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Atdol (Tramadol)

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Atdol is used to help relieve moderate to moderately severe pain. Atdol is similar to opioid analgesics. It works in the brain to change how your body feels and responds to pain. Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Other names for this medication:
Anazac, Axedol, Bludol, Bolodol, Cemadol, Dolmeri, Dolotram, Leedol, Nomadol, Painadol, Painex, Paintrol, Pentazen, Radol, Ramax, Ramcet, Redimol, Relidol, Sayodol, Simol, Stemadol, Takol, Tramafen, Tramest, Tramospas, Tranzat, Trydol, Ubitdol, Urgendol, Urogendo, Xtram, Zamadol, Zotadol

Similar Products:
Casodex, Rebetol, Nizoral, Acticin, Medrol, Prandin, Mestinon, Compazine, Aristocort

Also known as: Tramadol


{name} ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Atdol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Atdol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Atdol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Atdol dosage information

Side effects

The most common side effects associated with Atdol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Persistent infection of L cells with vesicular stomatitis virus: evolution of virus populations. Morphological studies by electron microscopy of the canine distempter virus. Many actin-binding proteins have been observed to have a modular architecture. 5) Integration of the input signal (transformation from head acceleration to eye position information) can be directly tested. Challenge with Bovine viral diarrhea virus by exposure to persistently infected calves: protection by vaccination and negative results of antigen testing in nonvaccinated acutely infected calves. The product was found to have a significant impact on the ability to detect several drugs of abuse, however, detecting the presence of the adulterant in urine had not yet been reported. MEK inhibitors may also be useful in treatment of advanced melanoma harboring other genetic mutations, such as NRAS and GNAQ/GNA11 mutations. Our results provide direct evidence for selective cooperating events in ERG-induced prostate tumorigenesis and offer a rational basis for combined therapeutic interventions against multiple oncogenic pathways in prostate cancer. The low failure rate, even in a population with a high caries increment, suggests that compomers are a suitable alternative to amalgam or other, tooth-colored materials when used as class II restorations in primary teeth. We consider a model of ballistic quasi-one-dimensional semiconducting wire with intrinsic spin-orbit interaction placed on the surface of a bulk s-wave superconductor (SC), in the presence of an external magnetic field.

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Clinical and microbiological profiles of infective endocarditis in a tertiary hospital in Aseer region, Saudi Arabia. Specialist registration in Victoria--training of specialists in endodontics. A meta-analysis of voxel-based morphometry studies on gray matter volume alteration in juvenile myoclonic epilepsy. Necessity for basic modifications in compensation for industrial accidents. Suppressed ROS generation was noted by the treatment of d-arb to compare with arbutin and hydroquinone. The results suggest that vigorous exercise may reduce the incidence of obesity among young African-American women.

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Glutathione S-transferase and UDP-glucuronyltransferase activity in primary cultures of rainbow trout gill epithelial cells. Diagnosis of prosthetic valve leakage by the transthoracic echocardiogram (TTE) technique is more difficult. The effects of L-tryptophan were apparent only in the case of one parameter, REM latency. The effects of voluntary regulation of positive and negative emotion on psychophysiological responsiveness. In addition, by using heterokaryon assays, we show that VP13/14 is capable of shuttling between the nucleus and cytoplasm of the cell, a property that may be attributed to three leucine-rich stretches in the C-terminal half of the protein that again bear similarity to the nuclear export signals of Rev and Rex.

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Current PTSD patients performed worse on attention, verbal memory, verbal fluency, and psychomotor speed. The GTPBP3 N-terminal domain mediates a potassium-independent dimerization, which appears as an evolutionarily conserved property of the protein family, probably related to the construction of the binding site for the one-carbon-unit donor in the modification reaction. Intra-GBM microstructures may be originated mainly from the podocyte. MEK inhibitor PD98059 and PI-3K inhibitors wortmannin and LY294002 inhibited a carbachol-induced increase in DNA synthesis. Omitting the random terms can lead to overestimation of the significance of weather on survival, and overoptimistic prediction intervals in simulations of future population behavior. The diagnosis of cat-scratch-disease-associated adenitis: diagnostic value of serology and polymerase chain reaction. The assembled complex displayed features typical for SNARE core complexes, including a profound hysteresis upon unfolding-refolding transitions.

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Factor structure and psychometric properties of the Italian version of the Gambling Related Cognitions Scale (GRCS-I). Serum thyrotropin concentration in children with isolated thyroid nodules. The present study demonstrated that PPARalpha activator fenofibrate decreased Ang II-induced generation of pro-inflammatory mediators such as TLR4, MMP-9 and TNF-alpha, but enhanced production of anti-inflammatory molecules like PPARalpha and 6-keto-PGF(1alpha) both in vivo and in vitro. Usefulness of a vaccination registry and the management of consent: the case of Quebec. However, no difference in plasma progesterone level on days 9-11 between control and treated cycles was detected and there was no difference between treated and control CL at day 11 with regard to CL weight or progesterone content. Syngas is produced by thermal gasification of both nonrenewable and renewable sources including biomass and coal, and it consists mainly of CO, CO2, and H2. The aim of this trial was to determine whether an aqueous cinnamon purified extract improves glycated haemoglobin A1c (HbA1c), fasting plasma glucose, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triacylglycerol concentrations in patients with type 2 diabetes. The susceptibility of TK-recombinant parasites to ganciclovir (GCV), a closely related nucleoside analogue, was evaluated by a simple measurement of the absorbance of Leishmania cultures grown in the presence of the drug. Rapid progress has recently been made in our understanding of the genetic factors involved in endocrine autoimmune diseases.

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Patients undergoing EMR for AMN at the ARJ over 4.5 years, from June 2008 to December 2012. Ideas from psychology about mental schemas are considered in relation to the phenomenon of systems consolidation and, specifically, about how prior knowledge can alter the rate at which consolidation occurs. Microbial hydroxylation of progesterone with Acremonium strictum. Significantly elevated tumor necrosis factor-alpha, tumor necrosis factor receptor-1 and -2, leptin, and C-peptide levels were found in the 3rd3 trimester as compared with the 1st1 and 2nd2 trimesters and with the nonpregnant controls. Recombinant PfSUB-1 expressed in a baculovirus system is secreted in the p54 form, noncovalently bound to its cognate propeptide, p31. COBRA and SPIKET compounds represent two new classes of tubulin targeting agents that show promise as anticancer drugs. In function the enamel readily fractured within the initial rod and interrod enamel above the parallel enamel covering the dentino-enamel junction.

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Homologous and heterologous carboxyl terminal peptide (CTP) linker sequences enhance the secretion of bioactive single-chain bovine LH analogs. In contrast, p300 recruitment and acetylated histones at the promoter were not detected in FXR-null mice. Losses of iron and copper were not compensated for in the presence of their inadequate intake in the subsequent 3 days of rest following the race. Patients with newly diagnosed metastatic testicular cancer and with HL that required chemotherapy were compared with age-matched healthy community volunteers. Inhibition of Tyr-phosphatases (vanadate) increases Tyr-phosphorylated PECAM-1 and blocks the activation of p38MAPK. This approach is considered to be highly relevant because these tissues are the actual targets of FA, and MN are a sensitive indicator for the mutagenic action of FA. The venae cavae and their major affluents and the prespinal system (lumbar and ascending lumbar veins, azygos, hemi-azygos, right superior intercostal and vertebral veins) are explored by catheterization. Design of endovascular grafts for abdominal aortic aneurysm repair. Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155.

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Using joint utilities of the times to response and toxicity to adaptively optimize schedule-dose regimes. Data presented here provide a basis for development of a simple test using an antibody microarray. At high P, where lines of equal f and of equal L are nearly parallel, this compensation is less effective. Dual graft LDLT can be a feasible solution to overcome the risk of small-for-size graft syndrome. The diameter of the nasolacrimal canal measured by computed tomography: gender and racial differences. To determine if interleukin-16 (IL-16), IL-17, and IL-18 are present at the murine fetomaternal interface during pregnancy as a first step towards investigating their roles in fetomaternal relationship. To evaluate the distribution and expression profile of Aspartyl/Asparaginyl beta-hydroxylase, ASPH in some tumor cell lines and tumor tissues. In a first step it was evaluated by meta-analysis, which clinical endpoints have been used for comparison of laparoscopic and conventional cholecystectomy. While intracellular HCV RNA levels were significantly increased when cells were pre-infected with AdHBV, HCV replication and virion secretion were not altered by simultaneous infection with AdHBV or AdHBV superinfection of HCV-infected cells.

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Sequential Effects of Foreperiod Duration as a function of the Frequency of Foreperiod Repetitions. Moreover, the synthesis priority order of the individual patches and the appropriate choice of completion scheme (i.e., directional or nondirectional) are both determined in accordance with a Hessian matrix decision value (HMDV) parameter. Single dosing with ICS/LABA combinations in mild persistent asthma improves small-airway function, and the effect is maintained over a 12-hour interval by regular use for 4 weeks. Although the strength of the independent association between VLBW and asthma was smaller in the African American population, the substantially increased prevalence of VLBW in this community may contribute to the disproportionately increased prevalence of asthma among African American children. Vitiliginous skin-blister fluid bFGF levels and serum levels were significantly higher in vitiligo patients compared with healthy normal controls. A combination of higher anesthetic concentrations with reduced exposure periods reduces the magnitude of this form of stress response. Cell-mediated immunity has long been believed to be critical for protection, and the importance of humoral immunity is also now recognized. Damage control orthopaedics, defined as primary external fixation of the femoral shaft fracture and subsequent conversion to an intramedullary nail, or primary IMN. Insertion of short transmembrane helices by the Sec61 translocon.

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Here, we targeted these time-dependent effects of cortisol during memory encoding and tested subsequent contextualization of emotional and neutral memories. However, immune responses lead to polyclonal antibody preparations that can vary by affinity and avidity. This adequate withdrawal movement suggests a more refined withdrawal reflex organisation than a stereotyped flexion of all joints to avoid tissue damage. Draft Genome Sequences of Vibrio cholerae O1 ElTor Strains 2011EL-301 and P-18785, Isolated in Russia. With all analytes, the dispersive effect of longitudinal diffusion was reduced as the field strength was increased, leading to enhanced migration velocities and faster separations. For ultrafiltration membranes, pore blocking was identified as the largest contributor to the observed flux decline.

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Ablation, flux, and atmospheric implications of meteors inferred from stratospheric aerosol. Ultrastructurally, cells treated with 1,2-DNB or 2,4-DNT showed increased numbers of autophagic vesicles compared to controls. From time to time examinations must be undertaken and the dosage of estrogens reduced. The most common mechanism of imatinib resistance involves specific mutations in the kinase domains of KIT or PDGFRA. New genetic associations detected in a host response study to hepatitis B vaccine. Hospitals and insurance industry speak up on malpractice liability insurance. The present study documented complications requiring reoperation after gastrectomy for gastric cancer and described surgical luvox dosing max management for each complication. Predictions of sorption in binary-adsorbate systems based on single-adsorbate data fits represented competitive sorption data reasonably well over a wide range of conditions. When mice deficient in L-gulono-gamma-lactone oxidase (Gulo(-/-)), the rate-limiting enzyme in ascorbate synthesis, were depleted of ascorbate and infected with K.

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Localized expression of angiopoietin 1 and 2 may explain unique characteristics of the rat testicular microvasculature. Details of paralysis among Cutter vaccinees are explained by this model, as well as the effects of multiple inoculation in monkeys. When BALB/cfC3H females are subjected to continous suction thymectomy, a procedure that results in retention of thymic remnants, the latent period before tumor development is significantly prolonged. Pretreatment with different milks decreased the adhesion and low pH and pepsin treatment reduced the adhesion of all tested strains except L. However, titers of free infectious virus were minimal and virus isolation often required the use of tissue explants. Additionally ex vivo specimens were examined using a topical contrast agent.

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We conclude that acute painful neuropathy can complicate the correction of high glucose levels in diabetic patients. Trypsin treatment of the EBV-receptor colum abolished its ability to retain VCA-positive cells. Application of virtual reality graphics in assessment of concussion. Moreover, this study demonstrates that low carbohydrate diet is safe to use for a longer period of time in obese subjects with a high total cholesterol level and those with normocholesterolemia. Anisakidosis is an underestimated cause of acute abdomen, and should be taken into consideration as a differential diagnosis in these conditions.

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Concerns related to its potential adverse effects on the kidney function in this setting appear unjustified. In order to study the localization of TGR5 in human gallbladders, a novel antibody was generated. The discrimination was carried out using allele-specific primers, which flanked the point mutation in the target gene and were ligated using a thermostable ligase enzyme only when the genomic DNA carried this mutation. activity of a periodic nature was noted, which was continuous or intermittent, lateralised or focal in the temporal region, appearing from the 4th to 7th day. This study shows that CEA is a safe, effective, and durable treatment for patients with symptomatic low-grade carotid stenosis associated with unstable plaque. Redirecting the inactivation pathway of penicillin amidase and increasing amoxicillin production via allergic reaction pepcid dose a thermophilic molecular chaperone. Of these, 12 were treated with guided tissue regeneration (GTR) using a resorbable membrane with collagen, 12 with enamel matrix derivative (EMD) gel and 12 with a modified Widman flap (MWF). These finding could be beneficial for counseling patients with SRMs. The aerial part of Acalypha australis were extracted with EtOH at room temperature.

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Clinical investigation of effects of digitaline Nativelle and cedilanid. Finding the undiscovered roles of genes: an approach using mutual ranking of coexpressed genes and promoter architecture-case study: dual roles of thaumatin like proteins in biotic and abiotic stresses. When water was absorbed to the internal structure of the material (SMCC), the water bands were first seen at higher wavelengths, then followed by a shift to lower wavelengths. The H atom attached to the carbonyl group was abstracted in formamide. Anchorage-independent growth of brain and mammary stem cells in vitro has been proved to be a useful tool to enrich and characterize neural and mammary stem cells. To describe the imaging features of POEMS, and to compare our experience of 8 cases to a review of literature. Isotretinoin is approved by the US Food and Drug Administration for the treatment of severe recalcitrant nodular acne. pylori adhesin and TFF1 was characterized using surface plasmon resonance, flow cytometry, nondenaturing polyacrylamide gel electrophoresis, coimmunofluoresence, and incubation with tissue sections. The models of myocardial ischemia were prepared by subcutaneous injection of isoproterenol or by cordarone drug classification ligation of coronary artery. The levels of two endorphines, endogenously occurring morphinomimetic peptides, were measured in serial samples of CSF from seven psychiatric patients.

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Lactic acidosis not hyperlactatemia as a predictor of in hospital mortality in septic emergency patients. In this pilot study, 30 patients who had been treated with BTX-A within the last 3 months answered a standardized questionnaire (the Freiburg questionnaire on aesthetic dermatology and cosmetic surgery). Studies on Paecilomyces muscardine of Cordyceps sinensis host insect. The reduced protein representation allows an efficient search for docking minima on the protein surfaces within. Attachment of alkali cations on beta-D-glucopyranose: matrix-assisted laser desorption/ionization time-of-flight studies and ab initio calculations. Studies on animal models have shown that the blockade of the CX3CL1/CX3CR1 pathway ameliorates the severity of atherosclerosis, while genetic epidemiology has confirmed that a genetically-defined less active CX3CL1/CX3CR1 pathway is associated with a reduced risk of atherosclerotic disease in humans. Fluctuating Hydrodynamics Approach for the Simulation of Nanoparticle Brownian Motion in a Newtonian Fluid. A retrospective chart review was performed for patients operated on for paraesophageal hernia at the Peter Lougheed Centre from 2004 to 2007 inclusive. In this review article we present basic principles of magnetically induced heat generation of magnetic nanoparticles for application in magnetic particle hyperthermia. Gold nanoparticles (GNPs) based dipstick competitive immunoassay was developed to detect organochlorine pesticide such as DDT at nanogram level (ppb).

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Multislice computed tomography (MSCT) is a promising noninvasive method of detecting coronary artery disease (CAD). The procedure was performed through bilateral minithoracotomies with video assistance. Southern analysis indicated the existence of at least one more metacaspase in the tomato genome. Perinatal cerebral WM injury seems to have major deleterious effects on subsequent development of fiber tracts both in the cerebral WM and more distally. Sufficient bone is gained to allow dental implant placement, an important functional outcome. Covariates included xanax drug other names baseline body mass index (BMI), physical activity level, and history of knee surgery. Supplemental AST and EBRT but not either supplement compared with brachytherapy alone was associated with a decreased risk of PCSM in men with high-risk PC. As 53BP1 is retained at irradiation-induced foci during HR, we propose that BRCA1 promotes displacement but retention of 53BP1 to allow resection and any necessary HC modifications to complete HR. This variability was discussed on the grounds of receptor theory, as the basis for a new method in receptor differentiation.

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The application of mathematical models to a sediment stability study is presented, with an emphasis on using models as a component of an effort to develop, refine, and potentially validate a conceptual site model (CSM) for sediment transport at a study site. Total body bone mineral content (BMC), arms and legs BMC, and lumbar spine bone mineral density were assessed by dual energy x-ray absorptiometry. Chronic allograft nephropathy is the most frequent cause of long-term kidney allograft loss. ATR-FTIR as a thickness measurement technique for hydrated polymer-on-polymer coatings. Unilateral acoustic neuromas were removed via the sigmoid sinus posterior suboccipital approach, one case bilateral acoustic neuromas was operated on in 2 stages. The secretion of total exportable proteins and of albumin, but not of fibrinogen, was stimulated by cGMP used alone or coupled with equimolar cAMP.

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Caspase activity was measured by cytofluorometry, immunocytochemistry, and immunoblot analysis. To investigate stimulus dependence of the gamma-frequency fluctuations of the membrane potential, we have recorded intracellularly responses of cells in cat visual cortex to presentation of moving gratings. Paw swelling was measured every 4 h for 48 or 72 h and decomposed by Fourier transformation. Net ion uptake by the roots per se was shown to display both the high affinity (system 1) and low affinity (system 2) mechanisms. Nanostructured mucoadhesive microparticles for enhanced preocular retention. Abnormal serum lipid profiles have been noted in patients with chronic hepatitis C virus (HCV) infection. The up-regulation of the hZnT5 transcript was mediated by transcription factor XBP1 through the TGACGTGG sequence in the hZnT5 promoter, and this sequence was highly conserved in the ZnT5 genes of mouse and chicken. The hematoma thickness, midline shift and their difference provided a database from which criteria could be derived, that is crucial for prognosis estimation.

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