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Imodium (Loperamide)

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Imodium is an anti-diarrhoeal medication. It works by slowing down the contraction of the intestines thereby decreasing the speed at which the contents pass through it. This allows more time for reabsorption of fluids and nutrients, making the stools more solid and less frequent.

Other names for this medication:
Allexit, Andial, Avistep, Bendiar, Cipromide, Diamode, Diariv, Diarlop, Dylock, Eldoper, Entril, Forasec, Fulomet, Imosec, Imotil, Imozol, Kaopectate, Klassak, Lomin, Lopamide, Loperamide, Loperia, Maalox, Metrofur, Neostep, Norstrep, Ridol, Triogyl

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Also known as: Loperamide


{name} A-D New Formula is used to treat diarrhea.

{name} A-D New Formula is also used to reduce the amount of stool in people who have an ileostomy (re-routing of the bowel through a surgical opening in the stomach).


This section provides information on the proper use of a number of products that contain loperamide. It may not be specific to Imodium. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Swallow the capsule whole. Do not crush, break, or chew it.

Drink plenty of water while using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For acute diarrhea: For oral dosage form (capsules): Adults and children 13 years of age and older—At first, 4 milligrams (mg) (2 capsules) after the first loose bowel movement, then 2 mg (1 capsule) after each loose bowel movement after the first dose has been taken. However, dose is usually not more than 16 mg (8 capsules). Children 8 to 12 years of age weighing more than 30 kilograms (kg)—2 mg (1 capsule) 3 times a day. Children 6 to 8 years of age weighing 20 to 30 kg—2 mg (1 capsule) 2 times a day. Children 2 to 5 years of age weighing 20 kg or less—Use the oral solution. Children younger than 2 years of age—Use is not recommended. For oral dosage form (oral solution): Children 8 to 12 years of age weighing more than 30 kilograms (kg)—2 teaspoonfuls (2 mg) 3 times a day. Children 6 to 8 years of age weighing 20 to 30 kg—2 teaspoonfuls (2 mg) 3 times a day. Children 2 to 5 years of age weighing 13 to 20 kg—1 teaspoonful (1 mg) 3 times a day. Children younger than 2 years of age—Use is not recommended. For oral dosage form (tablets): Adults and teenagers—The usual dose is 4 mg (2 tablets) after the first loose bowel movement, and 2 mg (1 tablet) after each loose bowel movement after the first dose has been taken. No more than 8 mg (4 tablets) should be taken in any 24-hour period. Children 9 to 11 years of age—The usual dose is 2 mg (1 tablet) after the first loose bowel movement, and 1 mg (½ tablet) after each loose bowel movement after the first dose has been taken. No more than 6 mg (3 tablets) should be taken in any 24-hour period. Children 6 to 8 years of age—The usual dose is 2 mg (1 tablet) after the first loose bowel movement, and 1 mg (½ tablet) after each loose bowel movement after the first dose has been taken. No more than 4 mg (2 tablets) should be taken in any 24-hour period. Children up to 6 years of age—Use is not recommended unless directed by your doctor. For chronic diarrhea: For oral dosage form (capsules): Adults—At first, 4 milligrams (mg) (2 capsules) after the first loose bowel movement, then 2 mg (1 capsule) after each loose bowel movement after the first dose has been taken. Your doctor may adjust your dose as needed. However, dose is usually not more than 16 mg (8 capsules) per day. Children 2 years of age and older—Use and dose must be determined by your doctor. Children younger than 2 years of age—Use is not recommended.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of loperamide can be fatal.

Overdose symptoms may include fast or irregular heartbeats, or fainting. A person caring for you should seek emergency medical attention if you pass out and are hard to wake up.


Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Imodium are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of loperamide in the elderly. However, elderly patients are more likely to have heart rhythm problems, which may require caution in patients receiving loperamide.

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Occluded central venous lines (CVLs) is a major problem in pediatric patients. Phosphatidylinositol depletion in GH3 rat pituitary cells inhibits sustained responses to thyrotropin-releasing hormone. Relatively low proportion of dystrophin gene deletions in Israeli Duchenne and Becker muscular dystrophy patients. Allergen exposure plays a major role in the development of sensitization, inflammation and symptomatic asthma. Progesterone levels were ovulatory, but the midluteal P peak 3 months poststerilization was significantly decreased. Contribution of 1-nitropyrene to direct-acting Ames assay mutagenicities of diesel particulate extracts. Effects of age and ethanol on DNA single-strand breaks and toxicity induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or n-nitrosodimethylamine in hamster and rat liver. Plasma corticosterone was suppressed until day 8, but was not significantly different from normal on day 11. Responses of neurons in the nucleus tractus solitarius to stimulation of heart and lung receptors in the rat. Statistical analysis was performed using statistical parametric mapping.

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Daily swimming forestalled this decline, leading to differences in daily energy expenditure between exercised and sedentary rats, which grew progressively larger. (3) No 5S RNA-23S RNA complex formation occurs in the presence of L5 and the C-terminal L18 fragment. Prior to this survey, Aedes decticus and Culiseta melanura were reported in Minnesota once previously. The results suggested the presence of two functionally distinct territories in the retrochiasmatic area. Our analysis suggests, for the first time, that exon inclusion levels of certain regulatory proteins can affect the activities of many transcription factors. This study aims to evaluate the association of the coronary artery-positive remodeling (CAPR) observed on cardiac computed tomography angiography (CCTA) with cigarette smoking. Total volume transfused of packed red blood cells (PRBC), fresh frozen plasma (FFP), platelets (PLT), and crystalloids during the initial 48h was extracted, along with an analysis for an array of cytokines by Enzyme Linked Immunosorbent Assay (ELISA) technique. Medico-economic effectiveness of dispensary care for patients with chronic nonspecific lung diseases in a rural locality. Remarkably, this gene expression defect is corrected during involution, resulting in delayed yet normal Xbra expression and viable embryos.

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The skin prick test end point was significantly (p less than 0.001, Wilcoxon W test) reduced after treatment in the allergoid-treated group and remained unchanged in the placebo-treated group. No FLHS was observed in hens that consumed a diet that contained non-chelated minerals. In in vivo animal studies, gestodene also has less androgenic activity compared with progestins found in older combination oral contraceptive formulations. Although it is known that emotion regulation strategies, such as cognitive reappraisal and expressive suppression, may have divergent consequences for emotional responses, the cognitive processes underlying these differences remain unclear. Recommendations of a Task Force of the the European Society of Cardiology and the European Resuscitation Council. However, significant evidence supports prolonged prenatal exposure as a risk factor for several adverse health effects. Subsequent typing of DNA samples of individual progeny snails showed that the 1.2-kb marker amplified by primer OPM-04 and the 1.0-kb marker produced by primer OPZ-11 segregated in the same dominant fashion with the resistant phenotype. Calcium phosphate cements (CPCs) are frequently used as bone substitute material. Chronic myelogenous leukemia following repeated radiation therapy for histiocytosis X. Co-inoculated recombinants induced localized symptoms on inoculated leaves but did not spread systematically, either because of a defect in BL1 and/or BR1 expression or due to the inability of the TGMV gene products to functionally complement their ACMV counterparts.

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Addressing and interpreting defense mechanisms in psychotherapy: general considerations. Antithrombotic benefits and hemorrhagic risks of direct thrombin antagonists. Psychopharmacologic agents may offer potentially effective treatment of child and adolescent anxiety disorders. The cytology features of ES are characteristic and a preoperative diagnosis is helpful for proper management of the case. Fifteen cows among a herd of 50 suckler cows and calves rapidly lost body condition and became dull and anorexic after grazing pasture containing bog asphodel (Narthecium ossifragum) during the summer of 1989. The effects on longitudinal smooth muscles were reduced by mianserin and ketanserin (0.375, 1.5 and 6 mg) and by methysergide (1.5 mg). Moreover, the modeling strategy can be extended to other biological processes. From their brief experience, the authors conclude that stereotaxic radiosurgery may be a promising treatment in locally controlling recurrent head and neck cancers that involve the BOS. Inhibition of UV light- and Fenton reaction-induced oxidative DNA damage by the soybean isoflavone genistein.

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Serum cytokine level fluctuations in chemotherapy-induced myelosuppression. Work hardening and work conditioning interventions: do they affect disability?. How high is the risk of mortality in aortic stenosis and pregnancy?. General anesthesia was induced with iv thiopental, and succinylcholine was given to facilitate tracheal intubation. High sensitivity, low affinity--paradox of T-cell receptor recognition. Because the dose response function for radiation myelopathy is steep, the volume effect is modest. Customized post-operative alignment improves clinical outcome following medial open-wedge osteotomy. The sensitivities of asynchronous and synchronous cells to TLM and BLM were expressed as biphasic dose-response survival curves.

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Immunochemical methods were used to identify the genetic origin of hypoxanthine phosphoribosyltransferase (HPRT) expressed in heteroploid, HPRT-deficient mouse (A9) cells and Chinese hamster ovary (K627) cells, after these cells were fused with chick embryo erythrocytes and selected for resistance to hypoxanthine-aminopterin-thymidine (HAT) medium. These features correspond to descriptions of primary xanthoma of bone. He made a full recovery following conservative antibiotic therapy. Although 6(1), 6(2), 6(4)- and 6(1), 6(2), 6(6)-substituted isomers were indistinguishable by this method, these isomers were distinguished clearly by digestion of branched oligosaccharides produced from each isomer by the aforesaid method, with B. Resource Allocation for Equity in the British National Health Service 1948-89: An Advocacy Coalition Analysis of the RAWP. On the derivative relationship between stapes movement and cochlear microphonic. Subacute stent thrombosis: evolving issues and current concepts.

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Macrophages (Mp) and the plasminogen system play important roles in tissue repair following injury. Forced unfolding of the fibronectin type III module reveals a tensile molecular recognition switch. Gel retardation analyses of interactions between a fragment of hr5 and extracts prepared from cells transfected with an IE1-encoding plasmid revealed the presence of three DNA-protein complexes. Alleviation of pain and improvement of function are the primary goals of surgical intervention. Benefits and risks of hypertension therapy from the cardiac viewpoint.

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Major histocompatibility complex-restricted H-Y-specific antibodies and cytotoxic T lymphocytes may recognize different self determinants. Conformal radiofrequency ablation of hepatocellular carcinoma with a multi-pin bipolar system. The database of 14 gynecological oncology departments from Turkey and Germany were comprehensively searched for women who underwent primary surgery for an ovarian tumor between January 1, 1998, and December 31, 2015, and whose final diagnosis was mBOT. Plasmon-phonon coupling in one-dimensional semiconductor quantum-wire structures. To evaluate recurrence after penile-sparing surgery (PSS) in the management of carcinoma in situ (CIS) of the penis in a large multicentre cohort of patients. The performance of such tests should be evaluated in different age groups before application in diagnosis. Experiments were performed in the Laboratory of Integrative Biology at Orbeli Institute of Physiology of National Academy of Science of the Republic of Armenia. These subjects would not have been classified as having prediabetes on the basis of fasting glycemia or post-OGTT values.

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Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Interactions between TCRs and these self-peptide-MHC ligands work positively to drive T-cell development in the thymus and negatively to delete or inactivate T cells with potential self-reactivity. Marihuana-derived material: biochemical studies of the ocular responses. Group B included 69 suspected breast cancer women with age range 26-38 years. Identification of differentially expressed genes in pathways of cerebral neurotransmission of anovulatory mice. Since none of the drugs produced any significant (p less than 0.05) change of adherence, no evidence of opioid mediated increased risk of postoperative bacterial infection could be found. A counterimmunoelectrophoresis inhibition test for the detection of hepatitis-associated antigen. Pilot scale investigations from the last 15 years show remarkable advances in the increase in nitrification efficiency and in the stabilization of the process. A medulloblastoma in an infant with abnormal cells in the cerebrospinal fluid.

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Photostationary state mixtures of both UA and IA efficiently sensitize the inactivation of dsDNA, and cDCBPR strongly protects ssDNA from UV damage, while TPR is a significant sensitizer. In the fetus between 80 and 120 days of gestation, staining for the enkephalins was observed in both the peripheral columnar and the central polygonal adrenal medullary cells. We retrospectively analysed the characteristics and clinical courses of 205 SBA patients from 11 institutions in Japan between June 2002 and August 2013. U18666A inhibits intracellular cholesterol transport and neurotransmitter release in human neuroblastoma cells. Automated Edman degradation indicated that the mature FaeD contained 777 amino acid residues and confirmed that FaeD is synthesized with a rather long signal sequence of 35 amino acid residues. Seborrhoeic dermatitis and dandruff are common scalp conditions.

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They stress the already unquestionable role of ultrasound screening as a valid, sensitive and useful device in the diagnosis of congenital dysplasia of the hip and emphasize that the earlier the examination is carried out, the easier it is to begin suitable treatment rapidly and with positive results. Among fee-for-service Medicare beneficiaries, the performance of carotid endarterectomy declined from 1999 to 2014, whereas the performance of carotid artery stenting increased until 2006 and then declined from 2007 to 2014. Steady-state binding assays and association kinetics performed at 4 degrees C using these agonists revealed specific binding to both the high- and low-affinity receptor. Scaling Theory of Mind in a Small-Scale Society: A Case Study From Vanuatu. Horse liver alcohol dehydrogenase is an NAD dependent enzyme which oxidizes a wide variety of alcohols. It appears that M-factor is synthesized as a larger precursor which is post-translationally cleaved and modified to yield the active pheromone. The following organs were included: liver, kidneys, heart, submandibular salivary glands, spleen and thymus. A review of the literature reveals neurontin drug classification only two cases of pediatric SNHL after RT without chemotherapy. The risk significantly decreased with years of abstention from smoking cigarettes. X-ray diffraction, nitrogen isotherms, and (1)H MAS NMR were used to characterize the unperturbed materials, while thermogravitric analysis with gas chromatography and mass spectrometry along with the (19)F MAS NMR were used to characterize the materials that were reacted with TFE.

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The experiments have been carried out for different sizes of biocatalysts particle, under substrate and product inhibitory effects. At the light microscope level, antibody binding was observed only in those regions of the brain where synapses are known to be present. Macroscopic and histological changes of the ileum HLA-B27 related diseases: therapeutic consequences. All injuries resulted from gunshot wounds and all were repaired. The prevalence of topics negative in tone and a lack of proactive stories reflect, but also create, a social sumycin drug context which can affect the process of recovery from traumatization.

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Truncated derivatives of xynB encoding the N-terminal 338 residues directed the synthesis of a functional xylanase, confirming that the region of XYLB, which exhibited homology with family F xylanases, constitutes the catalytic domain. Compare the clinical outcomes of DEB with second-generation drug-eluting stents (DES) for the treatment of ISR in a real-world population with a high proportion of ACS. This determinant is also expressed by mice of the b and e types, but not by mice of the d haplotype, from which the o haplotype was subdivided. During the paroxysms the HBO session promotes the change from the tachysystolic form of atrial fibrillation to the normosystolic form. A comparison of cardiac index in normal term pregnancy using thoracic electrical bio-impedance and oxygen extraction (Fick) techniques. Fourteen fresh-frozen above knee specimens underwent arthroscopic assessment with 1) intact ligaments, 2) after sectioning of the anterior inferior tibiofibular ligament, the interosseous ligament, and the posterior inferior tibiofibular ligament, and 3) after sectioning of the deep and superficial deltoid ligament.

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Failure of cholinergic blockade to prevent bronchodilatation following deep inspiration. Genetic analysis of the albendazole 400 mg over the counter role of cAMP in mediating effects of interferon. Fetal bovine serum does not coagulate and is free from contaminating microorganisms, antibodies, and anticoagulants, which are all known to reduce virus titers. The authors make a conclusion that medical service at the initial stage of its activities was not properly ready to accomplish a variety of hygienic missions. These results were used in hygienic standardization of this substance. Finally, the light chain (HA2) polypeptides from A/Bel/42 (HO), the A/Japan/305/57 (H2) and the two Hong Kong variants A/Aichi/2/68 (X-31) and A/Memphis/102/72 were also examined and found to contain carbohydrate which is antigenically related to chick embryo host antigen. Dialysate samples were obtained at 0 hours, midcycle, and at the end of exchange. AR-C239 did not change the tachycardia induced by stimulation of the cardiac nerve in dogs and, at least in this preparation, seems to be a specific alpha 1-adrenoceptor blocking drug. When normalized for total ribonucleic acid input (beta-actin), term placental expression of HLA-G was reduced for all forms of preeclampsia but not for intrauterine growth retardation or gestational hypertension. Trans sodium crocetinate (TSC) has been shown to increase oxygen diffusion to hypoxic tissues.

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Patients with chronic pouchitis are at risk of dysplasia and require surveillance of the pouch. The animals received either ibotenic acid or saline control injections into the dorsal striatum prior to training on the non-matching task. A series of 58 patients of what are the side effects of the antibiotic levaquin aortitis syndrome were analyzed from the standpoint of the pathogenesis and surgical treatment. Ge(100) 2 x 1 and c(4 x 2) surface reconstructions studied by ab initio total-energy molecular-force calculations. Circulating microRNAs: valuable biomarkers for diagnosis and prognosis of gastric cancer. It has been stated that detergent sclerosants may have more distal sclerosing capabilities than hyperosmolar sclerosants. Formulation of Tolmetin Ocuserts As Carriers for Ocular Drug Delivery System. : This study aimed to understand and analyze how processes of continuing education are experienced by professionals in the Centers for the Support of Family Health (NASF) and family health teams. Further evidence for haploid gene expression during spermatogenesis: heterogeneous, poly(A)- containing RNA is synthesized post-meiotically.

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These data suggest that development of a tendency to use conspecifics as sources of information about what foods to eat does not depend upon previous experience either of interaction with conspecifics or of feeding in social situations. Regulation of aggressive behaviors by testosterone in the non-breeding season may incur substantial costs. These results implicate the involvement of the epsilon 3 and zeta 1 subunits in neuronal signaling in the SCN and suggest that these subunits of the NMDA receptor channel are regulated by light and a circadian clock. These structures are thought to be identical to those of the characteristic intracytoplasmic inclusion bodies observed in the case of infantile digital fibromatosis. In most cases these calcifications concerned the superior patellar tendon, quadricipital tendon and pre-patellar zone. Four had erythrodermic and/or pustulous psoriasis, and two of these had concomitant hypocalcemia. Effect of prostaglandin E1 on ammonia concentration in blood of patients with hepatic resection. Chromosome replication related to cell division and increase in cell mass in synchronized cultures of Neisseria meningitidis. However, little is know about the organization of MDC1 complexes. Batches of riparin I with different crystal habits resulting in crystallization impurities were observed, which can be attributed to the presence of triethylamine.

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The occurrence of non-stationarities is then signalled if the output of the inverse filter exceeds a preset threshold. Capsaicin pretreatment significantly elevated hot plate and tail flick latencies in SHR subjects but was without effect in WKY rats. Molecular mechanisms of cryo- and xeroprotective effect of protectors are dealt with in the paper. Comparison of the inducing effect of dehydroepiandrosterone on hepatic peroxisome proliferation-associated enzymes in several rodent species. 35 patients with abnormalities of the vertebrobasilar system were studied via magnetic resonance imaging (11 saccular aneurysms, 10 vascular malformations, 9 basilar arteries with dolichoectasia, 5 thromboses of the vertebral or basilar artery). Detection of the urine jet phenomenon using Doppler color flow mapping.

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