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Antiplar (Clopidogrel)

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Antiplar is in a class of medications called antiplatelet medications. It works by preventing platelets from collecting and forming clots that may cause a heart attack or stroke. Antiplar is used alone or with aspirin to prevent serious or life-threatening problems with the heart and blood vessels in people who have had a stroke, heart attack, or severe chest pain.

Other names for this medication:
Antiban, Antiplatt, Asicom, Atheroz, Atormac, Blothin, Carpigrel, Cenoza, Cidogrel, Clofre, Clopigrel, Clopione, Clopisa, Clopivas, Clopiwa, Clospir, Closprez, Clotsafe, Compivas, Ecosprin, Grelet, Kabitrol, Locric, Myogrel, Neogrel, Oprin, Orawis, Plagril, Platloc, Psygrel, Stagrel, Starclop, Stromix, Synplatt, Thinrin, Torpido, Torplatt, Welgrel, Zoclop

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Also known as: Clopidogrel


{name} (clopidogrel) prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.

{name} is used to lower your risk of having a stroke, blood clot, or serious heart problem after you've had a heart attack, severe chest pain (angina), or circulation problems.


Usual Adult Dose for Acute Coronary Syndrome:

Unstable Angina (UA)/Non-ST-Elevation Myocardial Infarction (NSTEMI): -Loading dose: 300 mg orally once -Maintenance dose: 75 mg orally once a day -Duration of therapy: Optimal duration unknown. ST-Elevation Myocardial Infarction (STEMI): -Loading dose: 300 mg orally once (OPTIONAL) -Maintenance dose: 75 mg orally once a day, with or without thrombolytics -Duration of therapy: Optimal duration unknown. Comments: -Administer this drug in combination with aspirin 75 mg to 325 mg orally once a day. -The benefit of this drug for patients who undergo primary percutaneous coronary intervention is unknown. Uses: Prevention of atherothrombotic events in patients with non-ST-segment elevation acute coronary syndrome (UA, NSTEMI, those who are to be managed medically, those who are to be managed with coronary revascularization) and STEMI.

Usual Adult Dose for Ischemic Stroke:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Myocardial Infarction:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Peripheral Arterial Disease:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Detailed Antiplar dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause excessive bleeding.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Antiplar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid alcohol. It can increase your risk of stomach bleeding.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

If you also take aspirin: Ask a doctor or pharmacist before using medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to aspirin (such as salicylates, ibuprofen, ketoprofen, or naproxen). Taking these products together can increase your risk of bleeding.

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In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity. Each IRF5 polymorphism was genotyped in 1565 subjects using the TaqMan method and examined to determine whether it could explain the association with SLE. Community recruitment of households from Adelaide, Australia occurred from February to July 2007 using four methods: electoral roll mail-out, approaches to schools and community groups, newspaper advertising, and other media involvement. Nedd8 activates ubiquitination by increasing the efficiency of polyubiquitin chain assembly through its covalent conjugation to cullin molecules. Magnetic resonance imaging (FLAIR sequence) allows discrimination of different cytoarchitectonic areas of the human cerebral cortex.

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Genetics of complex psychiatric disorders: scientific foundations. In the field of urology, positron emission tomography has been evaluated in the relevant malignancies with promising results in certain areas and disappointing results in others. In nonazotemic cirrhotic patients with ascites, the combination of diuretics and octreotide improves systemic hemodynamics and inhibits the diuretic-related component of the activated renin-aldosterone axis, which in turn augments the portal hypotensive effect of diuretic-induced plasma volume depletion. Randomized trials of immunotherapies used to treat women with three or more prior miscarriages and no more than one live birth after, in whom all recognised non-immunologic causes of recurrent miscarriage had been ruled out and no simultaneous treatment was given. Rho-kinase upregulation at the spastic site and increased phosphorylation of myosin-binding subunit of myosin phosphates are key players in inducing vascular smooth muscle hypercontraction in this porcine model. The risk factors for the development of CD and the influence of CD on BCVA and on the success of trabeculectomy were analyzed and compared between the two groups. The method can, without hard programming work, be extended to arbitrarily high orders. This study was conducted to determine the canine position in relation to commissures in different maxillomandibular relationships among Egyptian and Saudi populations. Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia.

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Effect of a controlled-release urea supplement on rumen fermentation in sheep fed a diet of sugar cane tops (Saccharum officinarum), corn stubble (Zea mays) and King grass (Pennisetum purpureum). They were administered 2 measures of motor adaptation known to be sensitive to subcortical abnormalities in adult neurological disorders. The authors sought to determine how this dilemma is currently being played out in residency training programs, in which training directors must decide how best to integrate neuroscience teaching in a rapidly changing clinical landscape. In 18 patients with anorexia nervosa, plasma cholesterol and triglyceride concentral concentrations were repeatedly determined over a period of 14 mo. The shape space coverage has been found to originate mainly from the nature and the 3D-geometry (but not the size) of the central scaffold, while the number and nature of the peripheral substituents and conformational aspects were shown to be of minor importance. There are also lines with altered expression of neprilysin, the main degrading enzyme of Abeta and also models based on APOE. Accordingly, bounds are established for the probability of a child having a disease, given that both parents have it and taking the heritability of the disease to be known.

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DFNB79: reincarnation of a nonsyndromic deafness locus on chromosome 9q34.3. We examined the effect of local ischemic preconditioning on postradiation lipid peroxidation in the serum of total body irradiated rats. A randomized, placebo-controlled trial of sertraline in the treatment of night eating syndrome. A proposal for a goodness-of-fit test to the Arnason-Schwarz multisite capture-recapture model. In the case of patients no adaptation was observed during three successive nights. The DSM-IV observes that its own syndromal CD diagnostic criteria conflict with its definition of mental disorder, which requires that symptoms be considered a manifestation of internal dysfunction to warrant disorder diagnosis. A visual acuity test (for example, the Snellen eye chart) is the standard for screening for vision impairment in primary care, but its diagnostic accuracy is uncertain because no studies compare it against a clinically relevant reference standard. Differences in psychosocial and cognitive correlates were noted by gender group. Ionic regulation of signal transfer from adrenergic receptors in cardiac muscle. The best example is monitoring of cirrhotic patients by ultrasonography and determination of alpha-feto-protein every 6 months which has proved effective in reducing mortality due to primary liver cancer.

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To describe the prevalence of oral lesions and dental caries status in perinatally HIV-infected children. Membrane-bound trypsin is not affected by GPI-PLC, although it is solubilized by papain and by different detergents. Bisphosphonate-related osteonecrosis of the jaw: clinical correlations with computerized tomography presentation. Previous studies have shown that the B subunit of Cholera Toxin (CT), which binds and crosslinks ganglioside GM1, modulate intracellular calcium in murine neuroblastoma cells via the activation of L-type voltage-dependent calcium channels (VGCC). A rare case of metachronous double spinal dural arteriovenous fistula. Studies with chimeric monoclonal anti-TNF-alpha antibody treatment have been reported with dramatic successes. Continuous intravenous morphine infusion for postoperative analgesia following posterior spinal fusion for idiopathic scoliosis. In parallel experiments human bladder SMC were treated with platelet-derived growth factor-BB (PDGF-BB), heparin-binding EGF-like growth factor (HB-EGF) or fibroblast growth factor-2 (FGF-2). Reduction in this distortion by the use of continuous positive airway pressure (CPAP) or continuous negative pressure at the body surface (CNeg) was associated with a significant (P less than 0.01) lengthening of Ti.

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As nursing and healthcare become more global, supported by technology, the opportunities for distance mentoring increase. Respiration and the Oxidative Activity of Particulate Fractions from Developing Pepper Fruits (Capsicum Annuum L.). The key to a strong proposal is linkage among all of its sections, from the specific aims to the budget. Health informatics students have developed competencies using an instant message service, blogging, concept mapping, social bookmarking, and interacting a virtual environment. This case report presents two men out of 142 cases, aged 30 and 36, with epithelial iris cyst who developed precipitate level inside the lesions. Surgical removal of visceral adipose tissue: effects on insulin action. However, the plasma arc light produced significantly higher shear bond strengths at a greater light-tip distance. It has been higher sensitivity and ODI rocaltrol davis drug guide pdf in the patient treated by immunosuppressive agents. The toxic and mutagenic effects of butyl methanesulfonate (BMS) were compared among four diploid human lymphoblast lines, MIT-2, WI-L2, MGL8B-2 and GM 130. Application of the ethylene inhibitor 1-methylcyclopropene (1-MCP) allowed for the discrimination between ethylene-mediated changes and ethylene-independent changes related to the imposed conditions.

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Retrograde ureteral access after cross-trigonal ureteral reimplantation can be challenging. To investigate whether intraocular pressure (IOP) measured on the nasal side is affected after laser in situ keratomileusis (LASIK). Here we demonstrate that self-supporting macroporous frameworks of silver, gold and copper oxide, as well as composites of silver/copper oxide or silver/titania can be routinely prepared by heating metal-salt-containing pastes of the polysaccharide, dextran, to temperatures between 500 and 900 degrees C. Distended intestinal loops, inflammed serosa and mesenterial lymphadentis have been found during the operations. The fact that mammals are diploid sets a barrier to rapidly understand the function of non-coding and coding genes in the genome. Disc height and signal intensity of the nucleus pulposus on magnetic resonance imaging as indicators of lumbar disc degeneration. Generation of primordial magnetic fields on linear overdensity scales. Reduction of E-cadherin by human defensin-5 in esophageal squamous cells.

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Structural elements to convert Escherichia coli alpha-xylosidase (YicI) into alpha-glucosidase. We found that increasing viscosity of the growth medium (i) significantly limited bacterial dispersal and the diffusion of siderophore molecules and (ii) increased the fitness of individuals that produced siderophores relative to mutants that did not. One-stage laparoscopic bilateral upper pole nephrectomy for ectopic insertion of complete ureteral duplication. The three techniques based prilosec dosage gastritis on magnetic resonance imaging (MRI) are reviewed here. Neonatologists urge national plan to improve infant mortality rates. In varicocele patients, radioimmunoassay is used to determine the blood endothelin concentration in the spermatic vein and the antecubital vein separately. Image-guided localization of the internal auditory canal via the middle cranial fossa approach.

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Ethanol decreases the growth rate of normal cells, prednisolone increases it. Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL. Adrenaline sensing may provide an environmental cue for the induction of the Salmonella stress response in anticipation of imminent host-derived oxidative stress. The response to 2 mM cyclic AMP was inhibited by 0.5 mM serosal carbamazepine. The mechanism of action of citrinin on rabbit kidney alkaline phosphatase activity in vivo. On the existence of intermediate compounds between hemoglobin (wholly ferrous) and methemoglobin (wholly ferric). A comparison between glucose and acetate as precursors of milk fat in the rabbit. Animals were randomized to survival times of 3, 10, or 60 days (respectively, Groups I, II, and III). This what class of drug is benicar reminds us that the presence of diffuse ST-segment elevation in the precordial leads could be due to acute RCA occlusion.

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Available evidence shows that the employment conditions and associated work organization of most migrant workers are dangerous to their health. Clinical genetic testing for patients with autism spectrum disorders. Relations of the anterior pituitary corticotropic hormone (ACTH) and progesterone. The 24-h creatinine clearance was measured before anesthesia and 7 days after anesthesia. The interpretation of transmittance values greater than unity for evanescent waves is clarified with respect to the associated absorption losses. The TaqMan assay for the detection of Vbirio vulnificus was evaluated in pure culture, mice tissue which artificially contaminated Vibrio vulnificus and clinical samples. Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives. In the present study, we show that another VEGF family member, placenta growth factor (PlGF), was highly upregulated at all tumor stages in a ras-dependent manner.

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