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Amevan (Metronidazole)
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Amevan

Flagyl is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria. Treating certain infections caused by bacteria or amoebas. It may also be used for other conditions as determined by your doctor.

Other names for this medication:
Acuzole, Amebidal, Aminidazole, Amotein, Anerobia, Arilin, Biozyl, Birodogyl, Clont, Dequazol, Dumozol, Emedal, Entizol, Etronil, Filmet, Flagicure, Flagystatin, Flagystatine, Flanizol, Fortagyl, Gynotran, Metren, Metrin, Metroderme, Metronid, Metrosa, Metrozine, Metsina, Missilor, Monizole, Nidazol, Nidazyl, Perilox, Rhodogil, Rosaced, Taremis, Trichazole, Triconex, Tricozyl, Vandazole, Vertisal

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Also known as: Metronidazole

Description

Metronidazole vaginal is used to treat women with vaginal infections (eg, bacterial vaginosis).

Metronidazole belongs to the class of medicines known as antibiotics. It works by killing the bacteria or preventing their growth. However, this medicine will not work for vaginal fungus or yeast infections.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Amevan. Please read with care.

Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

This medicine is to be used only in the vagina. Use it at bedtime, unless your doctor tells you otherwise.

Do not get it into your eyes, nose, mouth, or skin. If this medicine does get into your eyes, wash them out right away with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.

This medicine comes with a patient information leaflet and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Wash your hands with soap and water before and after using this medicine.

Nuvessa™ is available inside a prefilled applicator. The applicator is open at one end where you will insert the plunger and has a pink cap on the other end where the medicine will come out.

Vandazole® is in a tube. You will use an applicator to put the gel into your vagina. The applicator has a plastic tube called a barrel that is open at one end and has a plunger (another piece of plastic that can move inside the barrel) at the other end.

To use the medicine:

To fill the applicator: For cream or gel dosage forms: Nuvessa™: With the pink cap still on, push the tip of the plunger into the open end of the prefilled applicator. Pull the cap off before you insert the applicator into your vagina. Vandazole®: Break the metal seal at the opening of the tube by using the point on the top of the cap. Screw the applicator onto the tube. Squeeze the medicine into the applicator slowly until it is full. Remove the applicator from the tube. Replace the cap on the tube. For vaginal tablet dosage form: Place the vaginal tablet into the applicator. Wet the vaginal tablet with water for a few seconds. To insert vaginal metronidazole using the applicator: For all dosage forms: Relax while lying on your back with your knees bent (or in any position that you feel comfortable). Hold the full applicator in one hand. Insert it slowly into the vagina. Stop before it becomes uncomfortable. Slowly press the plunger until it stops. Withdraw the applicator. The medicine will be left behind in the vagina. Remove the applicator from your vagina. Use each applicator only once, and then throw it away.

To help clear up your infection completely, it is very important that you keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. If you stop using this medicine too soon, your symptoms may return. Do not miss any doses. Also, continue using this medicine even if your menstrual period starts during the time of treatment.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For bacterial vaginal infections: For vaginal dosage form (cream): Adults—One applicatorful (500 milligrams [mg]), inserted into the vagina. Use the medicine 1 or 2 times a day for 10 or 20 days. Children—Use and dose must be determined by your doctor. For vaginal dosage form (gel): Nuvessa™: Adults and children 12 years of age and older—One applicatorful (5 grams [g]) inserted into the vagina once (at bedtime). Each applicatorful of Nuvessa™ contains 65 mg of metronidazole. Children younger than 12 years of age—Use and dose must be determined by your doctor. Vandazole®: Adults—One applicatorful (5 grams [g]) inserted into the vagina once a day (at bedtime) for 5 days. Each applicatorful of Vandazole® contains 37.5 mg of metronidazole. Children—Use and dose must be determined by your doctor. For vaginal dosage form (tablets): Adults—One 500 milligram (mg) tablet, inserted high into the vagina. Use the medicine once a day in the evening for 10 or 20 days. Children—Use and dose must be determined by your doctor.

Overdose

In cases of overdose in adults, the clinical symptoms are usually limited to nausea, vomiting, ataxia and slight disorientation. In a preterm newborn, no clinical or biological sign of toxicity developed.

There is no specific treatment for Amevan overdose, Amevan infusion should be discontinued. Patients should be treated symptomatically.

Storage

Store Amevan at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Amevan out of the reach of children and away from pets.

Side effects

The most common side effects associated with Amevan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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This study determines the time limits of cellular viability and metabolic function during SCS, and characterizes the relationship between cellular viability and energetic state using clinically relevant techniques in organ preservation. Determination of the phagocytic activity of cellular elements in the bronchial secretion cytological preparations of children. Morphological studies of fiber types of striated muscle fibers of the cremaster in the guinea pig. Dexamethasone increased serum lipase activity without any histologic damage to the pancreas in either group of dogs. Quantitative measurements of lung function in children by means of Compton backscatter. Plasminogen activator activity and thymidine incorporation in avian granulosa cells during follicular development and the periovulatory period. The patient was diagnosed as mild acute respiratory distress syndrome (ARDS). Work tasks and their distribution among 20 elderly aides (aged 45-65 years), working in open home-care service (clients living in their original flats or houses) and at service apartment houses (clients living in private flats constructed for the elderly and handicapped with service functions) were observed during whole work days.

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Their views of their ideal roles and subsequent uptake into formal new graduate transition programmes differed. To determine the completeness of documentation and accuracy of medical evaluation for a sample of emergency psychiatric patients. Multidetector computed tomography is a useful test for routine evaluation of suspected appendicitis in adults. Perioperative cleocin 150 mg 4 times a day correction of hypochromic anemia and iron metabolic disorders in patients with liver cirrhosis and portal hypertension. NAC is used as an mucolytic agent in adjunctive therapy of respiratory diseases causing the retention of secretions, as well as an antidote in the treatment of paracetamol poisoning. We studied the frequency and risk factors for loss of long-term non-progressor (LTNP) and HIV controller (HIC) status among patients identified as such in 2005 in the French Hospital Database on HIV (FHDH-ANRS CO4). Meningoradiculitis can present as a very short episode of radicular pain in addition to vertebral column pain without stiffness, as described in these three cases.

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