum markers and clinical data in diagnosing pancreatic cancer: a contrastive approach.

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Neuroprotective effect of a new variant of Epo nonhematopoietic against oxidative stress. The experiment was carried out on male Wistar rats, of 180-220 g body weight. Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Disorder-induced enhancement of the quantum size effects in quantum wires with a tunnel barrier. Advantages of the microagglutination test were that it required less time to perform, had a shorter incubation period, and used less antigen. Blockade of leukocyte function-associated antigen (LFA-1) in a murine model of lung inflammation. However, high levels of aggression have been observed between males under both laboratory and field conditions. Allergic reactions to house dust mites of the genus Dermatophagoides play an important role in the pathogenesis of asthma and other atopic diseases. Our experience shows that even a relatively new extracorporeal membrane oxygenation program can play an important role in that capacity and provide excellent outcomes for the sickest patients. Dietary restriction resulted in loss of body and liver weights, hepatic protein, free-alpha-amino nitrogen and RNA contents and liver cell size (liver weight/DNA ratio).

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Electrophoretic separation of creatine phosphokinase isoenzymes on acetate cellulose film. The mechanisms behind the observed responses were analysed and we also attempted to determine the physiological role of the sympathetic supply to the jejunal mucosa. WHO immunization programme and hospital procedure in the Melut district, upper Nile region, south Sudan, in the year 1983 (report). The developed methodology and tool are both flexible and easy to adapt to different regional contexts, allowing the user to introduce the regional relevant parameters identified on the basis of user expertise and regional data availability. The nature of the changes has been studied at 7 weeks after externalization using simple morphometry and a number of cytokinetic techniques (thymidine labelling, vincristine-induced metaphase arrest and the fraction-of-labelled-mitoses method), and comparisons drawn with the normal ileum. The effect of a new H2-antagonist, famotidine, on theophylline pharmacokinetics was compared with placebo and cimetidine in 26 patients affected by COPD. Interestingly at all levels of theory, we found that the most stable methylcarbamic acid conformer is significantly lower in energy than the lowest energy glycine conformer.

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A large proportion of referred patients had refractive problems only. This is a disadvantage for mechanistic studies, especially since BN rats have poor fertility. Addition of 17 beta-estradiol in the cell survival assay system partially abrogated the modulatory effect of verapamil. Snail, a zinc finger transcription factor, induces an epithelial-mesenchymal transition (EMT) in various cancer and epithelial cells. Phase transitions and superconductivity of black phosphorus and phosphorus-arsenic alloys at low temperatures and high pressures. Their use, as single agents or combination, is helpful in positive and differential diagnosis and provides nosological informations. This monitoring technique is a useful guide to the safety of temporary clipping during aneurysm surgery. In addition, a significant complication rate was identified with this procedure. The effect of repeated mild cold water immersions on the adaptation of the vasomotor responses.

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The anatomy of the venous system in the lower limbs is divided into a superficial network lying over the superficial aponevrosis. The effect of voluntary contraction on cortico-cortical inhibition in human motor cortex. Three-dimensional simulation of epicardial potentials using a microcomputer-based heart-torso model. Fibroblast interferon purified to homogeneity with regard to molecular weight also increased the spontaneous cytotoxicity of lymphocytes. Hmg2p stability was strongly affected by modulation of the mevalonate pathway through pharmacological or genetic means. Thus, 12 out of 25 patients with acute myeloid leukaemia and all of 5 patients with acute myelomonocytic leukaemia as well as 4 out of 5 patients with acute lymphatic leukaemia had increased serum beta 2-m levels.

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Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) measurements of the right coronary artery were determined both prior to and following the administration of AMI 227. Cellular differentiation: a theory based on simulation with computer graphics. As matrix is deposited onto these scaffolds, the global compressive properties increase. Given the limited number of dedicated components in auxin signaling, distinct properties among the ARF family probably contribute to the establishment of multiple unique auxin responses in plant development. Inflammatory mediators and the generation and release of reactive oxygen species by airway epithelium in vitro. Type I interferon was released from human lymphocytes cultured on cells infected with Herpesvirus and fixed with glutaraldehyde. Isolation of noncollagenous proteins from gingival connective tissue. The community-medicine specialist--Britain mandates health service reorganization.

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