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Bupropion is used in the treatment of depression and smoking addiction. This medicine helps by increasing the level of chemical messengers in the brain that relax the nerves and have a calming effect on the brain.

Other names for this medication:
Aplenzin, Budeprion, Bupdep, Bupraset, Bupron, Bupropion, Ession, Nicotex, Smoquit, Unidep, Zyban

Similar Products:
Lamisil, Indocin, Thorazine, Aldactone, Luvox, Ovral, Theolair, Ticlid


{name} SR is an antidepressant used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Too much of this medicine can increase your risk of a seizure.

You may take Bupropion XL with or without food.

Swallow the extended-release tablet whole and do not crush, chew, or break it.

You should not change your dose or stop using Bupropion XL suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the first 2 weeks of treatment. Talk to your doctor if you have trouble quitting after taking Zyban for 7 to 12 weeks.

Your doctor may prescribe a nicotine replacement product (such as patches or gum) to help you stop smoking. Start using the nicotine replacement product on the same day you stop (quit) smoking or using tobacco products.

Some people taking Bupropion XL (Bupropion or Zyban) have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with this medicine.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban.

Smoking cessation may also cause new or worsening mental health problems, such as depression.

This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use Bupropion XL.

Store at room temperature away from moisture, heat, and light.

Detailed Bupropion XL dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Bupropion XL can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Bupropion are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Drinking alcohol with Bupropion SR may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. This medicine can also cause seizures in a regular drinker who suddenly stops drinking at the start of treatment with this medicine.

Avoid driving or hazardous activity until you know how Bupropion SR will affect you. Your reactions could be impaired.

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Cellular immunity to SV40-induced tumor cells and solubilized tumor-associated antigens in immune mice using an isotopic footpad assay. When decreasing blood glucose to euglycaemic blood glucose levels, glucosuria persists so that the classical concept of a renal threshold for glucose excretion cannot be upheld in subjects with type 2 diabetes. The use of hyperoxia to induce chronic mild oxidative stress in RPE cells in vitro. Randomised controlled trials of the stavudine, lamivudine and nevirapine regimen, compared with any other regimens for treating HIV/AIDS, in antiretroviral treatment-naive or antiretroviral treatment-experienced adults. An explanation is given for the apparent disagreement in the published findings on the relative anti-rachitic potencies of ergocalciferol and cholecalciferol in the chick. Comparative studies conducted in France suggest the use of a positivity threshold allowing an increase in both sensitivity and specificity compared to the guaiac tests. Experimental study of the effect on the microfilariae of Onchocerca volvulus. Using the ILR, serial, long-term characterization of electrocardiographic events preceding AF onset was feasible, and typically demonstrated a varied pattern within individuals. Linear regression modeling with generalized estimating equations examined the overall and within-pair associations.

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CPTA-labeled antibody achieved the best tumor to normal tissue ratios when biodistributions of the different (67)Cu-chCE7 conjugates were assessed in tumor-bearing mice. This chapter describes methods for identifying and evaluating the molecular signals that derive from fibroblasts in human tumors. Cytologic examination of cerebrospinal fluid was performed in 1,021 patients, using Nuclepore and Millipore filter techniques. Correlation coefficient was 0.98 between the first two authors, 0.89 between the first author and semi-automated detection before median filtering and 0.91 after median filtering. It is shown here that this singularity is cured by plastic effects in the material, turning the singular solution to a regular crack. It was found that perpivaloyl iridoid glucosides 2, 3, and 4 were markedly cytotoxic against both L1210 and KB-3-1 cell lines. The mean change in MMSE score from baseline and reported adverse effects were compared between the two groups.

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Brain oxygen tension, oxygen supply, and oxygen consumption during arterial hyperoxia in a model of progressive cerebral ischemia. It is impossible to identify or refute clinically important differences between the alternative surgical operations. Our in vitro findings also strongly indicate that astrocyte morphological plasticity is under the control of RhoA and that manganese and L-glutamate regulate astrocyte morphology by modulating this switching molecule under culture conditions. The best treatment option depends on the type and location of lesion, the stage of the lesion, and the needs of the individual patient. A simple two-step electrochemical method is proposed for the synthesis of nanowire-based polypyrrole hierarchical structures. The phenotypic distinction of radial glial cells from the more specialized neuronal progenitors in the proliferative zones and from the migrating neurons in the intermediate zone of the primate fetal forebrain, based initially on morphological criteria, has been supported by their ultrastructural, molecular, and physiological characteristics.

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The incorporation of uracil and valine into the nucleic acid and protein fraction of buds, respectively, was high throughout bud development, perhaps indicating a high rate of turnover in the resting buds. Each lysozyme molecule is able to bind 11-48 oleic acids in various preparations. To test the functional significance of this correlated expression pattern, we ectopically overexpressed GDNF in somitic muscle during the period of motor axon outgrowth and found specific perturbations in the pattern of CaP axon growth. Advanced glycation end products (AGEs) are intimately associated with the diabetic complications and are deleterious to the wound healing process. To evaluate the value of incremental dynamic CT in the diagnosis of pulmonary sclerosing hemangioma (sclerotic hemangioma). Studies from several laboratories have shown that breast cancer patients have preexisting immunity to the HER-2/neu oncoprotein receptor (HER-2) in the form of elevated antibody titers and T-cell immunity. Consecutive patients had phacoemulsification with aspheric IOL implantation. In control mice, metastases were found in 3 out of 9 tumor-bearing mice, all of them being from tumors of the reproductive organs.

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Mechanisms of propofol-induced loss of consciousness remain poorly understood. Here we describe a method for the sensitive detection of a single-base mutation in DNA. Treatment of these recurrences is almost exclusively surgical and is not always easy to perform. In the period of spontaneous recovery, efforts are made to prevent fixed contractures using passive mobilization, splinting, nerve blocks, and electrical stimulation. The BFA System has shown consistency and it is a new tool to help researchers during lung perfusion studies. EFFECTS OF INJURIES CAUSED BY THE CICADA, MAGICICADA SEPTENDECIM, ON THE LATER GROWTH OF TREES. The ischemic damage or dysfunction in different models is obviously protected by Xinshuping. Current alcohol use was associated with being a male, polygamous family background, living alone or with friends, not being religious and self-rated poor academic performance. Women with fertility problems experience a higher prevalence of negative emotions than women without fertility problems. We also have described a miniature swine model of fully mismatched allogeneic composite vascularized thymokidney transplantation that induced transplantation tolerance.

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The DA-induced GH release was suppressed by concomitant infusion of FLA 63 (inhibitor of NE synthesis from DA) and by phentolamine, indicating alpha-adrenergic mediation of GH release. However, the immune mechanisms involved in neurovirulence remain poorly understood. Navigation-guided gap arthroplasty in the treatment of temporomandibular joint ankylosis. Hydrophobic residues Ala-18, Ile-32, Leu-36, and Leu-47 tend to cluster together on the surface of rat OM cyt b(5), blocking water access to the protein interior. Semi-structured interviews with purposively selected key informants representing government proponents and community members were conducted.

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This algorithm resulted in more uniformly distributed residual sound fields than a filtered-X least mean square algorithm. In contrast to other models, regular tissue defects were absent, and the model can therefore be used to evaluate the changes, both histological and mechanical, in the actively healing fascia, which may lead to incisional herniation. The effects of these inhibitors on O(2) uptake and on phosphorylation suggest the coexistence of phosphorylating and non-phosphorylating electron transfer systems in the fruit. This problem is currently being attacked from many different points of view, a strong indication of its current importance. Sleep studies were done within one to four weeks after stroke onset.

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The tasks involved listening to auditory speech, silent lip-reading (visual speech), and perception of meaningless lip movements (visual non-speech). Manipulation-specific activity was observed in the anterior middle frontal gyrus, the inferior frontal junction, and the inferior parietal lobe bilaterally. Elderly people and their family helpers are often isolated at home and do not have access to the professional psychological help that they require. The study used a descriptive correlational design by asking all FNPs in two rural western states to participate by answering a questionnaire. COX2 up-regulation by silica and IL-1 beta was eliminated by IL-1 ra.

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The ontogeny of mouse Mdr1a in duodenum and brain as well as Mdr1b in brain, kidney, and liver all share a similar developmental pattern: low expression at birth, followed by a gradual increase to mature levels at approximately 30 days of age. We analyze observational research situations using EHR data that do not require institutional review board approval. Coherence, collective rhythm, and phase difference distribution in populations of stochastic genetic oscillators with cellular communication. These minerals consist mainly of nano-goethite (alpha-FeOOH), which precipitates exclusively outside cells, mostly on polymer fibers emerging from the cells. cordubensis by exposing the preimaginal stages (prior to the prepupal stage) to 10 degrees C for at least 30 days, but adults emerged without diapause when the duration of exposure was of only 10 or 20 days. Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions. Thioredoxins 1 and 2 protect retinal ganglion cells from pharmacologically induced oxidative stress, optic nerve transection and ocular hypertension. Endobiliary brush biopsy: Intra- and interobserver variation in cytological evaluation of brushings from bile duct strictures. Baicalin down-regulated the expression of TLR4 mRNA and protein, decreased the activation of NF-KB in RAW264.

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Co-factors in liver disease: the role of HFE-related hereditary hemochromatosis and iron. These findings suggest that visual system activation during mental rotation reflects visual perception and can be dissociated from other network components whose response characteristics indicates an involvement in the mental spatial transformation itself. In these patients the severity of asthma improved significantly with potent acid suppression therapy. The purpose of this article is to prospectively evaluate the optimal scan delay for gadoxetate disodium-enhanced hepatic arterial phase MRI of hypervascular hepatocellular carcinoma (HCC) using MR fluoroscopic triggering and a slow-injection technique. We present a series of pediatric patients with rectal prolapse and describe their surgical management, and the subsequent care for those children developing recurrence. Urine concentration of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were also evaluated. Quantitative videofluoroscopic analysis of penetration-aspiration in post-stroke patients.

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Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy: potential role of insulin. Most diving is performed breathing air, and the inert gas of interest is nitrogen. The absorptive cells were not able to discharge lipid droplets of this size into the intercellular spaces and hence into the lamina propria, resulting in the accumulation of the large droplets within the mucosa. The risk versus benefit of a lower INR target range to offset bleeding risk remains uncertain. The presentation of a neo-self glycolipid, presumably by infectious assault of antigen-presenting cells, activates iNKT cells, which promptly release pro-inflammatory and anti-inflammatory cytokines and jump-start the immune system. We conclude that TFIIA tau is associated with undifferentiated cells during development, yet is down-regulated at the chromatin level upon cellular differentiation. Genes involved in inflammatory response pathways were up-regulated whereas genes involved in biotransformation and transport were down-regulated in colonic epithelial cell scrapings of inflamed mdra1 (-/-) mice at 25 weeks of age compared to non-inflamed FVB mice. The most striking difference is that tapping an upper jaw implant in a fully edentulous patient does not give lead to a silent period in the jaw closing muscles.

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This study provides normative data, divided by age and gender, for the Diabetes Self-Management Profile (DSMP), an empirically supported structured interview that assesses adherence with the type 1 diabetes treatment regimen. He was elected a Liberal M P for Dublin in 1880 but did not stand for re-election in 1886, the year of his death. New frontiers in improving atherectomy devices and in optimizing concomitant medical treatment are currently being explored. The S-HSOPSC, consisting of 14 dimensions, 48 items and 3 single-item outcome measures, is used both in hospitals and in primary care settings in Sweden for different purposes. GXR administered either in the morning or evening was associated with significant and clinically meaningful improvements in ADHD symptoms. Children with FASD scored significantly more poorly on sensory processing, sensory-motor, adaptive, and academic achievement measures, and demonstrated more problem behaviors at home and school. Extended maternal separations before age 5 were evaluated as a predictor of long-term risk for offspring borderline personality disorder (BPD) symptoms in longitudinal data from a large random community sample.

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Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Growth of vascular sympathetic axons into the hippocampus after lesions of the septo-hippocampal pathway: a pitfall in brain lesion studies. Pathogenesis of enteropathogenic Escherichia coli (EPEC) infections can be divided in three stages. In adhesion assays, alpha5B2 cells expressing integrin alpha5beta1 bound less effectively to fibronectin teated with neuropsin than intact fibronectin. We aimed to assess the effect of fluorescence-guided resection with 5-aminolevulinic acid on surgical radicality, progression-free survival, overall survival, and morbidity. Where HA resorption occurred, bone and bone marrow was seen adjacent to the implant. Results indicate a homotypic interaction dependent on the presumed oligomerization domain of the p51 proteins. The calculated transition frequencies and line intensities of the rotational transitions in the nu(3) region of N(2)O for the van der Waals ground vibrational state are in good agreement with the observed infrared spectra. Stromal fibrosis in the breast is a non-specific benign pathologic entity with wide spectrum of imaging finding. Doctors should confirm a history of fever by recording temperature.

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Synthesis and evaluation of novel chromone analogs for their inhibitory activity against interleukin-5. Priority of Botkin and his followers in investigation and introduction of new cardiotonics. In vitro assays utilising bacterial, yeast, protozoal, mammalian or human cell cultures singulair 10 mg at age exist for a wide range of toxic and other endpoints. Estimating the precipitation potential in urine-collecting systems. If such elements encode amino acids essential for the protein function, then early selection against mutations in this region will be beneficial for the virus. In the analysis of gene expression profiles, the selection of genetic markers and precise diagnosis of cancer type are crucial for successful treatment. Analogs of benztropine (BZT) that, like cocaine, act at the DAT have effects that differ from cocaine and in some situations block the behavioral, neurochemical, and reinforcing actions of cocaine. On the basis of the results, specific functions have been ascribed to each cell-type.

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Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver. This is, to our knowledge, the first reported case of primary prostatic immature teratoma containing an angiosarcoma component. In dispersed acinar cells prepared from guinea pig pancreas, peptides isolated from amphibian skin (caerulein, bombesin, litorin, and physalaemin) as well as eledoisin, a peptide isolated from the posterior salivary gland of a Mediterranean octopod, increased outflux of 45Ca, release of bound 45Ca, accumulation of cyclic GMP, and release of amylase. The main byproducts detected are formaldehyde (H2CO), carbon monoxide (CO), carbon dioxide (CO2), methane (CH4), and ethylene glycol (C2H4(OH)2). We introduce a compartment model of the human cochlear neuron to study the excitation and propagation process of action potentials.

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Bcl-2 is an independent predictor of breast cancer outcome and seems to be useful as a prognostic adjunct to the NPI, particularly in the first 5 years after diagnosis. The ninth reported case of primary signet ring cell carcinoma of the bladder is described. Oxidative phosphorylation in homogenates of normal and tumor tissues. Some features of life will not be peculiar to our planet, and alien life will resemble ours in such universals. Greater psychological distress was inversely related to frequency of prenatal care (0.7). Our findings showed that patients with silicosis exhibited elevated serum soluble Fas levels, an increased relative expression of the soluble fas and dcr3 genes in peripheral blood mononuclear cells, high levels of other variant messages of the fas transcript, relatively decreased expression of genes encoding several physiological inhibitors (such as survivin and toso), and dominancy of lower-membrane Fas expressers in lymphocytes, which transcribe soluble fas zyprexa scheduled drug dominantly, compared with soluble fas transcription in healthy donors.

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