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Benformin (Glibenclamide)
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Benformin

Benformin is a medicine used to treat type 2 diabetes mellitus. It helps control blood sugar levels and thus prevent serious complications of diabetes. It is also used to treat a menstruation-related disorder known as Polycystic ovary syndrome (PCOS) in women.

Other names for this medication:
Aviglen, Betanase, Betrol, Bionil, Combidos, Comdiab, Diabetnil, Duotrol, Eumet, Glibenclamide, Glibson, Glifil, Glime, Glitrac, Glucomin, Glucosafe, Glucotrac, Glunil, Glutowin, Glybid, Glybonil, Glyboral, Iscept, Melitus, Pionorm, Secrin, Sugatrol, Sugnil, Sugnl, Symet, Triglycomet

Similar Products:
Coreg, Lanoxin, Arava, Amaryl, Klonopin, Provera, Coumadin, Adipex, Motilium

Also known as: Glibenclamide

Description

{name} is an oral diabetes medicine that helps control blood sugar levels.

{name} is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

{name} is not for treating type 1 diabetes.

Dosage

Usual Adult Dose for Diabetes Type 2:

Doses provided as Benformin-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Benformin (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Benformin and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Benformin (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Benformin-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Benformin component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Benformin/metformin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Benformin dosage information

Side effects

The most common side effects associated with Benformin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before taking Benformin,

  • tell your doctor and pharmacist if you are allergic to Benformin, any other medications, or any of the ingredients in Benformin. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are taking bosentan (Tracleer). Your doctor may tell you not to take Benformin if you are taking this medication.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan); chloramphenicol; clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune); disopyramide (Norpace); diuretics ('water pills'); fluconazole (Diflucan), fluoxetine (Prozac, Sarafem); gemfibrozil (Lopid), hormone replacement therapy and hormonal contraceptives (birth control pills, patches, rings, implants, and injections); insulin or other medications to treat high blood sugar or diabetes; isoniazid (INH); MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); medications for asthma and colds; medications for mental illness and nausea; miconazole (Monistat); niacin; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); phenytoin (Dilantin); probenecid (Benemid); quinolone and fluoroquinolone antibiotics such as cinoxacin (Cinobac), ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), nalidixic acid (NegGram), norfloxacin (Noroxin), ofloxacin (Floxin), sparfloxacin (Zagam), trovafloxacin and alatrofloxacin combination (Trovan); rifampin; salicylate pain relievers such as choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan's, others), and salsalate (Argesic, Disalcid, Salgesic); sulfa antibiotics such as co-trimoxazole (Bactrim, Septra); sulfasalazine (Azulfidine); and thyroid medications. Also be sure to tell your doctor or pharmacist if you stop taking any medications while taking Benformin. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had G6PD deficiency (an inherited condition causing premature destruction of red blood cells or hemolytic anemia); if you have hormone disorders involving the adrenal, pituitary, or thyroid gland; or if you have heart, kidney, or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Benformin, call your doctor.
  • talk to your doctor about the risks and benefits of taking Benformin if you are 65 years of age or older. Older adults should not usually take Benformin because it is not as safe or effective as other medications that can be used to treat the same condition.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Benformin.
  • ask your doctor about the safe use of alcoholic beverages while you are taking Benformin. Alcohol can make the side effects from Benformin worse. Consuming alcohol while taking Benformin also rarely may cause symptoms such as flushing (reddening of the face), headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety.
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Benformin may make your skin sensitive to sunlight.
  • ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar and the amount of Benformin you may need.

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Highly dispersed ZnO nanoparticles with variable particle sizes were successfully prepared within an amphiphilic hyperbranched polyetherpolyol matrix via decomposition of an organometallic precursor in the presence of air leading to stable nanocomposites. Correlation between physiological measures, functioning, symptoms and medication levels were assessed in people with schizophrenia. In this study, we aimed to investigate the angiographic recurrent stent restenosis rate at 6-12 months after successful cutting balloon angioplasty (CBA) for the bare metal stent restenosis. Pseudomonas aeruginosa control in healthcare settings - Outpatient dialysis units are not augmented care units. Physiopathology of cerebellar symptoms: from Holmes to our times. The results indicate coordinated release of these granular products at the cellular level after reserpine treatment. Evaluation of satisfaction and use of electronic intervention for behavior change.

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Osteoarthritis severity increased until age 6 in this population. During anaesthesia, spontaneous ventilation prevailed in the isoflurane group, but at recovery no inter-group differences in respiratory rate were found. Mediators of the effects of rice intake on health in individuals consuming a traditional Japanese diet centered on rice. Endoscopic transsphenoidal approach is a minimally invasive surgical technique for the removal of sellar and parasellar lesions, which has been progressively accepted by neurosurgeons. To evaluate the efficacy and toxicity of ifosfamide in combination with cisplatin and vinblastine in non-operable non-small-cell lung cancer (NSCLC). Quantum-mechanical calculations have been performed in order to determine rate coefficients for the fine-structure transitions in the 5-1000 K temperature range. The quality of reporting in RCTs on the treatment of cancer pain conducted in China needs to be improved.

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All patients had wide radical excision of the melanoma, with or without concomitant or subsequent nodal dissection. The 55 K complex is partially precipitated by Brown-Norway anti-Lewis alloantiserum. Ten atopic patients with mild, stable asthma free of all asthma medications, allergen exposure, and respiratory tract infection for at least 4 weeks participated in a double-blind, random-order, crossover study. A clear understanding of the pathogenesis of fungal disease remains elusive. A key component of strategies to reduce antimicrobial resistance is better antimicrobial prescribing. Several nonsteroid antiinflammatory drugs (e.g., benoxaprofen, carprofen, and piroxicam) are known to induce photosensitivity reactions, but this has not yet been documented for ibuprofen. Adenoviral-mediated gene transfer to enhance neuronal survival, growth, and regeneration. Analyses that include disputed homology statements (1, gliointerstitial cell system 2, coelomic circulatory system) suggest that nemerteans form the sister taxon to the coelomate spiralian taxa rather than the sister taxon to Platyhelminthes. New pediatric risk factors for amblyopia: strabismic versus refractive. This work reports that hybrids between the Fe protein homologs of Methanosarcina acetivorans and the catalytic components of Azotobacter vinelandii can trap substrate CO through reduced electron fluxes.

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Revision surgery was performed, but one patient suffered another recurrence (lateral sphenoid wall with cavernous sinus infiltration) and was referred for gamma knife surgery. The major difference between the two methods boils down to differential short-term loss over the differential retention interval. In the following case report, we removed a well-fixed polyethylene titanium-coated RM acetabular cup with 20 years of follow-up, by significant wear of the polyethylene layer. Comparative Genomics of Non-TNL Disease Resistance Genes from Six Plant Species. We do not find protein expression of the transcription factor Oct-2, implicated by others as an alpha gene repressor. This is the first study showing high molecular identity between the P. Expression of copper/zinc superoxide dismutase and glutathione peroxidase in organs of developing mouse embryos, fetuses, and neonates. Undoped self-assembled GaN quantum dots (QD) stacked in superlattices (SL) with AlN spacer layers were submitted to thermal annealing treatments. The results revealed that the antigen with more determinants had a more potent inflammatory effect.

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Injections into medial striate cortex of one hemisphere produced labeled cells predominantly in mirror-symmetric loci in medial portions of contralateral striate cortex. Both BPCI providers achieved similar cost savings despite participating in different BPCI models. Knees with medial joint laxity during flexion resulted in an inferior postoperative outcome, and lateral joint laxity did not influence patient satisfaction or function. Some aspects of trachoma control and provisional estimates of the cost of vaccine production. This resulted in the rapid formation of progressively growing solid tumors from which permanent cell lines were established. Furthermore, by taking advantages of biocompatibility and diagnostic property enabled by AG73-MOF nanosheets, the elimination process of Hep in live rats is quantitatively monitored by coupling with microdialysis technology. Expression of immunological markers on leukemic cells before and after cryopreservation and thawing. Egr-1 binding activity was more rapidly induced in regenerating liver than mitogen-treated H35 and NIH 3T3 cells, remained elevated through 4 h posthepatectomy, and appeared to be dependent not only on new Egr-1 protein synthesis but on post-translational regulation of Egr-1.

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The results reveal that general principles include, but are not limited to, intellectual curiosity, mentorship, collaboration and protected time. The effect of pregnancy and treatment with 17 beta-estradiol on the transport of organic anions into isolated rat hepatocytes. T cell differentiation is governed by interactions with thymic epithelial cells (TECs) and defects in this process undermine immune function and tolerance. However, much incongruence still exists between the new sets of clades, on the one hand, and the present revised system or the still-viable parts of the 1959 system on the other hand. Some properties of chloramphenicol acetyltransferase, with particular reference to the mechanism of inhibition by basic triphenylmethane dyes. A report from the Boston Collaborative Drug Surveillance Program.

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All groups had a high intake of sodium and a deficit of potassium, calcium, iodine and magnesium. A new agar-free solid egg culture medium for Neisseria gonorrhoeae. Abnormal intraventricular flow patterns in left ventricular dysfunction determined by color Doppler study. In contrast, 3-dimensional planning uses the internal mammary vessels (IMVs) to localize the IMNs for planning. This substance represents, so far, the most effective and best-documented agent. Macrodomains mediate recognition of sequence motifs harboring adenosine diphosphate ribose (ADPR) modifications, thereby regulating a variety of cellular processes. A comparison of the miotic and inflammatory effects of biologically active polypeptides and prostaglandin E2 on the rabbit eye. In further contrast, neutrophils did not tolerate 1-5 mM ibuprofen.

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Robotic single-port cholecystectomy is feasible and comparable with standard laparoscopic cholecystectomy in the Veterans Administration medical center setting. Although dyspeptic symptoms are very common, the vast majority of patients have modest symptoms and rarely seek medical advice. This approach can drive cycles of design, build, test, and learn implemented by metabolic engineers to optimize the cell factory performance. To evaluate patient acceptance and the clinical feasibility of carbon dioxide compared with normal saline for uterine distension in outpatient hysteroscopy. ALS is a fatal neurodegenerative disease with manifestations of upper and lower motoneuron death and muscle atrophy accompanied by inflammation in the CNS and periphery. Between March, 2006 and August, 2009, 36 patients with degenerative lumbar scoliosis (19 males and 17 females) underwent procedures of decompression, bone implantation and pedicle screw fixation. The worldwide problem of osteoporosis: insights afforded by epidemiology. Likewise, conventional fixed bridges are often contraindicated in young individuals since large dental pulp chambers increase the risk of pulp necrosis, and acid-etched bridges are still considered temporary solutions due to questionable long-term retention. Sodium vanadate treatment of heat shocked cells greatly reduced levels of thermotolerance. The lack of uniformity in the diagnostic thresholds used in clinical trials on osteoporosis makes it difficult to compare the results of these trials.

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pertussis 165-9K/129G would induce the same immunity as the conventional vaccine and would avoid the administration of a harmful toxin to children. Proteins, associated with 50S-ribosomal subunits of Escherichia coli MRE600. 3p and 3d core-level widths in metallic technetium: A study by internal-conversion electron spectroscopy. The chronology of the borderline type dysplasia/carcinoma lesions starting from the very early to the more advanced infiltrating carcinomas will be shown. N-n-butyl haloperidol iodide preserves cardiomyocyte calcium homeostasis during hypoxia/ischemia. This case report outlines the hemodynamic response seen in two patients undergoing laparoscopic cholecystectomy and how their cases were managed. It can also be used to economically expand photography in a teaching environment. Hemodynamic function tests were performed in 8 out of 10 patients.

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MicroRNAs are regulators of many cellular events, but evidence for microRNA acting on the differentiation of human embryonic stem cells into a specific lineage has been elusive. Combined prophylactic administration of IL-1B and IFN-g provoked a marked decrease of neutrophil accumulation into the lungs, but was not accompanied by significant reduction of edema or hemorrhage. Propranolol for Off-Label Treatment of Patients With Melanoma: Results From a Cohort Study. ALDH activity in the liver had the highest elevation at 6 h, and then it decreased but was higher than the control value. In SHR, chronic antihypertensive therapy with either angiotensin receptor antagonists, an angiotensin-converting enzyme inhibitor, or a calcium antagonist specifically increased the normal endothelium-dependent relaxations to acetylcholine, probably because of their blood pressure-lowering effects, whereas the responsiveness of vascular smooth muscle to NO remained unaffected. Photoisomerization around a fulvene double bond: coherent population transfer to the electronic ground state?. It may be concluded that alpha1- and alpha2-adrenoceptor stimulation decreases the physostigmine-induced yawning behavior in rats. Using a double-blind, mixed measures design, 81 participants were administered a 330-ml drink containing either (1) 50 g glucose and 40 mg caffeine, (2) 10.25 g of fructose/glucose and 80 mg caffeine or a placebo drink and tested across a range of cognitive tasks, mood and physiological measures. Renal tubular dysfunction is characterized by a specific pattern of impaired proximal tubular transport mechanisms, with marked impairment of glucose transport. Thus, koff might be an independent factor in pharmacological activity.

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Effects of restraint and isolation stress and epidural blockade on endocrine and blood metabolite status, muscle glycogen metabolism, and incidence of dark-cutting longissimus muscle of sheep. In comparison to arbitrary orientations of the residue molecules in the individual complex depictions a consistent placement improves the legibility and comparability within the series. Immunological and electrophoretic study of the proteolytic enzymes from various Lactococcus and Lactobacillus strains. When monocytes were cultivated in vitro, no loss of cytocidal capacity occurred over the first 10 days of culture, whereas later on, when epithelioid and giant cells predominate in the cultures, mononuclear phagocytes had little cytotoxic activity. To investigate the potential role of prostaglandins (PGs) in tubal function in endometriosis. Shunt surgery versus endoscopic sclerotherapy for long-term treatment of variceal bleeding. The records of nine children with biopsy-proven MCNS who received two courses of cytotoxic therapy with either chlorambucil or cyclophosphamide were reviewed to evaluate the length of remission, associated side-effects and long-term outcome. Northern blot analyses confirmed that there was also an increase in the mRNA for IL-1 alpha and IL-beta in response to oxLDL in the isolated foam cells.

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With the development of theory along with computing power, quantum materials design-the synthesis of materials with the desired properties in a controlled way via materials engineering on the atomic scale-is becoming a major component of materials research. Concerns of patients, MDs are transforming transfusion medicine. Study of eosinophilia in relation to serum IgE level and cell mediated immunity (CMI) to soluble egg antigen (SEA) in human schistosomiasis mansoni. Furthermore, postsynaptic 5HT receptor activation (not the 5HT2 receptor subtype) probably exerts a facilitatory effect while presynaptic 5HT1A receptor activation exerts an impairing effect on the memory consolidation process, probably due to autoreceptor inhibition of 5HT release. Sound production in Pituophis melanoleucus (Serpentes: Colubridae) with the first description of a vocal cord in snakes. The increasing diversity of purpose-built, synthetic and biogenetically engineered pharmaceuticals has led to a revival of interest in the pharmacological possibilities for the treatment of voice disorders.

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Cloning and characterization of a novel beta-galactosidase-coding gene from Rhizobium meliloti. There is good evidence that prophylactic HPV vaccines are immunogenic and effective against targeted-type HPV infections and type-specific genital lesions, including high-grade cervical intraepithelial neoplasia (CIN), when administered prior to HPV infection. Utilization of videotape programs as educational enrichment for Spanish-speaking families and their deaf children: focus on parent-child-teacher interaction. It is shown that the widely adopted correction for non-constant specific radioactivity of precursor pool is not correct in general and could be used only for very stable RNAs. Some uses of television with hospitalized and handicapped children. An ecological study with spatial and time series analyzes of new confirmed cases of VL notified to the Brazilian Notifiable Disease Information System between 2002 and 2013, considering the 12 mesoregions of Minas Gerais.

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Brain thiamine concentration, transketolase activity and thiamine pyrophosphate (TPP) effect were not different (P greater than 0.05) among groups. Microstructural properties of Bi2Sr2Can-1CunOy multilayers grown by molecular beam epitaxy. Using data from interviews, a structured task, and observations of each ward team, he identified six domains of knowledge essential to teaching excellence in the context of teaching rounds: clinical knowledge of medicine, patients, and the context of practice, as well as educational knowledge of learners, general principles of teaching and case-based teaching scripts. Initial results reveal the high performance of this beamline, with an energy resolving power estimated to be over 10,000 at the argon L-edge and a spatial resolution better than 30 nm. Synthesis and antibacterial activity of new 2-substituted penems. Increasing the mass fraction of PEGMA while keeping the total polymer concentration constant led to a decrease in the elastic modulus (E) of the hydrogel, but caused a minimal increase in the swelling ratio (Q).

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Mitochondrial increase in volume density with exercise training: More, larger or better?. pulcher responded faster to the threat stimulus, reached a refuge faster and entered a refuge more likely when predator cues were perceived. 17-Hydroxycorticosteroid excretion rates of parents following death of their children from leukemia. Results showed a selective boost in understanding of action information, even when controlling for baseline performance. (3) What properties, presumably of the substrate organelles, marks them for specific absorption into autophagic vacuoles?. Appropriate drug delivery and reduction of side effects is also pivotal in the management of patients with COPD. The classical nomenclature and categorization of neoplastic and non-neoplastic nodular lesions of the liver are being revised due to the tremendous volume of information recently published on this issue. Prior pelvic surgery is the factor that usually causes this problem. We report a two colour flow cytometric analysis of the surface antigen phenotype of lymphocytes in the thymus and in thymoma in 24 patients and in 14 normal thymuses. Simulated voltammograms are generalized in the form of analytical equations to allow for reliable kinetic analysis without the prior knowledge of the rate law.

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Giant magnetoresistance for superparamagnetic particles: Melt-spun granular CuCo. A closely related member of the ets gene family, c-Ets-2, also contains two separate activation domains. There were no statistically significant differences between the two patient groups in the frequency of occurrence of ventricular tachycardias or ventricular fibrillation. Treatment of recurrent herpes simplex virus (HSV) infection with a vaccine was attempted as early as 1938. Both of these PC-SOD retained SOD activity in vitro and showed delayed plasma disappearance in vivo in rats. Transplantation of peripheral blood stem cells mobilized by haematopoietic growth factors in childhood. Effect of elevated dietary tryptophan on protein synthesis in rat liver.

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