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Nuvigil (Armodafinil)
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Nuvigil

Nuvigil is currently FDA-approved to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is commonly used off-label to treat attention deficit hyperactivity disorder, chronic fatigue syndrome, and major depressive disorder. It has been shown to improve vigilance in air traffic controllers. Nuvigil is approved by the U.S. FDA for the treatment of narcolepsy and shift work sleep disorder, and as an adjuvant therapy for obstructive sleep apnea. For narcolepsy and obstructive sleep apnea, Nuvigil is taken as a once daily 150 mg or 250 mg dose in the morning. For shift work sleep disorder, 150 mg of Nuvigil are taken one hour prior to starting work. Slow dose titration is needed to mitigate some side effects.

Other names for this medication:
Armod, Armodafinil, Biryth, Waklert

Similar Products:
Abilify, Silagra, Zetia, Aldara, Nimotop

Also known as: Armodafinil

Description

{name} (armodafinil) is a medication that promotes wakefulness.

{name} is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder.

Dosage

Take Nuvigil exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Nuvigil may be habit-forming. Never share Nuvigil with another person, especially someone with a history of drug abuse or addiction. Selling or giving away this medicine is against the law.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Nuvigil is usually taken each morning to prevent daytime sleepiness, or 1 hour before the start of a work shift to treat work-time sleep disorders.

You may take this medicine with or without food.

Nuvigil is usually given for up to 12 weeks. Follow your doctor's instructions.

If you are taking this medicine to treat sleepiness caused by obstructive sleep apnea, you may also be treated with a continuous positive airway pressure (CPAP) machine. This machine is an air pump connected to mask that gently blows pressurized air into your nose while you sleep. The pump does not breathe for you, but the gentle force of air helps keep your airway open to prevent obstruction.

Do not stop using your CPAP machine during sleep unless your doctor tells you to. The combination of treatment with CPAP and Nuvigil may be necessary to best treat your condition.

Taking this medication does not take the place of getting enough sleep. Talk with your doctor if you continue to have excessive sleepiness even while taking this medicine. Nuvigil will not cure obstructive sleep apnea or treat its underlying causes. Follow your doctor's instructions about all your other treatments for this disorder.

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Nuvigil is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Detailed Nuvigil dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, diarrhea, confusion, feeling restless or excited, fast or slow heart rate, chest pain, trouble sleeping, or hallucinations (seeing or hearing things that are not real).

Storage

Store at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Nuvigil is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Nuvigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: street drugs (such as methamphetamine, MDMA/"ecstasy").

This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication and for 1 month after stopping this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.

Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products or diet aids).

Caffeine can increase the side effects of this medication. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas), eating large amounts of chocolate, or taking nonprescription products that contain caffeine.

Nuvigil is very similar to modafinil. Do not take medications containing modafinil while using Nuvigil.

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Analytic survey of the information retrieval properties of methodologic MeSH terms and textwords selected to detect studies meeting basic methodologic criteria for direct clinical use in general adult medicine. Solid state NMR imaging of irreducible water in reservoir cores for spatially resolved pore surface relaxation estimation. The indications for and the efficacy of the desympathization in various levels of the main arterial bed affection are discussed. The transplanted patient should be closely followed, both early after transplantation and consistently thereafter, for early detection of such complications. How transcription factors affect chromatin structure to regulate gene expression in response to changes in environmental conditions is poorly understood in the green lineage. Effectiveness and risks related to enteric decolonization with oral streptomycin for glycopeptide-resistant enterocci carriers. Visual-optical characteristics of caged and semifree-ranging monkeys. To assess the analgesic efficacy compared with standard of care is the primary goal. Initially, investigators concentrated on clinical descriptions and diagnostic criteria. Concurrently measured withdrawal jumping was not affected by these drugs, and the sensitivity to the hypothermic effects of these drugs was reduced.

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ABCA12 is a member of the large superfamily of ATP-binding cassette (ABC) transporters, which bind and hydrolyze ATP to transport various molecules across limiting membranes or into vesicles. Brain shift and pneumocephalus are major concerns regarding deep brain stimulation (DBS). Systemic diseases can have direct and indirect effects on oral health, and, likewise, poor oral health can impact general health and wellbeing. The association between mountaintop mining and birth defects among live births in central Appalachia, 1996-2003. From these results, a possible mechanism of protein synthesis induced by malotilate can be proposed as follows: malotilate primarily affects the post-transcription process, promoting the RNA synthesis in the nuclear fraction without any changes of DNA synthesis, and these consequent increases of the polyribosomal RNA and t-RNA synthesis result in the enhancement of protein synthesis. DWIBS at 3T MR has the distinct advantages in detecting pelvic lymph nodes of cervical cancer. PGE1 did not significantly stimulate insulin secretion at glucose concentrations of 4.4 mM or less, but did at glucose concentrations of 8.8 mM or more, PGE2 augmented insulin release at 4.4 and 16.7 mM glucose, but not in the absence of glucose.

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Expression of Eph receptors and their ligands, the ephrins, have important functions in boundary formation and morphogenesis in both adult and embryonic tissue. Comorbid conditions contribute importantly to both total mortality and breast cancer-specific mortality among breast cancer survivors. Anticonvulsive effect of folic acid in homocysteine thiolactone-induced seizures. Glassy cell carcinoma of the colon with human chorionic gonadotropin-production. When both groups were considered together, there was a strong correlation between fasting ATLPL of both regions, and between the insulin responsiveness of gluteal ATLPL and abdominal ATLPL after a 6-hour infusion. In addition, when a series of 6 other anti-Ia monoclonal antibodies previously described were analyzed in a checkerboard test of binding inhibition at the cell surface level, they were found to closely mimic the reactivity pattern of either D1-12 or D4-22 antibody, suggesting that NG1 and NG2 Ia subsets express independent clusters of highly immunogenic epitopes.

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Niobium plates were electrochemically treated by Plasma Electrolytic Oxidation (PEO) with electrolytes containing phosphorous and/or calcium. We report a retrospective series of 850 patients treated by external irradiation for carcinoma of the eyelid at Institut Curie and we compare our results with other techniques: brachytherapy and surgery. Effects of peripherally and centrally acting analgesics on somato-sensory evoked potentials. The latter can have diverse clinical presentations and may be mistaken for SIADH. The modified drawer test has an improved reproducibility and correlation to generalized joint laxity over the conventional tests. A positive paternal germline selection has been reported for this mutation. All three groups of diabetics showed normal LDL cholesterol levels but lowered HDL cholesterol values, most pronouncedly in group II. Comparative study of infusion therapy options in patients with hemorrhagic shock.

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The linearized multistage model of carcinogenesis was used in the second method--the results obtained were highly conservative. Changes in the liver after penetration of a stomach ulcer into it (experimental-morphologic study). therapy would strongly support the hypothesis that SC DFO allergy is related to a direct effect on dermal mast cells and is not an immunological reaction. Unfortunately, there are few data regarding clinical features and epidemiology of alopecia areata in Korean patients, and its clinical course and treatment response rates are unpredictable. A rapid test-and-treat intervention, consisting of multiplex PCR testing of rectal swabs taken at enrolment, accompanied by targeted antimicrobial therapy if treatable pathogens were detected, was compared to the reference standard of no stool testing. Biochemical changes in the visual cortices of the mice after optic nerve ligation.

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A spin label consisting of cytidine substituted in position C5 with an 11-atom-tethered 5-membered ring nitroxide (DCAVAP) was incorporated into linear (dG-dC)n with Micrococcus luteus DNA polymerase or into a specific 34-bp Z-DNA-forming region of the 2.7-kb plasmid pRDZ8 with Thermus aquaticus DNA polymerase (Stoffel fragment). While popularly used, there is a dearth of knowledge concerning the experiences of CAM practitioners in terms of treating individuals with AS. Neuroendocrine cells in the gastrointestinal tract of wild boar. It most commonly is unilateral, is found almost exclusively in diabetics, is associated with gas-forming coliform bacteria, and is characterized by the presence of gas within the renal parenchyma. We postulate that this assembly domain is also found in myosin II from other species. Microscopic silicone in various tissues in the bodies of females with breast implants has led to the possible incrimination of these implants with connective-tissue disorders. Platelet-activating factor (PAF), a naturally occurring phospholipid, is a potent activator of various biological processes, including platelet aggregation.

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Chara plasmalemma at high pH: voltage dependence of the conductance at rest and during excitation. Here, we summarize our current view of the NPC as a dynamic hub for the integration of chromatin regulation and nuclear trafficking and discuss the functional interplay between nucleoporins and the nuclear genome. alpha 2-Macroglobulin was purified from plasma of five cystic fibrosis patients and five normal controls. These findings offer a molecular explanation for the typical scattered tumour cell growth in infiltrative lobular breast cancer. This report chronicles management of the case during the mixed dentition period. Cyclase response element-binding protein immunoreactivity was not altered in the dorsal or ventral striatum following acute or repeated amphetamine.

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Cell surface charge and cell division in Escherichia coli after X irradiation. Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired haemolytic disorder caused by the absence of glycosyl phosphatidylinositol (GPI)-anchored surface proteins resulting from a defect in one step of GPI-anchor biosynthesis. Interaction of nitric oxide with photoexcited rose bengal: evidence for one-electron reduction of nitric oxide to nitroxyl anion. Linear tri- and tetrapeptide precursors of 2,5-piperazinedione were prepared and their conversion to spirocyclic dipeptidase enzymes, the spirocyclic dipeptides (SpDp) were generated from the precursors by a two-step mechanism consisting in the proteolytic release of the C-terminal dipeptide ethyl ester and its subsequent spontaneous cyclization. For jitter and shimmer estimation, direct sampling or the use of a video cassette recorder with pulse code modulation are clearly superior. Morphology alone is inaccurate in discriminating lesion pathology, and use of EUS-guided FNA (EUS-FNA) improves accuracy.

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However, dual loading of iron and copper resulted in elevated concentrations of brain non-heme iron and copper in 15- and 63-d-old xanax drug pill rats compared with animals loaded with iron alone. CNTs are also increasingly functionalized post-synthesis with organic or inorganic agents to modify or enhance surface properties. Absence of the anomalous second length scale in the bulk of a terbium single crystal. Our data also implicate flotillin-rich actin-dependent membrane microdomains in T-lymphocyte uropod formation. Since a number of growth factors signal via protein tyrosine kinase, in this study we examined a possible involvement of protein tyrosine kinase in the IL-1 alpha-induced NF-kappa B. The soluble fractions, detected in the cells and influencing RNA synthesis, interact with RNA polymerase either increasing or decreasing the activity of the enzyme.

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To characterize the molecular determinant responsible for H-Y specific serological activity, H-Y positive immunoabsorbent cells were first subjected to various treatments which alter protein or carbohydrate structure and then tested for their ability to absorb H-Y antisera. The characteristics of these lesions and surgical conditions implicate the endoilluminator as the source of photic injury. We investigated the association between retinal vascular calibers and the long-term risk for stroke and its subtypes with particular focus on intracerebral hemorrhage. Sonography gave information concerning the phonema of resonance and articulation: a modification of the method, which also permitted sound production through an electroacoustic transductor kept in contact with the prelaryngeal skin, was made. How important is the CO2 chemoreflex for the control of breathing?. Patients received radiotherapy up to a planned total of 60-66 Gy, in 2 daily fractions of 1.5 Gy each and either lonidamine (450 mg p.o. Strictures have multiple causes and may be an important indicator of underlying abnormalities.

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Calcium uptake by isolated microvillous membranes was time dependent. A novel beta-galactosidase gene isolated from the bacterium Xanthomonas manihotis exhibits strong homology to several eukaryotic beta-galactosidases. This entity should be considered and appropriate screening tests performed in young patients with unexplained ischemic stroke or transient ischemic attack. The accuracy and consistency of these methods were then evaluated. Follow-up of these patients has shown that regular self-infusion at home is feasible and safe. Similarly, low contrast makes accurate border detection difficult. Prostaglandin E1 does not inhibit production of TNF and IL-1 by mononuclear cells after head-neck surgery. Taxonomy, prevalence, and experimental transmission of a protozoan parasite, Trichodina oviducti Polyanskii (Ciliata: Peritrichida) of the thorny skate, Raja radiata Donovan.

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Fluid mechanics of the stagnation point flow chamber and its platelet deposition. All patients could be tested with local anesthesia in the outpatient clinic except very young children. Simultaneous measurement of urethral opening pressure and urethral cross-sectional area during voiding generic xanax pill identifier 029 cystometry. The BMR values were compared with the calculated results from the Schofield equation (adjusted). Following posterior stabilization with a segmental instrument, pain was alleviated in all seven women, two showed improvements in neurological compromise, and performance status was improved in five. In a phantom with straight as well as constricted tubes, simulating healthy and stenotic vessels, nonpulsatile flow in the velocity range 0-1 m/sec was maintained.

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Characterization of recombinant guinea pig alkyl-dihydroxyacetonephosphate synthase expressed in Escherichia coli. To our knowledge, this was the largest study to characterize predictors of treatment seeking in adults with EDs. Study results suggest high efficacy of the loading-dose method, which was characterized by significant shortening of psychosis duration (five times shorter in experimental vs. Therefore, effective interventional strategies to prevent or alleviate muscle disuse atrophy should include both exercise (mimetics) and appropriate nutritional support. We aimed to construct a novel nano-assembly carrying apigenin (APG), a hydrophobic drug, and to evaluate its in vitro targeting ability for A549 cells overexpressing CD44 receptors. The usage of mannitol or dextran resulted in sticky powders and low yields, so further testing was not possible. Unilateral cryptorchidism was induced in newborn rats and when the rats reached adult age Leydig cell morphology and steroid biosynthesis were compared in scrotal and abdominal testes. The switch from Keppra to epitiram was easy and safe in our population, and epitiram can be considered as effective and tolerable as Keppra.

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The hereditary spastic mouse was studied as a model of cerebral palsy in childhood to test the hypothesis that intramuscular botulinum toxin A would prevent the development of calf-muscle contractures. Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. The constitutive and inducible hepatic cytochromes P450 of various feral Cricetid rodents (family Cricetidae, comprising various New World rats and mice, hamsters, gerbils and voles), have been examined in a relatively limited number of field and laboratory investigations. Psoriasis patients were compared to 884653 healthy control patients by a multivariate analysis adjusted for age, sex, country of origin, socio-economic status, cognitive skills and body mass index. It encodes a 9 kD protein showing a strong similarity with its human counterparts and to a lesser extend with its yeast counterparts. In pemphigus circulating IgG is present with the desmosomal cadherins desmoglein (Dsg) 1 and 3.

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The patient did not show any abnormalities of the extremities which contrasts with the finding of one previously reported patient with an overlapping deletion presenting with split hand and foot malformation (SHFM). Activated monocytes cultivated on calcium phosphate tablets led to cellular morphological modifications and to changes in the number of nuclei (from d 2 to 14). A woman was found to have 42 autosomes due to engagement of both chromosomes 14 in Robertsonian rearrangements, one with a chromosome 21 and the other with a chromosome 22: t(14q21q) and t(14q22q). Neonatal polychlorinated biphenyl treatment increases adult testis size and sperm production in the rat. elegans B-cell lymphoma 2 (Bcl-2) homolog cell death abnormal 9 (CED-9) associates with and remodels LIPID membranes. In the model of chlorpromazine cholestasis, TC infusion did not correct but rather aggravated cholestasis, whereas TUDC at nonsaturating doses reversed the cholestasis and only at very high doses caused some toxicity. Flap revisions were performed in 22 of the 57 patients to maximize aesthetic results. Population density gratings induced by few-cycle optical pulses in a resonant medium. We have some idea of which portions of the alpha chain of Gs interact with receptors and effectors, and we guess that the same is true of corresponding regions of other alpha chains.

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Experimental ilio-lumbar vein to iliac artery autografts were placed in 52 rats and analysed by light microscopy and histochemistry from 2 to 140 days after surgery. Selenium supplementation diminished both the depletion of vitamin C and the production of lipid peroxides, but did not affect the depletion of glutathione induced by alcohol in testicular tissue. In-situ graft viability assessment using clinical imaging devices provides comparable information to ex-vivo methods. The fourth inhibitor K252b has a moderate specificity for protein kinase C but also inhibits the three kinases just mentioned. However, antisera directed against the NP polypeptides isolated from gels did not show any cross-reaction, indicating that they lacked antibodies against the shared antigenic determinants. Proliferative potential, karyotype stability, multilineage plasticity and secretome profile make eMSC an attractive object for the regenerative medicine use. As many new drugs have not been in use for sufficiently long periods to assess their porphyrogenic activity, it is safer to avoid drugs in patients with porphyria. A smear from a leg ulcer stained by the Papanicolaou technique revealed fungi within the giant cells. Aromatases II and I are eluted with 0.25 M and 0.5 M Tris buffer, respectively, from diethylaminoethyl-cellulose column in an Mr 2 million soluble complex.

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Prospective cohort analysis with one baseline examination of relevant risk factors and 12 years of follow-up for CVD. Prevention of radiolesions of the small intestine by intrapelvic silicone breast prosthesis. Cell clones were characterized on gene expression level for PTEC markers such as P-glycoprotein (ABCB1), aquaporin1 (AQP1), and organic cation transport protein 2 (SLC22A2), and for kidney progenitor cell and podocyte markers. 1a-OH-D3, converted in the organism to the hormonal form 1.25 (OH)2D3, induces new bone formation, probably by direct influence on the cancellous bone tissue itself. Morphological and immunological comparison of caprine arthritis encephalitis and ovine progressive pneumonia viruses. Neuropeptides as central integrators of autonomic nerve activity: effects of TRH, SRIF, VIP and bombesin on gastric and adrenal nerves. The residual activity of full-length Src mutated at Tyr416 is efficiently repressed by Csk action, suggesting that regulation by C-terminal phosphorylation does not act by preventing phosphorylation at Tyr416. Endothelial cell spreading on fibrin requires fibrinopeptide B cleavage and amino acid residues 15-42 of the beta chain. Optical investigations in (In,Ga)As/GaAs quantum wells grown by metalorganic molecular-beam epitaxy.

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The impact of laparoscopy on the volume of open cases in general surgery training. The CMIT proved useful in the early immunodiagnosis of nematode infections and showed that parasite antigens purified by affinity chromatography retained a high degree of specificity and sensitivity in both the CMIT and serological tests. Induction of macrophage inflammatory protein 2 gene expression by interleukin 1 beta in rat lung. Proper positioning of this device is important for accuracy, and for some patients, minimizing the number of false positives may be challenging. Treatment of progressive muscular dystrophy with synthetic dl-a-tocopherol. Early modifications of the flow in the vertebral artery due to subclavian artery stenosis are presented. There was no evidence to suggest that the over-representation by native children pics of xanax pills blue was due to an increased propensity of Indian families to institutionalize their children nor were these patients more profoundly retarded or more physically handicapped than the non-Indian children studied. On the basis of the pattern of genetic transmission of these two characters it can be concluded that the HPFH determinant does not behave as an allele of the gamma beta delta complex.

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The present findings support the hypothesis that a decrease in inhibin production could be responsible for the secondary FSH surge observed early on estrus. The application of operative laparoscopy to gynecologic oncology. We compare our cytologic findings with those of the lesions considered in the differential diagnosis. We investigated the effects of exercise detraining on blood pressure, insulin sensitivity, cost of plavix medication and GLUT4 expression in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Mortality rates specific for these variables were projected to the nation as a whole with reference to the 1985 U.S. Our case highlights that in the setting of metastatic solid tumors, STLS must be in the differential diagnosis, to allow prompt initiation of prophylaxis and treatment.

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In five of six episodes where neutrophils were quantified on both day 1 and 2, the Il-8 peak occurred simultaneously with the neutrophil peak. Laboratory data on the eating rate of 240 foods-representing the whole Dutch diet-was obtained. The dose-response curves and interferon sensitivities of these clones were similar to those of the parent and third-generation clone from which they were derived. Expression of neural cell adhesion molecule (NCAM) in the healing process of gastric ulcer. Radiolabelled gamma ATP and gamma GTP were used as phosphate donors in vitro phosphorylation of recombinant Vpu. Assessing the need for anaerobic medium for the recovery of clinically significant blood culture isolates in children. Identify and describe representative instances of sub-optimal information management in a critical care Unit. Most studies have been conducted in this regard in CKD patients undergoing haemodialysis. A recombinant prostaglandin G/H (PGH) synthase gene has been expressed in vitro in bovine pulmonary artery endothelial cells and in vivo in rabbits by transfection with a plasmid using cationic liposomes.

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