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Insurol (Glimepiride)

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Insurol is an oral diabetes medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Insurol is not for treating type 1 diabetes.

Other names for this medication:
Adride, Asoride, Bestoglim, Bigonyl, Biopride, Diaprid, Diaser, Dipride, Gitae, Givov, Glador, Glimday, Glimestar, Glimide, Glimikare, Glimivir, Glimpil, Gluformin, Glymon, Iglim, Metapride, Metforise, Novaride, Odiglim, Swimet, Zipio

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Also known as: Glimepiride


{name} (glimepiride) is an oral diabetes medicine that helps control blood sugar levels.

{name} is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.

Insulin or other diabetes medicines are sometimes used in combination with {name} if needed.


Take Generic Insurol tablets orally with breakfast or the first big meal of the day. Do not crush or chew it. Take Generic Insurol at the same time once a day with water. If you want to achieve most effective results do not stop taking Generic Insurol suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An Insurol overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Insurol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Insurol if you are allergic to glimepiride, sulphonamides, or if you have:

an allergy to sulfa drugs; or diabetic ketoacidosis (call your doctor for treatment).

To make sure Insurol is safe for you, tell your doctor if you have ever had:

heart disease; liver or kidney disease; or an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Insurol may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using Insurol if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Insurol for a short time just before your due date.

Medications similar to glimepiride have caused severe hypoglycemia in newborn babies whose mothers used the medicine near the time of delivery. If you take glimepiride during pregnancy, stop taking this medicine at least 2 weeks before your due date.

If you breastfeed while taking glimepiride, call your doctor if your baby shows signs of hypoglycemia (extreme drowsiness, feeding problems, mottled skin, blue lips, feeling cold or jittery, or having a seizure).

Insurol is not approved for use by anyone younger than 18 years old.

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At 2-3 h after phenobaribtal administration, the drug has no effect on nucleoplasmic RNA synthesis and decreases nucleolar RNA synthesis. The cell-specific absorption mechanism for 57Co bleomycin and the transport behavior was examined under various parameters in an in vitro tumor cell system. The aim of this study was to describe the laparoscopic minimally invasive surgery (MIS) for a small series of ectopic EPS in small children and to show its feasibility and safety. It is usually associated with a disorientation of the cubocalcaneal joint. A serosa-mucosa movement of bicarbonate against concentration gradient was detected at this intestinal level. The implications of these findings for dental health educators, program planners and further research is emphasized in order to promote a more positive pattern of utilization among the various ethnic groups. Cells lacking Orp2 undergo aberrant mitosis, indicating that Orp2 is involved in generating a checkpoint signal. Effects of norepinephrine on transmembrane calcium transport in rat mast cells. Unexpectedly, female hpg mice exhibited dramatic ovarian and uterine growth after 15 or 30 days of continuous exposure to GnRH, with five- and eightfold increases in ovarian and uterine weights, respectively. Pharmacology of venules: some current concepts and clinical potential.

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Isolation and characterization of a human fibroblast interferon gene and its expression in Escherichia coli. Inversion of the liver and anomalous positions of the gallbladder are both rare. Photothrombosis was induced using a dye laser emitting at 692 nm. AH17, a new non-polyenic antifungal antibiotic produced by a strain of Spirillospora. Univariate risk ratios (RRs) of stillbirth were calculated by maternal education, country of origin, age, parity, and gestational age. We have systematically investigated the dependencies of the enantioselection by parameters such as the choice of solvent, the temperature, as well as the pH and bring to light many previously unsuspected and highly intriguing interactions.

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Detection of bilateral and symmetrical anomalies in technetium-99m-HMPAO brain SPECT studies. Evidence for the shift of the transition temperature in RBa2Cu4O8 by thermal-conductivity measurements. The palliation of brain metastases in a favorable patient population: a randomized clinical trial by the Radiation Therapy Oncology Group. Report of fertility in a woman with a predominantly 46,XY karyotype in a family with multiple disorders of sexual development. One consisted of a determinant in common between HLA-DRw1, 2 and 6 and the other a putative determinant in common between HLA-DRw4, and 5.

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Evaluation of an agar gel immunodiffusion test kit for detection of antibodies to Mycobacterium paratuberculosis in sheep. In vivo, the IgE-independent MC secretagogues, compound 48/80 and ACTH, induced anagen in mouse telogen follicles after intracutaneous administration, while inhibitors of mast cell degranulation (cromoglycate, tiacrilast) and antagonists of selected MC products (clemastin, ranitidine, ketanserin) significantly retarded the induced development of anagen follicles in these mice. Furthermore, pathway activity is modulated by Fringe modification of receptors or ligands, co-expression of receptors with ligands, mode of ligand presentation, and cell surface area in contact. In the absence of efficient receptors for LDL cholesterol, cells will be unable to use this component adequately for the manufacture of normally resilient arterial cell walls, resulting in accelerated arteriosclerosis. Some clones also contained additional flanking sequences from the B. Comparisons were performed using Cox proportional hazards multivariate adjustment and Kaplan-Meier analysis with log-rank. The results demonstrate that the proposed AGMOPSO algorithm can find better spread of solutions and have faster convergence to the true Pareto-optimal front. Clonogenic survival after LNA miR-210 inhibitor (78 nM) and concomitant irradiation were evaluated.

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General psychopathology as measured by the Minnesota Multiphasic Personality Inventory (MMPI), eating disorder diagnostic status (DSM-III-R), and clinical outcome were compared in a sample of 59 women 10 years after their hospital treatment for anorexia nervosa. These tools have the sensitivity necessary to detect small changes by combining statistical sampling principles with geometric analysis of the tissue microstructure. Reversible osteopenia in the lower leg was accompanied with plausible losses both in compact and trabecular bone. Both underweight and overweight/obesity were related to height: patterns differed by age and sex, being most evident at age 7 in both sexes, continuing at age 11 (but more so in boys), and disappearing by age 16. California surveillance data were used in a study of neurological function among 128 men poisoned by organophosphate pesticides in California from 1982 to 1990 and 90 referents. The Casella Slit Sampler or the Biotest Centrifugal Sampler--which is the more efficient?.

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Rationale for the use of peritoneal lavage as adjuvant therapy in peritonitis. Effect of raphe lesions on the development of acute tolerance to ethanol and pentobarbital. Routine blood tests and audiometric testing were performed before each course of chemotherapy. Resonance Raman and Fourier transform infrared studies on the subunit I histidine mutants of the cytochrome bo complex in Escherichia coli. Seven hundred and forty five subjects were examined as part of a health intervention programme at the work-site. Semiquantitative cultures of the catheter tip performed by rolling the catheter on the surface of an agar plate are the most popular. H-2 antigens as genetic markers: a two-dimensional gel electrophoretic study. The effects of TU-100 on drug metabolism have not been investigated. The aryl hydrocarbon receptor (AHR) mediates the toxic effects of halogenated aromatic hydrocarbons (HAHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PeCDF) and 2,3,7,8-tetrachlorodibenzofuran (2,3,7,8-TCDF).

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Dilational rheology of oil/water interfaces covered by amphiphilic polysaccharides derived from dextran. Observation of the changes of plasma proteins after long term plasmapheresis. A biologically motivated breast cancer incidence rate function was fit to data from a published case-control study conducted in countries whose incidence is high (Wales and the United States), moderate (Brazil, Greece, and Yugoslavia), and low (Japan and Taiwan). The benign acanthomas may be simulated by lesions which are not benign (e.g. We screened the genomes of 123 worldwide isolates of the major pathogen of wheat Zymoseptoria tritici for robust evidence of gene copy number can triamcinolone cause yeast infection variation.

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These results indicate that PTH-mediated desensitization reflects, at least in part, impaired cyclic AMP formation. Right atrial pressure and forearm blood flow during prolonged exercise in a hot environment. Infusion of bicuculline methiodide into the tectum: model specificity of pro- and anticonvulsant actions. Quantitative real-time polymerase chain reaction (qPCR) was used to detect the expression level of HOTAIR in GC tissues. Current Canadian neonatal research: memories of a gentle presence. To evaluate the effects flagyl 400 mg of moderate consumption of alcoholic beverages on the fibrinolytic system and to assess whether these effects could help explain the relation between moderate alcohol consumption and reduced coronary heart disease. Nuclear distribution of glutamate, gamma-aminobutyrate and aspartate within the normal human thalamus. Lopinavir induced an increase in the fluorescence of pZsProSensor-1 transfected SiHa cells, indicative of proteasomal inhibition.

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Postnatal changes in rat hypoglossal motoneuron membrane properties. However, little is known about the acceptability of online interventions. Social and economic factors in prosthodontic practice and education. In contrast, citrate and isocitrate diminished toxA transcription. Since scruin had not been purified, its identity as an actin-binding protein has not been demonstrated. Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut.

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We examined the effect of Rapatar on the metabolic status and protection against myocardial I/R injury in type 2 diabetic mice. Amongst the studied metals, Cr, Zn, Cd, and Ni were the main factors correlated with transcription levels, with effects on translation, apoptosis, immune response, response to stimulus, and transport pathways. Cardiovascular diseases, including hypertension, represent serious medical and social problem because they affect many people in industrialized countries in the world and, unfortunately, their incidence has not decreasing tendency. Some observations on Hatha Yoga: the Bandhas: an anatomical study. Regarding the operative effect in the arms, the decreased circumference of the arms ranged from 2 to 9 cm (average 5.3 cm). Furthermore, there was no evidence in the reported series that laparoscopic surgical procedures were superior to laparotomy in correcting infertility. Under normal physiological conditions they increase in amplitude and frequency with the increase in the filling rate and in intravesical volume. Pharmacokinetics, distribution, and metabolism of the novel bioreductive alkylating indoloquinone EO9 in rodents. Impact of what drug is like valium site of inseminate deposition and environmental factors that influence reproduction of dairy cattle. A pilot study: use of fludarabine for refractory dermatomyositis and polymyositis, and examination of endpoint measures.

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Moreover, PGE(2)-induced luminal chloride secretion was a prerequisite for alterations at TJs. From July 1987 through November 1988, we performed Kock pouch construction on 11 patients (ages 39 to 76 years). Fourteen studies were retained in the review, of which eight were conducted in the Netherlands. Nineteen CHF patients who were categorized as NYHA functional class II or is lipitor a safe drug to take III and had received optimal medical treatment including a CR program for 5 months were enrolled in this study. After 24 h the peritoneal fluid of newborn mice contained high amounts of interferon and high titres of HSV-1. Thoracic aortic atherosclerosis in patients with aortic regurgitation. We also determined that ER stress-induced ATF4 up-regulation was responsible for modulation of CHOP. Conformational analysis, by the method of atom-atomic potentials, has been carried out for five tripeptides containing gamma-glutamyl bonds and having general formula Glu(gamma)-X-Gly. These data suggested that patients with IgA nephropathy showed higher antibody response to mucosal stimulation than healthy controls.

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Deferral from donating blood of men who have sex with men: impact on the risk of HIV transmission by transfusion in France. This study was performed to evaluate if endoscopic intra-amniotic access is possible in primates. New intravenous sedative combinations in oral surgery: a comparative study of nalbuphine or pentazocine with midazolam. Hemocompatibility of hyaluronan enhanced linear low density polyethylene for blood contacting applications. Procedures for isolation and assay of translation-inhibitory ribosome-associated proteins. When GM-CSF and erythropoietin (Ep) were added simultaneously to the cultures, no significant change in the number of eosinophils compared to hrGM-CSF alone was observed. Studies were performed to investigate the effect of a polyphenol rich extract from black tea and vitamin E on bacterial lipopolysaccharide (endotoxin) induced IL-6 production, alterations in liver glutathione and antioxidant acute phase protein (caeruloplasmin) concentration, in rats fed on a synthetic diet for 21 days. Sometimes the morphological criteria--used to distinguish between 4 land snails species (Helix pomatia, Helix lucorum, Helix aspersa aspersa and Helix aspersa maxima)--are little pronounced and ambiguous.

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The studied patients all had at least 3 years of clinical follow-up. The varying weights of the aetiological role of HCV infection are gabapentin neurontin 300 mg oral cap compared among countries. Effect of axial bulbus length and preoperative squint angle on the effect of horizontal combined squint operations. A 6-year follow-up study of oral function in shortened dental arches. The dressing was able to support the skin, protect the laceration from further injury, shield the wound from exposure to infectious agents, and prevent transmission of blood or serum to other wrestlers. This condition is rarely reported and there are few reports among black Africans. These shifts provide a navigational map that, in a simulation of the Morris maze, can guide the animal toward its goal. Reflections on the the future cultural development of humanity in relation to advancing globalization. Year-round resource defence and the evolution of male and female song in suboscine birds: social armaments are mutual ornaments. There are only 12 cases of shoulder involvement reported in the English-language literature.

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Steroidal regulation of hydrolyzing activity of the dietary carbohydrates in the silkworm, Bombyx mori. In comparison with non-smokers, former and current smokers were at a significantly elevated risk of CRC with corresponding odds ratios of 1.36 and 1.96. In comparison to the PAP method, the indirect conjugated method presented slightly inferior staining intensities and significantly higher background staining. We have previously described the production of P1 in the Gram-positive Bacillus subtilis as intracellular inclusion bodies, from which the protein (BacP1) is easily purified (Nurminen et al., Mol. Kawasaki disease is usually a limited illness of early childhood. Reporter gene assays with extended promoter regions indicate the presence of negative regulatory elements and/or factor binding sites that reside between -1500 and the RARE located at -59, and that the promoter is down-regulated in MCF-7 tumor cells. Effect of mercury, lead and acetylphenylhydrazine (APHZ) on erythrocyte and bone marrow glucose-6-phosphate dehydrogenase (E.C. In patients with Stage I, T1 pulmonary adenocarcinoma, the post operative survival curve was compared between positive and negative cases of TGF-beta, and the result showed a tendency toward poorer prognosis in positive cases of TGF-beta. The author would like to share current concepts and new techniques which have overcome these problems and delivered satisfaction and happiness to many patients. The results were compared with the findings of a previous study of younger subjects.

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Homing in on an intracellular target for delivery of loaded nanoparticles functionalized with a histone deacetylase inhibitor. The level of inhibition subsequently decreased with lower concentration of the chemicals. Effect of unesterified cholesterol on the compartmentation of a fluorescent cholesteryl ester in a lipoprotein-like lipid microemulsion. Results of penetrating keratoplasty for aphakic bullous keratopathy. The induction of immunity was measured by monitoring the percentage of survivors after challenge. The clinical course was investigated through telephone interviews with the physician and/or patient, using standardized questionnaires. The repair of mismatched heteroduplex DNA has been implicated in the normal resolution of meiotic exchange events. RER, an evolutionarily conserved sequence upstream of the rhodopsin gene, has enhancer activity.

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Anastomosis by arteriovenous fistula for a vascular access in hemodialysis. We discuss various anomalies, branches, and lesions of the vertebral artery and surgical approaches with new methods of managing diseases in this area. Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein. The trypsin-catalyzed hydrolysis of monomolecular films of lysylphosphatidylglycerol. These results suggest that a vaccinia oncolysate, prepared with recombinant vaccinia virus encoding an immunomodulating cytokine gene will enhance antitumor responses in the host.

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