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Biproate (Divalproex)

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Biproate is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches.

Other names for this medication:
Devot, Dicorate, Dilex, Divalpro, Divalproex, Epirate, Epival, Epsoval, Napilex, Nepilex, Proval, Sodaval, Torvate, Trival, Valcontin, Valimep, Valowin, Valparin, Valporate, Valporil, Valporiv, Valprid, Valprol, Valric, Valtril, Valver, Velze, Vinchorate, Zorat, Zoret

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Also known as: Divalproex


{name} Sprinkles comes in different pill forms that are for different uses.

{name} Sprinkles tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. This medicine tablets are sometimes used together with other seizure medications.

{name} Sprinkles tablets are also used in adults to prevent migraine headaches, or to treat manic episodes related to bipolar disorder (manic depression).


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Drink plenty of water while you are taking this medication. Your dose may need to be changed if you do not get enough fluids each day.

Swallow the capsule or tablet whole and do not crush, chew, break, or open it.

If you cannot swallow a sprinkle capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away. Do not save it for later use.

You may need frequent blood tests.

If you need surgery, tell the surgeon ahead of time that you are using Biproate Sprinkles.

In case of emergency, wear or carry medical identification to let others know you use Biproate Sprinkles.

Do not stop using Biproate Sprinkles suddenly, even if you feel fine. Stopping suddenly may cause a serious, life-threatening type of seizure. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture and heat.

Detailed Biproate Sprinkles dosage information


If you overdose Biproate and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Biproate overdosage: shallow, breathing, weak pulse, sleepiness, feeling drowsy, loss of consciousness.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Valproic acid dosage information

Side effects

The most common side effects associated with Biproate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Biproate ER if you are allergic to it, or if you have:

liver disease; a urea cycle disorder; or a genetic mitochondrial (MYE-toe-KON-dree-al) disorder such as Alpers' disease or Alpers-Huttenlocher syndrome, especially in a child younger than 2 years old.

Biproate ER can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by a genetic mitochondrial disorder.

Tell your doctor if you have ever had:

liver problems caused by a genetic mitochondrial disorder; depression, mental illness, or suicidal thoughts or actions; or a family history of a urea cycle disorder or infant deaths with unknown cause.

Some people have thoughts about suicide while taking Biproate ER. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Using Biproate ER during pregnancy may increase the risk of serious birth defects that can develop early in pregnancy, even before you know you are pregnant. Using this medicine during pregnancy can also affect cognitive ability (reasoning, intelligence, problem-solving) later in your child's life. However, having a seizure during pregnancy could harm both the mother and the baby.

If you take Biproate ER for seizures or manic episodes: The benefit of preventing seizures or manic episodes may outweigh any risks posed by this medicine. There may be other medications that are safer to use during pregnancy. Do not start or stop taking this medicine without your doctor's advice.

Do not use Biproate ER to prevent migraine headaches if you are pregnant or you could become pregnant.

If you are not pregnant, use effective birth control to prevent pregnancy while using Biproate ER. Tell your doctor if you start or stop using hormonal contraception that contains estrogen (birth control pills, injections, implants, skin patches, and vaginal rings). Estrogen can interact with this medicine and make it less effective in preventing seizures.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

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To assess the frequency of chronic lung disease and factors associated with its development in term infants with severe respiratory failure who receive high-frequency oscillatory ventilation, or high-frequency oscillatory ventilation, and extracorporeal membrane oxygenation (ECMO). This review focuses on BAs as newly recognized signaling molecules that modulate cardiovascular function. To evaluate adverse pregnancy outcome in HIV infected women who received highly active antiretroviral therapy (HAART) from early pregnancy compared with untreated-maternal HIV infection. The occurrence of 4 bone fractures associated with birth by Caesarean section (CS) prompted us to examine the incidence and predisposing factors of bone injuries sustained during birth. TEE has assumed a pivotal role in the perioperative management of patients undergoing open-heart surgery. A 35-year-old woman in her 34th weeks of pregnancy with a thrombus on prosthetic mitral valve was scheduled for emergency caesarian section under general anesthesia.

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A naturally occurring single base-pair G to A transition, creating a 10/11 near-match close to the essential 11 base-pair core consensus of ARS1, was used to investigate the importance of near-match sequences. More research is needed to evaluate the most efficient and integrated clinical pathway from prehospital interventions to rehabilitation as well as the optimal treatment of older TBI patients. Dissecting aortic aneurysm involving an anomalous right subclavian artery and isolated left vertebral artery: case report and review of the literature. The plasma level of VK1 decreased in both groups, but VK2, especially MK-4, was high in the group with VK. In this study we demonstrate the presence of HILDA/LIF in the urine but not in the serum of kidney graft recipients during acute rejection episodes, whereas this lymphokine was detectable neither in the serum nor in the urine of kidney transplanted patients with stable renal function. The absence of a fiberglass post resulted in significantly higher strain values and more irreparable fracture modes than were noted in the other groups. Clinical aspects and therapy of acute and chronic liver insufficiency and hepatic failure.

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Risk of infant infection during labor in maternal viral hepatitis and new preventive methods. The effects of these forces on these structures were analyzed with different methods. Fractured and necrotic bones were examined by new silver impregnation techniques based on the catalytic activity of noroxin generic name the bone. Reproducibility of trunk isoinertial dynamic performance in patients with low back pain. Pulmonary complications in inhalation injuries with associated cutaneous burn.

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Accuracy of dual-source CT to identify significant coronary artery disease in patients with uncontrolled hypertension presenting with chest pain: comparison with coronary angiography. This study isolated a full length cDNA encoding DFR, designated as SmDFR (GenBank Accession No. Our findings revealed that the performance of the EWMA in the bactrim pediatric suspension real time detection influenza outbreak in Iran is appropriate. Mating type regulates the radiation-associated stimulation of reciprocal translocation events in Saccharomyces cerevisiae. Spironolactone was prescribed at a dose of 100 mg per day for three months.

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