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Brutiz (Ibuprofen)

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Brutiz is a common painkiller used to treat aches and pains. It blocks chemical messengers in the brain that tell us we have pain. It is effective in relieving pain caused by headache, migraine, nerve pain, toothache, sore throat, period (menstrual) pains, arthritis, and muscle aches.

Other names for this medication:
Alfam, Arthophen, Brufen, Bruzen, Citanz, Combiflam, Cypaflam, Diclospas, Dolgesic, Elbugesic, Genpril, Haltran, Ibifon, Ibrumac, Ibuclin, Ibucon, Ibuflamar, Ibugesic, Ibular, Ibumol, Ibupal, Ibuspa, Ibuspan, Inflapen, Lederflam, Lumbril, Maxofen, Mebufen, Methoprofen, Orthodex, Oysifen, Procartil, Pyrofen, Rufen, Samson, Somaflam, Subdu, Tizafen, Tizidal, Tricofen, Zupar

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Also known as: Ibuprofen


Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain. This medicine does not cure arthritis and will help you only as long as you continue to take it .

In addition, ibuprofen can be used to treat fever, menstrual cramps, and other conditions as determined by your doctor .

This medicine is available both over-the-counter (OTC) and with your doctor's prescription .


This section provides information on the proper use of a number of products that contain ibuprofen. It may not be specific to Brutiz. Please read with care.

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine .

To lessen stomach upset, you may take this medicine with food or milk .

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets and suspension): For fever: Children over 2 years of age—Use and dose must be determined by your doctor. Children 6 months of age up to 2 years—Dose is based on body weight and body temperature, and must be determined by your doctor. For fever lower than 102.5 °F (39.2 °C), the dose usually is 5 milligrams (mg) per kilogram (kg) (about 2.2 mg per pound) of body weight. For higher fever, the dose usually is 10 mg per kg (about 4.5 mg per pound) of body weight. The medicine may be given every six to eight hours, as needed, up to 40 mg per kg per day. Infants younger than 6 months of age—Use and dose must be determined by your doctor . For menstrual cramps: Adults—400 milligrams (mg) every four hours, as needed. Children—Use and dose must be determined by your doctor . For mild to moderate pain: Adults and teenagers—400 milligrams (mg) every four to six hours, as needed. Children over 6 months of age—Dose is based on body weight and must be determined by your doctor. The dose usually is 10 milligrams (mg) per kilogram (kg) of body weight every six to eight hours, as needed, up to 40 mg per kg per day. Infants younger than 6 months of age—Use and dose must be determined by your doctor . For osteoarthritis and rheumatoid arthritis: Adults and teenagers—1200 milligrams (mg) up to 3200 mg per day divided into three or four equal doses. Children—Dose is based on body weight and must be determined by your doctor. The dose usually is 30 milligrams (mg) to 40 mg per kilogram (kg) of body weight per day, divided into three or four doses. Infants younger than 6 months of age—Use and dose must be determined by your doctor .


If you overdose Brutiz and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Brutiz overdosage: uncontrolled eye movements, blue color around lips, mouth, and nose, slow breathing, feeling lightheaded.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Brutiz Childrens dosage information

Side effects

The most common side effects associated with Brutiz are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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However, ectopic expression of MH1 and, more notably, MH2 severely suppressed transcriptional activation of MCP-1 by Tat in astrocytic cells. In rats kept under standard conditions urinary aldosterone exretion rate (UAER) and plasma aldosterone concentration (PAC) showed a circadian rhythm with peak values at the beginning of the dark perioith a single dose of DOC (2 mg/kg sc) or given saline as drinking water UAER and PAC decreased to very low levels. Trauma patients and others with multiple limb impairments present a mobility challenge to all rehabilitation centers. Automatic delineation for replanning in nasopharynx radiotherapy: what is the agreement among experts to be considered as benchmark?. A discrete, topological criterion for phase-space localization is presented. The increasing number of adults with congenital heart disease (CHD) has prompted the development of recommendations for the management of these patients and for the organization of their healthcare. The standard analytical and preparative electrophoresis in polyacrylamide gel did not reveal qualitative differences in the fraction composition of c-RNA of the ascitic tumour cells (Zaidel hepatoma, Ehrlich carcinoma, NK/ly lymphoma) and normal liver cells.

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The study underlines the need for specialized wards treating demented patients with additional illnesses. Isolated nucleoli, nucleolar chromatin, and nucleolar DNA were used as templates for DNA synthesis in appropriately supplemented systems in which RNA polymerases other than RNA polymerase I were blocked by alpha-amanitin. Individualizing chemotherapeutic treatment of colorectal cancer. Here we describe a class of G-quadruplexes, which can bind to ethanolamine groups that widely exist in biomolecules and drug molecules. Global band power ratio and interhemispheric alpha band coherence were calculated. Magnetoencephalography (MEG) was used to measure the somatosensory evoked fields in six healthy males undergoing sacral surface therapeutic electrical stimulation, a recently introduced treatment for chronic urinary dysfunction.

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Observations on the production of hydrogen sulfide by Shigella alkalescens. In addition, evidence is accumulating to suggest that this model has flexible outcomes, depending on factors intrinsic and extrinsic to BD, and may follow several possible paths across the course of maturational development. Concentration of metals Cu, Co, Zn, Pb, Cr, Ni, Cd, and Mn were measured on 36 soil samples collected from the area and the same number of plant samples in order to establish the distribution of heavy metals in the area and to determine the effect of this distribution on the surrounding atmosphere and the possible effects on human life. Most patients could return to their normal routine in approximately 4 to 5 weeks. Regulation of Nitrate Reductase Activity in Corn (Zea mays L.) Seedlings by Endogenous Metabolites. As a result of formation of PtdIns with an added phosphate at the 3 position of the inositol ring, activation of the protein kinases PDK1 (phosphoinositide-dependent kinase 1) and PKB (protein kinase B)/Akt occurs. Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.

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Detection of mecA, mecR1 and mecI genes among clinical isolates of methicillin-resistant staphylococci by combined polymerase chain reactions. We assessed the in vitro effects of preincubation with escalating (50-200 nmol/L) concentrations of escitalopram (ESC) S-desmethyl-citalopram (S-DCT), and S-di-desmethyl-citalopram, (S-DCT) on platelet aggregation through the expression of major surface receptors using flow cytometry and quantitatively using platelet function analyzers in 20 healthy volunteers. It is well known that inhibition of prolyl oligopeptidase (POP) is involved in memory-related function. This article describes the successful extension of the stereotactic technique to the treatment of ocular melanoma: an eye fixation aid is attached to a noninvasive, relocatable Gill-Thomas-Cosman head frame together with a simple eye-movement tracking system. Preclinical studies have shown that erlotinib blocks the growth of human non-small-cell lung cancer (NSCLC) cell lines in vitro by inhibiting the receptor and the downstream protein phosphorylation. The CT scan revealed a heterogeneous tumor lyzing the right maxillary. Many types of glaucoma filtration surgery have been developed since the first attempts almost 180 years ago. All three compounds inhibited NF-kappaB signalling in this cell line, with heptaprenylhydroquinone being the most active.

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Recent work in Arabis alpina, a perennial relative of Arabidopsis, has uncovered subtle differences in control of a gene that represses flowering which contributes to the polycarpic habit. Depression in patients with HIV is under-diagnosed: a cross-sectional study in Denmark. Is combined hydrosoluble choline similar to glycerylphosphorylcholine?. Few studies have examined the relationship between cigarette smoking and novel risk factors for cardiovascular disease in a general population or have included a biochemical marker of current smoking. Persistent visual symptoms are rare, with typical visual aura sometimes being poorly distinguished from other visual disturbances. Tumor suppressor p27(Kip1) undergoes endolysosomal degradation through its interaction with sorting nexin 6. In addition to the direct applications, such assessment may indirectly support decision making by professional associations, government authorities, and other health care organizations that influence clinical practice behaviors.

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Among patients with limited prior HAART experience and adherence barriers that had not been assessed before randomization, no differences were found in virologic or immunologic response for DAART or IACM, compared with SOC, at 6 months. To target for hepatocytic cell, liposomes was modified by special ligand. Investigation of visiospatial disturbance after acute encephalopathy. The database of convicted drivers has been linked to databases with information about age, gender, and various socio-demographic variables, such as education and employment. This study further emphasizes the deleterious effects of air pollution on respiratory health in major populated cities such as Tehran and suggests that increased attention needs to be given to urgent control of air pollution problems.

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Decline in mortality in acute rheumatic fever in New Haven, Connecticut, 1920-1948. The assessment of the older adult with a physical disability: a guide for clinicians. In cells infected with herpes simplex virus, HSV-I, newly synthesized polypeptides accumulated in the nucleus at different rates, which did not change during the first 6 h after infection. To evaluate clinical results of arthroscopic treatment for posterior tibial tendon (PTT) lesions using a posterior approach. elegans, and Drosophila show that longevity can be altered by genetic manipulations. The effects of early life experience on later brain structure and function have been studied extensively in animals, yet the relationship between childhood experience and normal brain development in humans remains largely unknown. Radiotherapy can decrease locoregional recurrence and increase survival in mastectomy patients with T1 to T2 breast cancer and one to three positive nodes with negative estrogen receptor and positive lymphovascular invasion status. All procedures were successful, with no conversions to open surgery required. The rabbit cornea became totally opaque one month after alkaline burn. The postoperative success rate cannot be predicted by the radiographic position along the ductus nasolacrimalis.

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Typing has also been performed on all of the isolates using a microneutralization (MN) and the indirect hemagglutination (IHA) inhibition test. 25OHD was positively, and PTH inversely, associated with lumbar spine, total hip, and whole-body BMD. Universal health coverage and user charges: response to commentaries. Effect of PD fluid instillation on the peritonitis-induced influx and bacterial clearing capacity of peritoneal cells. With the complete sequencing of the class I region of the MHC in different haplotypes, we can now show that the beta block GMT profiles reflect amplification of the duplicated PERB11 segments and not the duplicated segments containing HLA-B and -C, and yet provide a signature that characterizes the entire block rather than individual loci. Art and the brain: the influence of frontotemporal dementia on an accomplished artist. The normal rates of nicotinamide adenine dinucleotide phosphate photoreduction and of photosynthetic phosphorylation observed in chloroplast fragments prepared from cells of the mutant strain indicated that the photosynthetic electron transport chain in the mutant is intact. In this birth cohort study, the authors examined the relation between prenatal exposure to maternal genital/reproductive (G/R) infections and schizophrenia in offspring. Endoscopic surgery represents a minimally invasive and highly successful procedure, complete removal of CP and lesions in the sinus can reduce the recurrence. PCI is based on photochemical reactions initiated by photosensitizing compounds localized in endocytic vesicles, inducing rupture of these vesicles upon light exposure.

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Clinical experiences with locally administered antihistaminic substances. This experiment suggests that future strategies in the prevention of VSMC migration, an initial step in the development of vascular lesions, may involve selective inhibition of the COOH domain of TSP-1. Radiologic study of arterial calcifications of the lower extremities in diabetic patients. The objective of this study was to develop effective RNAi methods for P. Lifetimes of epicardial rotors in panoramic optical maps of fibrillating swine ventricles. Because it occurs in species lacking prey chemical discrimination, such PETF may be a response to gustatory cues or to internal chemicals not encountered on surfaces or trails of uninjured prey. Ectopic expression of Pax2 in podocytes has been reported in various glomerular diseases , but the functional relevance remains unknown. The objective of the current study was to test two pathways through which child care may serve as a naturally occurring intervention for low-income children: a direct pathway through child care quality to child outcomes, and an indirect pathway through improvements in the home environment.

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Automated analysis of immunoglobulin genes from high-throughput sequencing: life without a template. Molecular mechanisms of glutamate neurotoxicity in mixed cultures of NT2-derived neurons and astrocytes: protective effects of coenzyme Q10. Data from 16,997 sample ED encounter records for injuries that included narrative cause of injury text were analyzed. When the summary mean per-act HIV transmission rates were calculated, the ratio of female-to-male HIV transmission in developing countries compared with that in the developed world was 341, whereas that for male-to-female transmission was 2.9. We investigated whether a high level of dissociation predicts self-cutting or other self-harm behavior in a Finnish general population sample of 4019 adolescents aged between 13 and 18 years. Each dose of both psychostimulant drugs also produced a significant decrease in dihydroxyphenylacetic acid (DOPAC) levels.

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Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788. The ABCA subfamily members are thought to transport lipid materials. Gangrenous staphylococcal infections localized on the lesions of acquired reactive perforating collagenosis. The geographically diverse strains were identical in appearance and serological reactivity. The specific binding between mature LOX and mature TGF-beta1 was demonstrated by immunoprecipitation and glutathione S-transferase pulldown assay in vitro. To research on the reliability of diagnosing achondroplasia (ACH) on single cell level and to provide a basis for preimplantation genetic diagnosis(PGD).

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In this case, we examined whether the cyclin D1 gene is amplified in carcinosarcoma of the tongue as well. The generated cell lines will be useful reagents for future mechanistic studies into the regulation and physiologic significance of autophagy. The leaf chloroplasts of Purple Leaf Yellow cultivar contain, in addition, large starch granules which are frequently in intimate association with these plastoglobules. Distribution of Nosema phyllotretae (Microspora, Nosematidae) Weiser, 1961 in populations of Phyllotreta atra (Coleoptera, Chrysomelidae) in Turkey. Ultimately, both pleural and pericardial effusions were controlled after the treatment with prednisolone at an initial dose of 50 mg per day. To identify equine homologues of gel-forming mucins and investigate their expression at different airway generations of healthy and RAO-affected horses. Further research is needed to confirm these results and to test the reliability of other language versions. The shift to striatal dominance over behavior may be a critical step in the progression of alcoholism. Measurement of the amount of oxidative damage to DNA is one tool that can be used to estimate the beneficial effect of diet on the prevention of colon carcinogenesis. A large fraction of the genomes of grasses, members of the family Graminae, is composed of retrotransposons.

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Investigation of an index to measure tooth wear in primary teeth. Trial eligibility and quality were assessed and study authors were contacted for additional information. When patients were grouped according to low or high risk according to the number of factors involved, the difference in disease-free survival between these groups was statistically significant. cruzi genes TcDPM1, TcGPI10 and TcGPI12 complement conditional yeast mutants in GPI biosynthesis. A parallel and incremental algorithm for efficient unique signature discovery on DNA databases. Diagnostic and prognostic significance of serum soluble interleukin 2 receptor in children with malignancies. Of nine laparoscopies, one was converted to laparotomy due to excessive blood loss during the procedure. The present study describes a mass spectrometry-based approach that allows effective discovery and quantification of irreversible cysteine modifications.

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Taken together, we show that loss of expression of members of the BMP family of ligands is a common finding in adrenocortical tumors and we provide evidence that BMP-dependent pathways are likely to be involved in the modulation of the malignant and functional phenotype of adrenocortical cancer cells. The toxic properties of arcelins may be related to their recognition of and interaction with the glycoproteins and other constituents of the membranes along the digestive tract of insects. This study investigated whether frequency spectrum analysis of the finger photoplethysmographic waveform variability (PPGV) could characterize a hypovolaemic response by using a blood donation as a model of controlled mild to moderate haemorrhage. Prior work within the taste aversion baseline of drug discrimination learning has demonstrated that the generalization function for individual rats is graded in nature. Resistance of baseline activity in the elevated plus-maze to exogenous influences. Parental bonding and personality disorder: the mediating role of alexithymia. Furthermore, the results of oviposition preference obtained in the field and in the laboratory have shown a preference for kale, indicating the presence of a positive correlation with performance. All data are analyzed using an Arden engine with the medical knowledge represented in Medical Logic Modules. A phenylethanoid glycoside (ilicifolioside A) and an aliphatic alcohol glycoside (ilicifolioside B), have been isolated from the aerial parts of Acanthus ilicifolius, together with eight known compounds.

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Recent progress in developing water-soluble steroids and steroids with enhanced oral efficacy foster optimism that certain neuroactive steroids will be developed for clinical use. They were compared with 15 prilosec dosing proprioceptors obtained from normal fresh cadavers. The current crystal structure reveals that AgI/II family proteins are extended fibrillar structures with the number of alanine- and proline-rich repeats determining their length. Aim of our study was to determine circulating levels of glycodelin for biochemical monitoring of women with vaginal bleeding and/or abdominal pain in early pregnancy. Morphological modifications of the intestinal wall produced by stenosis with special reference to the segment below stenosis.

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The degree of atheromatosis was similar in the patients with high levels of IgG for Chlamydia pneumoniae and in those with normal serology. The enzyme catalyzes the release of N-terminal acylamino acids, especially acetylamino acids, from acetylpeptides. Further studies are needed to confirm the usefulness of sertraline in the treatment of patients with BED and also in binge eaters with a less severe eating psychopathology. Integration of lipid utilization with Krebs cycle activity in muscle. For simple structures xenical tablets such as Markov trees, the 0-1 graph even coincides with the concentration graph.

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However, there are concerns regarding some inconsistent estimates, and so parsimonious consistent models were estimated. Effects of aureomycin and chloromycetin on bilirubin-urobilin metabolism. The treatment of large defect pseudoarthroses of the tibia by the Hahn-Brandes operation. Appearance of free iron and loss of growth inhibition coincided in patient serum samples taken daily during myeloablative therapy. Moreover, the cellular activity was apparently unaffected by the probe. These alterations not only prevent the formation of a hexamer but also distort the active site geometry resulting in a dimeric form of FabZ that is incapable of substrate binding. Mounting research supports the use of peer-assisted learning (PAL) as a teaching method in human and veterinary medicine. What the people would want if they knew more about it: bactrim gel a case for the social marketing of hospice care.

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Pathologic audit of 164 consecutive cases of vulvar intraepithelial neoplasia. Regulation of osteoblast gene expression and phenotype by polylactide-fatty acid surfaces. It is a novel and valuable tool for QA in IMRT dose delivery and for VMAT dose delivery. They considered that these procedures facilitate their work and improve the quality of care. In this paper findings from ten field studies in five different vine growing regions in Europe indicated that two to four applications of mancozeb at 1.6 kg a.i./ha as part of a spray programme caused minimal impact on naturally occurring populations of predatory mites which in turn was compatible with Integrated Pest Management programmes and the conservation of predatory mites. It can be applied to a variety of different data types, such as gene expression, protein levels, operons or phylogenetic profiles. Vascular and central nervous system lesions were frequently present, giant cell peritonitis, ascites, and multinucleated giant cells in the intestinal epithelial villi were less frequently observed. The impact of individual human immunodeficiency virus type 1 protease mutations on drug susceptibility is highly influenced zocor 40 mg by complex interactions with the background protease sequence. Bovine and rabbit, heavy and light microsomes were isolated from respiratory (tracheal) and vascular (aortic) smooth muscle.

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Two other homosexual males showed a previously latent positivity to syphilis tests at time 0. We searched the Cochrane Stroke Group Trials Register (last searched January 2008), the Chinese Stroke Trials Register (last searched March 2008), and the Trials Register of the Cochrane Complementary Medicine Field (last searched January 2008). In the orthopaedic literature, there is a wide range of clinical outcome measurement tools that have been used in evaluating foot and ankle procedures, disorders, and outcomes, with no broadly accepted consensus as to which tools are preferred. The large quantity of gp160 in the ER hence is a result of its slow transit through this compartment. A microfluidically cryocooled spiral microcoil with inductive coupling for MR microscopy. However, in order to obtain a high rate of success without adverse events, the knowledge of the vein diameter after tumescent anesthesia is recommended in order to use the optimal energy. It has been suggested that SOC activation requires fusion of endomembrane vesicles with the plasmalemma. One advantage of the hybrid micelles as drug carriers is their tunable release rate without sacrificing colloidal stability. Here, we report the tyrosine phosphorylation of vinexin alpha in v-Src-transformed NIH3T3 cells.

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Combined transcutaneous transethmoidal/transorbital approach for the treatment of medial orbital blowout fractures. This subpopulation shows a progressive decline in relative numbers during fetal life, accompanied by a rise in both the relative and absolute numbers of E-reactive thymocytes. The activity of some neurotransmitter-synthetizing enzymes in experimental cobalt epilepsy. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. Two-dimensional analysis when should lasix 20 mg daily be taken of ventricular fibrillation in the guinea pig. Sixty patients underwent a supravesical urinary diversion without concomitant cystectomy for intractable urinary incontinence. We found that rhodopsin mislocalization is a facilitated process for which a signal located within 322-326 aa (CCGKN) is essential. Ward atmosphere in acute psychiatric inpatient care: differences and similarities between patient and staff perceptions. Thermodynamic data reveal that the interaction between the TATA-box-binding protein (TBP) from this organism and DNA has an entirely different character to the same interaction in mesophilic counterparts. This unexpected result also indicates that the hydroxyl group is likely to be the most important group when the adsorption occurs from aqueous solution.

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