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Klonopin (Clonazepam)
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Klonopin

Klonopin is one of the products that belong to the bensodiazepine group and have a strong sedative effect. It is widely used among people with severe panic attacks and anxiety caused by depression treatment. Thanks to its unique features, Klonopin helps to stop convulsions and epileptic seizures.

Other names for this medication:
Almac, Alrest, Anxrea, Calmnir, Clodep, Clonapax, Clonatrac, Clonax, Clonaxyl, Clonazepam, Clonoasig, Clonopam, Clopam, Closis, Clotas, Clozipam, Clozorix, Deptune, Dipwell, Easyfeel, Eminaz, Epicloz, Epitril, Epizam, Estalonix, Ezinite, Jbcloz, Klopam, Nazee, Nupam, Onapil, Ozepam, Prasilex, Prasilife, Sezolep, Somnolex, Somnotril, Xitzen, Zepam, Zepamax, Zeptril, Zicam, Zolpidox

Similar Products:
Cipro, Maxalt, Casodex, Levlen, Dilantin

Also known as: Clonazepam

Description

{name} (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

{name} is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

{name} is also used to treat panic disorder (including agoraphobia) in adults.

Dosage

Take this medication by mouth as directed by your doctor, usually 2 or 3 times daily.

Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose, take it more often, or take it for a longer time than directed.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

Overdose

Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Side effects

The most common side effects associated with Klonopin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of clonazepam in children with seizure disorders. However, safety and efficacy in children with panic disorder have not been established.

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L-threo- or L-erythro-gamma-methyl-glutamyl are not carboxylated but both corresponding peptides are inhibitors of the reaction. Plasma exchange in the treatment of acute renal failure due to low molecular-weight dextran. Cell cycle analysis of lymph node cells shows that subpopulations of developing B cells retain the cell cycle profiles of their bone marrow counterparts. While thrombin had no effect, plasmin and trypsin converted low-affinity platelet factor 4 to a species with the same electrophoretic mobility and isoelectric point as beta-thromboglobulin. No adverse effects related to G-CSF administration were noticed. A systematic comparison of the risks of stroke and death due to carotid endarterectomy for symptomatic and asymptomatic stenosis. Endothelin stimulates phosphatidic acid formation in cultured rat mesangial cells: role of a protein kinase C-regulated phospholipase D. To describe the clinical, biochemical and molecular profile of WS in a tertiary care hospital in Mexico. Inactivation of the enzyme was found to coincide with the dissociation of the heterodimeric enzyme complex into subunits. Changes in resistance rates may be associated with outbreaks of resistant clones in K.

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Neurohormonal imbalances of prolactin and melatonin, with restricted blood flow to internal organs, may be the principal causes of aberrant reproduction, growth, and maturation in livestock consuming endophyte-infected tall fescue. Florida finds a practical solution for a vexing problem: a new form enables terminally ill patients and/or their legal designates to assure that EMTs respect their right to refuse resuscitation. Effect of Commiphora mukul (gum guggulu) in patients of hyperlipidemia with special reference to HDL-cholesterol. When the virus present in such early surviving cells was used to infect BHK-21 cells, it proved to be as virulent as the initial cytolytic FMDV and, furthermore, its ability to kill BHK-21 cells increased upon replication in the surviving cells. Amniotic fluid gamma-glutamyl transferase activity in trisomy 21 and neural tube defects. Cultures were incubated with BrdU for 30 min and fixed either immediately or after a delay of several hours. Working with dental school admissions committees to enroll a more diverse student body.

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Interference of scattering pathways in Raman heterodyne spectroscopy of multilevel atoms. We introduce an interactive, open source cheminformatics tool known as DataWarrior for herbicide discovery, complete with records for over 300 herbicidal compounds. Although both intravenous dipyridamole and adenosine have been used, the magnitude of hyperemia induced by these agents and the hyperemia to baseline blood flow ratios have not been quantified and compared. The combined sensor system provides reproducible SERS signals only in the presence of perfectly matched target DNAs, to probe DNAs as a result of single-stranded DNA-specific degradation by S1 nuclease. Statin Use and Risk of Community-Acquired Staphylococcus aureus Bacteremia: A Population-Based Case-Control Study. Most of the diagnoses of the patients were solid tumors with breast, colorectal, renal, and gastrointestinal. Recent advances have changed traditional concepts regarding late treatment and mechanisms of NAC action, but significant gaps in understanding persist.

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Three incidents of metabolic acidosis during hemodialysis in 3 different patients are presented. This approach could be adopted for population-based screening aiming to prevent this disease. Initiating inspiration outside the medulla does produce eupneic breathing. The majority of ovarian cancers in children and adolescents are stage I at diagnosis and conservative management with preservation of fertility is often possible. A computational fluid dynamics (CFD) software package, TASCflow, was used to model flow within a commercially available pump, the Aries Medical Isoflow Pump.

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PARP-1 upregulation and PAR polymer formation, indicative of PARP-1 activity, were observed during the first postnatal week simultaneously with the presence of abundant dying cells, some of which were not associated with active caspase-3. Our data suggest that ubiquitylation of Rad23 plays a stimulatory role in the degradation of ubiquitylated substrates by the proteasome. Plasma renin activity increased in each group, but the increases were significantly lower in the pregnancy groups as compared with the nonpregnant group. Thermodynamics and structure of liquid binary alloys calculated using an analytic pair potential. The objective of the study was to quantitatively investigate effects of alignment and joint types on mechanical properties of the thermoplastic articulated AFO. The affinity enrichment process commonly known as biopanning relies on subjecting a library of peptides on filamentous phage to a selection for binding to the target immobilized on solid support or in solution. The potential of synthetic and natural amphetamines to modulate cellular immune effector and regulatory mechanisms was evaluated in an in vitro exposure system. Over the past few years, considerable efforts and resources have been expended to detect, monitor, and understand at the basic level the many different facets of emerging and increasing resistance.

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Laser activation of tissue sealant in hand-sewn canine esophageal closure. Using belief networks to enhance sharing of medical knowledge between sites with variations in data accuracy. Adafenoxate (especially in high concentrations) markedly relaxed the NA-contracted arterial preparations. All patients demonstrated gradual resolution of calcific deposits after 1-3 weeks. Studies based on data in the SNRUBC have shown inequalities in survival and treatment indication by gender, regions and hospital volume. Evaluative data were collected from clients, their informal carers, community nurses, and general practitioners. Human cells metabolized this compound quite differently than cultured rat hepatocytes. Compression of the left renal vein (LRV) between the superior mesenteric artery and the aorta has been termed the nutcracker syndrome.

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However, when rabbit antiserum against PCBP was added to rat platelet-rich plasma, it resulted in aggregation of platelets by PAF. Patients treated with this drug have had no recurrent symptoms or tachycardias with a followup of 4-21 months. Antimicrobial activity of 5-oxothiazolidine-2-thione and rhodanine derivatives. High levels of sedentary time and low daily step counts were demonstrated in a Danish population of females with Rett syndrome. Nicotinamide adenine dinucleotide phosphate diaphorase neurons were classified into three groups based on somal size. The nucleotide sequence of 5S rRNA from an extreme thermophile, Thermus thermophilus HB8. Advanced laser delivery systems, particularly those that have been adapted to the indirect ophthalmoscope, have facilitated the visualization for treatment of tumors. In addition, Erdr1 overexpression significantly suppressed melanoma lung colonization, metastasis, and tumor growth in vivo. Use of control steady-state serum digoxin levels for predicting serum digoxin concentration after quinidine administration.

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This study determined angiotensin II (AII)-mediated vascular dysfunction in offspring middle cerebral arteries (MCA). Rat pups were subjected to MS from postnatal day 1 to 21 and received chronic escitalopram (ESC) as adults. These findings suggest an abnormality in monoamine metabolism in a small group of autistic children. The tested antioxidants affected the motility parameters, DNA integrity, and fertility of cryopreserved semen, but not the membrane integrity. A comparison of methods for self-adaptation in evolutionary algorithms. The first 35 residues of leader peptidase, which include the first hydrophobic domain and the carboxyl-terminal positively charged cluster, are sufficient to insert the amino terminus. Effects of two dual-function compounds, U92798 and U92032, on transient focal ischemia in rats. The expression of heat-shock proteins by both pathogen and host cells during the phagocytosis of Staphylococcus aureus and Pseudomonas aeruginosa, two bacterial how soon can i drink alcohol after taking flagyl species that colonize the airways of patients with cystic fibrosis, probably contributes to pulmonary inflammation in cystic fibrosis. Viruses that comprise the Pestivirus genus cause significant losses to the livestock industry.

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These cases also highlight the need to include and distinguish among several different measures of neglect in the clinical investigation of patients with hemispatial inattention. Captopril significantly enhanced plasma renin activity in both examined groups, and decreased blood serum aldosterone levels but only in healthy subjects. In part, the contradictory findings may be due to failure to account for the effects of proband comorbidity on risks in relatives. No analogy could be drawn between experimental keratin polypeptide antibodies and the human epidermal cytoplasmic antibodies which were detected in some patient sera. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Chrysophyceae, which exhibit both phagocytosis and photosynthesis, are an interesting subject for evolutionary study.

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These cases demonstrated two statistically significant findings with the use of CPM: (1) decreased use of narcotic analgesics and (2) decreased length of hospital stay. Nitric oxide synthesis by rat pleural mesothelial cells: induction by growth factors and lipopolysaccharide. Phosphorus and proton nuclear magnetic resonance studies in sarcoplasmic reticulum membranes and lipids. The challenge was to develop a computerized patient record, that would be versatile enough to tailor it to specific needs, while keeping it uniform enough to permit physicians to share data on the same patient. Application of the bacteriophage Mu-driven system for the integration/amplification of target genes in the chromosomes of engineered Gram-negative bacteria--mini review.

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It allows complete resection of the rectal mucosa and determines the quality of the postoperative course and the functional results. With this in mind, this paper envisions what the 21st century holds in store for OPC in terms of the driving forces that will shape our continued use of this material. Selective retrohippocampal lesions were made by means of multiple intracerebral infusions of NMDA centred on the entorhinal cortex bilaterally. The aim of the present study was to evaluate whether these children have mucosal signs of early developing CD, human leukocyte antigen (HLA)-DQ2/DQ8, and antibodies against deamidated gliadin peptides (DGP). The time dependent nature of the SOL makes swept klonopin medication generic -probe traces difficult to interpret. For example, does opiate dependency produce secondary anxiety and dysthymic syndromes in otherwise healthy persons?. The value of cerebral angiography in this disease entity and the possible etiology of the association of an aneurysm with a lipoma are discussed. Thrombosis of the basilic, axillary and subclavian veins, of undetermined origin. In triple-labeling experiments it was observed that the breakdown of vegetatively synthesized ribonucleic acid is not a significant source of precursors for ribonucleic acid synthesis during sporulation.

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