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Leukeran (Chlorambucil)
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Leukeran

Leukeran is used to treat certain types of cancer (such as leukemia, lymphoma). Leukeran belongs to a class of drugs known as alkylating agents. It works by slowing or stopping the growth of cancer cells.

Other names for this medication:
Chloramax, Chlorambucil

Similar Products:
Protonix, Dramamine, Aricept, Dulcolax, Depakote, Myambutol

Also known as: Chlorambucil

Description

{name} is used to treat several types of cancer, including Hodgkin's disease and certain types of leukemia or lymphoma.

Dosage

The Leukeran dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Leukeran to treat
  • your weight
  • how often you take Leukeran
  • other medical conditions you may have
  • results from certain lab tests you’ll have while you’re taking Leukeran
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Leukeran is available as 2-mg tablets that are taken by mouth.

Dosage for chronic lymphocytic leukemia

The usual dose of Leukeran for chronic lymphocytic leukemia (CLL) is 0.1 mg of drug per kilogram of body weight (mg/kg). This dose is typically taken once daily.

Intermittent dosing vs. daily dosing for CLL

In some cases, doctors may prescribe intermittent dosing for Leukeran for CLL rather than daily dosing. With intermittent dosing, the drug is taken once every 2 weeks or once each month. And in these cases, the dose of Leukeran given may be different than the typical dose given.

For some people with CLL, intermittent Leukeran dosing works better than daily dosing. In addition, certain side effects, such as changes in blood cell levels, may be reduced with intermittent dosing.

Dosage for lymphoma

Below we describe the typical doses of Leukeran for certain types of lymphoma that Leukeran is approved to treat.

Dosage for certain types of non-Hodgkin lymphoma (NHL), such as follicular lymphoma (FL)

The usual dose of Leukeran to treat certain types of NHL, such as FL, is 0.1 mg of drug per kg of body weight (mg/kg). This dose is typically taken once each day.

Dosage for Hodgkin lymphoma (HL)

The usual dose of Leukeran to treat HL is 0.2 mg/kg. This dose is typically taken once each day.

Pediatric dosage

The safety and effectiveness of Leukeran hasn’t been studied in children. But in some cases, Leukeran is prescribed for children with certain conditions. (Keep in mind that this is an off-label use of the drug. With off-label use, a drug that’s approved for certain uses is given or being studied for a different use.)

Because the Leukeran hasn’t been approved for use in children, the drug’s manufacturer hasn’t recommended a typical dosage for children.

If you have questions about pediatric dosage for Leukeran, talk with your child’s doctor. They can recommend a dosage of Leukeran for your child’s needs.

What if I miss a dose?

If you miss a dose of Leukeran, call your doctor’s office. You doctor or their medical staff can help you determine when you should take your next dose of the drug. And they’ll recommend whether you should take a dose to make up for the missed dose.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

It depends. The number of Leukeran treatment cycles you’ll receive may depend on several factors. These include the type and severity of your cancer, as well as your medical history.

In one study of people with CLL, the people took chlorambucil (the active drug in Leukeran) every 28 days for up to 12 months. And a review of studies found that, across several clinical studies of chlorambucil for CLL treatment, people took between 6 and 12 treatment cycles of the drug.

Leukeran is usually given every day for 3 to 6 weeks. But your doctor may recommend that you take it once every 2 weeks or once each month.

If you have questions about how long you’ll need to take Leukeran, talk with your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include agitation, fast heartbeats, skin rash, bruising, bleeding gums, nosebleeds, trouble breathing, or signs of infection (fever, chills, weakness).

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Isosorbide mononitrate dosage information

Side effects

The most common side effects associated with Leukeran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There haven’t been any interactions reported between Leukeran and other medications, herbs, supplements, or foods.

However, taking Leukeran with other drugs that cause similar side effects may increase your risk of those side effects. And doing so may also make the side effects worse for you. (For more information about the possible side effects of Leukeran, see the section “Leukeran side effects” above.)

To help avoid possible drug interactions, talk with your doctor and pharmacist before starting Leukeran. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

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To characterize the effect of the p.Gly144Trp and p.Lys164del mutations, both of which are present in the SNARE motif of GOSR2, we examined the corresponding mutations in the yeast orthologue Bos1. Receptive field properties of cells in the isthmo-optic nucleus. As a consequence, the end of the conus medullaris is still located within the sacral canal in animals older than 2 months. They were followed up to find out how many were compliant to recall visits and the reasons for noncompliance by noncompliant patients. Additionally, 35 previously reported cases of EV myocarditis supported with ECMO are presented. Thus, beta-neurexins are essentially N terminally truncated alpha-neurexins. Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylate cyclase and promotes proliferation of mouse primordial germ cells.

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Kinetic and equilibrium metal-ion-binding behaviour reflected in a metal-ion-dependent antigenic determinant in bovine prothrombin. Our findings suggest that the antigen cross-reacting with BP and its fragments in CSF appears in a spectrum of molecular weight species, with lower forms predominating in MS. Objectives and outcome of running an early inflammatory arthritis clinic. Thus, identification of the correct cause will help in implementing appropriate therapy. Stimulation by RCS cells also occurred with normal lymph-node cells from F1 hybrids, SJL/J times C57Bl/6, and SJL/J times ASW and from the H-2s identical ASW mouse strain. The effect of voluntary breathing (hyperventilation or breath holding) on the cardio-vascular system and the CNS in hypoxic conditions revealed a phasic dynamics of adaptation to hypoxia and intensification of cardio-vascular function on 6000 m. Verification of the origin of the supernumerary marker chromosome by SNP-array has provided a basis for prenatal genetic diagnosis.

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