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Biolar (Lorazepam)
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Biolar

Biolar, an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3- dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one. It is a nearly white powder almost insoluble in water. Each Biolar tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of lorazepam. The inactive ingredients present are lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Diamox, Wellbutrin, Sildigra, Rulide, Duricef

Also known as: Lorazepam

Description

{name} (lorazepam) belongs to a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). It is thought that lorazepam works by enhancing the activity of certain neurotransmitters in the brain.

{name} is a prescription medicine used to treat anxiety disorders.

It is dangerous to purchase {name} on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.

Dosage

Usual Adult Dose for Anxiety:

Initial dose: 2 to 3 mg orally per day, given 2 to 3 times per day Maintenance dose: 1 to 2 mg orally 2 to 3 times a day Comments: -The daily dosage may vary from 1 to 10 mg/day. -The dosage should be increased gradually when needed to help avoid adverse effects. -When higher dosage is indicated, the evening dose should be increased before the daytime doses. -Use of anxiolytic agents is typically not needed to treat anxiety/tension associated with the stress of everyday life. -Clinical studies have not evaluated this drug for efficacy in long-term treatment (e.g., greater than 4 months). Uses: -Management of anxiety disorders -Short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms

Usual Adult Dose for Insomnia:

2 to 4 mg orally once a day at bedtime Comments: -The dosage should be increased gradually when needed to help avoid adverse effects. -Clinical studies have not evaluated this drug for efficacy in long-term treatment (e.g., greater than 4 months). Use: Management of insomnia due to anxiety of transient situational stress

Usual Geriatric Dose for Anxiety:

Older or debilitated patients: -Initial dose: 1 to 2 mg orally per day, given in divided doses Comments: -The dosage should be increased gradually when needed to help avoid adverse effects. -The daily dosage may vary from 1 to 10 mg/day. -When higher dosage is indicated, the evening dose should be increased before the daytime doses. -Use of anxiolytic agents is typically not needed to treat anxiety/tension associated with the stress of everyday life. -Clinical studies have not evaluated this drug for efficacy in long-term treatment (e.g., greater than 4 months). Uses: -Management of anxiety disorders -Short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms

Detailed Biolar dosage information

Overdose

In cases of a suspected Biolar overdose, it is important to establish whether the patient is a regular user of Biolar or other benzodiazepines, since regular use causes tolerance to develop. Also, one must ascertain whether other substances were also ingested.

Signs of overdose range through mental confusion, dysarthria, paradoxical reactions, drowsiness, hypotonia, ataxia, hypotension, hypnotic state, coma, cardiovascular depression, respiratory depression, and death.

Early management of alert patients includes emetics, gastric lavage, and activated charcoal. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil.

Patients are ideally nursed in a kind, nonfrustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. Opportunistic counseling has limited value here, as the patient is unlikely to recall this later, owing to drug-induced anterograde amnesia.

Storage

Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Biolar is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Biolar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use this medication if you have narrow-angle glaucoma, or if you are allergic to Biolar or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), or oxazepam (Serax).

Before taking Biolar, tell your doctor if you are allergic to any drugs, or if you have:

glaucoma;

asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;

kidney or liver disease;

a history of depression or suicidal thoughts or behavior; or

a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

Biolar can cause birth defects in an unborn baby. Do not use Biolar without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. It is not known whether Biolar passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

The sedative effects of Biolar may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Biolar. Do not give this medication to a child younger than 12 years old.

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Human autoantibody to vasoactive intestinal peptide: increased incidence in muscular exercise. This study was initiated for the purpose of isolating the gene encoding ribosomal (r-) protein S10 which is assumed to be involved in the antitermination of transcription at the rRNA-encoding genes in Bacteria. In newly diagnosed patients of depression, inflammatory markers such as CRP, ESR and WBC count were significantly raised and Selective serotonin reuptake inhibitors SSRIs such as fluoxetine and escitalopram reduced them independent of their antidepressant effect. Bioinformatics analysis was applied to predict the functions of differentially expressed miRNAs in ED. There was no evidence of luteinization and only mild nuclear pleomorphism. A prospective cohort analysis was performed on patients diagnosed with RS/CSL in benign, open breast biopsy specimens over a 20-year period. New procedure for transport and enrichment for improving the culture evidence of Neisseria gonorrhoeae. It is suggested that the Alzheimer lesion involves an imbalance within specific kinases responsible for phosphorylation of different sites in neurofilaments.

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Experimental band structure of potassium as measured by angle-resolved photoemission. Bronze Award: Empowering Primary Care Physicians to Better Assess and Manage Pediatric Mental Health Problems. AGS is extensively researched for wide-spread implementation in sewage treatment plants. Effect of alpha-amylase inhibitors and other compounds on glucosyltransferase activity. The patient was severely hypotensive, oliguric, and developed a variety of dysrhythmias. Intraband inversion due to ultrashort carrier lifetimes in proton-bombarded InP. Campylobacter and Non-typhoidal Salmonella (NTS) are the two most common bacterial pathogens associated with acute gastroenteritis in children. As an application of the ablation technique, polyurethane films were micropored by the excimer laser ablation technique in conjunction with open-cell structured, small diameter grafts under development.

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An experimental study in rabbits compared corneal reaction to two types of sutures: 8.0 virgin-silk (Ethicon) and 7.0 Dexon (Davis-Geck). Attitudes towards passive smoking at restaurants and effects of the provision of information: A comparison between smokers and non-smokers via a web survey. The reliability of cardiac output obtained with the bolus technique is a problem. The lesions of idiopathic guttate hypomelanosis (IGH) are commonly seen in elderly persons, although this is an often unrecognized skin disease with an obscure etiopathogenesis. A comparison between microcrystalline and conventional phenytoin preparations: relative bioavailability and steady-state plasma concentrations. In adult parotid glands, our findings are discussed in correlation with those of other investigators. Published, peer-reviewed retrospective and prospective studies relevant to the association of plasma apolipoprotein levels with coronary artery disease in humans.

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A comparative study of branch retinal vein occlusion and central vein occlusion amongst Malaysian patients. Both lymphokine injected areas and controls showed significantly increased mitotic indices compared to untreated skin which was apparent only at 24 hr. Risk factors for EP were identified by logistic regression analysis. The three diagnostic tests evaluated have shown an adequate diagnostic accuracy to detect MDR and XDR tuberculoses. Cements were placed in a 3 mm diameter mold at the bonding interface and bonded to 6 x 6 mm stainless steel band specimens mounted to acrylic blocks. Predictive value of molecular subtyping in NMIBC by RT-qPCR of ERBB2, ESR1, PGR and MKI67 from formalin fixed TUR biopsies. VM-26 induced the total genome breakdown into discrete chromatin fragments containing 0.3 Mbp DNA. Haematological monitoring of the two patients showed pronounced fibrinogenolysis and alpha 2 antiplasmin consumption in one. Brisk-transient and brisk-sustained classes are not as distinct from each other as in the cat: centre size distributions overlapped almost completely and there was also substantial overlap of axonal conduction properties whether expressed in terms of latency or conduction velocity between two central stimulus sites.

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Transcriptomic changes at the gene and exon levels from whole blood can refine our understanding of the molecular mechanisms underlying the response to smoking. In India, it is estimated that there are approximately 6.8 million people who have vision less than 6/60 in at least one eye due to corneal diseases. Cardiac hypertrophy due to pressure or volume overloading leads to changes in myocyte shape which reflect gross anatomical alterations in ventricular geometry. Hemoglobinuric nephrosis has not previously been reported in an avian species. Over 3 years, we have been unable except once to detect viral infections by three methods. The diagnosis and treatment of auditory and vestibular disorders after head injury.

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MTX did not affect the percentage of CD4- and IL-17-positive cells in PBMCs. The finding that the GpATM peptide forms helical dimers in lipid bilayers supports the idea that GpA is a dimer in the erythrocyte membrane. The potential advantages and pitfalls in the intraoperative use of transrectal and transperineal sonography for guided intrauterine procedures are discussed and illustrated. How do individual neuronal precursors and their progeny cells acquire their own identity?. Motor nerve conduction velocities and sensory distal latencies were examined in 25 cases of congenital muscular dystrophy and the results correlated with the merosin expression in their muscle biopsies. This study provided a new perspective to understand the mechanism and discover probable biomarkers of HCC. On unannealed samples, capping the QDs with one monolayer of AlAs improves the spectral response, the open-circuit voltage and the fill factor. Effect of interferon-gamma on HLA class 2 expression by antigen-presenting cells inducing Dermatophagoides farinae-specific interleukin-2 responsiveness of lymphocytes in asthmatic children. GLI1, GLI2 and GLI3 form a family of transcription factors which regulate development by mediating the action of Hedgehog (Hh) morphogens.

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This proof-of-concept study sought to evaluate the effectiveness of single and combinatorial enzyme digestion of murine spleens. Correlation of shoulder laxity measured by these tests with generalized joint laxity was also assessed. Thus, the 3-hexyl derivative was the most potent inhibitor of the purified rat liver alcohol dehydrogenase, with a Kii value of 0.13 microM. The results of serological investigations of human type ABH antigens and antibodies of 116 sheep are presented. The location of the alpha 2-adrenoceptors relative to synapses is controversial. IMR-32 neuroblastoma cells were used as an in vitro cholinergic nerve cell model. After the release of amine and the generation of a phosphorylated histidine intermediate, the nucleophilic attack of an active-site water produced a hydrolyzed intermediate that subsequently transferred a proton back to His114.

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A porcine virus with rotavirus morphology, which was antigenically unrelated to previously described rotaviruses, is described. Increased mortality occurred in quail that either did not initiate egg laying or ceased egg laying completely. The morbidity of skull bone grafts is much less than other donor site of bone. In contrast to a control group of healthy horses, brain tissue was positive by this assay in all animals with neurological symptoms. The aim of this study was to translate the Attribution Questionnaire-27 (AQ-27) to the Italian language (AQ-27-I), and to examine the reliability and validity of this new Italian version. APPL2 Tg mice also showed the impaired hippocampal neurogenesis and presented the depressive and anxiety behaviors. Phase-contrast and transmission electron microscopy studies carried out throughout the course of the experiments demonstrated that the number of viable spermatogonia and meiotic prophase spermatocytes was relatively constant during 12 days of coculture.

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But reports indicate that some molluscs exhibit motivational states and cognitive capabilities that may be consistent with a capacity for states with functional parallels to pain. Possible changes in luminal surface charge densities of small intestine membrane in the 4-7.4 pH range exhibit varied influence on the absorption rate constants of the ionized and un-ionized species of sulfadiazine in rats ventolin cost . Heat shock protein is tightly associated with the recombinant human glucocorticoid receptor:glucocorticoid response element complex. Inapparent infections in the course of an epidemic of Australia-SH-antigen positive hepatitis. In the case reported here, examination of a patient who presented with delayed eruption of a primary central incisor led to the discovery of an impacted incisor and an associated isolated radiolucency. The rapid and widespread acceptance of laparoscopic cholecystectomy is without precedent in modern surgical history. Elicitation of alkaloid production was sensitive to aristolochic acid and enhanced by PLA2 products such as lysophosphatidylcholine and linolenic acid. In the ND group, higher UA-NE values were found in the group at UA-pH less than 7.20 than in those at UA-pH greater than or equal to 7.20, but UA-DOPEG values did not vary significantly with UA-pH. Determination of ceruloplasmin (Cp) activity in plasma can provide an objective measure of the health of dairy cows as well as it can be used for various diagnostic purposes. A highly repeated DNA from the genome of the wallaroo (Macropus robustus robustus).

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CD44 isoforms include an unspliced 80- to 90-kDa standard form (CD44S) and isoforms derived from alternative splicing of nine CD44 variant exons (CD44V). Transfusion-acquired hepatitis E infection misdiagnosed as severe critical illness polyneuromyopathy in a heart transplant patient. In fact, an early increase in tyrosine kinase activity was observed after ATPo-treatment and was prevented by specific PTPase inhibitors. Little variation was observed in the coelomic and amniotic fluid composition before 11 weeks of gestation. The antibody was equally effective when injected again during a second pregnancy. Disruption of epithelial barrier function has been hypothesized to contribute to allergic disease such as allergic rhinitis through increased passage of antigens and exposure of underlying tissue to these stimuli. Intermediate vibronic coupling in charge transfer states: comprehensive calculation of electronic excitations in sexithiophene crystal. p-Dimethylaminomethylbenzylamine was the most useful substrate and full details of its preparation are given. The correlation between local fluid velocity and local porosity is shown graphically and indicates that the average velocity increases with porosity, with no velocity for porosity equal to zero, as expected.

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Antibody to mouse interferon alpha/beta abrogates resistance to the multiplication of Friend erythroleukemia cells in the livers of allogeneic mice bactrim typical dosage . Investigating the pathogenic role of PADI4 in oesophageal cancer. A review was done on the current guideline and available literature for the mechanisms of action and perioperative management of OCPs, hormone replacement therapy (HRT), and antineoplastic hormonal modulators. Partial synchronization of cells in experimental leukemia L 5222 in rats. Kaplan-Meier survival functions were used to estimate actuarial survival at 1, 2, and 5 years after transplant. Contribution of cutinase serine 42 side chain to the stabilization of the oxyanion transition state. It is concluded that such effects on spindles may occur in man, maybe of such force as to detectably influence dynamic movements. When dendritic cells were incubated in vitro with antigen/antibody complexes in antibody excess, a marked reduction in surface staining was observed for MHC class II, CD1, CD44, and VLA-4 after 8 h in culture.

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Despite this, no disease-modifying treatments exist with clear clinical benefits, and the current best management of mitochondrial disease is supportive. Identification of a specific inhibitor for DNA ligase I in human cells. High precision displacement instrumentation for eccentric tablet machines. Left ventricular hypertrophy (LVH) constitutes a powerful independent risk factor in hypertensive heart disease. Surgical repair of bronchial rupture should only be omitted if extensive parenchymal pulmonary damage and/or suppuration are present. The development of the SRS-22 questionnaire involved its translation and back-translation, a final review by an Expert Committee, and testing of the prefinal version to establish its correspondence to the original English version. Fibronectin has a dual role in locomotion and anchorage of primary chick fibroblasts and can promote entry into the division cycle. Laminin was most prominent 3 days after resection and reacted with antibodies to B1, B2, S and M. The treatment of finger glomus tumours by raising a full thickness nail bed flap or finger pulp flap.

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Assessment of a percutaneous Hemopump in high risk coronary angioplasty patients. In embryos lacking one of the MSL proteins, the sub-nuclear localization of the other MSLs and of histone H4Ac16 is not detected. In vivo proton magnetic resonance spectroscopic examination of benzodiazepine action in humans. In many cases, this is sufficient to watch individual channel proteins open and close repeatedly in real time on metabolically intact cells. Physiotherapy in the treatment of temporomandibular joint disorders: a comparative study of four treatment methods. To report the in vivo confocal microscopic features and clinical characteristics of a case of bilateral corneal argyrosis. Prevention of irreversible ischemic damage in renal preservation by pharmacological manipulation. Our finding of increased endogenous IFN-gamma levels during infections, in particular in those caused by cytomegalovirus, provides an explanation for this association.(ABSTRACT TRUNCATED AT 250 WORDS). As with other SSRIs, the most common side effect of how much does iv flagyl cost paroxetine is nausea, which is usually well tolerated. Asymmetrical modulation of immune reactivity by central dopaminergic pathways was suggested by previous reports which described an association between alterations of immune response and peculiar patterns of dopamine asymmetries in pathological and physiological situations.

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