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Cadol (Tramadol)

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Cadol is used to help relieve moderate to moderately severe pain. Cadol is similar to opioid analgesics. It works in the brain to change how your body feels and responds to pain. Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Other names for this medication:
Acema, Anatram, Antram, Avdol, Bramadol, Combitram, Cosdol, Didol, Dolex, Dolmeri, Dolocet, Dolriz, Doltel, Domadol, Formador, Haledol, Inodol, Ivydol, Kamadol, Moludol, Mydol, Neutram, Nictram, Orchidol, Oshdol, Paintrol, Postadol, Ramcet, Relidol, Sigmadol, Soztram, Takol, Taramol, Traceta, Tramafen, Tramdop, Tramol, Tramospas, Trapidol, Trazac, Trectadol, Tridol, Tromfil, Victadol, Xtram, Zotadol

Similar Products:
Benicar, Imitrex, Nolvadex, Pyridium, Antabuse, Micardis, Neurontin

Also known as: Tramadol


{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Cadol ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Cadol ER.

Never share Cadol ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Cadol ER.

Cadol ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Cadol ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Cadol ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Cadol ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Cadol ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cadol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Cadol ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Cadol ER should not be given to a child younger than 12 years old. Cadol ER should not be given to anyone younger than 18 years old.

Do not give Cadol ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Cadol ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Cadol ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Cadol ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Oscillatory deformation and turbulent decomposition of chemical wave fronts are observed which are induced by a pronounced oscillatory flow excited spontaneously in a Belousov-Zhabotinsky solution layer with a free surface. Time-event coding and time-window sequential analysis examined whether reassurance preceded or followed child distress. The transolecranon approach, which provides complete posterior visualization and access to the distal humerus, is commonly used. Chondrosarcoma arising from an osteochondroma in a patient with hereditary multiple exostoses (osteochondromatosis). Clinical measurements were performed in eight patients during anaesthesia and postoperative ventilator treatment. Anagrelide suppresses megakaryocyte proliferation and differentiation. Only a certain number of the sporulated cells of the enterotoxigenic strains studied produced this toxin. Subjective visual vertical perception relates to balance in acute stroke. Inclusion criteria were as follows: 1) There was randomization between polyclonal or monoclonal antibodies and placebo or no therapy, and 2) Polyclonal or monoclonal antibodies were given as prophylaxis. Collective efficacy in Denver, Colorado: Strengthening neighborhoods and health through community gardens.

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The most important mental diseases with respect to the life insurance. The novel presentational technique makes this information readily accessible to non-specialists and highlights the need for disaggregation in future OPC studies. We look at how sequence variations that would affect the shape of the cardiolipin binding site might affect the protein-cardiolipin interaction, by modeling the binding of cardiolipin to the reaction center from Rhodopseudomonas viridis. The estimated time interval by which the hand position is mislocalized varied by only 12 ms as the TMS train duration increased by 100 ms. Subsequently, olfactory bulbs (OBs) were taken, proteins extracted, and run on two-dimensional gel electrophoresis with in-gel-protein digestion, followed by mass spectrometry and quantification of differentially expressed proteins. burgdorferi surface proteins that bind GAGs, is sufficient to convert a high-passage nonadherent B. To examine patterns of referral, management and survival of men with prostate cancer, and to document changes over time. Differences in plasma membrane organization of neuroblastoma cells grown in the differentiated and undifferentiated states. Evaluating hormonal mechanisms of vitamin D receptor agonist therapy in diabetic kidney disease: the VALIDATE-D study.

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Mice deficient for Atg5 (autophagy-related 5) specifically in neural cells develop progressive deficits in motor function that are accompanied by the accumulation of cytoplasmic inclusion bodies in neurons. Anorectal manometry and an incontinence questionnaire were administered 1 week preoperatively, 2 weeks postoperatively, 3 and 6 months postoperatively. Qualification and application of a surface plasmon resonance-based assay for monitoring potential HAHA responses induced after passive administration of a humanized anti Lewis-Y antibody. The degree of fixation is more or less proportional to the size of the peak of creatine phosphokinase. Holliday junction resolving enzymes are required by all life forms that catalyse homologous recombination, including all cellular organisms and many bacterial and eukaryotic viruses. Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis. Gastroduodenal fiberscopy revealed carcinoma of the ampulla of Vater, and early gastric cancer was suspected. In the whole blood RNA samples, expression of MMP9, CD14 and IL-1RN reflected pro-and anti-atherogenic drug effects. U0126 (400 microg kg(-1)) or vehicle was given as 60-min intravenous infusions starting either 30 min prior to MCAO or 30 min prior to reperfusion.

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Varicella vaccine was introduced to the infant immunization schedule in each province or territory between 2000 and 2007 as a result of the Canadian Immunization Strategy. Pyruvate kinase activity is controlled by a tightly woven regulatory network. T cell fate specification and alphabeta/gammadelta lineage commitment. In addition, methionine-containing peptides were captured using commercially available methionine-reactive beads, and relative quantitation of peptides was achieved by isotopic labeling of amino groups using activated esters of either nicotinic acid or D4-nicotinic acid. Our results have demonstrated satisfactory concordance index values, suggesting that both the 1998 and the 2006 Kattan preoperative nomograms can safely be used in Turkish patients with similar accuracy. Healing of extraction sockets in collagenase-2 (matrix metalloproteinase-8)-deficient mice. To investigate whether funding of drug studies by the pharmaceutical industry is associated with outcomes that are favourable to the funder and whether the methods of trials funded by pharmaceutical companies differ from the methods in trials with other sources of support. Systems biology approach to investigate biological phenomena seems to be very promising because it is capable to capture one of the fundamental properties of living organisms, i.e. Synthesis of Sendai virus polypeptides by a cell-free extract from wheat germ. These results suggest that manganese-induced stellation is suppressed by a mechanism involving glutamate transporters.

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Thirty consecutive patients with the obstructive sleep apnea syndrome (29 men, 1 woman) were analyzed by questionnaire, polysomnography and oral cavity measurement before and 6 months after uvulopalatopharyngoplasty to assess the surgical outcome and value of preservation of uvula in the operation. Here we will review recent data from both in vitro and in vivo studies analyzing the function of proteoglycans in the nervous system in order to provide possible explanations for their apparent lack of function. Secondly to prepare ethnobotanical inventory of the plant resources of the area, as well as to evaluate the conservation status of important medicinal and aromatic plants (MAPs) through rapid vulnerable assessment (RVA) procedure. Tolerance and acceptability of 14 surgical and hygienic alcohol-based hand rubs. NEPs should be distributing risk reduction supplies in addition to clean needles and should adopt strategies (e.g., outreach and more days/hours of operation) to encourage frequent attendance. LVEF measured during hospitalization for MI was a determinant for HRQoL 2.5 years later. Couples group therapy as an adjunct to lithium maintenance of the manic patient. The objective of the research reported here was to investigate barriers to research utilization and relationships between those barriers and participation in research, self-reported research utilization and education among paediatric nurses. Furthermore, we show that mSec22b, mUse1/D12, mSec20/BNIP1, and syntaxin 18 are recruited into COPI-coated vesicles formed in vitro. During embryogenesis, midbrain dopaminergic neurons are specified rostral to the midbrain-hindbrain organizer (MHO), and hindbrain serotonergic neurons are specified caudal to it.

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We searched for randomized, placebo-controlled trials examining pharmacotherapy of pathological gamblers. In retinoic acid (RA) receptor mutant mice, this latter process fails, and the outflow tract is shortened and misaligned as a result. 1.56-micros continuously tunable parametric delay line for a 40-Gb/s signal. The crystal structure is stabilized by inter- and intramolecular hydrogen bonds. We report a woman who received early mechanical embolectomy as a treatment of acute stroke with infective endocarditis. The pH value of this formulation remained constant at 5 after 37 days of storage at room temperature and the physical appearance of both formulations did not change. The treated diseases for which Blake drains were used comprised 181 cases of primary lung cancer, 44 cases of metastatic lung tumor, 57 cases of benign lung disease, 32 cases of mediastinal tumor, 6 cases of myasthenia gravis, 76 cases of spontaneous pneumothorax, 14 cases of chest wall and/or pleural tumor, 6 cases of empyema, and 4 cases of diaphragmatic disease. The study included 75 subjects: 41 patients with moderate-severe persistent allergic rhinitis due to a pollen allergy and 34 normal subjects. The purpose of this prospective study was to investigate the relationship between xerostomia during the day (XERday) and night (XERnight) and sticky saliva during the day (STICday) and night (STICnight) and dose distributions in different major and minor salivary glands among head and neck cancer (HNC) patients treated with primary radiotherapy (RT) or chemoradiation (CHRT).

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The use of recombinant cockroach allergens should allow mechanisms of cockroach-induced asthma to be investigated and may lead to the development of new approaches to asthma treatment. Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse. Evolutionary drivers of diversification and distribution of a southern temperate stream fish assemblage: testing the role of historical isolation and spatial range expansion. Antimicrobial inderal la 20 mg price activity of an abiotic host defense peptide mimic. RGS2 overexpression by retroviral infection in H295R cells caused a decrease in Ang II-stimulated aldosterone secretion but did not modify cortisol secretion. These findings support the hypothesis that in comparison to Caucasian girls, African American girls may be at lessened risk for developing eating disorders but may be at greater risk for developing obesity. Although there have been numerous publications on lumbar disc herniation (LDH) treated surgically, there has been little interest in sex differences.

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Segmental rigidity of the great vessels demonstrated by rapid angiography on paper bands. To test this hypothesis, we characterized the neural circuits and molecular profiles of the accessory olfactory epithelium in the sea lamprey (Petromyzon marinus). Antibacterial peptides (ABPs) with cancer-selective toxicity have received much more attention as alternative chemotherapeutic agents in recent years. A novel type II cytokeratin, mK6irs, is expressed in the Huxley and Henle layers of the mouse inner root sheath. One eye from each subject was selected at random for lens evaluation. The present results suggest that the non-metabolizable acid may be a risk factor of metabolic acidosis. Although the second liver resection for recurrent HCC can be performed safely and may improve survival, the disease-free survival rate after such resection therapy is low. Global gene expression profiles were compared in a subset of 180 participants. In seven children with refractory epilepsy due to ventolin hfa generic or equal affordable drug other pathologic diagnosis such as vascular or glial lesions, the dystrophic neuritic background was only found in one patient with a ganglioglioma and other features suggestive of an associated cortical dysplasia. Unlike CMS, chronic injections with MAM did not induce anhedonia-like symptoms in rats.

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The cells have been continuously maintained in this environment without morphological alteration or cessation of growth for more than 5 months. Immunohistochemical analysis of granulation tissue at day 14 revealed nitric oxide synthase (NOS) 2 was present in the majority of the cells in the granulation tissue. A snapshot of management practices and nutritional recommendations used by feedlot nutritionists in Brazil. BMP-4 did not olmesartan benicar 40 mg tablet increase ET-1 while BMP-2 increased it minimally in basal medium. Intra-ocular lens power calculation in patients with high axial myopia before cataract surgery. Pasteurized and freeze-dried whole milk, skim milk, and cream, spray-dried whole milk and skim milk, and condensed whole milk were made also.

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It is reasoned that the FSI is used in the fluorescence immunoassay the for measurement of quasi-quantification or quantification. Data from three RNA expression microarray experiments were used: one primary experiment using cDNA arrays profiling gene expression in cervical epithelium from viral cytopathic effect to invasive cancer, one experiment using Affymetrix arrays profiling gene expression in invasive cancerous cervical epithelium, and one experiment using Affymetrix arrays profiling gene expression in CIN cervical biopsy specimens. It also provides a suitable environment for malaria parasites to develop within the midgut lumen without inducing nitric oxide synthase expression. Longitudinal field study of sleep/wake factors influencing mentation report length. Understanding the role of aqueous solution speciation and its application to the directed syntheses of complex oxidic Zr chlorides and sulfates. The prognosis for most patients is good, although recurrence is common. The main purpose of this study is to show that verbal encoding not only facilitates but also impairs performance by taking task demand and characteristics of visual representations into account.

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Flow-injection chemiluminescent immunoassay for alpha-fetoprotein based on epoxysilane modified glass microbeads. Effects of excision of the ocular peduncles on the development of the male genital apparatus of Carcinus maenas Pennant. To study the effect of cortisol and dehydroepiandrosterone sulfate (DHEA-S) in fetal umbilical cord blood on term labor. Non-focal postoperative mental status changes can be challenging. Our data suggest that the reasons for doing so are convenience and discomfort about disclosing risky sexual behaviour to HIV care providers. In striking contrast, in NW Psychopterys and OW Sphedamnocarpus, CYC2-like expression is entirely absent or at barely detectable levels. The formation of O2 was established by observing the reduction of oxidized cytochrome c concomitant with MetHb formation at pH 9, and by showing that superoxide dismultase and norvasc 10 mg pfizer catalse inhibit cytochrome c reduction at that pH. Patients with relapsed or refractory solid tumors were treated with 9 mg/kg of cixutumumab as a 1-hour IV infusion once weekly. Chitosan (CHT) antiviral activity has been further investigated in the pathosystem Phaseolus vulgaris - tobacco necrosis virus (TNV).

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Elaborating patient information with patients themselves: lessons from a cancer treatment focus group. aureus carriage may be also implicated in the clinical course of allergic rhinitis and asthma. Oxidative stress that ensues, when the antioxidant defences are depleted, is accompanied by increases in ROS production in lung epithelial cells. Factors associated with fear-avoidance beliefs about low back pain. Short-term topical imiquimod treatment of partial-thickness burns in rats did not improve clinical appearance and scarring but rather decreased fibrosis. Successful introduction of Macaca nemestrina infants to their mothers after cesarean delivery. Importantly, a group of Ler autorepression mutants complemented an EPEC ler deletion mutant for transcription activation in a dosage-dependent manner, suggesting that Ler and possibly other autorepressors have an intrinsic compensatory mechanism that enables them to sustain mutations. The female patient first developed pain and weakness in the lower limbs and urinary incontinence at age 48, and was given a diagnosis of myelitis.

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Serum-neutralizing titer to this type, but not to 7 other types of avian adenovirus, was more than 4 times as high in convalescing chickens as in chickens from the flock bled 2 weeks previously, during the disease outbreak. The clusters of neoplastic cells were surrounded by basement membrane which demonstrated a focal discontinuity, probably reflecting malignancy of the tumours. Neem extract can be regarded as an immunomodulating and antimetastatic substance which holds promise for further experimental and clinical investigation. Pain studies require prospective patient enrollment to ensure accurate pain assessment. The present study investigates the clinical and radiological mid-term results of the modified Ludloff osteotomy, a proximal metatarsal osteotomy for surgical correction of severe metatarsus primus varus with hallux valgus deformity.

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