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Cardoplus (Losartan)

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Cardoplus is used to treat patients with chronic heart failure when therapy with specific medicines called angiotensin-converting-enzyme inhibitors (ACE inhibitors, medicine used to lower high blood pressure) is not considered suitable by your doctor. If your heart failure has been stabilised with an ACE inhibitor you should not be switched to Cardoplus.

Other names for this medication:
Angioten, Arapres, Asart, Cardon, Cardzaar, Cartan, Corodin, Corus, Cosart, Cozaarex, Czartan, Eklips, Hizaar, Klosartan, Lavestra, Loben, Logika, Lortaan, Losadrac, Losalet, Losartanum, Losatrix, Losavik, Losazide, Lostad, Lostat, Lozar, Lyosan, Maxartan, Medzar, Myotan, Omnitan, Ostan, Ozarium, Portiron, Rasertan, Rasoltan, Resilo, Sanipresin, Sedeten, Tacicul, Tarnasol, Temisartan, Tiasar, Xartan, Zaart

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Also known as: Losartan


Cardoplus (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cardoplus is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cardoplus is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cardoplus 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cardoplus 25 mg, Cardoplus 50 mg, and Cardoplus 100 mg may also contain carnauba wax.


Take Cardoplus tablets orally with or without food. Do not crush or chew it. Take Cardoplus once or twice a day at the same time. If you want to achieve most effective results do not stop taking Cardoplus suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cardoplus are:

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Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cardoplus as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cardoplus. Correct volume or salt depletion prior to administration of Cardoplus.

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The animals were randomized to receive either placebo or 1 mg/kg BW (low dose) or 15 mg/kg BW (high dose) of a novel TNF-alpha inhibitor comprised of two extracellular domains of the p55 TNF receptor linked together with polyethylene glycol. Plasma concentrations of TBPA were measured by rocket immunoelectrophoresis in 43 normal and 35 hypothyroid dogs. These phenomena are partly reversible, and ATPase activity is only partially recovered under highly limited conditions. The D allele may be associated with reduced depression prevalence and severity in female adolescents in the early stage of depression rehabilitation during the follow-up. Local eosinophil- and mast cell-related responses in abomasal nematode infections of lambs.

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Processing techniques for the demonstration of myelin basic protein in paraffin-embedded optic nerve: an immunoperoxidase study of the developing albino rat. The neurologic and unique radiographic changes in our case expand the previously reported findings in CNS angiocentric T-cell lymphoma. They were also more likely to feel that their relationship was egalitarian and that the division of labor in the household was satisfactory. Morphology and synaptic connections of ultrafine primary axons in lamina I of the spinal dorsal horn: candidates for the terminal axonal arbors of primary neurons with unmyelinated (C) axons. Achieving a complete understanding of these interactions requires the chemical synthesis of such oligosaccharides, but this remains challenging. Pseudomonas infections in children with human immunodeficiency virus infection.

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Volatilization of mercuric chloride by mercury-resistant plasmid-bearing strains of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Based on these findings, the controller was modified to account for short-duration, extremely elevated pressures. Exact exchange potential band-structure calculations for simple metals: Li, Na, K, Rb, and Ca. Early activation is associated with conformational changes in membrane macromolecules, and has been studied by measurement of fluorescence intensity or polarization of the membrane-localizing probes ANS, NPN, DPH and TMRITC. It was found that, if suitable image processing was carried on FCR test films, profusion could be classified with an accuracy equal to that of the diagnosis of pneumoconiosis with usual full-size films. Haematological investigation is essentially similar for all species. As a control group, six cervical discs specimens were obtained from three patients undergoing anterior surgery for traumatic burst fractures, and similar biochemical analyses were performed.

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Therefore, they are the initial targets to be investigated in Aspergillus niger. Perfluorocarbon heavy liquids in the management of posterior dislocation of the lens nucleus during phakoemulsification. In modelling studies, a relation between the two is often not made specific, but a correlation is biologically plausible. Xenotransplantation at a crossroads: prevention versus progress. The invasion was found to be progressive, with a progressively enlarging tumor invasion area and an increasing SA/TA ratio in all cases. The following strategies were compared: WF-EMR, universal ESD (U-ESD) and selective ESD (S-ESD) for lesions highly suspicious for containing submucosal invasive cancer (SMIC), with WF-EMR used for the remainder.

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To determine the role of the diepoxide in the ovarian toxicity of VCH and related compounds, a structure-activity study was conducted. In animals with sluggish spontaneous activity, however, no effects were detected in the proximal colon. They both labelled stereociliary antigens that were not detected in any other cell within the cochlear duct or the vestibular epithelial. Phonon modes of diamond (100) surfaces from ab initio calculations. Lastly, it is suggested that nurses would benefit in several ways from some education in ethics. The attitudes of psychiatric nurses and their perceptions of the frequency of in-patient aggression have not been explored in the Nigerian context. To characterize the perioperative alterations in polymorphonuclear leukocytes (PMN) function mediated by protein kinase C, we studied twenty six patients undergoing gastrointestinal surgery. The optimal postoperative analgesic strategy after video-assisted thoracoscopic surgery lobectomy remains undetermined. Role of human CD200 overexpression in pig-to-human xenogeneic immune response compared with human CD47 overexpression. This modification was apparent from a change in the initial movement direction.

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Eight (8) cases of solitary choroidal hemangioma associated with macular serous retinal detachment were treated with Argon green laser photocoagulation. Laparoscopic fistula excision and omentoplasty for high rectovaginal fistulas: a prospective study of 40 patients. To investigate the changes of expression and function of P-glycoprotein (P-GP) in cerebral cortex, hippocampus, liver, intestinal mucosa and kidney of streptozocin-induced diabetic rats. These results are crucial to the analysis of compounds suspected of promoting or inhibiting epidermal tumors. High-contrast dose, MT, and acquisition of immediate postcontrast scans all resulted in statistically significant improvement. No pathology could be identified intra-operatively, or on follow-up imaging. The immunocytochemical detection of growth hormone and prolactin in human prostatic tissues. The superstructure was placed on the implant after a 4-month healing period.

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A case of pigmented ameloblastic fibro-odontoma in the mandible of a 9-year-old Japanese girl is reported. Resonating-valence-bond state with fermionic charges and bosonic spins: Mean-field theory. The key properties of the proposed optical trap are its subwavelength dimensions, the tunability of the trapping frequency, the facile translation of the trap without moving the lens, and the potential for creating an array of traps. Adjuvant trastuzumab therapy has yielded conflicting results for overall survival, concerns about central nervous system (CNS) metastasis, and questions about optimal schedule. Role for protein kinase C in the modulation of glomerular PGE2 production by angiotensin II.

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Axonal uptake of horseradish peroxidase isoenzymes during Wallerian degeneration. Action of lead(II) and aluminium (III) ions on iron-stimulated lipid peroxidation in liposomes, erythrocytes and rat liver microsomal fractions. Ascaris not only presents as a smooth linear filling defect, as commonly described in the literature, but also in a variety of other shapes like parallel smooth filling defects, curves, and loops crossing the hepatic ducts transversely. Evaluation of human postprandial antral motor function using ultrasound. These findings provide novel empirical insight into the role that physical activity may play in terms of resiliency for the development of anxiety disorders. Such information can be useful in guiding novel research and following promising trends. A Proposal for Progression-Free Survival Assessment in Patients with Early Progressive Cancer. Results from a 15-20-year follow-up study of 35 7-12-year-old children with school refusal and 35 age- and sex-matched comparison children are reported.

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A 6-week-old girl presented with bronchiolitis secondary to respiratory syncytial virus. All the patients were followed for 3 months in the out-patient clinic. Most physician assistants were also satisfied with pay and fringe benefits. We conclude that M-T7 functions early in infection to (1) retard inflammatory cell migration into infected tissues and (2) disrupt the communication between sentinel immune cells at the site of primary virus infection in the subdermis and lymphocytes in the secondary lymphoid organs, thereby disabling the host from mounting an effective cellular immune response. The National Biomonitoring Specimen Bank (NBSB), a collaborative project of several U.S. The rodent control program of the Hillsborough County Health Department. Risk stratification by accelerated high-dose dipyridamole stress echocardiography in patients over 70 years of age. Since the TSH pulse attributes (pulse amplitudes, frequencies, interpulse intervals, mean TSH concentrations, by Cluster pulse algorithm) did not significantly change during E2 and E2/P4 replacements, the episodic character of TSH secretion virtually remained unchanged by sex steroid replacements.(ABSTRACT TRUNCATED AT 250 WORDS). Post-vaccination anti-poliomyelitis seroprevalence in an urban setting in Abidjan.

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Alkyne-stabilized ruthenium nanoparticles: manipulation of intraparticle charge delocalization by nanoparticle charge States. Pointers for the intelligent practice of occupational therapy in a tuberculosis institution. Use of combined exogenous gonadotropins and pulsatile gonadotropin-releasing hormone in patients with polycystic ovarian disease: a new approach to induction of ovulation. Uncertainty relation in fluctuations in the space and neurontin dose renal failure time domains in disordered optical media. Value of pre-gestational deafness-related mutation screening for the prevention and intervention of congenital deafness. These structures were identified morphologically as coccidioides immitis. A rapid desensitization of adenylate cyclase activity was observed in minutes upon treatment of intact cells with high hormonal concentrations. Utilizing decreasing sequences of uptake values to filter the images, a modified form of the standard persistence diagrams for 0-dimensional persistent homology as well as novel childhood diagrams are constructed. Torque teno virus (TTV) is a ubiquitous virus that is commonly associated with blood transfusion.

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Accurate processing and secretion in the baculovirus expression system of an erythroid-cell-stimulating factor consisting of a chimaera of insulin-like growth factor II and an insect insulin-like peptide. Transport and metabolism of glutathione isopropyl ester in cerebrospinal fluid. The aims of the study were to investigate whether, unlike naltrexone, EH-NX can stimulate LH secretion without the need of additional estrogen pretreatment and whether EH-NX has peripheral estrogenic effects upon the uterine weight, when administered chronically to long-term ovariectomized rats. These findings were common in cases with and without chronic pyelonephritis showing a considerable similarity to the glomerular changes of experimental focal sclerosis in rats or focal sclerosing glomerulonephropathy in human. Normal BALB/c spleen cells incubated for 2 days with Streptococcus pneumoniae R 36 a (Pn) vaccine in vitro acquired the specific ability to inhibit the T-independent anti-Pn response of fresh lymphocytes. We attempted to explore which P-CT parameters are best used in neoangiogenesis and neoadjuvant therapy for most effective evaluation. Reasonable stabilization may be achieved with fixation of every second rib. Additionally, evidence is shown suggesting the common ancestor of unikonts and bikonts was likely to have encoded at least two formins, a canonical Drf-type protein and a formin bearing a PTEN-like domain. Occurrence of ocular defects in children from nursery schools in the Prague districts 1,2,6,7 during 1969-71. Persistent hemoglobin F in donor blood may give falsely elevated acid-elution test in Rh-negative patient.

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Because of their particular circumstances certain districts may need to provide more than the levels set by the region, and clinicians and community physicians can work together to provide evidence for this. Using an ethnographic approach, reports were tape-recorded, and nurses were interviewed regarding their experiences. Chronic hemodialysis patients with a trajectory of longitudinal high or rapid accumulation of vascular calcification over time were at a higher risk of death. We observed two patients who had mid dermal elastolysis with wrinkling. During the past decade it has been demonstrated that insulin, apart from its effects on metabolism and ion fluxes, has acute effects on the cardiovascular system and capillary permeability. Eukaryotic translation initiation factor 5, eIF-5, has been purified to apparent electrophoretic homogeneity from overproducing Escherichia coli cells expressing the cDNA of the initiation factor under the control of the T7 promoter-T7 RNA polymerase system. The purpose of this study was to compare echocardiographic findings in ischemic stroke patients with diflucan and antibiotics at the same time and without OSA. Effect of a liquid diet on the protein composition of rat parotid saliva. We retrospectively reviewed T1-weighted MR images of 381 patients aged from 7 days to 24 years to evaluate the bone marrow change in thoracic wall and shoulder, pelvis and proximal femur and upper and lower extremities. Introduction of fluorophore at specific branches of biantennary glycopeptides.

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Special procedures are performed with increasing frequency in the PACU. Due to the high concentration of drugs such as nicotine in these liquids, there may be toxic, and possibly fatal consequences. Impaired organ protection may be a potential pitfall of using TRPV1 inhibitors for pain control. Dislocation of the testis as a delayed presentation of scrotal trauma. IFN-related thrombotic microangiopathy (TMA) is a rare but severe complication, with a fulminant clinical onset and a possibly life-threatening outcome that may occur years after a well-tolerated treatment with IFN. The results confirmed that the MAL6T-MAL6S promoter was co-ordinately regulated, repressed by glucose, induced by maltose, and that basal expression was more active in the MAL6S direction than in the MAL6T direction. Histologically, 6 of the 7 study cases were bronchiolo-alveolar carcinoma (BAC) of variable cytological type or papillary adenocarcinoma with a thin fibrovascular stroma without apparent destruction of the alveolar wall. In utero ethanol exposure retards growth and alters morphology of cortical cultures: GM1 reverses effects.

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We have investigated the photoionization of gas-phase and ion-beam desorbed dopamine using femtosecond laser pulses at wavelengths of 800, 400, 267, and 200 nm. Effects of bentonite and monensin on selected elements in the stomach and liver of fauna-free and faunated sheep. Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in Mice. In contrast, treatment of acute disease does not result in any improvement of both microbiological and histopathological parameters. Twenty-five patients who reported no olfactory function since birth were evaluated by olfactory testing, sinonasal endoscopy, and MR imaging. Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases. These results are consistent with a mechanism in which cruciform formation is initiated by the formation of a single-stranded bubble, 10 base-pairs in length, near the center of the palindromic sequence. 24-hour blood pressure monitoring and psycho-physiologic tests in the diagnosis and choice of treatment for arterial hypertension.

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Taken together, these results fail to support earlier hypotheses that blood-borne active metabolites contribute significantly to the immunosuppressive actions of 6-thiopurines. The roles of intracellular mechanisms of contraction were compared in aortas from genetically hypertensive and normotensive rats by investigating the contractile activities of prostaglandin F2 alpha (PGF2 alpha) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the absence of extracellular calcium. In contrast to several other cytotoxic agents, melphalan did not inhibit monocyte phagocytosis. However, if the anxious patient is becoming dysfunctional or symptomatology is severe or persistent enough to warrant the use of medication, BZs are certainly the is it safe to take 20 mg of prilosec twice a day drugs of choice. Angioscopic vein inspection was carried out using Olympus 1.4 and 2.2mm angioscopes in patients undergoing femoropopliteal/distal bypass. Dual responsive supramolecular hydrogel with electrochemical activity. Metoclopramide may cause reversible nonthrombocytopenic vascular-type palpable purpura. Multidecadal stability in tropical rain forest structure and dynamics across an old-growth landscape. Beta-thalassemia major is a complex medical problem found worldwide.

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