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Prandin (Repaglinide)
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Prandin

Prandin is used to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Prandin helps your body regulate the amount of glucose (sugar) in your blood.

Other names for this medication:
Eurepa, Novonorm, Rapilin, Regan, Reglide, Repaglinide, Repamon, Repide

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Also known as: Repaglinide

Description

{name} (repaglinide) is an oral diabetes medicine that helps control blood sugar levels by causing the pancreas to produce insulin.

{name} is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

{name} is not for treating type 1 diabetes.

Dosage

Usual Adult Dose for Diabetes Type 2:

Individualize therapy: Dose preprandially 2, 3, or 4 times a day -For patients not previously treated with antidiabetic agents or whose glycosylated hemoglobin (HbA1c) is less than 8%: Initial dose: 0.5 mg orally with each meal -For patients previously treated with antidiabetic agents or whose HbA1c is 8% or higher: Initial dose: 1 or 2 mg orally with each meal Dose Adjustments: Based upon blood glucose response, double the preprandial dose up to a maximum meal time dose of 4 mg until satisfactory glycemic response is achieved; allow at least 1 week to assess response after each dose adjustment. Recommended Dose Range: 0.5 to 4 mg orally with each meal Maximum Daily Dose: 16 mg per day Comments: -Fasting blood glucose concentrations are generally used to adjust doses, however, postprandial glucose levels may be used in patients whose pre-meal blood glucose levels are satisfactory but whose overall glycemic control (HbA1c) is inadequate. -When hypoglycemia occurs in patients taking this drug in combination with a thiazolidinedione or metformin, the dose of this drug should be reduced. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Detailed Prandin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A repaglinide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Prandin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

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Calculation of the magnetic flux density distribution in type-II superconductors with finite thickness and well-defined geometry. Myoblasts were pre-treated with the antioxidant N-acetylcysteine (NAC) or the glutathione depleter, diethyl maleate (DEM), and injected into infarcted murine hearts. Preclinical management of the emergency by the established physician. To evaluate the presence of VcA-3 as an indicator of toxigenicity and as an epidemic strain marker, phage production and the presence of phage and cholera toxin genes were assayed in 98 strains of V. Searches were applied to the following electronic databases: the PubMed (1977-2008), the Cochrane Library, EMBASE, AMED, Chinese BioMedical Literature Database, and CBM. To help obviate these problems a one-stage method of immediate palatal reconstruction was needed to obturate the palate and restore facial contour. Acute cardiovascular, antiarrhythmic and toxic effects of tetrodotoxin (TTX) in unanesthetized dogs. These genes specify terminal as distinct from central cell fates, program pattern along the anteroposterior and dorsoventral axes of the termini, and also control endoderm specification and terminal morphogenetic movements. We tested the hypothesis that multiphasic, low-dose monophasic, and high-dose monophasic oral contraceptives share a common protective effect against functional ovarian cysts.

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The role of occult hepatitis B virus (HBV) infection and Torque teno virus (TTV) infection in the development of hepatocellular carcinoma (HCC) in chronic hepatitis C patients is still uncertain. The overall rate of malformations was 120 per 1000 in the study group and 123.9 per 1000 in the control group. Muscarinic M2 and M3 receptor subtypes have been pharmacologically distinguished in airway smooth muscle. It was most active at pH 8.8 for the hydrolysis of Boc-Ala-Ala-Pro-Glu-pNA. In four dogs we studied the effects of histamine doses of 0.05, 1.0, and 20 mg.

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Turbulent stress measurements downstream of six mechanical aortic valves in a pulsatile flow model. Natural killer- and antibody-dependent cellular cytotoxicity potentials of malignant and non-malignant lymphocyte subsets and the effect of alpha-interferon. Andrographolide inhibits arrhythmias and is cardioprotective in rabbits. Cell-specific down-regulation of the beta 3-adrenergic receptor. Factor IXa binding was found to be particularly efficient to peptide corresponding to the factor VIII sequences Lys1804-Lys1818 and Glu1811-Gln1820. Three parameters representative of the rheologic properties of blood were investigated: whole blood filtrability, red cell filtrability and morphology.

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Decreased antibody-dependent cellular cytotoxicity in minimal change nephrotic syndrome. To recommend guidelines for the management of tuberculosis (TB), particularly in high-risk groups including poor and homeless people, aboriginal Canadians, immigrants from countries where TB is highly prevalent and people with HIV infection. We have measured the binding of 125I-collagen in denatured conformation to antibodies and to cold-insoluble globulin (CIG) in sera of patients undergoing orthopedic surgery. Progesterone concentration in defatted milk of dairy cows in early pregnancy. Tunneling nanotubes mediate rescue of prematurely senescent endothelial cells by endothelial progenitors: exchange of lysosomal pool.

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First-round treatments following diagnosis were analysed, using multiple logistic regression to adjust for confounding. Neuritic deposition of agrin on culture substrate: implications for nerve-muscle synaptogenesis. Serum inhibin levels also declined with aging, with serum concentrations significantly lower in men older than 40 and markedly lower in men over 80 years old. The utility of the distance geometry approach for analysis of data and design of experiments is discussed. Similarly, when the load force decrease rapidly, it was depressed to 11.1-12.9 ms and 10.6-16.4 ms, respectively. To distinguish among these possibilities, lateralization of spoken language, signed language, and nonlinguistic gesture have been compared in deaf and hearing individuals. These gas chromatographic/mass spectrometric methods are highly specific tests which can be used on a routine basis for the confirmation of 19-nortestosterone administration to athletes as well as for therapeutic monitoring following administration of the drug.

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The outcome of our study indicates that the development of the novel RT-qPCR-IA will provide rapid and accurate evaluation of the inhibitory efficacy of compounds towards HIV-RT activity. Synovial chondrometaplasia: a case report with spontaneous regression and a review of the literature. DNA degradation was enhanced twelve-fold in the presence of iron and GHQ and three-fold in the presence of iron and glutathione (GSH) as compared to iron alone. Much of the research on managing emotional needs after cancer has been completed with breast cancer survivors and more work is needed with diverse groups of survivors. Calcium requirement in compound 48/80 induced histamine release from rat mast cells in vitro.

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The application of OT technique in humans demands more clarity and further development of this technique may successfully prove its utility as an effective treatment for oocyte incompetence. Intervertebral disk repair by protein, gene, or cell injection: a framework for rehabilitation-focused biologics in the spine. Lipoprotein composition in insulin-dependent diabetes mellitus with chronic renal failure: effect of kidney-pancreas transplantation. Indications for paediatric tonsillectomy GP versus Consultant perspective. Use of a therapeutic scoring system in the intensive care of severe traumas. Phylogenetic relationships within the complex have been difficult to determine, because there are groups of closely related species, as well as individual species, that are highly divergent. A comparison of the utilization of thymine and thymidine as precursors for deoxyribonucleic acid synthesis in Bacillus subtilis, and their specific inhibition by 6-(p-hydroxyphenylazo)uracil and caffeine. Intracellular signal transduction by kinase-mediated phosphorylation is essential for the survival and growth of lymphoma cells.

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The use of 99Tcm-Technegas in the investigation of patients with pulmonary thromboembolism. Profilin-1 is a ubiquitous, actin-binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. In contrast to this, animals inoculated with cells underexpressing uPA developed hind limb paralysis significantly later (days 25-29 postinoculation) and displayed decreased tumor metastasis. The axon hillocks and initial segments of both neuronal types receive a synaptic input, which is more common on spiny cells. NMR microscopy has been used to monitor the formation of the gel layer in hydrating hydrophilic polymer tablets. Here, we show that DWARF catalyses the C-6 oxidation of 6-deoxocastasterone (6-deoxoCS) to castasterone (CS), the immediate precursor of brassinolide.

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Stable association of viral protein VP1 with simian virus 40 DNA. Subsequently, limited targets for an intervention can be defined. The need for balancing invasiveness and adequacy of sellar tumor exposure has recently led to the description of multiple endoscopic endonasal transsphenoidal approaches. In this paper, we rely on a particular factorization of the rotation matrix to simplify the mechanical formulation of systems containing rigid bodies. We hope that knowledge from apparently disparate fields of science and medicine integrated into a working theoretical framework will allow generation and testing of new hypotheses on the pathophysiology and diagnosis of trandate generic name , and therapy for, a variety of human illnesses reflecting systematic alterations in the principal effectors of the generalized stress response. Phonon scattering and energy relaxation in two-, one-, and zero-dimensional electron gases. These two cell types also exhibit different patterns of alpha v beta 3 localization in vitro, possibly as a result of developmental differences in ligand-binding properties. Immunohistochemical stains for phosphatase and tensin homologue (PTEN), phosphorylated Akt, mTOR, S6 and 4E-BP1 were performed for 887 cases, and the results were correlated with clinicopathological characteristics.

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The relationship between daphnetin analgesia and central neurotransmitters of monoamines. The effects of changed mechanical properties of the middle ear on bone conduction are usually not considered in patients who simultaneously suffer from middle ear and inner ear diseases. This was accompanied by no significant change in the proportion of PBMCs bearing the gamma delta-T-cell receptor antigens. This led to the conclusion that the metatarsal artery should be used for toe MP joint grafts, while the unilateral proper digital artery is suitable for toe PIP joint grafts, together with indocin and alcohol concomitant or dorsal cutaneous vein. Determination of unbound L-tryptophan in human plasma using high-performance liquid chromatography with fluorescence detection.

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Anti-idiotypic immune responses against adjuvant-free isologous IgM monoclonal antibodies and their augmentation by complex formation between IgM and albumin in bovine serum. Hypothalamic VIP immunoreactivity, however, was found to be unchanged in the three strains of mutant mice, indicating that the high concentration of VIP in the hypothalamus does not derive from the adenohypophysis through retrograde flow. infection, BALB/c mice (Itys) were not able to control the growth of S. Erratum: Large and irregular shift of photoluminescence excitation spectra observed in photochemically etched porous silicon. Levels of IGFBP-1 and -3 in the medium were measured by EIA and RIA, respectively and binding activities of these IGFBP were evaluated by Western ligand blot.

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Universal poroelastic mechanism for does alcohol affect effexor hydraulic signals in biomimetic and natural branches. Spiral water-fat imaging with integrated off-resonance correction on a clinical scanner. Recurrent inversion of the puerperal uterus managed with the Ocejo operation. Dental caries experience, periodontal health, and oral hygiene status were recorded using decayed, missing, and filled surfaces (DMFS), periodontal index (PI), and simplified oral hygiene index (OHI-S). The symptoms or deficits are related to psychological factors but not intentionally produced or feigned. Thus, this response is unique in that it can be driven by either of two Ags. We investigated the effect of endogenous and exogenous nitric oxide (NO) on the release of irET-1. Monte Carlo simulation of cluster diffusion in a triangular lattice.

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