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Cardoplus (Losartan)
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Cardoplus

Cardoplus is used to treat patients with chronic heart failure when therapy with specific medicines called angiotensin-converting-enzyme inhibitors (ACE inhibitors, medicine used to lower high blood pressure) is not considered suitable by your doctor. If your heart failure has been stabilised with an ACE inhibitor you should not be switched to Cardoplus.

Other names for this medication:
Angioten, Arapres, Asart, Cardon, Cardzaar, Cartan, Corodin, Corus, Cosart, Cozaarex, Czartan, Eklips, Hizaar, Klosartan, Lavestra, Loben, Logika, Lortaan, Losadrac, Losalet, Losartanum, Losatrix, Losavik, Losazide, Lostad, Lostat, Lozar, Lyosan, Maxartan, Medzar, Myotan, Omnitan, Ostan, Ozarium, Portiron, Rasertan, Rasoltan, Resilo, Sanipresin, Sedeten, Tacicul, Tarnasol, Temisartan, Tiasar, Xartan, Zaart

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Also known as: Losartan

Description

Cardoplus (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cardoplus is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cardoplus is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cardoplus 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cardoplus 25 mg, Cardoplus 50 mg, and Cardoplus 100 mg may also contain carnauba wax.

Dosage

Take Cardoplus tablets orally with or without food. Do not crush or chew it. Take Cardoplus once or twice a day at the same time. If you want to achieve most effective results do not stop taking Cardoplus suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cardoplus are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cardoplus as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cardoplus. Correct volume or salt depletion prior to administration of Cardoplus.

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Eight (8) cases of solitary choroidal hemangioma associated with macular serous retinal detachment were treated with Argon green laser photocoagulation. Laparoscopic fistula excision and omentoplasty for high rectovaginal fistulas: a prospective study of 40 patients. To investigate the changes of expression and function of P-glycoprotein (P-GP) in cerebral cortex, hippocampus, liver, intestinal mucosa and kidney of streptozocin-induced diabetic rats. These results are crucial to the analysis of compounds suspected of promoting or inhibiting epidermal tumors. High-contrast dose, MT, and acquisition of immediate postcontrast scans all resulted in statistically significant improvement. No pathology could be identified intra-operatively, or on follow-up imaging. The immunocytochemical detection of growth hormone and prolactin in human prostatic tissues. The superstructure was placed on the implant after a 4-month healing period.

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A case of pigmented ameloblastic fibro-odontoma in the mandible of a 9-year-old Japanese girl is reported. Resonating-valence-bond state with fermionic charges and bosonic spins: Mean-field theory. The key properties of the proposed optical trap are its subwavelength dimensions, the tunability of the trapping frequency, the facile translation of the trap without moving the lens, and the potential for creating an array of traps. Adjuvant trastuzumab therapy has yielded conflicting results for overall survival, concerns about central nervous system (CNS) metastasis, and questions about optimal schedule. Role for protein kinase C in the modulation of glomerular PGE2 production by angiotensin II.

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Axonal uptake of horseradish peroxidase isoenzymes during Wallerian degeneration. Action of lead(II) and aluminium (III) ions on iron-stimulated lipid peroxidation in liposomes, erythrocytes and rat liver microsomal fractions. Ascaris not only presents as a smooth linear filling defect, as commonly described in the literature, but also in a variety of other shapes like parallel smooth filling defects, curves, and loops crossing the hepatic ducts transversely. Evaluation of human postprandial antral motor function using ultrasound. These findings provide novel empirical insight into the role that physical activity may play in terms of resiliency for the development of anxiety disorders. Such information can be useful in guiding novel research and following promising trends. A Proposal for Progression-Free Survival Assessment in Patients with Early Progressive Cancer. Results from a 15-20-year follow-up study of 35 7-12-year-old children with school refusal and 35 age- and sex-matched comparison children are reported.

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Accurate processing and secretion in the baculovirus expression system of an erythroid-cell-stimulating factor consisting of a chimaera of insulin-like growth factor II and an insect insulin-like peptide. Transport and metabolism of glutathione isopropyl ester in cerebrospinal fluid. The aims of the study were to investigate whether, unlike naltrexone, EH-NX can stimulate LH secretion without the need of additional estrogen pretreatment and whether EH-NX has peripheral estrogenic effects upon the uterine weight, when administered chronically to long-term ovariectomized rats. These findings were common in cases with and without chronic pyelonephritis showing a considerable similarity to the glomerular changes of experimental focal sclerosis in rats or focal sclerosing glomerulonephropathy in human. Normal BALB/c spleen cells incubated for 2 days with Streptococcus pneumoniae R 36 a (Pn) vaccine in vitro acquired the specific ability to inhibit the T-independent anti-Pn response of fresh lymphocytes. We attempted to explore which P-CT parameters are best used in neoangiogenesis and neoadjuvant therapy for most effective evaluation. Reasonable stabilization may be achieved with fixation of every second rib. Additionally, evidence is shown suggesting the common ancestor of unikonts and bikonts was likely to have encoded at least two formins, a canonical Drf-type protein and a formin bearing a PTEN-like domain. Occurrence of ocular defects in children from nursery schools in the Prague districts 1,2,6,7 during 1969-71. Persistent hemoglobin F in donor blood may give falsely elevated acid-elution test in Rh-negative patient.

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