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Capxcel (Capecitabine)
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Capxcel

Capxcel is used in the treatment of cancer of breast, colon, and rectum. It may be also used to treat other conditions, as determined by the doctor. It is used alone or in combination with some other medicine as a part of chemotherapy.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Adalat, Cordarone, Ilosone, Abhigra, Antabuse, Lozol, Skelaxin

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Capxcel for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capxcel for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capxcel dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capxcel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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We retrospectively evaluated the outcome in post-cystectomy urethrectomy cases at our institution from 1994 to 2000. Innovative Bimolecular-Based Advanced Logic Operations: A Prime Discriminator and An Odd Parity Checker. lacked the resistance gene) and also lacked several polymorphic microsatellite alleles from RL6107 that are specific to chromosome 5B. Ontology-based Vaccine and Drug Adverse Event Representation and Theory-guided Systematic Causal Network Analysis toward Integrative Pharmacovigilance Research. Based on the results of this study, the no-observed-adverse-effect level (NOAEL) for GTC-H was 1200 mg/kg/day for males, the highest dose tested, and 400mg/kg/day for females based on reduced body weight gains. 2AA mutagenicity was detected in the presence of cytochrome P450 inhibitors such as alpha-naphthoflavone (ANF), clotrimazole and N-benzylimidazole to study the contribution of CYP isoenzymes to the activation process. Rewarding effects and reinstatement of MDMA-induced CPP in adolescent mice.

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In the L-PAM experiments the LD50/30 and WBC counts were determined as normal-tissue end points. A t-test was used to evaluate the statistical significance between the groups. Assessment of current prescribing practices using World Health Organization core drug use and complementary indicators in selected rural community pharmacies in Southern India. Studies that measured the percentage of underlying somatic diseases after a diagnostic evaluation or naturalistic follow-up period in adult patients initially diagnosed with FSS were included. By varying the right pump speed, we were able to observe the dynamic response of the left atrial pressure (LAP) and simulate conditions that result in atrial suction. TCM Syndrome Differentiation conducting in peri-operative stage might be useful to explore the patterns of Syndrome alteration which provided a basis for preventing peri-operational complication and elevating success rate of operation.

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This marker has been used successfully in marker-assisted selection in the flax breeding program. Through monitoring the effect of H0-NBAR on liposome shape by cryoelectron microscopy, it is clear that membrane morphology is not radically changed. For instance, current pedagogical practice often requires that students demonstrate being in either or both of the following two states: 1) Having grasped the meaning of some relevant theory, concept, law or model, 2) Being able to apply that theory, concept, law or model fruitfully to new instances. Effect of organic acids and nitrogen source on alcoholic fermentation: study of their buffering capacity. The DExD/H containing RNA helicases including RIG-I, MDA5 and LGP2 were analysed in silico in a wide spectrum of invertebrate and vertebrate genomes. The effects on both types of care remained significant after adjustment for mental disorder and functional impairment. Despite their significance, quantifying proteolytic activity in vivo remains a challenge. Three separate aspects common to all the assessments are infective load estimation, exposure pathway identification, and risk estimation. A comparison of histamine, methacholine, and exercise airway reactivity in normal and asthmatic subjects.

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Effect of bile acids on atherosclerosis induced by cholesterol sols. However, directly mapping the dynamic CBV change by the NSIR signal change is based on the assumption of slow water exchange (SWE) around the capillary regime without cerebral blood flow (CBF) effects. In this paper a novel robot neuro-rehabilitation for upper limb, with many merits, is developed. As an application, the Genetic Analysis Workshop 12 German asthma data are analyzed using the proposed methods. Magnesium sulfate, ammonium sulfate, and glucose have low positive influence on the enzyme production. In conclusion, prompt investigations and management of cardiac complications should be performed immediately during PA-induced metabolic crises. Local corticosteroid injection is commonly used to treat sports-related tendon injuries. Their opening probability and transition time constants between open and closed states are voltage-dependent.

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Plasma amino acid concentrations during late rehabilitation in patients with traumatic brain injury. Changes in regional lung density were related to regional dose to define a dose-response curve (DRC) for RT-induced lung injury using three-dimensional planning tools and image fusion. A novel splice site mutation of the arginine vasopressin-neurophysin II gene identified in a kindred with autosomal dominant familial neurohypophyseal diabetes insipidus. A retrospective review of 205 dedicated color and pulsed Doppler sonographic studies of mesenteric arteries was performed in 205 patients. The high sensitivity, rapidity and reproducibility of the BRSV Real Time RT-PCR make this method suitable for diagnostic and for the evaluation of the efficiency of new vaccines. It has been demonstrated that they induce G to A hypermutations in the nascent retroviral DNA, resulting from the cytosine (C) to uracil (U) conversions in minus-stranded viral DNA. Recovery style contributed more to engagement than did insight, appears to be dynamic in the short term and is orthogonal to insight. We concluded that the increased susceptibility of the polyamine-deficient E.

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Immunohistochemistry was performed to assess change in the basilar artery. These studies indicate that inhibition of apoptosis by V5 significantly improves islet function following isolation and improves islet graft function following transplantation. Asbestos and fine glass fibre, which induce high levels of chromosome aberrations and polyploidy in Chinese hamster permanent cell lines, were found to cause no increase in chromosome damage or polyploidy in primary human fibroblasts or in human lymphoblastoid lines. In contrast, the DMM for infant mortality indicates continued convergence since 1950. Importantly, comparisons of different samples with a strong statistical power are possible with InFlow microcopy. Progesterone is an essential regulator of all major reproductive events and progestins and antiprogestins are widely used in the treatment of many different gynaecological and obstetrical disorders. Treatment of transcription and mRNA export (TREX) cells permanently expressing Strep-tag-labeled FGFR1-IIIc with dekafins resulted in receptor phosphorylation. Sofosbuvir, MK-3682, dasabuvir, or combinations of sofosbuvir and ledipasvir or sofosbuvir and velpatasvir had decreased efficacy against infection with the DBN3a sofosbuvir escape variant. The results also showed that the structure of the dental epithelial cells in Polypterus was different from that in teleosts and gars, but that the function of the dental epithelial cells was similar to that in teleosts possessing well-mineralized cap enameloid. The principle of the Nuss procedure is remodulation of the chest using a steel bar inserted by means of two small skin incisions along the axillary lines.

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However, increased scientific understanding of the central and peripheral physiology of sexual response could help to identify the pathophysiology of sexual dysfunction from disease and medical interventions, and also to ameliorate or prevent some dysfunctions. Impaired fibrinolytic function secondary to elevated plasminogen activator inhibitor-1 (PAI-1) levels has been implicated in ischemic stroke. Emergency craniotomy in patients with intracranial metastatic gestational trophoblastic tumor. Health-related safety: a framework to address barriers to aging in place. Regular inspection and cleaning can prevent many fungus-related problems.

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Utilization of nitrogen, phosphorus, calcium, and iron by men on different breakfasts. Center for Spinal Disorders and Injuries, Bibai Rosai Hospital, Japan. While hospital phototherapy is effective, the number needed to treat according to current guidelines varies considerably across different infant subgroups. The Rho GTPases play a critical role in initiating actin polymerization during phagocytosis. The recent increase in foodborne disease associated with the consumption of fresh vegetables stresses the importance of the development of intervention strategies that minimize the risk of preharvest contamination. The patient was a 47-year-old man with myasthenia gravis of Ossermann IIB type. Enterovirus 71 (EV71) is mainly known as a cause of hand-foot-and-mouth disease (HFMD) but sometimes associated with neurological disease, even as fatal brainstem encephalitis. Intraocular pressure control and complications with two-stage insertion of the Baerveldt implant.

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Retrospective analysis of 27 consecutive patients with previously untreated HNSCC who underwent PET-CT imaging in addition to chest radiography (CXR) as part of their metastatic workup. Therefore, the objective of the present study was to examine the biomechanical effects of capsular changes in a cadaveric model. In the present study we investigated the potential of poly(amidoamine) (PAMAM) dendrimers as drug carriers of CPT through aqueous solubility studies. To provide baseline data for research into behaviourally appropriate management systems for deer. However, worldwide co-circulation of two distinct B lineages (Victoria and Yamagata) and difficulties in predicting which lineage will predominate each season have led to the development of quadrivalent influenza vaccines (QIV), which include both B lineages.

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Combining this Multiplex approach and the new Soft-Pulse-Adding-Mixing (SPAM) method considerably increases the signal-to-noise ratio of the conventional MQMAS experiment. Cortical depth dependence and implications on the neuronal specificity of the functional apparent diffusion coefficient contrast. Although this viral disease is still unknown in LA, its vector - the whitefly - has recently been found. A new species of kukri snake (Squamata: Colubridae: Oligodon Fitzinger, 1826) from Con Dao Islands, southern Vietnam. The cells were then transplanted into the tibialis anterior (TA) muscle of mdx (X-linked dystrophic) mice.

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Role of volatile oil pretreatment and skin cholesterol on permeation of ion-paired diclofenac sodium. Among the stilbene derivatives, resveratrol and cassiagrol A (stilbene dimer) displayed antitumor and antimetastatic actions through the inhibition of tumor-induced neovascularization in in vitro and in vivo models. Thousands of patients die unnecessarily each year because of compromised patient safety in hospitals. alpha-Methylepinephrine was more potent than epinephrine in lowering blood pressure. The results of the electrophoretic mobility shift assay and isothermal titration calorimetry suggested that a 28 bp core segment of the ica operator is implicated in the cooperative binding of two IcaR dimers on opposite sides of the duplex DNA. Recent studies have reported several non-hematopoietical effects of EPO. neurological dysphonias are normally associated to dysarthrias and play an important role when determining the correct diagnosis. The multiplex PCR method made the malaria detection more sensitive and specific than the microscopic examination and should be suitable for the diagnosis of malaria in mixed endemic areas, large-scale epidemiological studies, follow-up of drug treatment and donor blood screening. Multiple copies of genes encoding the catalytic subunit (c) of protein phosphatase 2A (PP2A) are commonly found in plants. The aim of the present study was to elucidate the impact of grape cultivars, growing area and the vinification/fermentation process on the ability of red wine polyphenol extracts to increase human endothelial nitric oxide synthase (eNOS) promotor and enzyme activity.

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We have developed a new algorithm, FINE, to enhance the spatial resolution and localization accuracy for closely-spaced sources, in the framework of the subspace source localization. Permanent magnets are used to provide passive radial support and electromagnets to maintain axial stability of the rotor. Studies on redox-competent copper and iron indicate that redox activity in Alzheimer disease resides exclusively within the cytosol of vulnerable neurons and that chelation with deferoxamine or DTPA removes this activity. Selection of patients with hepatocellular carcinoma for sorafenib. Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. The clearance of Gd from linear GBCA was limited in both the normal and impaired renal function mouse models. Sub-acute transmissible spongiform encephalopathies (TSEs), or prion diseases, are affections in which little is known of their etiology.

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This is evidence that human movement planning approaches statistical optimality by representing the task-relevant movement variability. Recurrent meningitis associated with a petrous apex cephalocele. Continued interactions and communication among these two disciplinary communities is essential and can be achieved by the creation of an interdisciplinary research coordination network. Heterogeneity of serum activities of matrix metalloproteinases in chronic endometritis. Other QTL for coleoptile growth were levaquin tablets identified throughout the genome. Kinematic assessment of robot assisted upper arm reaching single-joint movements. It was proposed that the activation of SAPK/JNK signal pathway plays one of the central roles in cellular stress response to low-power nonionizing radiation. Rheological measurements were performed to determine the critical percolation concentration (c(p)).

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Apart from their chemotactic properties, some chemokines such as fractalkine contribute to what is the generic form of protonix platelet activation. It is recommended that other species, such as a productive organism (algae), be included in the next study, once the water reservoir had high levels of herbicides. The objective of this study was to examine whether cellular LOXL4 may provide an effective target for cell-meditated immunotherapy in invasive tumours associated with LOXL4 overexpression. Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma. Identification of a major non-structural protein in the nuclei of Rift Valley fever virus-infected cells. This review covers the mechanisms and indicators of malnutrition in ARF cases and the types of nutritional support that may be used. Mortality is substantial and reinfection can strongly influence outcome. Physician ownership in specialty hospitals raises the bar for health care and the ire of Senator Breaux. The female sex, the young age, the large tumour size and the atypical histological pattern of the tumour all indicated a very poor prognosis. Shallow scoop and deep scoop dehorning caused a prolonged cortisol elevation which returned to control values within 8 hours and 6 hours, respectively.

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Tumor cell-specific gene expression in 19 primary melanomas and 22 melanoma metastases was analyzed using oligonucleotide microarrays after laser-capture microdissection of melanoma cells. Mitochondrial DNA mutations in iPS cells: mtDNA integrity as standard iPSC selection criteria?. Recent data are available for the use of MMF in HCV patients with autoimmune manifestations, mainly for autoimmune cytopenias and vasculitic features. 3H-ACh in superfusate fractions was fractionated and quantified by ion exchange chromatography. Differential effects of endocrine dysfunction on the axial and the appendicular skeleton.

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The assessment of skin viability using fluorescein angiography prior to amputation. Carrageenan-based hydrogels for the controlled delivery of PDGF-BB in bone tissue engineering applications. Furthermore, PRAS40 phosphorylation by Akt and association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mTOR. In this study, we showed a strong synergistic effect of Ara-C with either our Mnk inhibitor (MNKI-8e) or short hairpin RNA (shRNA) mediated knockdown of Mnks in MV4-11 AML cells. Weaning initiates a rapid and powerful anabolic phase in the rat maternal skeleton. MAb 3G2 recognized with high specificity an antigen ionically bound within the primary cell wall and in the culture medium of microcluster cells. The discovery of a second receptor for prostaglandin D2, chemoattractant receptor-homologous molecule expressed on T helper type 2 (CRTH2), has revived significant efforts into the development of small-molecule antagonists for allergic diseases as the receptor is predominantly expressed on cells such as eosinophils, TH2 cells and basophils, which are major pro-inflammatory cells in diseases such as asthma and allergic rhinitis. Spinal cord ischemia after elective stent-graft repair of the thoracic aorta. The ability of saturating levels of GR, and added inhibitors, to prevent the actions of the three modulators (cis-acting element, GR, and TIF2) but not the currently investigated C-terminal fragment of E1A-13S (E1A-133C) indicates that E1A-133C alters GR properties via a second pathway that is downstream of the common step for the original three modulators.

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Also to describe a physical therapy intervention strategy for posterolateral knee pain secondary to hypomobility or malposition of a fabella. To observe the effect of various peritoneal dialysates on the ultrastructure of the peritoneal mesothelium. To demonstrate the expression and location of CX3C chemokine, fractalkine, and its receptor, CX3CR1, in the iris/ciliary body and thus establish their roles in experimental autoimmune anterior uveitis, an animal model of human acute anterior uveitis. NOS3 -786 C/T rs2070744 polymorphism in DCM may serve as a marker for more rapid progression of heart failure. The induction of apoptosis in 3T3-L1 preadipocytes by capsaicin was mediated through the activation of caspase-3, Bax, and Bak, and then through the cleavage of PARP and the down-regulation of Bcl-2. This article reviews the basic mechanisms and possible cosmetical and clinical implications of the recent advances in cutaneous vitamin E research.

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Fluorographic control for effectiveness of bronchopneumonia treatment. Septic arthritis due to Salmonella enteritidis associated with elavil 25mg tab infliximab use. After treatment with esomeprazole, patients showed improved HRQL. The risks of influenza-related complications and hospitalization, as well as healthcare use and costs, were lower for patients prescribed oseltamivir than for those with no antiviral prescription. Malrotation with small bowel volvulus is probably the most worrying of possible causes because if untreated for too long, it can result in massive bowel necrosis. Plasma total lipids and triacylglycerol concentrations were lower in F and SF than in C rats. We compared the effectiveness, side effects, and cost of different chemical pleurodesis agents used in patients with malignant pleural effusion. We propose the Deformable Dot Cluster Marker (DDCM), a novel fiducial marker for high-speed tracking of non-rigid surfaces using a high-frame-rate camera. This classification scheme is as good as others of much greater complexity.

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Trinorsesquiterpenoids from the root extract of Pentalinon andrieuxii. Effect of fines on length of checkout and overdues in a medical library. An assessment of intellectual disability among Aboriginal Australians. The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children. To describe the results of a series of biopsies obtained at the time of vertebral augmentation in presumed osteoporotic VCF, with special reference to the presence of unmineralized bone (osteomalacia) and occult or unconfirmed plasma cell dyscrasia. Increased IFN-gamma protein in bronchoalveolar lavage fluid of anti-IP-10 antibody-treated F344 rats following Sendai viral infection. INFLUENCE of folacin and vitamin B12 on pyridine toxicity in rats. Mast cell infiltration was similar in the treatment and control groups.

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