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Anitryp (Amitriptyline)

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Anitryp is sometimes used off-label, meaning not FDA approved, for certain conditions. Some providers will use this medication to treat nerve pain. This can be helpful for people who have diabetes or fibromyalgia and haven't felt relief with other medications.

Other names for this medication:
Amiclozor, Amitar, Amitin, Amitone, Amitop, Amitrac, Amitrim, Amitrip, Amitriptyline, Amitrix, Amitrol, Amitryn, Amitryptyline, Amitwix, Amline, Amrea, Amtran, Amypres, Anitryp, Arpidox, Cotrip, Crypton, Eliwel, Emotrip, Eptanol, Estiline, Goldep, Latilin, Latiln, Libral, Librodep, Limbival, Lodep, Nextrip, Normaline, Ristryl, Ronet, Tablin, Tadamit, Tridep, Tryline

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Vantin, Asacol, Leukeran, Cleocin, Microzide, Daklinza, Sovaldi

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Also known as: Amitriptyline


{name} (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

{name} is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Anitryp dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline can be fatal.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Anitryp are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with amitriptyline.

Avoid driving or hazardous activity until you know how Anitryp will affect you. Your reactions could be impaired.

Avoid exposure to sunlight or tanning beds. Amitriptyline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

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Studies on the oxidative half-reaction of p-hydroxyphenylacetate 3-hydroxylase. The results indicate a possible protective role of HuSePl-Fr1 in treatment of infertile men due to genital infections. We conclude that a good relationship exists between dose and duration of suppression of ovarian function. Orthodontic brackets made of different materials (stainless steel, gold, ceramic, plastic) were bonded to the upper and lower second premolars in 40 subjects receiving fixed orthodontic appliances. Severe pulmonary vascular disease was found during pregnancy in a 31 year old woman with a large ventricular septal defect. Extent of alpha 2-receptor-mediated autoinhibition of vasoconstrictor nerve responses in mesenteric resistance vessels from normotensive and hypertensive rats. Fetal ascites and oligohydramnios: prenatal diagnosis of a vasotec normal dosage sialic acid storage disease (index case). Snyder-Theilen feline sarcoma virus P85 contains a single phosphotyrosine acceptor site recognized by its associated protein kinase. Involvement of alpha 1- and beta 2-adrenergic stimulation in the induction of hepatic DNA synthesis in carbon tetrachloride-intoxicated rats.

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