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Azicin (Azithromycin)
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Azicin

Azicin is a macrolide antibiotic of azalides group. Azicin inhibits RNA-dependent protein synthesis of sensitive microorganisms. It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Other names for this medication:
Altezym, Azadose, Azibiot, Azicu, Azilide, Azimac, Azimakrol, Azimed, Azimit, Azinix, Azinom, Azithromycinum, Azitrix, Azitromicina, Aziwok, Azomac, Azromax, Aztrin, Clearsing, Doyle, Ericiclina, Goldamycin, Gramokil, Ilozin, Maczith, Magnabiotic, Misultina, Neozith, Nifostin, Opeazitro, Phagocin, Toraseptol, Triamid, Tridosil, Tromix, Ultreon, Vectocilina, Vinzam, Zedd, Zertalin, Zifin, Zinfect, Zistic, Zithrogen, Zitrim, Zocin, Zycin, Zymycin

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Also known as: Azithromycin

Description

Azicin (Azicin tablets and Azicin for oral suspension) contain the active ingredient azithromycin, a macrolide antibacterial drug, for oral administration. Azicin has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl) oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Azicin is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C38H72N2O12, and its molecular weight is 749.00.

Azicin, as the dihydrate, is a white crystalline powder with a molecular formula of C38H72N2O12∙2H2O and a molecular weight of 785.0.

Azicin is supplied as tablets containing azithromycin dihydrate equivalent to either 250 mg or 500 mg azithromycin and the following inactive ingredients: dibasic calcium phosphate anhydrous, pregelatinized starch, sodium croscarmellose, magnesium stearate, sodium lauryl sulfate, hypromellose, lactose, titanium dioxide, triacetin, and D&C Red #30 aluminum lake.

Azicin for oral suspension is supplied in bottles containing azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or 1200 mg azithromycin per bottle and the following inactive ingredients: sucrose; sodium phosphate, tribasic, anhydrous; hydroxypropyl cellulose; xanthan gum; FD&C Red #40; and spray dried artificial cherry, creme de vanilla, and banana flavors. After constitution, each 5 mL of suspension contains 100 mg or 200 mg of azithromycin.

Dosage

Use Azicin as directed by your doctor.

Take Azicin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Do not take an antacid that has aluminum or magnesium in it within 1 hour before or 2 hours after you take Azicin.

Azicin works best if it is taken at the same time each day.

To clear up your infection completely, use Azicin for the full course of treatment. Keep using it even if you feel better in a few days.

Ask your health care provider any questions you may have about how to use Azicin.

Overdose

If you take an overdose of Azicin you should visit your doctor or health care provider immediately. Symptoms of Azicin overdosage include discomfort in the stomach, diarrhea, retching and nausea.

Storage

Keep the medicine in a cupboard, away from heat and direct sunlight.

You may need to keep liquid medicine in the fridge – check the instructions on the bottle. Make sure that the medicine doesn’t freeze.

Make sure that children cannot see or reach the medicine.

Keep the medicine in the container it came in.

Side effects

The most common side effects associated with Azicin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Azicin is contraindicated in patients with known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide drug.

Azicin is contraindicated in patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior use of azithromycin.

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Traditional open surgical repair for mycotic aneurysms of the thoracic aorta is associated with significant morbidity and mortality. Overall, P-gp, Bcrp, and Mrp4 were positively expressed in mouse cervicovaginal tissues, and their expression can be regulated by the estrous cycle or by exogenous hormones. Human vascular SMCs and ECs were extracted from umbilical cord vessels. Solitary Pulmonary Capillary Hemangioma of Adult Cases: Clinicopathologic Characteristics as an Unrecognized Entity. Characterization of a patient with atypical amegakaryocytic thrombocytopenia. Standardization of BMD values obtained in two different DXA devices was done according to the method developed by International DXA Standardization Committee (IDSC), using the European Spine Phantom (ESP) to obtain the specific constant value. In this study, we report the effects of Pseudomonas 3-oxo-C(12)-HSL on the growth and suppression of virulence factors in other bacterial species that frequently co-exist with Ps. However some of these observations need to be confirmed including larger sample size with broader age range and using other msp2 genotyping method.

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We conclude that autophagy plays a critical role in cell reprogramming by regulating cytoplasmic remodeling, facilitating the transition to a less differentiated cell identity. This article investigates the prevalence of unpaid caregiving by local authority district in England and Wales, using data from a new question on caregiving in the 2001 Census. For curves that require surgical correction, spinal fusion is the surgical treatment, and superior mesenteric artery syndrome is a possible complication. Radiological picture of the thorax in constitutional hemolytic anemia. Continuity of medical care by a single healthcare provider was associated with decreased likelihood of incarceration, suggesting that the provider may play an important role in designing interventions to prevent incarceration in this high-risk population. A case and review of bowel perforation secondary to metastatic lung cancer. For the first time, to test elegant and simple counteraction hypothesis as a general mechanism we utilized fluorescence, circular dichroism, Fourier transform infrared spectroscopy, and dynamic light scattering to study the counteraction of GdnHCl-induced denaturation of BM by the trehalose.

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We further compare the requirements of different septate junction components for the integrity of the blood-brain barrier and provide evidence that two of the six Claudin-like proteins found in Drosophila are needed for normal blood-brain barrier function. A core feature of genetic contribution toward any complex human behavior is familial resemblance. RNA interference (RNAi) mediated by siRNA leads to suppression of STAT3 expression in colon cancer cell lines. Both live and inactivated IB vaccines are used extensively, the latter requiring priming by the former. Although the function of Naf1p and its human ortholog NAF1 has been delineated in detail, that of Shq1p and its putative human ortholog SHQ1 remains obscure. Cell biology of the neurovascular unit: implications for drug delivery across the blood-brain barrier.

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Elevated NOX4 mRNA levels were detectable as early as 24 h after the onset of ischemia and persisted throughout the 30 days of follow-up period, reaching a maximum between days 7 and 15. Women who abuse prescription opioids: findings from the Addiction Severity Index-Multimedia Version Connect prescription opioid database. Developing new drugs to treat tuberculosis is of critical importance but even more important is developing strategies that ensure that there is no further amplification of drug resistance around the world especially in high burden low resource settings. Results showed that visuospatial short-term deficits appear earlier than visual short-term ones. This has necessitated an adaption of the legislation regarding Trichinella surveillance and control, in order to ensure and document public health while also allowing trade of livestock and meat without unnecessary restrictions. This has led to the suggestion that colonic choriocarcinomas may arise from the more typical adenocarcinoma a process of further dedifferentiation.

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In this review we discuss regulatory mechanisms by which intercellular junction proteins are influenced by inflammatory mediators to influence intestinal epithelial barrier function and address potential therapeutic strategies to strengthen the barrier and restore mucosal homeostasis. Pragmatic language disorders (PLDs) are difficult to diagnose in a cost-effective manner, and there are few assessment tools that yield quantitative data. Among young women reporting facial pain, clinical TMD subtypes, pain impact, treatment utilization, and additional characteristics other than somatization with pain were similar between races. Force heterogeneities in particle assemblies: from order to disorder. In the remaining 2 patients with an unchanged level of blood tumor cells, one patient mounted a T-cell response, whereas the other did not. Compliance and toxicity of adjuvant CMF in elderly breast cancer patients: a single-center experience. Because video-laryngoscopy offers potential advantages compared to established airway management techniques, further studies theophylline syrup are required to evaluate the significance of video-laryngoscopy in prehospital emergency medicine.

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