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Alpam (Alprazolam)

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Alpam is commonly used to treat anxiety and panic disorders. It falls into a category of medications called benzodiazepines. They are known to affect the central nervous system components and produce a calming effect, thus decreasing brain activity.

Other names for this medication:
Aderta, Albiz, Almac, Alpam, Alzex, Anlzium, Belfa, Ecsit, Elzopam, Eurolam, Exiten, Fluprax, Mebasap, Mebrin, Mentolift, Optizole, Propnix, Resolin, Sertamax, Somnarest, Somnirest, Tagat, Tenil, Tenschem, Tenscure, Trika, Trustin, Xycalm, Zolar, Zolax, Zolipax

Similar Products:
Daklinza, Estrace, Dilantin, Lamisil, Glucotrol, Levaquin, Fulvicin, Allegra

Also known as: Alprazolam


{name} (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.

{name} is used to treat anxiety disorders and anxiety caused by depression.

{name} is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

It is dangerous to purchase {name} on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alpam XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alpam XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpam XR dosage information

Side effects

The most common side effects associated with Alpam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alprazolam in the elderly. However, elderly patients are more likely to have unwanted effects (eg, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness) and kidney, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

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However, activation of the phosphatidylinositol 3 (PI3)-kinase/Akt survival signaling pathway was compromised in capn4(-/-) MEFs under all challenges regardless of the cell death outcome, and blocking Akt activation using the PI3-kinase inhibitor LY294002 abolished the protective effect of calpain to STS challenge. Extended care (23 h) could be a better option in some circumstances. We found that the level and activity of endogenous LIMK1 is increased in invasive breast and prostate cancer cell lines in comparison with less invasive cells. Studies were performed on 36 patients with clinically diagnosed NF-1 and compared to normal healthy controls. The paper deals with the results of an electropolygraphical study of night-sleep structure, as well as a clinical and experimental-psychological study of 27 patients with deforming muscular dystony. The rhizosphere effect on bacteria antagonistic towards the pathogenic fungus Verticillium differs depending on plant species and site. We hypothesize that strict volume control strategy (salt-restricted diet, extended dialysis sessions and dry weight clinical assessment and reassessment in every session) could prevent progression of left-ventricular damage and, therefore, progressive increment in cardiac biomarker levels over time. Decreased levels of BDNF were also negatively correlated with HAM-D scores. Under the effect of azoester the rate of oxygen consumption by mitochondria increases and there occurs their sharp swelling. Various branches of phase-locked solutions are identified, and their stability is analysed for different types of delay distributions.

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We show that CD11c/A(beta)(b) mice with MHC class II expression restricted to CD11c-expressing DCs develop airway neutrophilia rather than allergic airway inflammation. Preliminary investigation to determine the cytotoxicity of various cryoprotectants on southern African abalone (Haliotis midae) embryos. This study proposed a new method to approximate the normalizing constant of the DP with high accuracy and reliability. Less reliably, increased rates of responding were sometimes observed when MgCl(2) was combined with low (ineffective) or high (rate-decreasing) doses of cocaine. That hypothesis predicts that an inactivation of these receptors should enhance the sensitivity to drug rewarding effects. Neither synergistic nor additive effects on the inhibition of MPA-induced proliferation of C4HD cells were observed as a result of the combination of these ASODNs. Disorders of the fetal heart sounds as the sole indication for a termination of pregnancy. Little is known about the interaction and selectivity of different members of the p53 family (p53, p63, and p73) and the MDM2 family (MDM2 and MDMX). However, PGF(2alpha) and T were significantly stimulated by metabolites of phytoestrogens in the bovine steroidogenic CL cells. Most patients treat VRI with over-the-counter remedies that have been demonstrated to produce marginal clinical benefits.

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Determination of the incidence and severity of hoarseness after cardiac surgery. The dengue epidemic on the island of Madeira resulted in 122 hospitalizations. A suggestive clue to the presence of this polymorphism could be a higher than normal free T4/free T3 ratio. The survey leads to the conclusion that infant food sold in Beijing was contaminated with high concentration of furan, which leads to high exposure of infant or baby. Examination of levels of each cellular DNA polymerase in these preparations from each step of both purification procedures revealed that DNA polymerase beta had a greater tendency to copurify with bovine parvovirus and Kilham rat virus than did DNA polymerases alpha or gamma. Search of The Cochrane Library, MEDLINE, EMBASE and CINAHL in November 2000 and subsequently June 2006. The results suggest that galactin-3 has a pathophysiological role in canine gastric carcinoma. Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects.

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Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. Depressive illness afflicts a significant portion of the population worldwide. Polymyxin-agarose inhibited the growth of Escherichia coli and Pseudomonas aeruginosa, but not Bacillus subtilis. This study aimed to provide a population-based estimate of human papillomavirus (HPV) seropositivity for women in a rural African context and to evaluate the impact of HPV serostatus on subsequent acquisition of HIV outside a clinical setting. They did not cause of any retinal and choroidal vascular disturbances. Phase 2 studies established subcutaneous injection of 100 mg of enfuvirtide twice daily as the dosage of choice. Examination of lymph nodes in resected colon segments with colorectal carcinoma. We diagnosed monoclonal gammopathy in a blood test that showed elevation of serum immunoglobulin G and the Kappa chain. Imaging agents that can non-invasively monitor apoptosis in response to these new drugs could therefore help streamline the drug development process. Access to this technology is easier than ever before with the opening of several simulation centres throughout the world and the availability on the market of more sophisticated and affordable patient simulators.

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Diagnosis and treatment of the common idiopathic photodermatoses. Knee arthroscopy is the most common orthopaedic procedure performed in the United States, and there are few randomized studies comparing local anesthesia, in conjunction with propofol, with regional anesthesia for knee arthroscopy. Reversible changes in cup area, cup/disc area ratio, rim area, cup volume, rim volume, mean cup depth, and maximum cup depth were associated with decrease in IOP. Current investigations indicate that different signaling pathways may be involved in Bcl-2 phosphorylation, likely dependent on the kinases activated by the various stress stimuli. Three outreach activities by a school of nursing, in partnership with community agencies, provided learning experiences in primary and secondary preventive health care for graduate and undergraduate nursing students while addressing health needs in the community. Increasing numbers of genes have been assigned functions in the regulation and execution of angiosperm senescence. The flow of sap in Populus tremuloides was studied by the thermoelectric method immediately prior to and at several periods of time after radical girdling. Mrs A, a 38-year-old married white woman with a history of OCD, reported visualizing faces of witches and gorillas out of floor tiles. In this study, a computer simulation is provided of a treatment in which the stimulation current is computed by nerve fiber cell membrane potential feedback so that the level of the current is automatically instead of manually adjusted.

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The diaphragmatic tissues were exposed to procaterol (10(-8)-10(-6) M), and muscle contractility was assessed. Further evaluation is necessary to better describe the role in Argentina and the effect of ICULN service on patient outcomes and on staff. The effectiveness of local anesthetic wound infiltration for treatment of postoperative pain appears to be variable and partly dependent on the surgical procedure. The behaviour of mammalian skin epithelium under strictly anaerobic conditions. SOUs may help organisations that are attempting to streamline patient care while maintaining their quality of service delivery. We have determined that I-mfa, an inhibitor of several basic helix-loop-helix (bHLH) proteins, and XIC, a Xenopus ortholog of human I-mf domain-containing protein that shares a highly conserved cysteine-rich C-terminal domain with I-mfa, inhibit the activity and DNA binding of the HMG box transcription factor XTcf3. It also limits their probability of long-range movements and thus lowers the probability of mis-rejoining and chromosome aberrations. Based on the previously determined NMR structure of the native protein, showing a ferredoxin-like fold and the peculiar presence of an unstructured N-terminal segment, we show here, at a molecular level using NMR spectroscopy, that indeed S. In different forms of blepharoptosis, distinctive metrics of lid saccades occur. After 24 h mechanical distraction with hyperphysiological magnitude, however, F-actin of osteoblasts became reorganized and disrupted, and protein levels of actin and tubulin alpha decreased.

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Interaction proteomics of the HMGA chromatin architectural factors. In a prospective study we scanned the retina in 188 patients with a macular hole stage III or IV (Gass classification). One cause may be the increased proportion of NAPL that is hydraulically isolated due to capillary trapping in heterogeneously-wetted materials. Starting from a singleton chromanone high throughput screening (HTS) hit, we describe a focused medicinal chemistry optimization effort leading to the identification of a novel series of phenoxymethyl-dihydrothiazolopyridone derivatives as selective positive allosteric modulators (PAMs) of the metabotropic glutamate 5 (mGlu5) receptor. This study aims to test the ability of IL-1beta and TNF-alpha to stimulate CCL2 and CCL7 protein production in rat astrocyte cultures, and to elucidate signaling pathways involved in the cytokine-stimulated chemokine upregulation. Pain and function improved significantly less after knee arthroplasty than after hip arthroplasty, but the 2 procedures led to similar improvements in life evaluation, mood, and subjective health. An asynchronous algorithm for the integration of reaction-diffusion equations for inhomogeneous excitable media is described. Adipose aspirates were collected from 12 adult female patients after conventional liposuction of the abdomen and were then preserved by an optimal cryopreservation method with added cryoprotective agents (0.5 M dimethyl sulfoxide and 0.2 M trehalose). This concept of multistep control allows to quantify the individual influence of any parameter on mitochondrial oxidative phosphorylation and is extremely helpful to analyze the metabolic consequences of enzyme deficiencies in skeletal muscle occurring in mitochondrial myopathies. In human primary vaccination, the HLI level rose sharply within 4 weeks after vaccination, turning to decline gradually to settle at a level higher than that of the conventional neutralizing antibody (NA).

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In this paper, we report the use of near-infrared (NIR)-emitting alloyed quantum dots (QDs) as efficient optical probes for high contrast in vivo imaging of tumors. Late referral of patients with impaired renal function to renal units causes more frequent problems of vascular access, longer hospitalisation, more medical complications, higher costs and higher mortality. It was found that the parameters of dynamic viscosity correlate with the time of motion of protein solution in a porous polymeric carrier. Similarly, both compounds completely prevent the upregulation of GFAP. This pilot study suggests that LCM exhibits safety and efficacy profiles which make it an optimal candidate as a first-choice drug against post-stroke NCSE in elderly patients. Here, we describe methods for the isolation and quantification of polysome complexes from plant tissues. Precise control of the molecular weight was demonstrated for the first time in flow for conjugated polymers by accurate addition of catalyst to the monomer solution. In particular, they suggested (a) a change of coordinates to strain basis before the application of Theorem 1 of Haller and (b) the use of a nondimensionalized time computed from Theorem 1. use, whenever possible, hands-free kits to reduce EMF exposure, both for drivers and passengers.

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Herpesvirus saimiri-induced lymphoproliferative disease in howler monkeys. This non-randomised, non-blinded, non-significant risk, multi-site pilot study assessed the short-term acceptability of the SILCS diaphragm among women with no previous diaphragm experience. Arabidopsis separase functions beyond the removal of sister chromatid cohesion during meiosis. This technique has been thoroughly characterized in the laboratory and validated by field testing, facilitating simultaneous measurements of temperature and horizontal wind in the mesopause region of the atmosphere (80-105 km). MR imaging revealed an expansive intramedullary lesion with cortical breakthrough and soft tissue extension. Interest in the neuropsychology and neuropsychiatry of frontotemporal dementia (FTD) has escalated in the past decade, as evidenced by the accompanying 10 special topic papers from research groups in the UK, France, North America and Australia addressing a wide range of theoretical and clinical issues. These genes, frdC, frdA and frdB, respectively, are organized in an operon. The amount of transferrin expression in brain cells decreased linearly with the increase of SCAT concentration in seawater. Plyometrics may be safely introduced as early as the third or functional phase of recovery.

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To model chronic inflammation, mice were implanted with osmotic pumps that delivered tumor necrosis factor-alpha. The properties and clinical applications of streptomycin therapy. Rates of exchange of phosphate ions in humans, rabbit, and chicken blood. The posttear OCT images showed a discontinuity in the RPE with the CNV adherent to the retracted RPE. Early diagnosis enabled rapid specific treatment that improved the health of the patient and her baby. Myocarditis has been described during and after a wide variety of infectious agents: viral, rickettsial, bacterial, protozoal, and metazoal diseases may cause cardiac inflammation. Of the 21 participating obstetricians, 71.4 percent indicated that postpartum depression screening would become their standard care. A general affinity method to purify peroxidase-tagged antibodies. In-hospital mortality, composite complication rates, and intensive care unit and total hospital lengths of stay of those who underwent a minimally invasive approach were compared with those who underwent a standard median sternotomy. CT scan showed well-circumscribed tumour with no relation to the overlying skin.

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In lymphoid tissues of animals with MC-tumor and Ehrlich ascites cancer, strong MI-activity appeared early in the regional axillary lymph nodes, while weak activity was observed consistently in the distant mesenterial lymph nodes. The results of this study confirm that the treatment is more challenging for smoking alcoholics than for non-smoking ones and support the efficacy of topiramate in the smoking reduction among male alcoholic smokers who adhered to the treatment. The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras. We review a number of high-level cortical signals and their application for CNPs, including intention, motor imagery, decision making, forward estimation, executive function, attention, learning, and multi-effector movement planning. Given the high prevalence of occult head injury detected in this study, further study is warranted to estimate the prevalence of occult head injury in lower aygestin medication risk populations of abused children.

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The gene expressions for bcl-2, p53, and WT1 mRNAs were examined by using the semi-quantitative reverse transcript-polymerase chain reaction. Randomised trial: One cycle of anthracycline-containing adjuvant chemotherapy compared with six cycles of CMF treatment in node-positive, hormone receptor-negative breast cancer patients. The simultaneous method, in which the tenormin tab TEOS and TIP were simultaneously impregnated into a PP matrix, resulted in mixed oxides with highly dispersed titanium oxide species in the SiO2 matrix, while the sequential method produced the mixed oxide with separate SiO2 and TiO2 phases which were connected by Ti-O-Si bands at the interface. Blood samples were collected from 25 patients with wet AMD and 25 age-matched healthy controls. Diagnostic value of determining the post-heparin lipoprotein lipase. Role of surgery of cavities in therapy of pulmonary tuberculosis. The effects of capecitabine on two breast carcinoma cell lines were evaluated by the status of both cell proliferation and apoptosis and mRNA levels of TP and DPD were also determined. Patients did not complain of dry eye symptoms and tear functions were not compromised after LASIK enhancement. Treatment with tacrolimus ointment did not increase the ceramide fractions toward or to normal.

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The mean sagittal vertical axis for each standing position and during gait was compared using a repeated measures analysis of variance. Due to difficulties to obtain bone grafts often the bone substitutes are used. When combined with heavy resistance training, Cr supplementation increases M-CK mRNA expression, likely due to concomitant increases in the expression of myogenin and MRF-4. At the same site the presence of fructose-1, 6-diphosphatase-activity could be assumed, but there was no glucose-6-phosphatase activity. Outcomes of early risk stratification and targeted implantable cardioverter-defibrillator implantation after ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. Bioactivity of male (sperm transmitted) mouse mammary tumor virus as influenced by donor, recipient and age at treatment. T cell receptor-independent CD4 signalling: CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP. Independence of firing correlates of anatomically proximate hippocampal pyramidal cells.

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During functional magnetic resonance imaging scans, individuals read positive (eg, You are beautiful), negative (eg, You are ugly), and neutral (eg, You are human) comments that could be either about the self or about somebody else (eg, He is beautiful). Testosterone and acute stress are associated with fibrinogen and von Willebrand factor in African men: the SABPA study. Resetting the circadian clock is another intervention that can lead to increased life span and well being, while clock disruption is associated with aging and morbidity. Brain and meningeal biopsy disclosed a necrotizing granulomatous inflammation of small and medium-sized subarachnoid vessels. Retropubic prostatectomy: a comparison between its results and those of previous methods over a three year period. Drug users are an especially complex population among those studied in HIV risk behavior research.

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Revascularization of coronary artery disease in diabetes mellitus. Furthermore, the photoreduction kinetics starting from the biaxin antibiotic type FAD cofactor in the fully oxidized redox state, FAD(ox), have been probed by UV/Vis spectroscopy. N-Ethylmaleimide slowly inactivated the enzyme, the rate being greatly increased by P-glycolate, but not by magnesium or phosphate ions. DNA polymerase activity was associated with the replicating nucleoprotein complexes but not with the slower sedimenting complexes. Recent research underscores the gaps that exist between evidence-based medical practices and the care that many patients actually receive.

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The single modality of intravenous bolus IL-2 at the dose level of 72,000 IU/kg is clinically ineffective in NPC patients. We performed immunohistochemical analysis of the expression levels of BMP signalling components in pancreatic cancer and correlated these with survival. The Orange Plan aimed to establish specific health-care services, social-care services, and the coordination of agencies for persons with dementia. A 65-year-old woman presented with a ruptured dissecting aneurysm of the M3 portion of the middle cerebral artery (MCA) manifesting as disturbance of consciousness and motor aphasia. This disease syndrome is predominantly amaryl generic name caused by Mycoplasma pneumoniae, Chlamydia psittaci, Coxiella burneti and various viruses. Hereditary angioedema (HAE) is an autosomal dominant disease (Mendelian Inheritance in Man 106100) caused by an inherited deficiency of C1 inhibitor (C1-INH) function.

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Activity of phosphatases and succinic dehydrogenase in the trigeminal ganglion of the corticosteroid-treated mouse. The Medical Outcomes Study 36-item Short-Form (SF-36) was used to measure the quality of life of the women with different patterns of Sheng-Hua-Tang use. To determine the feasibility of a conservative (expectant) approach to major blunt renal laceration with urinary extravasation and devitalized renal segments. Propofol at a concentration of 1 mg/ml significantly reduced cell viability after 12 h. Both developing and developed countries face dilemmas under the current condition of increasing mental and physical health morbidity globally. Lymph node metastasis is the most important prognostic factor for colon cancer patients. These data indicate that action potential threshold is indeed lowest in the axon.

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A randomized clinical study evaluating the safety and efficacy of a new, reduced-volume, oral sulfate colon-cleansing preparation for colonoscopy. Novel therapeutic strategies are warranted for the treatment of metastatic melanoma as conventional therapies are inefficient. Small bodies framed by the membrane proper and containing granular and fibrillar components were formed. Hemodynamic overload is a what is the medication provigil sufficient stimulus for LIF expression in the adult mammalian heart. Magnetic resonance imaging is a relatively recent technique and its applications to osteoarthritis have been limited. Plant balances every physiological index and makes sure that physiology damage is the least and production is the greatest. Terridecase, the immobilized form of the enzyme proved to have the highest activity. The expression of clusterin mRNA and protein in nonpigmented ciliary epithelial cells was significantly downregulated by TGF-beta1 in vitro. Logic-based models represent biomolecular networks in a simple and intuitive manner without describing the detailed biochemistry of each interaction.

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