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Cytoxan (Cyclophosphamide)
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Cytoxan

Cytoxan is used to treat various types of cancer. It is a chemotherapy drug that works by slowing or stopping cell growth. Cytoxan also works by decreasing your immune system's response to various diseases.

Other names for this medication:
Cyclomet, Cyclophosphamide, Cycloxan, Cycram, Cycrame, Cydoxan, Cyphos, Eldamide, Endoxan, Ledoxan, Neophos, Neosar, Oncomide, Oncophos, Oncoxan

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Also known as: Cyclophosphamide

Description

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cyclophosphamide is also used for some kinds of kidney disease.

Cyclophosphamide interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with cyclophosphamide, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

Dosage

Take Cytoxan tablets by mouth. Swallow Cytoxan with water. Take your doses at regular intervals. If you want to achieve most effective results do not stop taking Cytoxan suddenly.

Overdose

If you overdose Cytoxan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature at or below 25 degrees C (77 degrees F) away from moisture and heat. This medicine can be stored at room temperatures of up to 30 degrees C (86 degrees F) for a short time. Protect from temperatures above 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cytoxan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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When the type of day-nursery was taken into account as adjustment factor, the results showed a significantly lower percentage of failures in the amoxicillin group (P less than 0.03). Rats were exposed to noise before or after the toluene exposure, or exposed to ASA by gavage simultaneously with toluene. Classification of fibromyalgia: criteria of the American College of Rheumatology. The expression of similar idiotypes on anti-b6 antibodies has been found in rabbits of all VHa allotypic types thus far studies. Here, a case of massive adrenal haemorrhage secondary to metastasis of lung cancer that led to the death of the patient is reported.

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Transferring from an acute hospital and settling into a subacute facility: the experience of patients with dementia. Paraproteinaemia: use of idiotypic determinants as specific markers for tumour activity. Eight cases of spinal osteoblastoma in children and adults are reported, demonstrating the spectrum of the disease, pitfalls of diagnosis and treatment, and prognosis. Interval breast cancers in the Screening Mammography Program of British Columbia: analysis and classification. Classes of compounds evaluated include all-trans-retinoic acid and its esters, ring-modified analogs of all-trans-retinoic acid and its esters, side-chain-modified analogs of all-trans-retinoic acid and its esters, analogs in which both ring and side chain have been modified, all-trans-retinol and derivatives, all-trans-retinyl amine derivatives, all-trans-retinal derivatives, all-trans-retinoic acid amides, 13-cis-retinoic acid and derivatives, and 5,6-epoxyretinoids. Acknowledging uncertainty when prognosticating outcomes, and in particular death, may help in facilitating patient-centred care in context of a critical illness. The hypothesis that this study aimed to test was that nasal CPAP with a mouth leak and subsequent unidirectional airflow across the nasal mucosa causes an increase in nasal mucosal blood flux and a fall in both nasal volume and minimal cross sectional area.

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Comparison of Legionella pneumophila isolates by arbitrarily primed PCR and pulsed-field gel electrophoresis: analysis from seven epidemic investigations. Although not corroborated in all the studies focussing on this matter, prevalence data show an increase number or epilepsy patients between prisoners, and is also found altered electroencephalograms in some violent people. The yield from acid-ethanol extracts of platelets has been reported to be 0.5 microgram/unit of platelets. This unique chromatin packaging at certain gene promoters provides these genomic loci the ability to convey instructive epigenetic information to the zygote, potentially expanding the role and significance of the sperm epigenome in embryogenesis. The paraneoplastic syndromes are effects of cancer that occur at sites remote from the primary tumor and its metastases. Response properties of primary somatosensory cortical neurons responsive to cold stimulation of the facial skin and oral mucous membrane. Strong impact of anthropogenic contamination on the co-occurrence patterns of a riverine microbial community. Recent advances in Chinese medicine for contrast-induced nephropathy.

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A wireless batteryless deep-seated implantable ultrasonic pulser-receiver powered by magnetic coupling. Here, we investigate induction of long-lived immunity against the 2009 H1N1 virus after skin vaccination. Based on Timm staining in control P10, P20, and P30 rats, the terminal sprouting in CA3 appears to be new growth of axons and synapses as opposed to a failure of normal regression of synapses. Alternate in vitro-in vivo passage thus appears to potentiate tissue-specific protein expression by established liver cell lines. Adsorption-site-dependent electronic structure of catechol on the anatase TiO2(101) surface. Changes in lipid composition of plasma lipoproteins after total hepatectomy in the rat. The antitumor activity against hepatocellular carcinoma was evaluated in vitro and in vivo, respectively. The extended spectrum of membrane structures indicating Golgi enzyme activity becomes obvious. All 86 patients, who had undergone a posterolateral thoracotomy at our institution between October 2007 and March 2008, received a questionnaire 1 year after the surgical procedure and were contacted by phone 1 week later. Career development needs assessment in cancer prevention and control: focus on research in minority and international settings.

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Surprisingly, wortmannin, at low concentrations, inhibits Raf-1, B-Raf, and MAPK activation in response to IL-8 and C5a demonstrating a role for phosphatidylinositol 3-kinase in the activation of Raf kinases in G protein-coupled receptor systems in human neutrophils. Immunochemical evidence of pyruvate dehydrogenase (E1) deficiency. Most serious concerns should be directed to subjects having preexisting arterial or venous wall alterations or hemostatic disorders. Thirty residents in general surgery performed 2 open partial gastrectomy training events on a porcine model. Influence of orthodontic premolar extraction therapy on the eruption of the third molars: A systematic review of the literature. Multicopy genes that are part of the normal gene catalog of a plant species must have evolved to avoid these silencing mechanisms or their consequences. In the nephrotic syndrome PGE2 excretion rate varied considerably during basal conditions, remission was accompanied by an increase in the PGE2 excretion, and both basal PGF2 alpha excretion rate and the normal response in PGF2 alpha water loading were reduced.

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Delayed Reconstruction of a Traumatic Cloaca Following Obstetric Anal Sphincter Rupture. The core oligosaccharides of Pseudomonas fluorescens lipopolysaccharides. The emetic stimuli used were electrical stimulation of the supradiaphragmatic vagal communicating branch (SVCB) or intraduodenal injection of hypertonic saline. We measured bone mineral density (BMD) in the zyrtec generic 5mg lumbar spine and hip using dual-energy x-ray absorptiometry (DXA) in premenopausal and postmenopausal healthy women who participated in our placebo-controlled tamoxifen chemoprevention of breast cancer trial. Drift of ferrocolloids through a cylindrical grid by magnetic force. A detailed three-dimensional finite element model for radial keratotomy has been developed. A patient with an interstitial deletion in Xp22.3 locates the gene for X-linked recessive chondrodysplasia punctata to within a one megabase interval.

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There was always one menstrual cycle without treatment between every treatment cycle. As we learn more about the coevolutionary process, however, it is becoming increasingly evident that coevolution may also keep populations moderately maladapted much of the time. Even for the most studied system, anode-grown Geobacter sulfurreducens, the mechanisms underpinning each process and how they connect is largely unresolved. Human dental mesenchymal stem cells (MSCs) are considered as highly accessible and attractive MSCs for use in regenerative medicine, yet some of their features are not as well characterized as other MSCs. Blood conservation is a team sport and to make significant strides requires participation and input by all care providers. A marked reduction in secretagogue-induced in vivo and in vitro amylase discharge followed ingestion of either the CDE or E diet. Molecular forms of human growth hormone and prolactin, secreted by cultured pituitary tumor cells. The purpose of this report is to describe a case of idiopathic segmental infarction of the great omentum, in a Tunisian woman, who presented with acute right hypchondrial pain simulating cholecystitis. beta-Aminopropionitrile prevents bleomycin-induced pulmonary micardis tablets fibrosis in the hamster. Favorable subgroups were identified consisting of 123 ambulatory breast cancer patients with no soft tissue metastases, 373 ambulatory lung cancer patients with primary absent or no extracerebral metastases, and 65 ambulatory patients with other primaries and no extracerebral metastases.

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Cold Kit PSMA PET Imaging: Phase I study of 68Ga-THP-PSMA PET/CT in patients with prostate cancer. Intravenous infusion of insulin in doses which increase plasma insulin to physiological levels, induced vascular dilatation and increased muscle sympathetic nerve activity during a euglycaemic glucose clamp. Similar experiments with tumor cell subpopulations, selected by Hoechst 33342 dye diffusion, confirmed that while cytotoxicity to both bright (oxygenated) and dim (hypoxic) cells was increased by combining each alkylating agent with SR-4233, the enhancement of the effect was relatively greater in the subpopulation of dim cells. In contrast, CD error was the most frequent in severe dementia group. Normal tension glaucoma (NTG) is a subtype of glaucoma in which intraocular pressure is within the statistically normal range. We found that substance P, neurokinin A and neurokinin B induced the formation of inositol phosphates in a concentration-dependent manner with similar potencies (EC50S: 3.6, 5.7 and 21.3 nM, respectively), but at concentrations tested (0.1-1.0 microM) these peptides had no effect on cAMP levels. This case is unique in pharmacological respect as it presents the first reported DP treatment with promazine. Instead such peptides were clipped by cytosolic peptidases before efficient transport. However, when BD-IF complexes protonix ppi dosage of various Mt were analyzed by chromatography on Sephadex G-150, IF activity migrates together with BD and not at the distance characteristic of native IF. In France, a law concerning biomedical research came into operation on 20 December 1988.

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Immunological activity in gel diffusion (GD) of the Fraction PII and PIII was specific for sera of B. A quantitative review of pregabalin efficiency and an analysis of the main side effects reported in these studies was then performed. Tenth categories of total and HDL cholesterol fail to independently predict death risk in middle-aged Turkish adults. All patients undergoing hip arthroscopy at 1 institution were prospectively assessed with a modified Harris hip score obtained preoperatively and postoperatively at 3, 12, 24, 60, and 120 months. Two reviewers determined unilateral olfactory bulb and tract volumes and temporal lobe volumes in two separate sessions. The correlation between in vivo and in vitro dissolution of clarithromycin (CAM) tablets was examined. Deep-seated lipomas can present with symptoms very different from those of the common subcutaneous variety. Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase. The beta chain of the GPIIb molecule on ruminant leukocytes and platelets is not labelled by the sulfo-NHS-biotin method. Two macrolide-resistance determinants were cloned from a mycinamicin (Mm)-producing Micromonospora griseorubida strain in Streptomyces lividans and Streptomyces parvulus.

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