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Calcirol (Calcitriol)
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Calcirol

Calcirol is the active form of vitamin D, normally made in the kidney. It is also known as 1,25-dihydroxycholecalciferol. It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes.

Other names for this medication:
Admax, Alfabond, Alfacalcirol, Alfarich, Arachitol, Arcium, Aristrol, Biocal, Biocitral, Calbec, Calcibest, Calcirol, Calcitriol, Calday, Caldix, Calfa, Calgel, Calosto, Caltive, Calzem, Cholical, Dmcal, Estovon, Koncal, Kurecal, Laretol, Netxod, Novadee, Refirm, Rical, Statbone, Zaxial

Similar Products:
Levitra, Skelaxin, Mestinon, Nimotop, Chloromycetin, Detrol, Vermox, Theolair

Also known as: Calcitriol

Description

Generic Calcirol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Calcirol are intestine and bone. Generic Calcirol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Calcirol may also act on the kidney and the parathyroid glands. Generic Calcirol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Calcirol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Calcirol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Calcirol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Calcirol produces other independent beneficial effects. Calcirol is also known as Calcitriol. Generic Calcirol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Calcirol is Calcitriol. Brand name of Generic Calcirol is Calcirol.

Dosage

Generic Calcirol is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Calcirol suddenly.

Overdose

If you overdose Generic Calcirol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Calcirol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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However, when paying attention to the sizes of the parameter estimates (weights), these two groups show a clear difference. To investigate which co-stimulation-induced signaling events mediate this protection, we analyzed the activity of Ras, Rac-1, mitogen-activated protein kinases (MAPK) and several transcription factors in TCR-activated NOD T cells in the presence or absence of CD28 co-stimulation. A statement of measurement uncertainty describes the quality of a clinical assay analysis result, and uncertainty models of clinical assays can be used to evaluate and optimize laboratory protocols designed to minimize the measurement uncertainty associated with an assay. Thirty-two patients with early extraction of the mandibular third molar before or during orthodontic treatment were examined. The work should highlight the necessity of an individual approach of prescription of the best correction. Despite data indicating decreased utility, axillary staging remains overutilized in women with advancing age. In this article the authors review what it takes to become truly 24 by 7 compliant. The NMR spectra indicate that, of the organic components observable by 1H HR-MAS NMR, aliphatic components preferentially sorb to the clay surface, while carbohydrates and amino acids mainly remain in the supernatant. Enkephalinergic afferents of the centromedial amygdala in the rat.

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The purpose of this study was to identify factors that predict venous thrombosis or stenosis and to evaluate the role of Doppler ultrasonography in assessing the upper venous system of pediatric patients requiring multiple central vascular catheters. Although both groups were equally successful, learning to perform AWs is safer, faster, and less difficult than learning CWs. Family-physician factors associated with glycemic control of patients with diabetes mellitus. Nonfasting serum levels of TSH, free T(4) (fT(4)), T(3), and rT(3) were available in 1025 subjects followed up for incident dementia until 2005. When data from the three years was combined, we found no significant increase in the number of referrals to the MHCOP in the darker months (Chi squared value 1.375, p value (2 tailed) 0.2409). To document internet access and health related usage patterns by families of children in a large paediatric emergency department (ED), and to discover if parents want the internet to become a tool for transferring medical test results. Most of these genes code either for cell adhesion molecules (L-selectin, integrin-beta2) or for factors inducing cell adhesion molecules (IL-1beta, IL-8, EGR1), suggesting that prognosis of this disease may be related to a defect in lymphocyte trafficking.

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Severe long-term radiation-related morbidity was noted in one patient who required reirradiation for a relapsed hemangioma. For example, during tail deceleration the proximal portion of the fifth finlet achieves a mean angle of approximately 75 degrees with the xz plane, while the distal portion of this finlet is oriented at 110 degrees. Overweight females with asthma experience significant challenges because of their weight, more persistent and severe disease, specific comorbidities, and lower rates of obtaining psychosocial resources. Following Mac1-sap treatment there was a near total loss of microglia, these microglia-depleted cultures displayed a significant increase in PI uptake and astrogliosis 1 day after OGD compared to non-depleted cultures. Patient Reported Outcome (PRO) assessments can assist health professionals to tailor their health practices to the individual needs of patients and improve patient care over time. Hydrophobic and charged surfaces may favour the self-assembly process by recruiting proteins and modifying their interactions. Predicted protein-protein interaction sites from local sequence information. Electronic-based alcohol screening and brief interventions for university students with problem drinking behaviours forms an important means by which to identify risky drinkers. In this review we highlight how two differing signalling molecules, Insulin-like Growth Factor-1 (IGF-1) and myostatin, regulate key steps during muscle development. Phylogenetic analysis showed that CarNAC3 belonged to the NAP (NAC-like, activated by APETALA3/PISTILLATA) subgroup of the NAC protein family.

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Further more, the thermotropic behavior of the xerogel is studied by differential scanning calorimetry (DSC) and polarized optical microscopy (POM), which shows typical optical textures of liquid crystals. Failure, to provide these requirements often results in failure to thrive and secondary nutritional disorders. Careful and systematic reporting of the examinations should avoid the devastating consequences of either overlooking a sarcoma or overtreating a benign lesion. We sought to identify the genetic basis of PPCD linked to chromosome 20 (PPCD1) by screening the 26 positional candidate genes between these markers in a family previously mapped to the PPCD1 region. These plans are closely aligned in their aims and intervention design, having emerged from a shared theoretical base. Scanning electron microscopy of the surfaces of hamster embryo cells transformed by herpes simplex virus. Nude mice were found to have a lower level of CNPase than their heterozygous littermates. The E2F family of transcriptional regulators activate or repress gene expression during specific phases of the cell cycle and control various processes including proliferation, apoptosis and differentiation.

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A summary of the findings of each article is provided as a table within this introduction. We determined binding of Natalizumab and its effects on the frequency, transmigratory behaviour and suppressive function of Tregs. Fasting plasma glucose and insulin concentrations were measured at baseline and every 30 min during the OGTT. Chitinase gene (chi) of bean which has been cloned in recombinant binary plasmid vector, pBI121 with 35s promoter of Cauliflower mosaic virus (CaMV), were used for transformation of soybean using strain LBA4404 of Agrobacterium. Representative scar sites were scored clinically according to Vancouver General Hospital Burn Assessment Scale (pigmentation, vascularity, pliability, height, pain, itchiness).

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For treatment, vaginal atrophy, climacteric symptoms and, most importantly, the psychological and relational adjustment process to illness induced changes have to be considered. Leading pharmaceutical companies are increasingly making biotech acquisitions to help them refill their pipelines, but what makes a good acquisition target and what will be the impact of the present financial crisis on deals. The historical background for the study of brain function among hypertensive patients is reviewed. The empirical data consist of 26 open-ended interviews with 23 patients receiving palliative care at home, at a palliative day care, in a palliative bed unit in hospital or in a nursing home in Norway. Recent studies have shown that dysfunction of the epidermal permeability barrier itself plays a primary role in the etiology of atopic dermatitis. Hypoxia in the neonate is known to alter the activity of hepatic and pancreatic enzymes involved in lipid and carbohydrate metabolism. According to Schellhammer theory of the relation between chemical structure and fluorescent quality, and referring to the synthesized benzothiazolyl pyrazoline compounds, the authors designed 1-benzimidazolyl or 1-benzothiazolyl, 3-phenylic derivatives, which posses fluorescent property. Biological nutrient removal with limited organic matter using a novel anaerobic-anoxic/oxic multi-phased activated sludge process. Treating physicians should be aware of the possibility of late recurrence in patients who have had complete correction of their clubfoot deformity. Under oxidant exposure, a lung sphingomyelinase (SMase) is activated and displays continued ceramide generation and pro-apoptotic signaling, thus leading to the pathological apoptosis that causes lung injury.

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Mucormycosis (zygomycosis) in a heart-kidney transplant recipient: recovery after posaconazole therapy. Heritability, genetics and association findings in anorexia nervosa. This finding was exactly the opposite of what one previous study suggested. Chromatography of the crude venom on DEAE Sephadex A-50 with ammonium acetate buffer by two stage elution yielded 13 fractions. MR evaluation of factors predicting the development of rotator cuff tears. To identify barriers and enablers for the immunization of this specific target group, we conducted 11 focus group discussions with adolescents with and without migration background, mothers with Turkish and Russian migration background, and physicians in private practice in March 2011. In addition, TNFRSF19 was negatively regulated by adipogenic transcription factor CCAAT/enhancer-binding proteins (C/EBP). One hundred and seventeen ponies were surveyed for the seasonal prevalence of strongyloid parasites, particularly cyathostomes, and for host- and age-related differences in these infections. Comprehensive theoretical calculation of the masses of yeast phospholipid and sphingolipid molecular species, based on fatty acyl and headgroup heterogeneity, is next used to tentatively assign ions of interest. SOTA is a divisive method: the clustering process is performed from top to bottom, i.e.

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The reduction in desmin expression and creatine kinase activity was, however, reversible upon the removal of TGF-beta. We showed that selenite-induced apoptosis as evidenced by cleavage of poly(ADP-ribose) polymerase was reduced in NIH 3T3 cells treated with ATM small interfering RNA, suggesting the involvement of the DNA damage regulator ATM. Spatial vectorcardiography as a means of differentiating the electrocardiographic patterns of bundle branch block from those of ventricular hypertrophy. We describe an extrabursal endoscopic technique where the bursa is not entered but excised in its entirety under endoscopic vision. We provide evidence of potential physiological roles for KLKs in cervico-vaginal physiology: in desquamation of vaginal epithelial cells, remodeling of cervical mucus and processing of antimicrobial proteins. Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.

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Using an electro-microchip, a nanogold probe, and silver enhancement in an immunoassay. Mice heterozygous for a null mutation in Tbx1 develop conotruncal defects. Both the pharmacokinetic advantages over other anticonvulsant drugs and the lack of pharmacological interactions with oxcarbazepine may point to this drug as a first-line treatment for the management of partial and tonic-clonic epilepsy.(c) 2001 Prous Science. We have investigated the expression and cellular localization of doublecortin in the developing rat retina using immunocytochemistry and Western blot analysis. Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer. Analysis of the HIV-1 data set by PAQ was consistent with phylogenetic analysis of the same data, and the EIAV rev variants were partitioned into two overlapping groups. Repeated intraventricular injections of ACTH 1-24: the effects of home or novel environments on excessive grooming.

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Moreover, hypothermia markedly reversed I/R-induced activation of Fas/caspase-8, the increase of Bax and decrease of Bcl-2. Patients with thick HNM without clinical evidence of in-transit, regional, or distant metastatic spread at presentation were identified from the Surveillance Epidemiology and End Results database. Acuity for letter recognition is known to be worse when multiple letters are presented with narrow interletter spacings than with wide spacings. Epidemic increase in overweight and obesity in Chinese children from 1985 to 2005. Reproducibility of pTV calculations is probably influenced by interobserver variability and may be reduced by relying on experienced observers.

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A case of hand self-mutilation in six years old girl with totals persistent obstetric brachial plexus palsy was presented. We used single-agent VNR administration for nine cases of taxane-resistant non-small cell lung cancer, and an antitumor effect was seen in four cases. endocrinologist, ultrasound scan specialist, surgeon and biologist to put in perspective questions and answers about ET. Loss in sensitivity may well be offset by gains in the capacity of WIC clinics to screen more children. Our objective was to determine national variation in the costs for leukodystrophy patients and to evaluate differences in their care. Does age play a role in recovery from sports-related concussion?. Adiponectin and RBP4 are associated with altered insulin resistance in critical illness.

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Cyclic AMP maintenance of rabbit reticulocyte haem and protein synthesis in the presence of ethanol and benzene. Cardiomyopathies in adolescents: dilated, hypertrophic, and restrictive. Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells. Because some forms of schizophrenia appear to be attributable to early developmental perturbations, many animal studies have examined the influences of various developmental manipulations on PPI in adulthood. Pulsus paradoxus in cardiac tamponade: a pathophysiologic continuum. Virol 24:231--248, 1977) we reported on the provenance of the DNA sequences in 26 herpes simplex virus type 1 (HSV-1) X HSV-2 recombinants as determined from analyses of their DNAs with at least five restriction endonucleases. Valproic acid increases CXCR4 expression in hematopoietic stem/progenitor cells by chromatin remodeling. Differential growth and transmission in cats of feline leukaemia viruses of subgroups A and B. War-related trauma is associated with increased asthma risk in these elderly civilians.

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Proximal to the lesser trochanter the stress decreases as the femur geometry diverges significantly from a cylinder. p27(-/-) mice showed thicker retina and less retinal function than those of other mice. Novel syntheses of peptidyl ketones and peptidyl diketones on polymer support are described. In this study, we define the minimal sequence requirements for a functional telomere and identify specific basepairs that appear to be important for telomere resolution. If the previously described compounds were not prodrugs, it would not be necessary to maintain the O,N-acetalic characteristic. While PRP did not meet noninferiority criteria, the seroprotection rate and geometric mean concentration (GMC) were high, indicating a clinically robust immune response. Vein wall fibrotic injury following deep venous thrombosis (VT) is associated with clarinex cost without insurance elevated matrix metalloproteinases (MMPs).

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The group that received L-365,260 (0.mg/kg) paired with the test environment subsequently showed increased activity in that environment in a drug-free test day. The anesthetic management of these patients should be targeted to maintain perfusion of the vital organs and to control the blood clotting disorders. Understanding the unusual regioselectivity in the nucleophilic ring-opening reactions of gem-disubstituted cyclic sulfates. Synthesis, anticonvulsant and neurotoxicity evaluation of some new pyrimidine-5-carbonitrile derivatives. In a comparison of the simple amount of administration, oral exposure required 102 times or more amount by intravenous injection for detection by an X-ray scanning analytical microscope. No significant decrease in K(i) was observed in the rhAPC-treated group, correlating with a lack of change in BAL parameters and indicating no significant antiinflammatory effect with rhAPC.

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Competitive antagonism by phentolamine of responses to biogenic amines and the transmitter depakote er maximum dose at a neuroglandular junction. Frontal lobe patients not only have difficulties in keeping the effort required for writing, but also to organize the ideas in the written texts. Urethrolithotomy and trimming and epilation of the neourethra seem to be appropriate treatments for urethral calculi associated with hairballs after urethroplasty. By combining three intraoperative parameters with the existing preoperative risk score, a new prediction model was developed that more accurately predicts postoperative AKI. Observations on the decarboxylation of glutamine by Clostridium welchii. Immunohistologic study of thyroidal medullary carcinoma and pancreatic insulinoma.

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These informative fragmentation patterns all could be effectively used for structural elucidation of lipid species containing a carboxyl group. The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells. Experimental results on an independent benchmark dataset signify the efficacy of the method. The aim of this study was to prove the efficacy of antegrade sclerotherapy for varicocele testis in patients with azoospermia and in patients with cryptozoospermia (less than 0.1 million spermatozoons/mL ejaculate). We also sought to explore the relationship between cognitive functioning and WMHs in this population. To do so, blood samples were simultaneously withdrawn upstream (in the cardioplegia line) and downstream of the myocardium (in the left coronary ostium) 10 and 30 minutes after aortic crossclamping. This paper describes five patients to demonstrate the cerebral consequences of immobilisation allowing only passive movements, which implies a prolonged absence of actual motor commands. The proposed inversion formula yields to a filtered backprojection algorithm but the filtering step is implemented using quincunx wavelet filters.

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The case presented is that of osteomas on the left mandibular body and condyle that were successfully treated via an intraoral endoscopic surgical approach. A molecular docking investigation has been carried out on cytotoxic prenylated flavonoids from Lonchocarpus haberi with cancer-relevant chemotherapeutic targets known to be inhibited by flavonoids. Chronic paroxysmal hemicrania: a case report and review of the literature. It is important to emphasize the possible risk of abdominal wall defects in newborns to pregnant women taking carbimazole or methimazole. Temporal estimates of these proliferation events suggest an earlier origin for these what does tramadol 50 mg look like hybrid species than previously supposed.

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At lower doses, the observed size was larger than predicted, which was also true for the ethanol tenormin generic or brand name soluble solutes. Soluble cell extracts from simian virus 40 transformed mouse 3T3 fibroblast cells (SV101) and nontransformed mouse BALB/c-3T3 cells were compared as microtubule assembly systems. An alternative technique uses 1D-PAGE, which results in a mixture of proteins in each gel band. The purpose of this paper is to present findings of an integrative literature review related to emotional intelligence (EI) and nursing. PCDD/F, PCB, HxCBz, PAH, and PM emission factors for fireplace and woodstove combustion in the San Francisco Bay region. It has been shown to enhance the nuclear transport of the HIV-1 pre-integration complex, activate transcription of cellular and viral promoters, and arrest the cell cycle at the G2/M check-point.

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The American Society for Microbiology addresses issues of research integrity in several ways. Antiviral activity of ribavirin in rotavirus gastroenteritis of mice. Variable response (absorbance) is explored as a function of the factors flow rate and length of the reaction coil. These results support the conclusion that EPBL is a germ cell mutagen and its effects are more pronounced during the post-meiotic stage. Response of Schwann cells in the inferior alveolar nerve to distraction osteogenesis: an ultrastructural and immunohistochemical study.

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A young 17-year-old patient developed CSF ascites due to the drainage of CSF into the peritoneal cavity via a ventriculoperitoneal shunt. Spontaneous isoniazid-resistant mutants were characterized by molecular methods allowing identification of the most commonly encountered resistance-conferring mutations. Temporary epicardial pacing following cardiac surgery is a simple method, more effective than transcutaneous pacing and easier to implement than transvenous pacing. Results from in vitro studies suggest that the stability of ziconotide can be maximized by diluting commercial ziconotide formulations as little as possible, decreasing the concentration(s) of the drug(s) compounded with ziconotide, and compounding ziconotide with powders (rather than solutions) of other intrathecal drugs. We report herein an immunohistochemical study of BRCA1 and BRCA2 distribution in a rather unusual tissue (an ovotestis), which addresses this issue. Corresponding to its importance in cell count homeostasis in the body, apoptosis is a tightly regulated phenomenon. Our investigation demonstrated that lentivirus-mediated RNAi silencing targeting ABCC2 might reverse the ABCC2-related drug resistance of NPC cell line CNE2 against cisplatin. Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases. Biologically relevant exposure science for 21st century toxicity testing.

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