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Capecitabine is used to help treat patients with Dukes' C colon cancer (colon cancer that has spread to lymph nodes in the area close to the colon), after having surgery. This medicine is also used to treat metastatic colorectal cancer (cancer of the colon or rectum that has spread to other parts of the body).

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Lozol, Zyvox, Suprax, Mellaril, Geodon, Tenormin, Nimotop, Eulexin, Zithromax


{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).


Usual Adult Dose of Capecitabine for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capecitabine for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capecitabine dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capecitabine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Capecitabine if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Capecitabine is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Capecitabine .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Capecitabine and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Capecitabine, and for at least 2 weeks after your last dose.

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Cholinergic signaling controls information processing and plasticity in neuronal circuits, but the mechanisms underlying the regulation of cholinergic synaptic strength on different time scales are unknown. The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer. Face membership authentication using SVM classification tree generated by membership-based LLE data partition. Epistaxis is the most common symptom in patients with hereditary hemorrhagic telangiectasia. nucleatum could hardly be reduced with chlorine e6, and only to a certain extent with BLC 1010 and laser only.

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We compared the results obtained by the Roche Cobas Amplicor HIV-1 Monitor Ultrasensitive Test (MCA, manual sample preparation) with those by the Versant HIV-1 RNA 3.0 assay (bDNA). Together with histology, podoplanin may serve as a powerful biomarker to predict the risk for oral cancer development in patients with OPL. Preoperative plasma potassium level was determined 1-3 days before surgery. Gastroscopic observations on changes in the mucosa in infectious hepatitis. Both groups displayed activation of left inferior frontal gyrus (IFG), left superior temporal gyrus (STG), and cingulate. As far as our knowledge, this is the first case report of NCC in Saudi Arabia. Therefore, its effect on disc area might be especially important to explain the structural strength of the ONH in the pathogenesis of glaucoma. Steatocystoma simplex, an entity not previously described, to my knowledge, occurred in 16 women and 14 men. Comparison between apoptosis cells count and ATP-bioluminescence assay in ovarian cancer chemosensitivity testing in vitro.

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In the absence of other clinical or imaging evidence of biliary tract disease, conservative management is advised. Numeric methods offer a unique perspective into the mechanisms behind such clinical measures. Therapeutic options for toxic thyroid nodules (TTNs) are surgery, radioiodine (RAI), and percutaneous ethanol injection (PEI). The estimation of liver triglyceride content by 133Xe clearance. While total habenular lesion completely deprived the fasciculus retroflexus of AChE-stained fibres, a direct effect on the enzyme distribution in the interpeduncular nucleus was only apparent as its rostral pole. Some of these had a narrow tail, and (3) elongated narrow fragments in a row parallel to the apical surface of one or more epithelial cells.

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Osteonecrosis associated with short-term oral administration of bisphosphonate. This paper reports a study to test a proposed model of factors (demographic variables, computer experience and perceived technology characteristics) influencing the efficient use of a computerized nursing care planning system by hospital clinical nurses. Increased homocysteine contributes to the pathophysiology of several chronic inflammatory diseases. Preventive treatment with insecticides at high dosing rates before planting of a new crop- soil drenching- is a common practice in some tropical intensive cropping systems, which may increase the risk of leaching, soil functioning, and pesticide uptake in the next crop. Two major design issues are addressed: one is to acquire the sensor signal with a proper amplitude despite a wide range of variation and the other is to handle the noise contaminated signal which is caused by a motion artifact.

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Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival. The rational and irrational aspects of fear in the countertransference will be discussed. It has previously been shown that prior contraction of rabbit ear artery by equieffective histamine, KCl or serotonin concentrations increased norepinephrine (NE) responsiveness. A newly designed tungsten carbide tip (Cariex TC, KaVo) and a diamond-coated tip (Cariex D, KaVo) in combination with an airscaler (Sonicflex 2003L, KaVo) and two different flow rates of two coolants were investigated. A dynamic workstation, called Oxidesk, was evaluated to determine the possible contribution to healthy behaviour and the impact on perceived work performance. The authors studied whether the amount of IV dextrose administered at the initial visit was related to an RVA as well as which other clinical and treatment parameters were associated with an RVA. The possible relationship between the different variables (age, aetiology, debit), and progress, as well as response to treatments was analysed. It has been reported that CB cells transplanted into an injured liver displayed hepatocyte-like phenotypes.

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Semen results provide new information on the semen-bone Pb relationship. With the highest dose (400 mg/kg), a significant increase was obtained after single and repeated administration. With this aim, we used them to implement a client-server architecture based on software agents. basiretorsa and their structures were identified as N-phenyl-2-naphthalenamine( I ), dibutyl phthalate( II ), diisobutyl phthalate( III ), 1-phenyl-ethane-1, 2-diol( IV ), 2-hydrox-gamma-benzaldehyde( V ), diethyleneglycol monobenzoate( VI ), uracil( VII ), thymine( VIII ) and thymidine( IX ). The aim of this review is to discuss the potential usefulness of a novel class of biochemical markers, neoepitopes, in the context of the US Food and Drug Administration (FDA) Critical Path Initiative, which emphasizes biomarkers of safety and efficacy as areas of pivotal interest. Although basic and instrumental activities of daily living are known to be associated with chewing ability in the elderly, an association between higher levels of competence and chewing ability has not been evaluated in the elderly. We conclude that the effect of diabetes on renal lipid metabolism may reflect, in part, the accelerated glucose flux.

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Peripartum heart failure: the underestimated role of frequent diseases in the Sudan-Sahelian area. Bioinformatics tools were employed to annotated the biological function of differently expressed genes. Formation of the seal, and subsequent rupture of the membrane for whole cell recording, requires a specific sequence of changes in pipette internal hydrostatic pressure. Inpatient units have been starved of resources to pay for community mental health teams. Striking up-regulation of genes involved in innate immunity processes included the leukocyte chemoattractants serum amyloid A1, 2 and 3 (Saa1, 2, 3). Eleven patients were studied 10 days to 2 weeks after an apparent successful portoenterosotomy while four others were clinically well and anicteric three to four years postoperatively. In contrast to the rapid cleavage of mitogen-activated protein kinase kinases by LeTx, the degradation of these transcription factors occurred at a relatively late stage after LeTx treatment. The lamBD genes encoding the putative autoinducing peptide precursor (LamD) and its processing protein (LamB) were overexpressed using the nisin-controlled expression system, and culture supernatants were analyzed by liquid chromatography/mass spectrometry (LC/MS) to identify overproduced LamD-derived peptides. Numerical examples are presented and comparisons with measurement are performed.

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To begin addressing how the individual HSs may interact with one another in a complex, we linked the beta-globin gene to both the HS2 and HS3. Increased production of very low-density lipoprotein (VLDL) is a critical feature of the metabolic syndrome. Response variations will be of value in improving the biofidelity characteristics of dummies for crashworthiness evaluations. Furthermore, in the 37 European rabbits analysed, which included healthy rabbits and rabbits with clinical symptoms of myxomatosis, 14 nucleotide substitutions were obtained but no amino acid differences were observed. However, many women with preeclampsia had soluble fms-like tyrosine kinase 1 concentrations similar to normal pregnant women. There are few examples of trophic cascades strong enough to alter the abundance and composition of entire plant communities. Chloramphenicol in typhoid, paratyphoid and typhus, and other infectious diseases. To analyze the morphological aspects of the healing process occurring in open skin lesions in rats under administration of raw extract from Jatropha Gossypiifolia L. Eleven histopathologic characteristics were selected from the existing literature and used in a blinded evaluation of sections. We conclude that protease inhibitors contribute to the formation of atherosclerosis by promoting the upregulation of CD36 and the subsequent accumulation of sterol in macrophages.

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Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. One sub-group that has been identified is patients who respond rapidly to spinal manipulation. The rapid evolution of signal peptides is mainly caused by relaxed selection on non-synonymous and synonymous sites. Long-term outcomes of children with transanal endorectal pull-through and a review of the literature. Although some joint degeneration is inevitable in the long-term, TRO is an effective salvage procedure for treating AVN after unstable SCFE.

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Downregulation of Bcl-2 by RNAi potentiated the redistribution of Bax and cytochrome c and reversed cisplatin-resistance. The data generated illustrates the value of mesocosm experiments in environmental assessment and how the consideration of functional and structural endpoints of natural communities together with in situ single species bioassays can improve the evaluation and prediction of pesticide effects on stream ecosystems. This effect is accompanied by a significant reduction in cellular lipoperoxidation. TMS is a highly sensitive technique to evaluate cortico-spinal conduction abnormalities in MS that may have no clinical correlate and in monitoring the course flagyl antibiotic and drinking alcohol of the disease. The Effects of Mandibular Advancement Device on Pressure Pain Threshold of Masticatory Muscles: A Prospective Controlled Cohort Study. TRADD reverses these roles, employing a Pelle-like surface to interact with either receptor TNFR1 or adaptor FADD. Eventually, all three cases progressed to biliary cirrhosis and hepatocellular carcinoma, which occurred at 17 months, 4 years, and 7 years, respectively. To provide a current profile of the practice of child neurology, report the attitudes of child neurologists toward practice, and analyze the supply of child neurologists. Often this marks a period of rapid growth for the oocyte and is necessary to coordinate meiotic progression with the developmental events of oogenesis. The recent occupational safety and health literature was identified as a potential source for identifying which strategies are being utilized and evaluated as a means of controlling or preventing chemical hazards.

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Derivatives of pyrazinecarboxylic acid: 1H, 13C and 15N NMR spectroscopic investigations. Although the way FIC1 deficiency leads to PFIC1 remains unclear, some reports suggest that the loss of FIC1 function results in decreased activity of the farnesoid X receptor (FXR) in PFIC1 patients. More than 100 VOC were identified in the fruit and juices studied by GC-MS. Nevertheless, there is no direct evidence to support this assumption. It is well known that adenine-based purines exert multiple effects on pain transmission. Cerebrovascular reactivity and autonomic drive following traumatic brain injury. Between September 1999 and March 2001, a total of 91 couples with infertility were recruited at Al-Hammadi Hospital, Riyadh, Kingdom of Saudi Arabia and Badeea Hospital, Jordan. In addition, the possible causes of low serum PTH levels in the setting of primary hyperparathyroidism are discussed. Effects of adiponectin transgenic expression in liver of fenofibrate 145 mg nonalcoholic steatohepatitis model mice. Meta-analysis: outcomes of total knee arthroplasty in the haemophilia population.

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KiSS-1 and GPR54 genes are co-expressed in rat gonadotrophs and differentially regulated in vivo by oestradiol and gonadotrophin-releasing hormone. Physiological and biological features of OSE cells grown in 3D culture more closely resemble characteristics of OSE cells in vivo than when grown by classical 2D approaches. Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1. The drug remained in the juxtascleral site for at least 5 atenolol 50 mg uses in telugu weeks. Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Variable Temperature Infrared Spectroscopy Studies of Aromatic Acid Adsorbate Effects on Montmorillonite Dehydration.

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A novel combination of three codon inserts in the pol coding region of HIV-1 RNA was identified in a highly antiretroviral experienced study subject with HIV-1 infection. Characterization of LtsA from Rhodococcus erythropolis, an enzyme with glutamine amidotransferase activity. This case also highlights the possible role of upcoming adjuvant chemotherapeutic agents. Bladder cancer incidence and risk factors in men with prostate cancer: results from Cancer of the Prostate Strategic Urologic Research Endeavor. The equivocal role of silicone oil in the treatment of traumatic endophthalmitis. The R240Q2 mutation converts the isomerase substrate, cofactor, and inhibitor kinetic profiles to the 4-14-fold higher affinity profiles of 3beta-HSD1. Assuming axial symmetry, tomographic reconstruction is used convert the beam deflection data to refractive index. teen birth rate highlight the continued importance of improving reproductive health outcomes. These studies provide fundamental insights into the organisational principles of molecular networks and how these give rise to emergent properties such as amplification and feedback loops, and may eventually shed light on the origin of life. We describe the magnetic resonance imaging (MRI) of the internal acoustic canal (IAC) of 3 such patients and postulate a cause for these findings.

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Under such conditions, dietary administration of 1000 ppm annatto neither induce DNA damage in blood and colon cells nor aberrant crypt foci in rat distal colon. We provide clear evidence that in conifers, seed-parasitizing insects do not need to discriminate between fertilized and unfertilized plant ovules when ovipositing their eggs. The empirical curves of the deviations can be applied to the systematic error estimation of the parameters. Anti-Ro antibodies were found in all cases and skin eruptions cleared by 7 months of age, concurrent with the waning of the maternally derived antibodies. Autopsy showed abscess formation at the celiac trunk resulting in an aortogastric fistula. De-repression of heat shock transcription factor-1 in interleukin-6- treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1. Despite growing evidence regarding nonsynostotic plagiocephaly and their repercussions on motor development, there is little evidence to support the use of manual therapy as an adjuvant option.

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A joint transmission and reception (Tx/Rx) beamforming problem is formulated to maximize the achievable rate by mitigating self-interference (SI). MiR-455-5p might serve as a novel biomarker in gastric cancer by targeting RAB18. Induction of apoptosis in human breast cancer and trophoblast tumor cells by galectin-1. The aim of the study was to assess the use of Non Steroidal Anti-Inflammatory Drugs (NSAIDs) in patients with a history of osteoporotic vertebral fractures. Therefore, it can not diminish the electrostatic repulsion among the negatively charged DNA strands of the three-stranded intermediate formed during the strand exchange reaction. The response of the sebaceous glands of female rats ovariectomized at birth to testosterone.

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Intra-articular clodronate for the treatment of knee osteoarthritis: dose ranging study vs hyaluronic acid. Particularly, several groups have demonstrated that this powerful imaging methodology is very effective in the evaluation of osteomyelitis, infected prostheses, fever of unknown origin, and AIDS. He had undergone transapical mitral valve replacement for mixed mitral stenosis and mitral regurgitation. To investigate the prevalence and timing of cervical cerclage placement in multiple gestations. This report deals with the possibility that there is a specific change of the lithium transport across the membrane of erythrocytes from patients with essential hypertension. Myasthenia gravis (MG) is now recognized as an autoimmune disorder in which antibodies to acetylcholine (ACh) receptor lead to impairment of neuromuscular transmission. Recognition of these factors is important for understanding the characteristics of patients at a higher risk of conversion.

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Cloning and molecular characterization of a novel gene strongly induced by the adenovirus E1A gene in rat thyroid cells. The estimation of low levels of 14C in biological samples by alkaline extraction and liquid scintillation counting. Evaluation of the efficacy of antifungal drugs against Paracoccidioides brasiliensis and Paracoccidioides lutzii in a Galleria mellonella model. Sorption of trace metals on human hair and application for cadmium and lead pre-concentration with flame atomic absorption determination. Little is known about the prevalence and risk factors of alcohol problems among older people (especially those aged 75 years and more). Using this model, we found that cell transfection depended strongly on the local cell-pDNA microenvironment as defined by the 2D vs. We have recently documented the presence of an ovulation-inducing factor (OIF) in the seminal plasma of alpacas and llamas.

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