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Angilock (Losartan)

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Angilock belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by relaxing blood vessels so that blood can flow more easily. It is taken by mouth. It may be used alone or in addition to other blood pressure medication.

Other names for this medication:
Angioten, Biortan, Cardon, Cartan, Cosart, Covance, Cozzar, Czartan, Eklips, Faxiven, Fortzaar, Forzaar, Hypozar, Klosartan, Lacine, Loplac, Lorista, Losacar, Losacor, Losamet, Losapres, Losardil, Losart, Losartanum, Losartax, Losartec, Losartil, Losazide, Losium, Lostad, Lotan, Lotar, Loxibin, Medzar, Mozartan, Normatens, Omnitan, Osartil, Prosan, Repace, Sarlo, Sartens, Satoren, Sedeten, Tacicul, Tensaar, Zartan

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Also known as: Losartan


Angilock (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Angilock is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Angilock is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Angilock 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Angilock 25 mg, Angilock 50 mg, and Angilock 100 mg may also contain carnauba wax.


Take Angilock tablets orally with or without food. Do not crush or chew it. Take Angilock once or twice a day at the same time. If you want to achieve most effective results do not stop taking Angilock suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Angilock are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Changes in renal function including acute renal failure can be caused by drugs that inhibit the reninangiotensin system and by diuretics. Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on COZAAR. Monitor renal function periodically in these patients. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Angilock.

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Here, we quantify this concern by comparing the sample sizes needed by the two strategies when the markers exclude the disease-related polymorphism. Sperm kinematics of cryopreserved normozoospermic specimens after artificial stimulation. Effect of anti-mouse IgG on some complement-requiring alloantibodies of the mouse. Prospective randomized comparative study of hemodynamic changes between ultrathin transnasal and conventional transoral esophagogastroduodenoscopy in percutaneous endoscopic gastrostomy placement with modified introducer method under sedation. Influence of antagonistic bacteria on quantity of staphylococci in the oral cavity. Ethnic patterns of thyroid cancer incidence in the United States, 1973-1981. The activity of this system is enhanced by chronic administration of alkylating agents, and the role that this may play in carcinogenesis is discussed. The model includes demographic, education and labour market variables.

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The physiological activity, however, seems to be higher with acidic ARS, which also contributed to the vital staining effect on rat skull. Radionuclide limb blood flow is a simple and reliable diagnostic test which is superior to the assessment of peripheral pulses or their ankle to brachial pressure index in resolving diagnostic problems in vascular surgery. Diaspirin crosslinked hemoglobin is a resuscitative solution with excellent oxygen-carrying capacity. As yet, there has been no comprehensive comparison of the relative predictive value of metabolic imaging parameters, perfusion/antibody uptake mismatch, Tl-201 redistribution, or ejection fraction response data. This is the first reported case of epithelial ovarian carcinoma metastatic to the intramedullary spinal cord. Size 19mm and 21mm tissue annulus diameter valves have been studied for use in small aortic roots. An improvement in the inflow of the distal grafts was achieved in 22 of these 23 patients in 26 limbs. Streptozotocin diabetes and sugar transport by rat ileal enterocytes: evidence for adaptation caused by an increased luminal nutrient load.

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The emergency room physicians express that treatment of undocumented migrants is no different from the treatment of any other person. Modulation of N-methyl-D-aspartate receptor activity by oxidative stress conditions in chick retinal cells. Medline, Embase, PsycInfo, Health and Psychosocial Instruments and Google scholar were searched, grey literature was sought and the reference lists of relevant articles were checked to identify instruments. Mice deficient in p53 exhibit increases in Bcl-2 and decreases in Bax protein levels in several tissues as determined by immunohistochemical and immunoblot methods. This study aims to compare two groups of choroidal melanoma patients treated with either I-125 brachytherapy or enucleation in the Asian Indian population. After six months of CRT, the correlation between 2D and 3D echocardiography for analysis of LVDV was 0.98, 0.91 for LVSV, 0.96 for LVEF, and 0.85 for LV mass. I: Is it due to depression of activity within the brainstem reticular formation?.

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Most PME patients are homo-zygous for a p.Gly144Trp mutation and develop similar clinical presentations. On the immortality of the germ line: genetic and biochemical mechanism. Spatial coding of visually guided arm movements in primate motor cortex. This contradicts the idea that oral aluminum plays a role in etiology of dialysis dementia. Here, cells are electropermeabilized in the presence of plasmid DNA and monitored with a temporal resolution of 2 ms. To show that understanding the lived experiences of Vietnam veterans, at time when men and women returning from Operation Desert Storm were welcomed back by their country, would allow for the development of more effective treatment approaches in working with Vietnam veterans. Effect of brushing and thermocycling on the shade and surface roughness of CAD-CAM ceramic restorations. We propose that (1), (2) and (4) may be responsible for the high yields of bicozamycin and, possibly, of some other antibiotics produced by Streptomyces sp.

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Effect of Tripterygium wilfordii on the remission of proteinuria in patients with nephrotic syndrome. Senior UK scientists have recently acknowledged that lead exerts neurotoxic effects at blood lead levels even as low as 10 micrograms/dL. These tanycytes possessed ciliated apical surfaces and basal shafts extending into the substance of the medulla and pons where they intermingled with specific neuronal fields. A global push to reduce the amount of saturated and trans-fatty acids, added salt and sugar in processed food, and to enhance fruit, vegetable and whole grain intake, while limiting energy intake, exists for most populations. Generation of human female reproductive tract epithelium from human embryonic stem cells. Platelet activation by polymorphonuclear leukocytes: role of cathepsin G and P-selectin. Late postoperative left ventricular function and ventricular hypertrophy after prosthetic valve replacement for aortic regurgitation. Pancreatic EC cell tumors show several different morphological features compared with related intestinal tumors despite similar cytogenetic alterations on chromosome 18.

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Effects of breeding season, testosterone and ACTH on the corticosterone response of free-ranging male fence lizards (Sceloporus undulatus). At pH greater than 6, the nitro group of nifedipine is reduced in a four-electron step to a hydroxylamino group. Posture effect on seating interface biomechanics: comparison between two seating cushions. Thus, the understanding of cellular and molecular mechanisms that underlay and link inflammation, obesity, and cancer is crucial to identify potential targets that interfere with this important route. Humoral response to oligomeric human immunodeficiency virus type 1 envelope protein. An 8-mm-long Screw-Vent implant was threaded into the site to function as a dental pin via mechanical retention. Streptococcus sanguinis is a health-associated commensal, a known early colonizer of the acquired tooth pellicle, and is naturally competent. Status of sonography in the diagnosis of the pathologic shoulder. Early ribonucleic acid synthesis begins at approximately 4 h and continues to 8 h. Fas ligand and APO2.7 were variably expressed by conjunctival cells, but in a significantly higher percentage of cells in pathological eyes than in normal ones.

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A significant decrease in dialysing efficiency was observed only with the Ab-Gambro dialyser, in which the dialysance of the small molecules decreased more than that of the large. Efficacy of low-dose topical mitomycin C treatment for primary acquired melanosis. Chilina sp., found abundantly in Patagonian fresh water bodies, is an intermediate host in the biological cycles of several digenetic trematodes. Thus, RDW can act as a useful tool to predict SIRS in patients undergoing cardiac surgery with extracorporeal circulation. KA treatment inhibited the ability of other chicks, or auditory and somatosensory information, to suppress DVs. There were nine Group II afferents, three Group IV, and four unclassified afferents.

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Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells. Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14. There were no significant differences in the serial biomechanical measurements at the sites of the healing osteotomies, in the radiographic measurements, or in the ultimate strength of the sites of the osteotomy between the two groups. NADPH oxidase was activated and the ERK1/2 signal pathway was involved in the proliferation process of fibroblasts treated with thrombin. These observations are intended to form a baseline for comparision with the results of future morphological studies of trabeculation arising in response to different aetiological factors. Thrombocytopenia occurred in 3 of 6 patients treated with menogaril 60 mg/m2/day. A link between cell movement and gene expression argues that motility is required for cell-cell signaling during fruiting body development. This study indicated that the progression level and tumor budding of ECS for cervical lymph node metastasis were useful prognostic factors in OSCC patients. Prevalence and influential factors for asthma among adults in Chinese. Transformation-dependent silencing of tumor-selective apoptosis-inducing TRAIL by DNA hypermethylation is antagonized by decitabine.

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The changes in gene expression induced by PLC are similar to those previously shown to be associated with phorbol ester-induced monocytic differentiation of HL-60 cells. Making public health a shared value across the various sectors is a politically challenging strategy, but such collective action is crucial. Although most authors find a strong correlation between palaeodiversity and sampling proxies, weak correlation is recorded in some datasets. Finally, this analysis has provided the first sequence information available for several of the acetylated ribosomal proteins and for one non-acetylated ribosomal protein, which is clearly the product of the MFT1 gene (Garrett, J. Quality of Life Assessment should be Part of Oral Health Evaluations in Day-to-day Practice. The Authors report three cases of renal vein thrombosis after transplantation.

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Our results indicate that the apparent decrease of PP-ribose-P availability in the presence of allopurinol was due to competition between adenine and hypoxanthine salvage pathways into nucleotides, and not to the synthesis of inosine. In vitro results from 26 different CML blood samples displayed variation in cytotoxicity of MTN (1 microgram/ml) alone alone and in the resulting synergistic inhibition of DNA biosynthesis with the combination of SNT (10 micrograms/ml). The stimulating effect on HC II-dependent antithrombin activity was almost totally abolished by treatment with chondroitinase AC I, heparinase or heparitinase, while chondroitinase ABC or chondroitinase AC II had little or no effect. Yet, this attribute has mostly been overlooked because of the inherent speed limitation of existing imaging strategies. Aspiration of the nasal septum: a new complication of cocaine abuse. The main purpose of this study is to explore the additive-constitutive nature of common amino acids in their contribution to the partition coefficients of small peptides. Antibody recovered by affinity purification with rat erythrocyte membrane preparations contained both lymphocytic and anti-HTA reactivity. This work further clarifies the relationship between the availability of PABA and success of the parasite, an issue of debate from classic studies showing reduced parasite load in individuals on milk-fed diets. To evaluate the effectiveness, safety, and stability of contact Ho:YAG laser thermal keratoplasty for low to moderate hyperopia.

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The presence of the N-terminal amino acid tyrosine is essential for the interaction of opioids with their receptors, and this finding indicates that the LTA4 hydrolase can inactivate dynorphin fragment 1-7. Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells. After excluding all patients whose elevated AFP levels had any identifiable cause (positive AF acetylcholinesterase, AF blood contamination, fetal malformation or aneuploidy, multiple gestation, etc), 5743 cases were analyzed. In this review, we summarise key metabolic isotope effects and integrate them into the corpus of plant primary carbon metabolism. Factor VIII (FVIII) is the nonproteolytic cofactor for FIXa in the tenase complex of blood coagulation. Effect of impurities on electron motion in two dimensions in a strong magnetic field. To investigate experimental mechanisms of reversible cerebral dysfunction, we produced fosamax 70 mg side effects transient focal cerebral ischemia in five baboons by unilateral perfusion of internal carotid territories with platelet microemboli generated endogenously. CMD was assessed using the Clinical Interview Schedule (Revised). Most prominent were the differences in the content of mitochondria and the formation of intracytoplasmatic filaments and desmosomes.

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Characteristics of Unruptured Compared to Ruptured Intracranial Aneurysms: A Multicenter Case-Control Study. Human Sertoli cells produce inhibin in vitro: an additional marker to assess the seminiferous epithelium development. Ultrasound-Assisted Posteromedial Portal Placement of the Elbow Joint to Prevent Ulnar Nerve Injury. Risk identification using structural concepts: the potential carcinogenicity of praziquantel. The present study examines the sensitivity and specificity of the Center for Epidemiologic Studies Depression Scale (CES-D) as a screening instrument for post-stroke depression. Although velocity of shortening is not affected by preload status, fractional shortening is inversely related to preload.

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During sporulation some bacteria produce parasporal inclusions which are toxic for insect larvae. However, there remain multiple treatment options, including the newer macrolides, third-generation cephalosporins, beta-lactam/beta-lactamase inhibitor antibiotics, and the newer fluoroquinolones. Subtle glucocorticoid excess in patients with adrenal incidentaloma. The need to develop and improve sustainable energy resources is of eminent importance due to the finite nature of our fossil fuels. Subjects were 167 adults who participated in one of two outpatient treatments for marijuana dependence and completed the 3-, 6-, and 12-month posttreatment follow-ups. During single electrode voltage clamp, DYN decreased inward current in a portion of DRG neurons under conditions that predominately isolated calcium current. In this paper, we describe the problems caused by chemical burns in this case (lye), the surgical treatment, and possible complications. Chiefly, these reconstructions aid in the detection of intratumoral fat/calcification and clearly demonstrate the tumors relationship and effect with the adjacent bronchi. TGA/DTA results confirmed the weight loss and the exothermic reaction due to desorption of chemisorbed water.

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Scenarios were constructed with one-quarter (scenario 1), one-half (scenario 2), or three-quarters (scenario 3) of potential retirees working half-time for an additional 10 years. Prefrontal leucotomy in treatment of post-encephalitic conduct disorder. In vivo, Bm-wt LPS promoted scant activation of splenic DC subsets and limited recruitment of monocyte- DC like cells in the spleen, conversely to Bm-wadC LPS. Allergic reactions and complications of diabetes mellitus are commonly seen in emergency departments and primary care settings. A case report of Vibrio furnissii bacteremia and cellulitis in a malnourished patient without an apparent site of entry. In a second investigation the electrically evoked stapedius reflex thresholds were obtained in adults who underwent a cochlear implant surgery using the same anaesthetics for anaesthesia. Limbic pathology in schizophrenia: the entorhinal region--a morphometric study.

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These include depletion of microbially accessible carbon pools, reductions in microbial biomass, a shift in microbial carbon use efficiency, and changes lipitor 20 mg tablet in microbial community composition. Vertebral bone density in non-amenorrhoeic hyperprolactinaemic women. ICU utilization and costs are common outcomes in studies evaluating palliative care interventions. The HPV status of the specimens positively correlated with the pathological diagnosis, and since AFIC automatically and correctly located every cell, it was possible to directly compare morphology and HPV status in the same cell. Here, we have attempted to develop a web interface which combines the information from functional genomic studies across different genetic backgrounds with DNA markers so that they can be readily deployed in crop improvement. Increasing the dose of a competitive inhibitor, therefore, should potentially increase the level of blockade. This likely involves site-directed Fenton-chemistry in which Fe(II) bound to metal binding sites on the protein undergoes peroxidation to form active oxygen species that convert proximal amino acid residues to carbonyl derivatives. Cost-effectiveness was calculated as the incremental cost relative to the incremental benefit, the benefit was estimated using quality-adjusted life years. Protein-free oviduct-conditioned medium for complete bovine embryo development. A set of fusion proteins containing heat-stable enterotoxin (STa) and maltose-binding protein were engineered.

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Cellular cooperation in the expression of murine delayed-type hypersensitivity (DTH). Yet, relative to that of their herbivorous insect prey, the genetic structure of natural enemy populations has been little studied. The analysis of undiluted highly concentrated samples can cause contamination of the system, while the dilution step is time consuming and as the case for any sample preparation step, also potentially leads to precipitation, adsorption or degradation of the analytes. The PI3K/Akt/mTOR pathway plays a crucial role in the pathogenesis of colon cancer. Moreover, the loss of one cell surface antigen by a spontaneous mutant of A. Three infants under the age of 2 months presented with danocrine neck masses--a clinical suspicion of malignancy, lymphadenopathy and teratoma.

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Noncontingent positive and negative feedback during maximal exercise. Glycolitho-, sulfolitho-, deoxycholic and 3-beta-hydroxy-5-cholenoic acids induced para que sirve el enalapril maleato de 5 mg similar but less pronounced changes of alpha 1-Pi, whereas transferrin remained unaffected. Diethylamine, guanidine, thiocyanate, or urea were applied, by either principle at various concentrations, and thiocyanate, or urea were applied, by either principle at various concentrations, and thiocyanate at an optimum pH. This study was done to assess the awareness about eye donation amongst attendants of critically ill and deceased patients, their willingness to donate eyes, the efficacy of grief counselling by Eye Donation Counsellors (EDC), its impact on the conversion rate and the reasons for poor donation rate. In this context, these results should encourage further investigation on the pathophysiologic role of migration inhibitory factor in cutaneous inflammatory reactions and immune responses. Thus, in this study, we probed the transcriptional activity, DNA-binding competence, and functional activity of select nuclear receptor mutants in cellular and animal model systems and used this information to define the sequence constraints of functional steroid nuclear receptor cis-regulatory elements. Here, we show that concentrations of TIMP-1 are significantly higher in breast carcinomas than in fibroadenomas. Geometric features as well as possible functional properties of the substrate binding sites at the pentamer interfaces are described. Extent of engagement of various cardiovascular effectors to alterations of carotid sinus pressure. Experiments performed with a cell-free system in tris-EDTA buffer, pH 7.4, indicate that the high-speed supernatant fraction of the rat uterus contains all the factors necessary to transform the 8S cytoplasmic oestradiol-receptor complex to the nuclear complex.

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Firstly, quantitative PCR were performed to determine the level of MiR-132-3p. In 2010, EUSOMA published a position paper, describing a set of benchmark quality indicators (QIs) that could be adopted by breast centres to allow standardised auditing and quality assurance and to establish an agreed minimum standard of care. Significant differences were not observed in the expression of MC1R and TYR between the two different coat colours, and the expression of ASIP was not detected in the mink skin of either coat colour. Bulk milks contained approximately 4 times more milk proteinase activity than the composite milks from individual healthy cows. Comparative analysis of the sedimentation profiles suggested that the biological activity zones of both preparations in the sucrose density gradient had close sedimentation constants. The break-up probability follows a three-parameter Weibull distribution, from which one prilosec type drugs can deduce the capsule rupture characteristics. The occurrence of jitter and shimmer, however, did not differ significantly across the groups. Five had associated adduction nystagmus of the contralateral eye. Five patients with severe refractory IMNM who were treated with HiCy without stem cell rescue were identified.

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