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Estrace (Estradiol)

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Estrace is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estrace is responsible for the development of female secondary sexual characteristics such as the breasts, widening of the hips, and a female-associated pattern of fat distribution.

Other names for this medication:
Bestradiol, Conjugase, Divigel, Edval, Espauz, Estogen, Estraderm, Estradiol, Estrofem, Evafem, Evalon, Evaride, Menocare, Mixogen, Oestrogel, Premarin, Progynon, Progynova, Sandrena

Similar Products:
Norvasc, Duphaston, Azulfidine, Imodium, Daklinza, Lanoxin, Risperdal, Buspar

Also known as: Estradiol


Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.

Some estradiol products placed directly into the vagina are used for "local" treatment of vaginal menopause symptoms (such as dryness, burning, and irritation). Other vaginal estradiol products are used for treating vaginal menopause symptoms and symptoms that affect other parts of the body (such as hot flashes). This type of vaginal estradiol has "systemic" effects, meaning that it can affect parts of the body other than where the medicine is directly applied.

This medication guide provides information about {name} Vaginal for local treatment of vaginal symptoms of menopause (such as dryness, itching, irritation, and pain during sexual intercourse).


This section provides information on the proper use of a number of products that contain estradiol. It may not be specific to Estrace. Please read with care.

It is very important that you use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects.

This medicine is to be used only in the vagina. Use it at bedtime unless your doctor tells you otherwise.

This medicine comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

To use the vaginal ring:

This medicine is contained in a ring that you or your caregiver will put into your vagina. The ring will slowly release small amounts of medicine for your body to absorb. Your caregiver will show you how to insert the ring. Do not remove the ring from the sealed pouch until you are ready to use it. Once the ring is in place inside your vagina, you should not be able to feel it. If you feel uncomfortable, the ring may not be inserted far enough. Gently push the ring farther into your vagina. If you feel pain, talk to your doctor. You will leave the ring inside for 90 days (3 months), unless your doctor tells you a different schedule. After that time, remove the ring and insert a new one. If you forget to remove the ring after 90 days, call your doctor for instructions. The ring may move down into the lower part of your vagina accidently. This can happen if you strain to have a bowel movement. Use your finger to gently push the ring back into place. If the ring comes all the way out of your vagina, rinse it off with warm water and put it back in. Call your doctor if the ring comes out several times. If you need to remove the ring, hook your finger through the ring and pull it out.

To use the Imvexxy™ vaginal insert:

The insert should be used only in your vagina. Do not swallow. Keep your hands clean and dry while handling the insert. Push an insert through the foil of the blister package and hold it with the larger end between your fingers. You may choose to put the insert into your vagina using the lying down or standing up position. Put the insert about 2 inches into your vagina, with the smaller end up, using your finger. Most women will start by using a new insert every day for two weeks, then change to using a new insert only 2 days each week. Carefully follow the schedule that your health caregiver tells you to.

To use the Vagifem® vaginal insert:

The tablet should be used only in your vagina. Do not swallow the tablet. Each vaginal tablet comes packaged inside an applicator. Do not take the tablet out of the applicator. If the tablet comes out of the applicator but has not fallen out of the package, carefully put it back into the applicator for insertion. If the tablet falls out of the applicator, throw it away and use a new applicator that still has the tablet inside it. Keep your hands clean and dry while handling the tablet. Take the applicator out of the plastic wrap before using it. Use the applicator only one time and then throw it away. Use a new applicator for each dose. Most women will start by inserting a new tablet every day for two weeks, then change to inserting a new tablet only 2 days each week. Carefully follow the schedule that your health caregiver tells you to.

To use the Divigel®:

Open the packet and use the entire contents of a packet on the skin of either right or left upper thigh once a day. Apply the gel to the right or left upper thigh on alternate days to avoid potential skin irritation. Do not apply the gel on the face, breasts, or irritated skin or in or around the vagina. Allow the gel to dry after application before dressing. Avoid fire, flame, or smoking until the gel has dried. Do not wash the application site within 1 hour after applying the gel. Avoid getting the gel into your eyes. Wash your hands after each application.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine. Grapefruit and grapefruit juice may change the amount of this medicine that is absorbed in the body.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For vaginal dosage form (gel): For atrophic vaginitis, hot flashes, and other symptoms caused by menopause: Adults—At first, 0.25 grams applied on the skin of either right or left upper thigh once a day. Your doctor may adjust your dose as needed up to a maximum of 1.25 grams once a day. Children—Use is not recommended. For vaginal dosage form (ring): For atrophic vaginitis, hot flashes, and other symptoms caused by menopause: Adults—One vaginal ring inserted into the vagina for 3 months. Your doctor may adjust your dose as needed. Children—Use is not recommended. For vaginal dosage form (insert): For treatment of atrophic vaginitis caused by menopause: Adults—10 micrograms (mcg) or one insert into the vagina once a day for 2 weeks, followed by one insert 2 times a week. Children—Use is not recommended. For treatment of painful sexual intercourse caused by menopause: Adults—At first, 4 micrograms (mcg) or one insert into the vagina once a day for 2 weeks, followed by one insert 2 times a week (every 3 to 4 days). Your doctor may adjust your dose as needed. Children—Use is not recommended.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Wrap the used vaginal ring in tissue or toilet paper and throw it in the trash can. Do not flush it down the toilet.

Detailed Estrace dosage information

Side effects

The most common side effects associated with Estrace are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of estradiol vaginal gel, insert, or ring in the pediatric population. Use of estradiol vaginal gel, insert, or ring is not indicated for use in children.

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Ultrastructural study of glomerular basement membrane in diabetic rats by the quick-freezing and deep-etching method. In the semidilute regime, the blended films became rounded owing to an increase in bundles cozaar medication type interpenetration between PHICs as compared to that in the dilute regime, whereas the morphology of unfractionated PHIC films remained unchanged as compared to that in the dilute regime. The prognostic value of long non coding RNAs in cervical cancer: A meta-analysis. Changes in the oral microflora in patients with acute leukemia and related disorders during the period of induction therapy. The Centers for Disease Control is responsible for the collection and evaluation of data characterizing the source of seafood-borne illness. The aim of this study was to determine the contributions of COX-1 and -2 to the production of specific prostanoids by unstimulated and stimulated intestinal epithelial cells. Evaluation of an automated system of measuring erythrocyte aggregation in dysglobulinemia treated by plasma exchange.

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Tritium splitting from solid, gamma irradiated uracil-5-T and uracil-6-T. The deduced amino acid sequence of the mature enzyme contains an HEXXH motif characteristic of zinc metalloproteases and is homologous to other known enzymes belonging to the thermolysin family. In addition, a longitudinal study was performed on 40 of these patients (20 with antral gastritis and 20 with duodenal ulcer) who underwent eradicating treatment. These results are based on interviews of 3,258 randomly selected non-institutionalized adult residents of Edmonton, conducted by trained lay interviewers using the Diagnostic Interview Schedule (DIS) and the Goldberg General Health Questionnaire (GHQ, 30-item). Human alpha 1(I), alpha 2(I) and alpha 1(III) cDNA probes and RNA dot hybridization were employed to quantitate collagen mRNA changes after adding silica dust into the media of human 2BS fibroblasts. Our data suggest that miR-200b regulates EMT of chemo-resistant breast cancer cells by targeting FN1. Using solution (cosedimentation) and solid phase experiments (sedimentation with Sepharose filamentous actin and ELISA), we have demonstrated that purified dystrophin is able to bind filamentous and monomeric actin. Leukotriene-like material released in the cardiac effluent was assayed against synthetic leukotriene C4 (LTC4). Education in early detection of oral squamous cell carcinoma: a community outreach program.

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Data from 28 ICUs in university and secondary nonteaching hospitals from 1998 to 2004 were available. A number of hematologic and immunologic parameters that reflect erythrocyte and platelet damage and host defense mechanisms against infection were studied in 20 patients undergoing cardiopulmonary bypass during coronary operations. Diagnostic problems in infectious colitis in the framework of an HIV infection. Metabolic activity of microflora in the colon according to the concentrations of short chain fatty acids in the feces of elderly patients in distant periods after hemicolectomy revealed in various degrees of violation of the microbiota of the colon. When adsorbed onto bentonite particles and incubated arcoxia tablets in the presence of non-phagocytic cells the protein facilitated the penetration of the particles into the cells.

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