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Capehope (Capecitabine)

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Capehope is used to help treat patients with Dukes' C colon cancer (colon cancer that has spread to lymph nodes in the area close to the colon), after having surgery. This medicine is also used to treat metastatic colorectal cancer (cancer of the colon or rectum that has spread to other parts of the body).

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Amaryl, Panadol, Rogaine, Azulfidine, Valium, Remeron, Hydrea

Also known as: Capecitabine


{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).


Usual Adult Dose of Capehope for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capehope for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capehope dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Lamivudine dosage information

Side effects

The most common side effects associated with Capehope are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Follow your doctor's instructions about any restrictions on food, beverages, or activity.

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Analysis of the genetic constructs involved in the alterations of EECs on the EECs provide evidence for the cAMP responsive elements as the main mediator. However, the prognostic significance of ST-segment depression with adenosine in patients with normal MPI is not known. Our data thus indicate a role for TmTNF in host defense against mycobacteria by contributing to induction and regulation of Th1-type cytokine and chemokine expression leading to development of bactericidal granulomas expressing iNOS, which critically determines susceptibility versus resistance of the host to mycobacterial infections. The new method can measure the velocity very quickly and is easy to use. Tim16 is a J-like protein that forms a stable subcomplex with Tim14 and recruits it to the translocase. Our data lead to a novel concept of membrane binding and activation of 5-LO, suggesting that arachidonic-acid-containing lipids, which are present in nuclear membranes at higher fractions than in other cellular membranes, may facilitate preferential membrane binding and insertion of 5-LO through increased membrane fluidity and may thereby modulate the activity of the enzyme. Understanding the roles of endogenous voltage gradients, ion flows, and electric fields will contribute to the basic understanding of numerous morphogenetic processes and the means by which they can robustly restore pattern after perturbation. Clinical experiences with the antihistamine Dabylen (diphenyldimethylaminoethyl ether).

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The circadian rhythm regulating floral attractiveness and reward in S. The study exposed 2 strains of mice (CBA/J/J x C57BL/6J and A/J) to chronic cigarette smoke. We conduct grand canonical Monte Carlo simulations and free energy analysis for a gate adsorption phenomenon, which is experimentally observed in flexible frameworks of porous coordination polymers. Although the SR proteins dASF/SF2 and B52 caused defects in ommatidia structure, only B52 impaired normal axonal projections of photoreceptors and neurogenesis in visual ganglia. The results of treatment of 1420 patients, suffering choledocholithiasis, are presented. This review aimed to use the concept of induration distribution analysis to estimate the induration size demarcating positive from negative results in a group of children with suspected tuberculosis, and to compare this cut-off with available guidelines for interpretation of the Mantoux test in the diagnosis of tuberculosis in children. An experimental study on protective effects of Schwann cell cooperation with ECM gel to neurons in rat dorsal root ganglion. Immediately after dry needling in the experimental group, the mean pain intensity was significantly reduced, but the mean pressure threshold and the mean range of motion of cervical spine were significantly increased.

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Effect of lead on calcium homeostasis in the isolated rat hepatocyte. It was of great importance to remind the healthcare providers and health policy makers that high prevalence of depressive and/or anxiety symptoms was found in patients with somatic diseases but with low percentages of previous diagnosis or treatment in the departments of neurology at the general hospitals in urban China. However, any tentative results from the review on potential treatment effects can be used to plan better quality research studies that are of a design appropriate for outcome comparison with conventional therapy. We also evaluated operation time, analgesia, staple line position, postoperative pain score, technical failures, postoperative complications, need for repeated procedures, and patient satisfaction. Learn the significance of prompt identification, treatment, and education of patients with community-acquired pneumonia. Conjugate addition/Ireland-Claisen rearrangements of allyl fumarates: simple access to terminally differentiated succinates. HIV-1 clade C env clones obtained from an Indian patient exhibiting expanded coreceptor tropism are presented with naturally occurring unusual amino acid substitutions in V3 loop. Moreover, we show that human T-cell leukemia virus type 1 protease can be similarly regulated through reversible glutathionylation of its two conserved cysteine residues. Low levels of walking increase the likelihood of having MetS in both white and nonwhite older adults. To determine if PATE is expressed in other accessory tissues of the male genital tract, RT-PCR of the epididymis and seminal vesicle was performed.

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Modulation of synaptic GABAA receptor function by zolpidem in substantia nigra pars reticulata. The ailments of sickle cell trait cases are like persons with normal hemoglobin. Results showed that the addition of specific HuIgG antigen reduced the P1/P2 ratio in five of the six fibers tested. Using optical imaging of intrinsic signals, we found that there are a group of surface-responsive regions located in area 18, along the area 17/18 border, that tend to overlap the singular points of the orientation-preference map. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. In addition, mutations of these genes can affect the D-Titin gene activity, which suggests that the three genes are involved in similar morphogenetic and myogenetic processes. Short- and long-term efficacy of levamisole as adjunctive therapy in childhood nephrotic syndrome. Although micromolar MTX concentrations are present in the eye 4 h after infusion, the lower concentration achieved in vitreous humor may contribute to persistence of IOL. The reduction of proinflammatory cytokines production by WBC stimulated with pathogen-associated molecular patterns is not a generalized phenomenon following murin haemorrhagic shock.

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Zinc oxide nanoparticles/glucose oxidase photoelectrochemical system for the fabrication of biosensor. Inhibition of neuropathy target esterase expressing by antisense RNA does not affect neural differentiation in human neuroblastoma (SK-N-SH) cell line. Utilization of emergency center services by older adults with a psychiatric diagnosis. Interestingly, in this study, CALB1 expression showed the largest difference. Multiple Factor Analysis of the Autonomous Nervous System during PTCA. For comparison the CScore scoring functions from Sybyl were used, and consensus scores were calculated thereof. Male Wistar rats were submitted to maternal deprivation for 3 h daily during postnatal days 2-14, and were sacrificed at 4 or 12 weeks of age. These channels exhibit different relaxation times, each with its own temperature dependence. Laser-driven hard-x-ray generation based on ultrafast selected energy X-ray absorption spectroscopy measurements of Ni compounds. The Siemens Iso-C three-dimensional fluoroscopy unit in rocaltrol tablet nedir the combination with the Stealth Treon computer volumetric navigational system was used.

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In spite of the high diversity of individual expression levels, characteristic protein expression patterns were recognized and patients were grouped according to the similarities found. Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity. Spectrophotometric determination of uric acid based on fading of o-hydroxyhydroquinonephthalein-palladium(II)-hexadecyltrimethyl-ammonium complex. The high rate of secondary haemorrhages in subarachnoid haemorrhages induced us to carry out checks of the behaviour of various coagulation parameters. Prestigious scientists from different lines of research contribute to this Special Issue on EI, assessing important theoretical and empirical topics on this construct. Survey study with data collection at home visits, followed up by self-reports about falls at home visits one year later. gallicum population nodulating common bean in America are discussed.

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Both local mutagenesis through nonhomologous end joining (NHEJ) and gene replacement via homologous recombination (HR) are stimulated by target cleavage. The patient is alive and well without evidence of recurrent disease or metastasis at 10 months from transurethral resection. Core biopsies were harvested at assist device implantation and removal. Parenteral nutrition with standard solutions in paediatric intensive care patients. Also, the counterparts of these molecules, TNF receptor (TNFR) I and II as well as CD30 and CD40, were analysed immunohistochemically. Beyond stroke: description and evaluation of an effective intervention to support family caregivers of stroke patients. To understand the molecular mechanism behind these mitotic errors, we analyzed the consequences of fisetin treatment on the localization and phoshorylation of several mitotic proteins. During these processes, the coactivator Yorkie partners with the transcription factor Scalloped to mediate Hippo pathway-regulated cellular functions. Synthesis, antiviral, antituberculostic, and antibacterial activities of some novel, 4-(4-substituted phenyl)-6-(4-nitrophenyl)-2-(substituted imino)pyrimidines.

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Subtractive DNA cloning is one of the most efficient and comprehensive methods available for identifying eukaryotic genes regulated under specific physiological conditions, including inflammation and host response. While C3-pRBR interaction is not required for viral replication in cycling cells, it may play a role during infection of differentiated cells in intact plants. For deposit contracts to impact population health, ongoing participation will need to be higher. The agonistic Jo2 anti-Fas antibody reproduces human fulminant hepatitis in mice. The peak of the occurrence of acute respiratory illnesses that caused patients to seek medical care always coincided with the peak of influenza virus activity. There is an urgent requirement of specific and sensitive biomarkers in order to improve diagnosis, guide molecular targeted therapy, and predict and examine therapeutic response across a wide spectrum of disease. Mitral valve re-replacement for impaired bioprosthesis after 19 years in a patient undergoing steroid treatment. The paper specifies the parameter ranges corresponding to normal colon tissue, including some previously unpublished ones. Twenty-four patients with type I cysts, 17 with type II cysts and 25 healthy women were evaluated. The autogenous fibular was first harvested and non-evenly split into two halves in a longitudinal manner.

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Thus, the development of a novel and efficient strategy targeted towards the preparation of a range of compounds from biomass-derived sugars is required. ATTEMPTS: a heparin/protamine-based triggered xalatan storage instructions release system for the delivery of enzyme drugs without associated side-effects. If the fetal atrial flutter is resistant to these therapies, a combination of other congenital cardiac diseases or organic abnormalities should be considered. These observations on differences in recognition of nanoparticles by macrophages have important implications in the relationship between the potentially toxic health effects of nanomaterials and their applications in the field of nanomedicine. Effects of random and systematic variations in unresolved cloud on recorded radiance and on target discriminability. The response of the metabolic network of the red blood cell to pyruvate kinase deficiency. Publication bias has been recognized as a problem in ecology and evolution that can undermine reviews of research results. In contrast to solid organ transplantation (SOT), AB0 blood group incompatibilities are of minor importance in haematopoietic stem cell transplantation (HSCT).

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Significant correlation between rectal DVH and late bleeding in patients treated after radical prostatectomy with conformal or conventional radiotherapy (66.6-70.2 Gy). Thermochemolysis provided the same characterization of molecules either unbound or bound to the compost matrix as that reached by a previously applied sequential chemical fractionation of the same compost materials, thereby indicating that thermochemolysis is a more rapid and equally efficient tool to assess compost molecular quality. A sharp decrease in solution ionic strength did not result in the release of the adsorbed DNA, indicating that DNA adsorption prilosec omeprazole 10mg tablet on the NOM-coated silica surface is irreversible under the studied solution conditions. While the original Berry phase (for an isolated system) is the flux of a monopole field through the loop traversed by the magnetic field, the environment-induced modification of the phase is the flux of a quadrupolelike field. The cells expressing alphaIIb/alphavbeta3 have enormous potential for facilitating drug screening for antagonists either to alphavbeta3 intracellular interactions or to alphaIIbbeta3 receptor functions. Total necrosis of the parenchyma occurred only after combined complete occlusion of nodal veins and lymphatics.

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Although maintenance of bone integrity depends on the action of sex hormones in both sexes, menopause is a much more obvious indicator of estrogen deficiency than is the subtle decrease of testosterone in aging men. In this way, the catalytic effect may be consistently explained on the basis of a pair site reactivity model framed on the second-order static density response function. A 64-year-old woman suffered hematoma and bleeding from a pseudoaneurysm probably originating from a branch of the right IMA 16 years after breast implant surgery. The findings alluded towards GC-compositional partialness playing a vital role, which is reflected in the consequential positive correlation between the GC contents at different codon positions. Nineteen patients had antibodies to stratified epithelia (in 9 directed against an antigen of 70 kd). Here, we develop a geometric approach that circumvents this computational difficulty and allows one to study properties of the model without knowing the exact position of the minimum. The applicability of this procedure to humans is still largely unknown. The MO.MA proximal cerebral protection device is first placed in the external and common carotid arteries. Movement between these phases was not linear or continuous, but showed emergent and adaptive properties in which specific triggers and set-backs were often critical. Model limitations include the absence of further importations and additional control measures.

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It is also related to the exercise of power within the relationship of care and therefore may be a relevant factor if older adults are forced to accept increased dependency. Anthropometric and metabolic characteristics including hepatic steatosis assessed by ultrasonography. The NFLTs evaluated by the two versions A4.01 and A6.01 were compared with respect to the C/D ratio and MD score. To evaluate the effectiveness and tolerability profile of tapentadol prolonged release (PR) in a cohort of head and neck cancer (HNC) patients affected by background pain due to painful mucositis during intensity modulated radiation therapy with or without cisplatin with definitive and adjuvant intent. Immunohistochemistry is a powerful tool to detect neurotransmitter (NT) presence in different brain structures with a high spatial resolution. To assess the role of acute infiltration by polymorphonuclear leukocytes (PMNLs) in the pathogenesis of chronic pyelonephritis (CPN), rats were either treated with colchicine to depress leukocyte motility or rendered neutropenic with a single dose of cyclophosphamide. Despite counseling regarding the poor outcome of cervical pregnancies, the patient wished to continue the pregnancy. We discovered several ENZ (PYCR1, QPRT, and HSPA6) and PPI (CASC5, ZBTB32, and CSAD) binding sites on proteins that have been seldom explored in cancer. Transcription shutoff was significantly impaired and delayed in GG rTBP cells upon infection with poliovirus compared with the cells that express wild-type recombinant TBP (wt rTBP). Our work thus uncovers ubiquitin ligases in a mechanistic link between noncanonical Wnt signaling and PCP/CE.

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Dispersed rat lactotrophs were treated with bromocriptine (10(-10) M) for either 30 min or 3 h to investigate its effect on cell morphology using light and electron microscopy and ultrastructural morphometry. Fourier transform infrared (FT-IR) and confocal Raman microspectroscopies were used to identify the deposited materials on explanted IOL. Valuing empathy and emotional intelligence in health leadership: a study of empathy, leadership behaviour and outcome effectiveness. The method is based on the concentration differences of certain elements (potassium and phosphorus) between frozen-hydrated and frozen-dried states of the tissues as applied formerly to sectioned material by others. In experimental extracapillary glomerulonephritis (EG) podocytes migrate, proliferate and change phenotype, and play a pivotal role in crescent formation. These results taken together with computer simulation suggest the existence of appreciable amounts of monomeric species in solution at both pH 6.0 and pH 8.5 at low concentration of liganded protein. Informed consent was waived by the local institutional review board given the retrospective nature of the study.

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