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Avlotrin (Trimethoprim)
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Avlotrin

Avlotrin (sulfamethoxazole / trimethoprim) is absorbed by the body and begins to kill bacteria within 1 to 4 hours after taking your dose. For more common problems like urinary tract infections and ear infections, most people will start to feel relief after a few days.

Other names for this medication:
Bacsul, Bactekod, Bactelan, Bacticel, Bactipront, Bactoprim, Bactricid, Baktar, Baktimol, Bakton, Biotrim, Biseptrin, Bitrim, Comox, Cotrimstada, Diseptyl, Ditrim, Dotrim, Drylin, Eliprim, Esbesul, Forcrim, Gentrim, Globaxol, Infectrin, Licoprima, Methotrin, Neotrim, Nopil, Novotrim, Noxaprim, Oribact, Primadex, Primotren, Septra, Servitrim, Sulfamethoxazolum, Sulmetrim, Sumetrolim, Suprimass, Theraprim, Triforam, Trimecor, Trimethazol, Trimethoprim, Trisolvat, Trisul, Urisept

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Also known as: Trimethoprim

Description

Sulfamethoxazole and trimethoprim combination is used to treat infections including urinary tract infections, middle ear infections (otitis media), bronchitis, traveler's diarrhea, and shigellosis (bacillary dysentery). This medicine is also used to prevent or treat Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP), a very serious kind of pneumonia. This type of pneumonia occurs more commonly in patients whose immune systems are not working normally, including cancer patients, transplant patients, and patients with acquired immune deficiency syndrome (AIDS).

Sulfamethoxazole and trimethoprim combination is an antibiotic. It works by eliminating the bacteria that cause many kinds of infections. This medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain sulfamethoxazole and trimethoprim. It may not be specific to Avlotrin DS. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects (eg, crystals in the urine). .

For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (liquid or tablets): For treatment of bacterial infections: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 10 to 14 days. Your doctor may adjust this dose if needed. Children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 40 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 8 milligrams (mg) per kilogram of body weight of trimethoprim, given in two divided doses every 12 hours for 10 days. Weighing 40 kilograms (kg)—4 teaspoonfuls (20 mL) of oral liquid or 2 tablets (or 1 DS tablet) 2 times a day for 10 days. Weighing 30 kg—3 teaspoonfuls (15 mL) of oral liquid or 1 ½ tablet 2 times a day for 10 days. Weighing 20 kg—2 teaspoonfuls (10 mL) of oral liquid or 1 tablet 2 times a day for 10 days. Weighing 10 kg—1 teaspoonful (5 mL) of oral liquid 2 times a day for 10 days. Children younger than 2 months of age—Use is not recommended. For treatment of bronchitis: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 14 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended. For treatment of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults and children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 75 to 100 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 15 to 20 milligrams (mg) per kilogram of body weight of trimethoprim each day, given in equally divided doses every 6 hours for 14 to 21 days. Weighing 80 kilograms (kg)—10 teaspoonfuls (50 milliliters (mL)) or 5 tablets (or 2 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 64 kg—8 teaspoonfuls (40 mL) or 4 tablets (or 2 DS tablets) 4 times a day for 14 to 21 days. Weighing 48 kg—6 teaspoonfuls (30 mL) or 3 tablets (or 1 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 40 kg—5 teaspoonfuls (25 mL) or 2 ½ tablets 4 times a day for 14 to 21 days. Weighing 32 kg—4 teaspoonfuls (20 mL) or 2 tablets (or 1 DS tablet) 4 times a day for 14 to 21 days. Weighing 24 kg—3 teaspoonfuls (15 mL) or 1 ½ tablets 4 times a day for 14 to 21 days. Weighing 16 kg—2 teaspoonfuls (10 mL) or 1 tablet 4 times a day for 14 to 21 days. Weighing 8 kg—1 teaspoonful (5 mL) 4 times a day for 14 to 21 days. Children younger than 2 months of age—Use is not recommended. For prevention of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim once a day. Children 2 months of age and older—Dose is based on body size and must be determined by your doctor. The usual dose is 750 mg of sulfamethoxazole and 150 mg of trimethoprim per square meter (m[2]) of body surface each day. This is given in equally divided doses two times a day for 3 days a week on consecutive days (eg, Monday, Tuesday, Wednesday). However, the dose is usually not more than 1600 mg of sulfamethoxazole and 320 mg of trimethoprim per day. Children younger than 2 months of age—Use is not recommended. For treatment of traveler's diarrhea: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 5 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended.

Overdose

Often, no treatment is needed for an antibiotic overdose. Usually, you'll need to watch for stomach upset and possibly diarrhea. In those cases, you should give extra fluids.

Storage

Store at room temperature between 20 to 25 degrees C (68 to 77 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Avlotrin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sulfamethoxazole and trimethoprim combination in the elderly. However, elderly patients are more likely to have a folate deficiency, age-related kidney or liver problems, and may be more likely to experience unwanted side effects (eg, severe skin rash, increased potassium in the body, or problems with blood clotting or the immune system). There may be an adjustment in the dose for elderly patients receiving sulfamethoxazole and trimethoprim combination.

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Degradation of unstable interleukin-1 alpha mRNA in a rabbit reticulocyte cell-free system. Certain strains degrade even highly chlorinated PCBs through 3,4-dioxygenation. Patterns of silver staining on NORs of prematurely condensed muntjac chromosomes following RNA inhibition. This contrasts with standard murine leukaemia virus which is only found as a monomer within cells. In this work, we describe the synthesis and formulation of polymeric nanoparticles (NPs) and soluble homopolymers (Ps) encoded with multiple copies of a peptide substrate for proteases. Experimental models of colitis showed that Hp has a protective role in inflammatory colitis, most likely by inhibiting the production of Th1 and Th17 cytokines. Preferred Reporting Items for Systematic Review and Meta-Analysis will be used to inform the reporting of this study. A healthy 34 year old, male (70.2 kg, 168 cm) had lower leg fracture during rugby football and was scheduled for open reduction and fixation.

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Long-term outcome of laparoscopic surgery for T1 cancer patients of the colorectum. Bacteria able to convert oleic acid to 10-hydroxystearic acid were isolated from the ovine rumen. Choroid plexus papilloma presenting with cerebrospinal fluid rhinorrhea and otorrhea: case report. Incorporation was assessed in control disks maintained in the absence of applied current at 37, 41, and 43 degrees C. Disposable polystyrene microtiter plates were coated with rabbit immunoglobulins anti-Brucella melitensis antigens and then incubated with sera of Brucellosis patients and sera of not infected normal subjects as a control, to standardize the conditions of the different steps of the assay. Regulation of noradrenergic and peptidergic development: a search for common mechanisms. Both cats had IgG monoclonal gammopathy, Bence Jones proteinuria, increased numbers of bone marrow plasma cells, and high values for relative serum viscosity. Stabilization of sample temperature in a surface-science vacuum chamber to 0.03 K and quartz-crystal microbalance frequency to 0.06 Hz over 0.5 h. In contrast, some experimental studies suggest that larger hydrated ions should be considered and even specified for each type of ion. Effects were also examined in cycling cells to determine whether they were more sensitive to damage then noncycling cells.

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The nature and the degree of tissue changes in the prostate following fulguration with the roller ball are well controlled and predictable. Metabolism of calcium, phosphorus, and vitamin D are intimately related and the requirement of these nutrients should take into account this relationship. In the process, I utilize JSML2009 guideline of laboratory examination. The authors reviewed the material of the National Cancer Institute in Milan and the major international papers on adjuvant therapies of GCT of the testis. Telokin represents a new structural set in the superfamily which we call the I set. The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic mice. Polypeptide elongation factor 1 was isolated from yeast postribosomal supernatant. Functional outcomes deltasone dose of microsurgical reconstruction of delayed complications following head and neck cancer ablation. Given that a potential neurotoxic effect of PB has not yet been completely elucidated, the present investigation used neural SH-SY5Y cells to evaluate the effect of PB on the cellular viability, cell apoptosis, modulation of the cell cycle, oxidative stress, and genotoxicity variables, which indicate neurodegeneration.

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Such a quantitative difference may contribute to the pathogenesis of reactive arthritis by affecting the clearance of immune complexes. In this report we have analyzed the binding of a strain of Streptococcus dysgalactiae to fibronectin. We aimed to fill the research gap by examining the effects of structural similarity on Chinese-character crowding. Thus, a reduction of the DoE from five to three factors was possible (11-13 media), making DoE solubility studies feasible compared to single SIF solubility studies. Mitotic cycle of diploid and polyploid cells of regenerating rat liver. Despite these issues most can be treated safely and often as an outpatient. The effect of weight loss on the electrocardiogram abnormalities of obesity appears to depend upon diet duration and upon whether protein and mineral nutritional status is maintained. Of the 11 children, two survived with no morbidity, two children (B and C of the third triplet pregnancy), died 2 and 19 days after delivery, respectively, can i drink alcohol when taking claritin and seven were stillborn. Percutaneous coronary intervention for chronic total occlusions: value of preprocedural multislice CT guidance.

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The region of the genome encoding the glucose-6-phosphate dehydrogenase gene zwf was analysed in a unicellular cyanobacterium, Synechococcus sp. The scalloped gene encodes a novel, evolutionarily conserved transcription factor required for sensory organ differentiation in Drosophila. Allergic contact dermatitis to costus: removal of haptens with polymers. Dynamic changes in reflectance anisotropy from the Si(001) surface during gas-source molecular-beam epitaxy. It seems that Mini-Oct has the potential to serve as a transcriptional modulator for genes regulated by different octamer-binding factors. Comparison of fecally polluted and unpolluted sediments showed few determinant classes in unpolluted sediment and a complex composition of several determinant classes in polluted sediment. Differences between isolates from different geographical locations were found and some strains appeared antigenically more complex than others.

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Second, a forced degradation study showed an increase in acidic species and a decrease in basic species when sampled on-line over 7 days. We conclude that the increased incidence of breathing movements produced by pilocarpine are due, in part, to increased arousal at the expense of quiet sleep. Single-particle cryo-EM using alignment by classification (ABC): the structure of Lumbricus terrestris haemoglobin. Comparative efficiency of different methods of helminthological diagnoses. We applied the DSA imaging protocol to record changes in the visualization of coronaries and myocardial perfusion induced by a vasodilator drug, nitroprusside. The diabetic rabbits were maintained for 2 months with blood glucose levels in the range 20--40 mmol/l. There may be unaccounted variables that influence survival, warranting further prospective studies.

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By contrast, the induction of T-cell proliferation was positively correlated with the presence of DR molecules on the tumor cell lines. The autosomal dominant spinocerebellar ataxias (SCAs) are a clinically heterogeneous group of neurodegenerative diseases. In none of the cases were the dogs able to distinguish all the individual scents of monozygotic twins living in the same environment if the scents were presented to them separately. Students in Arm 1 attended a 3.5-day on-site course in Biostatistics and completed a 3.5-week on-line course in Research Ethics. Urban expansion has widespread impacts on wildlife species globally, including the transmission and emergence of infectious diseases. Transfer of mannose from the labeled mannolipid to the endogenous protein was demonstrated. Maternal serum alpha-fetoprotein screening: a report of the Forsyth County project. We previously reported that transgenic tobacco overexpressing the swpa4 peroxidase (POD) gene from sweetpotato exhibits increased tolerance to stress. These results confirm the high diagnostic accuracy of pertechnetate scintigraphy to detect ectopic gastric mucosa if associated with H2-receptor-blocking agent premedication.

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Cadmium and indium defects in ceria and their interaction with oxygen vacancies and small polarons. Although both rimmed vacuolated and regenerating fibers had increased immunoreactivity against tubulin and tau protein, tau protein in the former was more highly phosphorylated than that in the latter. Serum viscosity and hyperviscosity syndrome in IgG multiple myeloma. Modified implosive (flooding) therapy: treatment of phobias in London. Subjective Sleep Quality in Temporomandibular Disorder Patients and Association with Disease what drug can be used instead of zantac Characteristics and Oral Health-Related Quality of Life. Increasing LV stiffness during the development of CHF progressively shortens the early filling deceleration time and augments the early filling deceleration rate. 77, 5764-5768), leading to an alteration in alpha 2-macroglobulin conformation. CT-guided transthoracic cutting needle biopsy of intrathoracic lesions: comparison between coaxial and single needle technique.

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