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Antram (Tramadol)

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Antram is an oral medication that is used to help relieve ongoing moderate to moderately severe pain. Antram is similar to opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.

Other names for this medication:
Acema, Acuvin, Anazac, Arodol, Bolodol, Contradoc, Cradol, Dolomed, Dolotram, Domadol, Mandol, Movon, Neutram, Opigesic, Pentazen, Rimol, Soztram, Tandam, Tramadol, Tramot, Trapidol, Trasic, Tromfil, Trydol, Vardol, Victadol, Zytram

Similar Products:
Mellaril, Aricept, Soma, Leukeran, Abhigra

Also known as: Tramadol


{name} ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Antram: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Antram is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Antram dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nevirapine dosage information

Side effects

The most common side effects associated with Antram are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Antram if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Antram should not be given to a child younger than 12 years old. Antram ER should not be given to anyone younger than 18 years old.

Do not give Antram to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Antram. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Antram is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Some new concepts on the treatment of bleeding in the third trimester of pregnancy. The degree of nasopharyngeal obstruction among the adenoidal subjects was evaluated with an adenoidal-nasopharyngeal ratio parameter obtained from soft tissue radiograph of nasopharynx, and was related to the results of tympanometric evaluation of the adenoidal subjects. Microcystin concentrations in cyanobacteria and their accumulation in rainbow trout (Oncorhynchus mykiss) and freshwater mussels (Hyridella menziesi) in Lakes Rotoiti and Rotoehu (New Zealand) were investigated. Support for research in basic gerontology in the United States of America is briefly described. She had an unremarkable post-operative recovery, without requiring whole blood or platelet transfusions. The study included 20 participants (14 men and six women) who lived in rural areas and had experienced their first AMI. Prophylactic donor lymphocyte infusions after moderately ablative chemotherapy and stem cell transplantation for hematological malignancies: high remission rate among poor prognosis patients at the expense of graft-versus-host disease. Many studies to date seem to support the concept that human immunodeficiency virus (HIV)-specific CTL responses contribute to the control of viral replication, and thus delay the onset of disease.

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There are conflicting data on whether coexisting poor urethral mobility could further compromise surgical success. We obtained, and aligned, a diverse set of 32 HIV-1 genomes and pursued genomewide HLA-DR4 epitope profiling by querying with respect to classifier predictions, as obtained under each of the four peptide representation schemes. More than a century ago, inflammation and infection were considered to have atherogenic effects. Test-retest reliability for two indices of ventilatory efficiency measured during cardiopulmonary exercise testing in healthy men and women. Effect of components of dang-gui-bu-xue decoction on hematopenia.

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To study the reaction and perspective of the patients participating in a clinical heart failure trial, particularly in relation to whether the trial subsequently proved to be positive, negative or neutral. The effect of morphine on host defense during Leishmania donovani infection in golden hamsters was studied. Prevention or modification of varicella using zoster immune plasma. Does access to bed-chair pressure sensors reduce physical restraint use in the rehabilitative care setting?. The annual incidence of hospitalization is climbing in pediatric inflammatory bowel diseases, accompanied by rising intestinal resection rates for CD and stable colectomy rates for UC. After a standard hybridization reaction, a scanner records the intensity of the two fluorochromes. There is some evidence that progression to cirrhosis is more rapid. Branchlet nutrient concentration in hoop pine (Araucaria cunninghamii) relative to family, stable carbon and oxygen isotope ratios and growth rate in contrasting environments. To describe a technique for suturing a dislocated intraocular lens (IOL) using an intraocular cowhitch knot without IOL extraction. Our successful results and high patient satisfaction make it a favourable option that should be considered when faced with this reconstructive challenge.

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Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis. At removal, a small contrast leak from the transhepatic tract was seen. This study demonstrates that initial antepartum hemorrhage during the second trimester and low Apgar score at birth increase the risk of PVL in preterm infants born to mothers with placenta previa. Observations on the use of preserved venous hemografts in experimental aortic defects. Our aim was to develop a conceptual framework of PROs for hormone-refractory prostate cancer (HRPC) to support measurement clarity.

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Longer pain duration was associated with greater gray matter in the posterior cingulate, hippocampus, midbrain, and cerebellum. To investigate the effect on bone healing, Ad.BMP-2 (10(11) particles in 200 mul saline) was unilaterally injected into iliac crest defects and into tibial osteotomies. The ratio of this unfolding force to hydrodynamic friction per DNA contour length is measured in nanochannels with two different diameters. Vitamin D deficiency resulting from malabsorption may be a factor in the etiology of low bone mineral density (BMD) in patients with CF. Expression of constitutively nuclear FoxO1 in beta-cells prevented the proliferative and antiapoptotic actions of GLP-1 in cultured beta-cells and the increase in pancreatic beta-cell mass in response to Exendin4 in transgenic mice. To obtain more insight into information of signal transduction of EGF-receptor-mediated pathway response to the stimulation of hepatic stimulator substance (HSS).

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Distinct differences include higher phenolics, flavonoids, and 5-(hydroxymethyl) furfural (HMF). Several compartments can be defined with different diffusion and boundary properties. This slow positivity appears to index ease of processing or integration. The objective of this study was to determine the effects of EtOH, Ang II, and the combination of Ang II and EtOH on DNA synthesis, cell number, cyclic AMP (cAMP) production, and Mitogen-Activated Protein Kinase (MAPK) or (p44/42) activities in murine primary VSMCs. THE INFLUENCE OF ROOTSTOCK ON THE MINERAL COMPOSITION OF VALENCIA ORANGE LEAVES. Arterial stiffness indexes in acute ischemic stroke: relationship with stroke subtype. This feedback mechanism can lead to the instability if the frontal Marangoni number exceeds a critical value. ATGs showed a reduction of the number of adherent leukocytes and muscle infiltrates suggesting that preoperative therapy with ATGs may have an advantageous effect on primary non-function and on chronic rejection as well as a positive influence upon IRI. It also reduced the economic burden of insertion in a new catheter.


Owing to the timesavings in performing chemical synthesis under microwave irradiation, the technique has become an emerging partner in solid-phase organic synthesis. As a gene of interest is removed from its original chromosomal locus by the induction of Cre recombinase, deletion is complete and instantaneous. The sex determination gene doublesex controls which of these primordia will develop and which will be repressed. Results also revealed that in older but not younger infants, the initial or first looks were directed toward the appropriate expression and that older infants also looked proportionately longer to the incongruent expression during the latter half of the test trials. The purpose of this study was to describe the sonographic findings of Zenker diverticula. He was sent to Paris on the order of Louis Napoleon, king of Holland, at the expense of the Dutch government. mpk1Delta cells also exhibit severe defects in lipid metabolism, including an abnormal accumulation of phosphatidylcholine, diacylglycerol, triacylglycerol, and free sterols, as well as aberrant turnover of phosphatidylcholine. Clinical trials should focus on treating patients with hormones during or soon after anticancer treatment. We enrolled all patients waiting to undergo knee replacement surgery due to osteoarthritis, for one-month period. Here we report that loss of Atg7 (autophagy-related 7), a gene essential for autophagy, leads to neurodegeneration.

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Expression profiling revealed a potentially novel regulation of auxin metabolism and transport in an ABA deficient mutant, sis7-1/nced3-4/sto1-4. Hens fed a vitamin D deficient diet produce eggs which develop the same embryonic defect. The program has the flexibility to solve two design problems: combining all markers into the smallest number of reactions, or alternatively, selecting a subset from many available markers to design an efficient and robust multiplex. A total of 254 premature infants were enrolled in the present study. Affinity chromatography is potentially the most selective method for protein purification.

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The authors are currently performing a genome-wide scan to identify the disease ambien dosage women locus. (2) With two-piece type of implants that can tolerate vertical loading of 5,000 N, plasticity analysis suggested the possibility of screw area fracture after applying 500 N in a 45-degree direction. A number of past studies have demonstrated increased expression and activation of MMPs in both myocardial and vascular remodeling processes. Eosinophil and other leucocyte changes in burned patients, with special reference to adreno-cortical activity. ELISA and western blots revealed high titres of IgG against hard ticks (but not soft ticks) in the sera from both cases. The results indicate that unmarried teen births are positively related to low socioeconomic status, single-parent family households, and minority populations. The social brain hypothesis and its implications for social evolution. Pin1 mRNA expression in blood samples from patients with lung cancer, controls with benign lung disease, and healthy subjects were determined by a real-time reverse transcriptase polymerase chain reaction. The prediction was measured in terms of OR (odds ratio), sensitivity/specificity, and receiver operating characteristic curves. Radial tenderness, focal swelling, and abnormal supination/pronation are associated with wrist fractures in children.

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To further investigate the mechanism of nasal secretion closely related to the innervation patterns in nasal mucosa with emphasis on the acetylcholinesterase (AChE)-positive fibers and peptidergic terminals in nasal mucosa as well as trigeminal ganglion (TG) cells. This paper reviews previous research examining community-level contextual effects regarding smoking and substance use more generally and identifies important limitations of this extant work, thus defining an agenda for future empirical studies. Follicular development, acquisition of mature oocytes, and pregnancy after 2 weeks of leuprolide acetate administration during the midluteal phase. Furthermore, all empirical information on contraceptive safety and efficacy should be assembled in a database to provide the knowledge needed by veterinarians and managers to determine benefits/risks of currently available contraceptives in felids, both domestic and wild. Stopping the baby-trade: affirming the value of human life through the invalidation of surrogacy contracts: a blueprint for New Mexico. The myeloproliferative neoplasms: insights into molecular pathogenesis and changes in WHO classification and criteria for diagnosis. Pigmented basal cell carcinoma simulating melanoma in a burn scar. Osteosarcoma is the most frequent malignant bone tumor in children.

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Further, estimated stress levels were similar regardless is generic allegra the same of whether the salamanders metamorphosed early or late, suggesting that the density effect on stress is long-lasting even once realized density has been reduced through mortality or early metamorphosis. They were divided in three diagnostic categories based on their serum 25 vitamin D levels. Pityriasis lichenoides with ulceronecrosis and hyperthermia: a rare variant of pityriasis lichenoides et varioliformis acuta. Heterogeneity in maple syrup urine disease: aspects of cofactor requirement and complementation in cultured fibroblasts. Nanoparticle release from nano-silver antimicrobial food containers. It was possible to separate by PAGE, HSV-induced markers not only from cells undergoing lytic infection by the virus but also from viable cells from squamous cell carcinoma of the head and neck and the urogenital tract. Widened luminal intercellular spaces of esophageal superficial epithelium are not responsible for the induction of reflux symptoms in patients with GERD. Although several studies have implicated the growth inhibitory protein p27(Kip1) (p27) in the control of myocyte growth and hypertrophy, little is known about the molecular mechanisms that regulate p27 expression in the cardiovascular system. Positive changes in eating behaviour correlated with higher quality of life scores in many of the domains assessed, including leisure, financial situation and perceived mental health.

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The interaction and electron transfer (ET) between rubredoxin (Rd) and rubredoxin:oxygen oxidoreductase (ROO) from Desulfovibrio gigas is studied by molecular modelling techniques. Enhanced encapsulation of insulin in between the fused lipid bilayer indicates that the magnetocochleate has potential as a delivery vehicle for an active pharmaceutical incipient. Endothelin-1 was unable to rescue cardiac myocytes from apoptosis when administered after the decrease in mitochondrial membrane potential. Use of dexmedetomidine to facilitate extubation in surgical intensive-care-unit patients who failed previous weaning attempts following prolonged mechanical ventilation: a pilot study. The aim of this pictorial review is to illustrate the various late appearances of the injured spinal cord. In order to investigate the role of central and peripheral mechanisms in nasal trigeminal sensitization/desensitization processes, the present work recorded psychophysical (intensity ratings) and psychophysiological (skin conductance) responses to allyl isothiocyanate volatile nasal stimulation--during normal breathing--in monorhinal condition after a controlateral stimulation of the other nostril. There is insufficient evidence to support or refute the theory that the bias from improper methods of allocation concealment and examiner masking affect the magnitude of clinical outcomes in periodontology trials. Water vapor as an active scalar in tropical atmospheric dynamics.

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Possible mechanisms for the thiocyanate effect are discussed in terms of an inability to separate acid and base in the secreting membrane. Endothelial dysfunction and intima-media thickness in relation to cardiovascular risk factors in patients without clinical manifestations of atherosclerosis. Furthermore, the importance of the synergistic stimulation of the ATPase activity of Hsp70 is demonstrated. Adenylate cyclase regulates elongation of mammalian primary cilia. Gender analysis after elective open heart surgery: a two-year comparative study of quality of life. A comparative study of heart rate variability tests and lipid profile in healthy young adult males and females. We have been studying natural mutations occurring in association with congenital disorders in the alpha/beta-hydrolase fold domain of neuroligin (NLGN), butyrylcholinesterase (BChE), acetylcholinesterase (AChE). We demonstrate that a pufferfish WT1 transgene can be expressed and spliced appropriately in transgenic zebrafish, contrasting with the situation in transgenic mice. Our study suggests that the Ser26Trp mutation may cause a primary demyelinating neuropathy that is not associated with a specific clinical phenotype.

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Thus the transition of HSP90-family proteins to a state with self-oligomerization ability is essential for preventing the precipitation of substrate proteins. Case of partial necrosis of the gingival crest after re-operation for apical periodontitis. Sequence analysis of the direct repeat region in Mycobacterium bovis. This article recommends a knowledge-based partnership between compounding pharmacists and pharmaceutical manufacturers to improve compounding activities and quality assurance methods to ensure that compounded medications are safe. We present a case report of a 3-year-old girl who developed myositis ossificans after a low protonix packet 40 mg -energy supracondylar fracture of the humerus despite having been treated without manipulation, surgery, or physical therapy. Spin label study of detergents in the region of critical micelle concentration. This convenient test is a practical tool both for regular determination of visual acuity and for detection of false statements by means of an atypical psychometric function. Histopathology revealed six papillary carcinomas, 16 follicular adenomas and three Hurthle cell tumours.

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This is in contrast to mutation of T200 to valine, which resulted in ablation of signaling in both cell types, while only abolishing receptor down-regulation in fibroblasts. Some aspects of the hydrolysis of proline peptides by a prolineless mutant of Escherichia coli. The patient with annular pancreas died of cardiovascular complications after one months. There is a temporal relationship between TP1 and DNA breaks: TP1 nuclear levels increase and the frequency of DNA breaks become less prominent as spermiogenesis is reaching completion. Although there is a long-standing clinical impression of radiosensitivity, in vitro studies have yielded conflicting results.

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Split LT of deceased donor organs may have the potential to resolve the serious organ shortage in Japan. The mean age of the patients was 10.4 years (range, eight to thirteen years) at the time of injury and 13.6 years (range, eight to seventeen years) at the time of surgery, representing a mean delay in diagnosis and treatment of 3.2 years. Using mathematical models, we show that this behaviour is best explained as a local response of the immediate segment contacting the resource. In veterinary medicine, GnRH and its agonists (GnRHa) are widely used to overcome reduced fertility by ovarian dysfunction, to induce ovulation, and to improve conception rate. Distant cancer effects on standardised testing of peripheral vision.

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Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. The reason for this subjective alleviation might be due to reduced inflammatory reaction, changes in blink mechanism or the fact that patients are more confident about their appearance. At 1 year after shunting, both CrCl and SrCr flagyl 250mg tablets levels tended towards pre-shunt levels and the increase in PI did not persist. In rats, slow muscles exhibit aerobic metabolism, in fast muscles--anaerobic one. Ethanol metabolism end-products affect the structure of the proteasome, and, therefore, change the proteasome interaction with its regulatory complexes 19S and PA28, as well as its interacting proteins. A strong argument for the addition of L-T3 to L-T4 monotherapy has been lacking until recent genetic studies indicated a rationale for such therapy among a small fraction of the hypothyroid patient population.

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BRP and HRP (wild-type and immortalized) were grown in physiological/high glucose for 7 days, and then returned to physiological glucose for another 24, 48 or 72 h. The use of chromic oxide as an index material in digestion trials with human subjects. We propose a scaled version of the Rosenzweig-MacArthur model using both Type I and Type II functional responses that incorporates the size dependence of interaction rates. Radiofrequency ablation of liver tumors (I): biological background. Knowledge of this time course enabled centrally disconnected motor nerve endings to be identified as the site of both phases of the steroid action. We found that BC1 RNA is expressed by a specific subset of neurons (but not by non-neuronal cells) in the central and peripheral nervous system of the adult rat. In contrast, the delta13C values and BMI were in phase: an increase in BMI resulted in an increase in the delta13C values. Self-report questionnaires and structured interviews assessed symptoms, functioning, and qualitative social network and support features. Patients undergoing total laryngectomy without partial pharyngectomy or radiation treatment (except irradiation through small ports for a T1 or T2 glottic carcinoma) were included.

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A 2-year-old healthy child presented with progressive unilateral proptosis. Decades of research have linked the neurotransmitter serotonin (5-HT) to prosocial behavior. Most methods for next-generation sequencing (NGS) data analyses incorporate information regarding allele frequencies using the assumption of Hardy-Weinberg equilibrium (HWE) as a prior. Fourteen community-living chronic and 14 subacute inpatient stroke survivors volunteered. Placental floor infarction complicating the pregnancy of a fetus with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency. In a prospective study, we investigated whether out-migrants are a selection of high-risk individuals and whether rural-to-urban migration results in risky sexual behaviour for HIV incidence. The transcription profile of adhered and non-adhered AML 14.3D10 cells was shown to be both technically and biologically reproducible. At the same time it maximizes the spacing between markers, the heterozygosity, and the number of alleles. While several agents are commercially available, these chemicals can alter oral microbiota and have undesirable side-effects such as vomiting, diarrhea and tooth staining. The present study examined the effects of ambroxol and erdosteine, bronchial expectorants, on the cytokine synthesis, granule enzyme release, and free radical production in rat alveolar macrophages activated by lipopolysaccharide.

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Tamoxifen efficacy depends on the formation of clinically active metabolites 4-hydroxytamoxifen and endoxifen which have a greater affinity to the oestrogen receptor and ability to control cell proliferation as compared to the parent drug. Our results show genome-wide interplay between mRNA production and degradation, and that alternative modes of such interplay determine the kinetics of the transcriptome in response to stress. Based on N-domain sequences 3 and 4 different CEA subgroup genes, respectively, were identified. Dopamine and adenosine receptor antagonists did not influence relaxing effects of AKR. En bloc excision of the PNF is a useful method in recalcitrant chronic paronychia. In vivo gene transfer to dissect neuronal mechanisms regulating cardiorespiratory function.

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