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Biotrexate (Methotrexate)
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Biotrexate

Biotrexate is a diagnostic aid. It is used to test if the adrenal glands are working properly. Biotrexate is used in the diagnosis of certain problems of the adrenal glands. These glands are located near the kidneys. The adrenal glands produce a steroid chemical called cortisol (hydrocortisone) that helps the body respond to stress or illness.

Other names for this medication:
Alltrex, Beltrax, Caditrex, Carditrex, Cytotrex, Dermotrex, Folitrax, Imutrex, Merex, Methocip, Methorex, Methotrexate, Metorex, Metrex, Mexate, Neotrexate, Nidtrex, Oncotrex, Onotrex, Plastomet, Remtrex, Rextop, Roxate, Tevatrex, Throtex, Trixilem, Vibzi, Zexate

Similar Products:
Zyprexa, Uroxatral, Chloromycetin, Periactin, Famvir, Strattera

Also known as: Methotrexate

Description

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Dosage

This section provides information on the proper use of a number of products that contain tamoxifen. It may not be specific to Biotrexate. Please read with care.

Use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not take it for a longer time than your doctor ordered.

Medicines used to treat cancer are very strong and can have many side effects. Before using this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Shake the oral liquid well before each use. Measure the medicine with a marked medicine cup. The average household teaspoon may not hold the right amount of liquid.

Swallow the tablets whole with a glass of water. Do not break, divide, crush, or chew it. You can take the tablets with or without food.

Tamoxifen sometimes causes mild nausea and vomiting. However, it may have to be taken for several weeks or months to be effective. Even if you begin to feel ill, do not stop using this medicine without first checking with your doctor. Ask your health care professional for ways to lessen these effects.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (solution, tablets): For breast cancer: Adults—20 to 40 milligrams (mg) per day. Doses greater than 20 mg are given as 2 divided doses per day (morning and evening). Children—Use and dose must be determined by your doctor. For breast cancer as additional treatment: Adults—20 milligrams (mg) per day for 5 to 10 years. Children—Use and dose must be determined by your doctor. For reducing the risk of developing breast cancer in high-risk women: Adults—20 milligrams (mg) per day for 5 years. Children—Use and dose must be determined by your doctor. For reducing the risk of developing invasive breast cancer in women with ductal carcinoma in situ: Adults—20 milligrams (mg) per day for 5 years. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Biotrexate and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Biotrexate dosage information

Side effects

The most common side effects associated with Biotrexate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Biotrexate if you are allergic to Duloxetine, other SNRIs or to any of the medication's components. Do not take Biotrexate if you have taken recreational drugs such as ecstasy (MDMA), ketamine, LSD, poppers (amyl nitrate), narcotics or benzodiazepines. Do not take Biotrexate if you are taking other medications, including erythromycin, alpha-blockers, antifungal medications (ketoconazole and itraconazole), medications for HIV (ritonavir, saquinavir, nelfinavir and atazanavir), certain antibiotics (telithromycin), alprazolam (Xanax), anticoagulants (warfarin), antidepressants (Elavil, Asendin, Anafranil, Norpramin), MAOI antidepressants (Marplan, Nardil, Eldepryl, Emsam, Zelapar), SSRI antidepressants (fluvoxamine), herbal remedy St. John’s Wort, NSAIDs (Advil, Motrin, Aleve, Naprosyn), clopidogrel (Plavix), diazepam (Valium), digoxin (Lanoxin), diuretics ('water pills'), linezolid, flecainide (Tambocor), medications for diabetes, lithium (Eskalith, Lithobid), medications for anxiety and Parkinson's disease, methylene blue, medications for mental illness (Clozaril, Haldol), medications for migraine (Axert, Relpax, Frova, Amerge), medications for seizures (Tegretol, Dilantin), sedatives, sibutramine (Meridia), sleeping pills, tramadol (Ultram), tranquilizers, and vinblastine (Velban). Do not take Biotrexate if you experience seizures (convulsions or fits). Do not take Biotrexate if you suffer from or have history of cardiovascular disease, liver or kidney disorders, hypotension, leukemia, peptic ulcer disease, rhinitis, glaucoma, epilepsy. Do not take Biotrexate if you have a history of fainting, mania (feeling overexcited, irritable or not being able to think clearly) or severe depression. Do not take Biotrexate if you have recently undergone a surgery. Do not to consume alcohol, drive or operate machinery while using Biotrexate, as it can lower your blood pressure, causing dizziness, drowsiness. Biotrexate is not for use in patients under age 18 years.

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The patient was treated for a familial hyperlipoproteinemia type IIa. In addition, cytoplasmic staining is often not appropriately investigated by a specific antibody assay, leading to decreased clinical sensitivity of the ANA test. While not all pineal gland calcifications lead to neurodegenerative disorders, they should be strongly considered in the presence of any symptoms as a reason to initiate further investigations. Experiments reported here suggest that MPIF is an important mediator of fibrin deposition and cellular infiltration characteristic of cell-mediated immune response. When channels were expressed with a combination of alpha 3 and beta 4 subunits, 5-HT (10 to 300 microM) reversibly inhibited an inward current activated by 100 microM ACh in a concentration-dependent manner. Our analysis constitutes a general framework for dynamic soaring and more broadly energy extraction in complex winds. Based on the measurements of ATPase activity of these polypeptides, we concluded that the ATPase site is located in the A beta and A gamma HCs, which may have their origins in each head of the two-headed fragment of Tetrahymena 22S ciliary dynein. Neither the magnitude nor the timing of luteinizing hormone (LH) pulses in plasma were affected by drug-induced decreases in 5-HT. It is shown that such an analysis can provide useful information on secondary structure when the degree of hydrogen bonding to both the NH undergoing exchange and the neighboring carbonyl group are taken into consideration. These data indicate that GSH hepatic uptake is mediated neither by BBBP nor BTL.

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Detection of chorionic alpha 2-microglobulin in the endometrium in the secretory phase of the menstrual cycle and in male sperm. Postoperative complications after surgical management of incomplete ossification of the humeral condyle in dogs. Ultrastructural detection of basic nucleoproteins: alcoholic phosphotungstic acid does not bind to arginine residues. In cystic fibrosis subjects the time spent below pH 6.0 was significantly greater during the 1st h in the small bowel than in normal subjects. It was decided to repair the artery as there was no evidence of adequate circulation supply or the patency of the ulnar artery preoperatively. coli, yeast and baculovirus grown in insect cells have not produced soluble conformations or acceptable yields. Determination of creatine phosphokinase activity in the blood serum.

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Comparison of virus isolation, immunofluorescence and electron microscopy for the diagnosis of animal viruses. Cardiac tamponade as an initial manifestation of systemic lupus erythematosus in early childhood. There is limited research to demonstrate how scapular kinematics and shoulder-related physical characteristics are affected in water-polo players, who undertake swimming and repetitive throwing activity. Analysis of partial gag and env gene sequences of HIV type 1 strains from southern Africa. TBDD is absorbed after oral, dermal, or intratracheal administration in rats, stored in the liver and adipose tissue, and eliminated in the feces through biliary excretion. Both IC and BM reactivity could be blocked with Concanavalin A (500 and 1000 micrograms/ml respectively) and anti-human fibronectin serum. Ezrin is a member of the TERM family and is a key protein in cytoplasmic membrane-cytoskeleton interactions. We evaluated the impact of ambient air pollution on outpatient physician visits for otitis media in a population-based birth cohort. Hyaluronectin binds to laminin and blocks laminin-dependent process formation by astrocytes. This study aimed to examine the information and functions found within sleep apps, determine if the information is based on empirical evidence, and whether or not user ratings were affected by these factors.

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Non-A, non-B hepatitis-related hepatocellular carcinoma in a chimpanzee. The Impact of Lateral Bladder Neck Preservation on Urinary Continence Recovery After Robot-Assisted Radical Prostatectomy. The interaction is more favored as the cavity size of cyclodextrins is larger, the molecule being more tightly bound with gamma- than with beta-cyclodextrin. The PADCP was useful to induce a pulsatile flow in a centrifugal pump. Modified-hypernetted-chain determination of the phase diagram of rigid C60 molecules. Furthermore, GL-V9 suppressed their upstream protein kinases activation by reducing phosphorylated forms of serine/threonine kinase AKT and c-Jun N-terminal kinase. Cervical myelopathy due to ossification of the posterior longitudinal ligament. No risk factors were associated with major or overall complications. Xylitol production using recombinant Saccharomyces cerevisiae containing multiple xylose reductase genes at chromosomal delta-sequences.

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They are also found in some noncholinergic regions, including adrenergic sympathetic postganglionic terminals, the peptidergic terminals in the posterior pituitary, and adrenal chromaffin cells. Effect of streptomycin on cellulase production by Trichoderma viride. Intrapulmonary sublesions detected before surgery in patients with lung cancer. The Lateral Habenula and Its Input to the Rostromedial Tegmental Nucleus Mediates Outcome-Specific Conditioned Inhibition. Chitin is a polymer of N-acetylglucosamine, which assembles into microfibrils of about 20 sugar chains. In Escherichia coli and Xenopus oocytes, this photoactivated adenylyl cyclase (bPAC) showed cyclase activity that is low in darkness but increased 300-fold in the light.

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In this study we analysed factors associated with differences in PLE-related distress in a sample of 200 non-clinical participants recruited by snowball sampling. The reasons for the disagreement may have to do both with insufficient accuracy in the theory and with uncertainty in the nature of the unfolded state of proteins. To determine the minimal clinically important difference and the patient acceptable symptom state for visual acuity and visual function, 2 key visual outcomes for patients undergoing cataract extraction, as an aid for evaluating the outcome of cataract extraction. A new scattered dendrites were usually found directly dorsal to the soma in lamina VIII. This theory suggests a possible link between the cognitive and the neurological levels. Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes.

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A case of pituitary apoplexy occurring in the context of physical effort is reported. It is argued that appreciated tools from biochemistry and also low-level Petri nets can yield only part of the desired results, whereas executable high-level net models lead to a number of valuable additional insights by combining symbolic analysis and simulation. These patterns suggest that in these two species, the expression of the different vimentin forms might be differently regulated. Pharmacy carries on for shuttered East Houston Regional Medical Center. Chi square was used to test differences between institutions used and health insurance type. A supine diastolic blood pressure below 90 mmHg was achieved in 65 percent of the patients, irrespective of age, sex, activity, smoking habits, and presence of diabetes or previous antihypertensive therapy.

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To compare magnetic resonance angiography (MRA) with Intra-arterial digital subtraction angiography (IA-DSA) in detection and characterization of intracranial aneurysms. NGS-pipe: a flexible, easily extendable, and highly configurable framework for NGS analysis. A 62-year-old woman died after repeated myocardial infarction, with no articular symptoms but with a fever of unknown origin and a positive rheumatoid factor. The author identified clinical parameters and developed thresholding strategies that facilitate semiautomated three-dimensional craniofacial imaging and modeling. Here, we sequenced Mexican strains of the human pathogen Acinetobacter baumannii sampled from the same locale over a 3 year period to obtain insights into the microevolutionary dynamics of gene content variability. Effects of GT and GT components on digoxin solubility were also examined. Airway management with fastrach laryngeal mask versus spritztube: a prospective randomised manikin-based study. At post-mortem examination a mycotic-thrombus originating from the right atrium was found obturating the tricuspid valve.

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why not drink alcohol with methotrexate 2018-04-26

EEG results can become normal in both adults and neonates when the acute stage is over. Separate groups of rats of three ages (6 month, 15 month or 24 month) were trained in a two-lever operant chamber on one of two versions of a paired-trial delayed response task involving either matching or non-matching of the choice response to a sample lever. Effects of insulin on ribonucleic acid synthesis in toad urinary bladder. Fourteen of these 17 patients have since undergone laparoscopy during IVF. The major proteins of complement alternative pathway C3, factor B and factor H were produced constitutively by skeletal muscle cells at a rate of 50 to 150 ng/10(6) cells/ml and factor I was expressed 20 ng/10(6) cells/ml.

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Quantitative analysis of myelin and can you take 80 mg of protonix daily axolemma particle distribution in C57BL/Ks diabetic mice and the effects of ganglioside treatment. Effect of liver disease on pharmacokinetics and toxicity of 9-beta-D-arabinofuranosyladenine-5-phosphate. Facilitation of extubation with physician-assisted cyberphysiologic ventilatory stabilization: common sense, compassion, and sensitivity really enhance outcomes!. Mutation in the hemagglutinin of A/N-WS/33 influenza virus recombinants influencing sensitivity to trypsin and antigenic reactivity. The effect of unconscious interoceptive afferentation on the spatial organization of the electrical activity in the human cerebral cortex. Orthostatic hypotension (OH) predicts mortality in hypertensive persons with diabetes mellitus, but no increase in mortality has been found among random samples of home-dwelling persons with OH.

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The developmental blockade appears to be imposed on early thymocyte differentiation and/or expansion. Position of control surfaces (i.e., flippers, fin, flukes, peduncle) provides a generally stable design with respect to an arrow model. Neovascular glaucoma following central retinal vein obstruction. Atrial ejection force in patients with atrial fibrillation: comparison between DC shock and pharmacological cardioversion. The development of an HS quality-of-life measure, HS-QoL, has been recently described. Malnutrition in infancy and its tenormin 50 mg price in kuwait early and late sequelae in the bone development. Systematic analysis of the magnetic susceptibility in the itinerant electron model. Analysis of the improvement in sky coverage for multiconjugate adaptive optics systems obtained using minimum variance split tomography.

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Adiponectin gene polymorphisms are associated with type 2 diabetes. Compared with an existing approach, the results show that incorporating the new feature representation to the link prediction algorithms has significantly improved the performance. The Biken M protein also fails to bind to the Nagahata viral nucleocapsids. The patients presented with hypo- and hyper-pigmented macules over the body, resembling dyschromatosis universalis hereditaria in addition to punctuate palmoplantar keratosis. Of the 791 residents studied, 60 were prescribed clopidogrel, 248 were on aspirin and 326 were prescribed a PPI. Thought disorder and communication deviance as predictors of outcome in youth at clinical high risk for psychosis. A 52 kDa protein was identified as tubulin by immunoprecipitation with a tubulin-specific monoclonal antibody, and was shown to be phosphorylated in the presence of spermine and polylysine. DNA in dormant spores of Bacillus species is in an A-like conformation. Dynamics of pulmonary gas exchange and provera pill to start period heart rate changes at start and end of exercise. H-NS lies near the top of the hierarchy orchestrating acid response centred on RcsB-P/GadE regulatory complex, the general direct regulator of glutamate-, arginine- and lysine-dependent acid resistance pathways.

is low dose methotrexate an immunosuppressant 2018-09-01

Complement-mediated follicular localization of T-independent type-2 antigens: the role of marginal zone macrophages revisited. Brain nuclei involved in vagal release of gastric serotonin (5-HT) were investigated in urethan-anesthetized rats acutely implanted with gastric cannula. de Haas-van Alphen effect in two-dimensional thin films of pure bismuth. The coupling and uncoupling of the two eyes during saccadic motor learning was studied using the technique of intrasaccadic target displacements to provide a precise visual-motor error proportional to the commanded movement. The LELC presented a morphological spectrum from undifferentiated to squamoid or glandular differentiation. New patients were commenced on preferred medicines, but patients receiving another medicine from a therapeutic class included in the program were not automatically switched to the preferred medicine. Traditionally, construction of adenoviral vectors is complex and time consuming. The effect of the carcinogenic hair dye component 2,4-diaminoanisole (2,4-DAA) on thyroid and pituitary morphology was studied. Eighteen patients with unilateral osteoarthrosis of the hip were investigated in a trial which involved the injection of nine with bupivacaine and nine with normal saline. We suggest that enhancement of Fcgamma R is one of the mechanisms by which interferon exerts some immunostimulating effects in vivo.

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This article documents incidence and prevalence of domestic violence, cultural and historical influences, legal issues, and specific challenges to ending domestic violence in Russia. The possibility of cytokine facilitated tumor growth is discussed. Space-time relations: the effects of variations in stimulus and interstimulus interval duration on perceived visual extent. This report describes the effects of GLPG1790, a new potent pan-EPH inhibitor, in human embryonal rhabdomyosarcoma (ERMS) cell lines. The proposed model accounts for important characteristics such as switching between sinus rhythm and AF, varying P-wave morphology, repetition rate of f-waves, presence of atrial premature beats, and various types of noise. On the basis of immunodiffusion reactions with isolated 229E/RNP it was concluded that human convalescent sera reacted specifically with the 229E/RNP antigen. Injection of as few as 2 million bone marrow cells from PGE2-treated mice into steady-state mice or animals hematopoietically rebounding following a sublethal injection of cyclophosphamide significantly suppressed total CFU-GM proliferation in recipient mice within 6 hours. Almost all the adults injected responded and the geometric mean responses were approximately 15 mug/ml of antibody protein in individuals vaccinated subcutaneously with two preparations of group A vaccine. Luciferase reporter gene assay using VEGF promoter revealed that angiostatin-endostatin fusion protein (hAE) and its corresponding fusion gene delivery on Human Microvascular Endothelial Cells (HMEC-1) resulted in more potent synergistic anti-angiogenic effects than endostatin-angiostatin fusion protein (hEA).

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We present a case in which the presence of major intraabdominal trauma shifted clinical attention away from the mediastinum. virginiana possess duplicated subterminal telomere clusters, heterochromatin, 5S and 45S rDNAs orderly intermixed and share this complex cytomolecular architecture with the common type of a B chromosome. The findings using nuclear magnetic resonance in 11 unselected patients with adult dose of singulair hypertrophic cardiomyopathy were compared with those in equal numbers of normal subjects and patients with electrocardiographic features of left ventricular hypertrophy. The patients reported in this paper illustrate the wide spectrum of clinico-pathological conditions of this anomaly. We tested the association of seven single nucleotide polymorphisms (SNPs) in four candidate genes with the efficacy of glimepiride.

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Drug statistics in 1993: benzodiazepines are more and more drugs for the elderly. The proteinase profiles of the two holotrich species differed and inter-species differences were also apparent among species of suprax dosage sinusitis the genus Entodinium. Second, serum levels of the drug frequently fail to correlate with the degree of nephrotoxicity in individual patients. The established HBE4-E6/E7 cell line resembles morphologically the basal cells of the normal human bronchial epithelium and is nontumorigenic. Mechanisms of phase transitions between commensurate and incommensurate phases. PHYSICAL ACTIVITY AND BODY FAT IN ADOLESCENTS LIVING WITH HIV: A COMPARATIVE STUDY. Further studies are needed to define the diseases in which this antienzyme plays an active part and to determine the mechanisms causing the difference. One of 13 patients not responding to MVMJ had a transient response to radical radiotherapy. Fleeting, sterile peripheral corneal infiltrates can occur following LASIK. In the present study, clones containing a 34-kb region of p4180A were saturated with Tn5, and 71 unique mutations were recombined into p4180A by marker exchange.

methotrexate dosage calculator ectopic 2015-07-05

Anesthesia induction is often accompanied by a period of hemodynamic instability, which could be deleterious in patients with coronary artery disease (CAD) and left ventricular dysfunction undergoing coronary artery bypass graft (CABG) surgery. We have tested the murine muscle cell line C2C12 as a surrogate for myotropism and have found that there is a slight, but reproducible difference in the replication of virus clones bearing the M RNA segment of La Crosse/original virus compared to clones bearing the M RNA segment of Tahyna-181/57 virus, as determined by viral titer, antigen expression, and plaque formation. We demonstrate immunoreactive mouse atrial natriuretic factor (ANF) in the IgG fraction prepared from ascites or serum of mice bearing an anti-rat ANFArg101-Tyr126 hybridoma. Correlations were also computed using the model with selective hair-cell damage. Expression from the lasB-lacZ fusion was enhanced when PAO1(pTS400) was grown in a defined medium containing elevated levels of zinc (6.0 micrograms ml-1). Additionally, the expression of the mitogen-activated protein kinase (MAPK) family was significantly inhibited by LMWF when compared with controls. Premortal neurological symptomatology (PNS) existed in 5 cadavers. The reaction was stopped by filtration across a cellulose nitrate membrane.

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All randomized clinical trials evaluating the clinical effects or safety of the use of ginseng monopreparations (Panax ginseng or P. Synthesis and biological evaluation of a series of gem-dichlorocyclopropanes as antitumor agents. The median (range) of the concentration of syn-PLA2 in SF was 210 micrograms/l (80-1480 micrograms/l) in culture-positive septic arthritis, 460 micrograms/l (270-1040 micrograms/l) in reactive arthritis, 780 micrograms/l (120-2710 micrograms/l) in osteoarthritis and 230 micrograms/l (80-1400 micrograms/l) in traumatic joint effusions. Here, we review the applications of the increasingly available genotyping tools and whole-genome sequencing data, and argue for a better integration of population genetics findings into malaria-control strategies. In conclusion, redundant H1-mediated silencing of heterochromatin is important to maintain cell homeostasis and to avoid an unspecific IFN response. Such experiments indicate that myoepithelial contractions serve to accelerate the salivary flow and to support the secreting acinar cells and prevent back-flow of fluid from the luminal system into the glandular tissues. We have developed a mathematical model which describes pressure-inflow relationships in the coronary circulation. The broad spectrum of biological and molecular effects induced by simian virus 40 and polyoma virus is, at least phenotypically, reminescent of the pleiotropic impact exerted on target cells by nonviral mitogens and by certain growth-promoting steroid and polypeptide hormones. On the basis of the injury severity score and age, death was found to have been inevitable or highly likely in 92 cases. We conclude from our results that these changes are not caused by a change in the dynamics of the Trp residue itself, but exclusively by an increased effective dielectric constant of the microenvironment of Trp48 and by changes in mobility of the mutated residues.

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