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Alfacal (Calcitriol)
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Alfacal

Alfacal is an active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia. Alfacal is a biologically active calcitrophic hormone with anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities.

Other names for this medication:
Admax, Alcee, Alfacal, Alfacalcirol, Alfacip, Alfarich, Alphadol, Arcium, Biocal, Bonestat, Bonetuf, Calbec, Calbory, Calcicare, Calcirol, Calcit, Calcitriol, Calcor, Caldikind, Caldix, Calosto, Calotec, Calsonic, Calsure, Caltin, Caltop, Calvical, Calzem, Carcal, Cholical, Citroj, Denscal, Estovon, Fovit, Koncal, Kurecal, Minroset, Netxod, Nutribone, Osteobel, Politrol, Primacal, Rical, Ritoca, Rolsical, Septriol, Statbone

Similar Products:
Colospa, Starlix, Zyvox, Sinequan, Urispas

Also known as: Calcitriol

Description

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are available in the foods that you eat. Vitamin D is necessary for strong bones and teeth.

Lack of vitamin D may lead to a condition called rickets, especially in children, in which bones and teeth are weak. In adults it may cause a condition called osteomalacia, in which calcium is lost from bones so that they become weak. Your doctor may treat these problems by prescribing vitamin D for you. Vitamin D is also sometimes used to treat other diseases in which calcium is not used properly by the body.

Ergocalciferol is the form of vitamin D used in vitamin supplements.

Some conditions may increase your need for vitamin D. These include:

Alcoholism Intestine diseases Kidney disease Liver disease Overactivity of the parathyroid glands with kidney failure Pancreas disease Surgical removal of stomach

In addition, individuals and breast-fed infants who lack exposure to sunlight, as well as dark-skinned individuals, may be more likely to have a vitamin D deficiency. Increased need for vitamin D should be determined by your health care professional.

Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough calcium in the blood). Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with kidney disease in patients who are undergoing kidney dialysis.

Claims that vitamin D is effective for treatment of arthritis and prevention of nearsightedness or nerve problems have not been proven. Some psoriasis patients may benefit from vitamin D supplements; however, controlled studies have not been performed.

Injectable vitamin D is given by or under the supervision of a health care professional. Some strengths of ergocalciferol and all strengths of alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are available only with your doctor's prescription. Other strengths of ergocalciferol are available without a prescription. However, it may be a good idea to check with your health care professional before taking vitamin D on your own. Taking large amounts over long periods may cause serious unwanted effects.

Dosage

Generic Alfacal is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Alfacal suddenly.

Overdose

If you overdose Generic Alfacal and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alfacal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Problems in children have not been reported with intake of normal daily recommended amounts. Some studies have shown that infants who are totally breast-fed, especially with dark-skinned mothers, and have little exposure to sunlight may be at risk of vitamin D deficiency. Your health care professional may prescribe a vitamin/mineral supplement that contains vitamin D. Some infants may be sensitive to even small amounts of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol. Also, children may show slowed growth when receiving large doses of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol for a long time.

Studies on doxercalciferol or paricalcitol have been done only in adult patients, and there is no specific information comparing the use of doxercalciferol or paricalcitol in children with use in other age groups.

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Sphingosine-1-phosphate (S1P) signalling via G protein-coupled receptors is important for the regulation of cell function and differentiation. Here we report the case of an 18-year-old woman with chronic myeloid leukemia (CML) who became pregnant while undergoing treatment with dasatinib. Cremophor administration at a dose level of 50 microl kg-1 intravenously 1 day before exposure to irradiation (6 Gy) protected the liver and kidney as indicated by the recovery of levels of hepatic aminotransferase, urea and lipid profiles to normal values. On the bonding of FeO2 in hemoglobin and related dioxygen complexes. The gross anatomy of the lower eyelid is analogous to that of the upper eyelid, however, the lower eyelid has a more simplified structure with less dynamic movement. Patients who have concomitant severe conduction disturbances and significant coronary disease may well receive a pacemaker before a revascularization procedure. Nursing staff have been involved in all phases in the development of the CDSS, which at present is ready to be implemented and systematically evaluated.

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SAMs on Pt(111) exhibited differences in molecular packing and a lower density of disordered regions than SAMs on Au(111). A collection of 56 bacteria isolated from different surfaces in the marine environment were assayed for their effects on the germination of spores from the common green alga Ulva lactuca. Sudden degeneration of the optic nerve and its clinical implications. The Akt signaling pathway is important for survival and growth of cancer cells. Yet, audit and feedback has not consistently been found to be effective. Together, these results suggest that activated human T cells, whether lupus-derived or normal-derived, contain biologically active ERalpha proteins. Therefore, the forward reaction passes through the quaternary complex Enz . Adsorption of cationic and anionic surfactants on carbonate materials is investigated in this study.

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Lamellar body count (LBC) in amniotic fluid is being used to identify infants at risk of respiratory distress syndrome (RDS) who would benefit from surfactant prophylaxis or very early therapy. Strikingly, the addition of growth factors (in the presence of serum) resulted in loss of polarity although the cells retained growth responses to both factors. In addition, although NPY overexpression did not significantly affect the mortality rate in Y2-/- and wild-type mice, it abolished KA-induced mortality in Y1-/-mice. To study the pattern of general practitioner prescribing of PC4, the most commonly used method of hormonal emergency contraception, in England and Wales. SUMMARY STATEMENTS: This is the first study to correlate sagittal balance (C2-C7 SVA) to myelopathy severity. We examined the immunoreactivity of these surface structures with antibodies against G(i)2alpha and G(o)alpha. In the retinas of high-salt loading diabetic animals, obviously increased intracellular edema was observed by TEM in ganglion cells and mitochondrial swelling was observed in glial cells. Some have questioned the need for intraoperative PTH monitoring (IPM) in the presence of positive nuclear scanning.

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To determine the prevalence of depression and its association with visual field impairment, quality of life, objective assessment of visual function, and glaucoma severity in elderly patients with glaucoma. Successful transplantation is highly dependent upon the availability of a suitable donor and the appropriate tissue match, which remains a problem. The decision to initiate prophylaxis needs to be made in consultation with the patient, the family, and a clinician with experience in treatment of persons with HIV infection. But interpretation of these fossils has been hampered by poor phylogenetic resolution. Four central elements of the principle are examined: threat, uncertainty, prescription and action. Insulin and leptin also stimulated metallothionein production, although the effect was small. One patient with vascular graft reconstruction developed graft infection during hospitalization and 5 developed graft infection during the follow-up.

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Rifampicin was stopped because it was considered as the most possible cause responsible for the rapidly progressive glomerulonephritis (RPGN). Using two peptide libraries (a 9-mer and a 15-mer) displayed on phage, novel GST-peptide interactions were identified using human GST A1-1, GST P1-1 and GST M2-2 as targets. A retrospective analysis of 1,036 consecutive patients was evaluated. Plasma levels of brain derived-neurotrophic factor and catecholamine metabolites are increased during active phase of psychotic symptoms in CNS lupus: a case report. Evidence for involvement of microtubules in the action of vasopressin in toad urinary bladder. Hes7, a bHLH gene essential for somitogenesis, displays cyclic expression of mRNA in the presomitic mesoderm (PSM). The pituitary-adrenal and gonadal responses following stress were evaluated in the squirrel monkey.

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Another three were discarded for location of their optimal parameters on the parameter search boundaries. Under the diagnosis of benign parotid tumor, the tumor mass was removed with adequate margin. Seventeen independent risk factors were examined using multivariate logistic regression analysis to develop a profile of patients most likely at risk from iatrogenic gall bladder perforation (IGBP) during laparoscopic cholecystectomy. We confirmed this structure by using a number of characterization techniques including nuclear magnetic resonance spectroscopy, zeta potential, circular dichroism, and dynamic light scattering. Vitamin D3 is determined in livestock feed supplements by high pressure liquid chromatography (HPLC).

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With an adjusted cut-point the PCL is an acceptable and brief screening instrument for PTSD in older adults. Alterations of intralesional and lymph node gene expression and cellular composition induced by IL-12 administration during leishmaniasis. Recent advances in the understanding of vincristine pharmacokinetics and pharmacogenetics, and potential methods of preventing neurotoxicity are reviewed which could enable dose escalation and dose individualisation in order to enhance the therapeutic index. Effect of continuous subcutaneous treprostinil therapy on the pharmacodynamics and pharmacokinetics of warfarin. The TP53 gene promoter is not methylated in families suggestive of Li-Fraumeni syndrome with no germline TP53 mutations. To determine whether the RhoA/ROCK pathway is involved in the regulation of corporal apoptosis and whether administration of insulin or fasudil, a specific ROCK inhibitor, could ameliorate ED in streptozotocin-induced diabetic rats. In a cross-sectional study design, 9991 inderal medication tremors children, aged 13-14 years in 61 primary schools in 32 districts of Istanbul were evaluated. This paper suggests a way to integrate different parameters into one index and results obtained by a newly developed index. The protein fold comprises an eight-stranded beta-barrel, six short helices, and a large unstructured Omega-loop.

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This review discusses the role of the blood coagulation system, particularly thrombin, as a tool to coordinate blood vessel formation. Histological analysis revealed that the uteri of Lgr4(K5 KO) mice displayed altered epithelial differentiation characterized by a reduction in the number of uterine glands. Efficiency of travoprost versus fixed-combination latanoprost/timolol. Pediatric rhegmatogenous retinal detachments are rare, accounting for less than ten percent of all rhegmatogenous retinal detachments. Liver cell proliferation and failure of X radiation to produce hepatomas in rats. Characteristics of carotid artery disease (CAD) and presenting cerebrovascular symptoms in an aged group. The addition of the DNP created challenges that resulted in a re-evaluation of the leveling of informatics competencies across the nursing curriculum. Severe crowding and a dilacerated maxillary central incisor in an adolescent. A prospective study of acute viral hepatitis with particular reference to hepatitis A. Patients with hemoglobin (Hb) variants may produce false HbA1c measurement.

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Detection in human breast carcinomas of an antigen immunologically related to a group-specific antigen of mouse mammary tumor virus. Bound thrombin from crushed clots is composed of alpha-thrombin and the N-terminal regions of alpha- and gamma-chains of fibrinogen. ETV6 rearrangement was detected by fluorescence in situ hybridization and EN fusion transcripts were verified by reverse transcription (RT-PCR) assay. When the LCR was initiated by electrical stimulation of the cut superior laryngeal nerve the response was not reduced by bupivacaine indicating that the most likely site of action of bupivacaine is the chemoreceptors in the laryngeal mucosa. The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. The effects of rye chromosomes 1R and 5R on androgenesis in cultured anthers of wheat--rye substitution lines was studied as dependent on the cultivar origin of the rye chromosomes and on the wheat genome (A or D) subjected to substitution. Thermolysin was shown to target mainly the side effects of theophylline medication AA 43-44 bond of the 22 kDa sequence at physiological pH. Advection of small particles with inertia in two-dimensional ideal flows is studied both numerically and analytically. The anti-complement immunofluorescence (ACIF) technique was evaluated for the diagnosis of human cytomegalovirus (CMV) infection in a group of sera derived from renal transplant recipients and donors by comparing it with the indirect immunofluorescence (FA) and complement fixation (CF) TESTS. At an electrophysiological level, this cognitive function contributes substantially in determining the amplitude of the N400.

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Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients. In addition, we found that a helix 3 mutation of the HoxA-13 homeodomain behaves as a dominant negative form. Rare genetic variants of human red cell 2,3-diphosphoglycerate mutase (DPGM) and monophosphoglycerate mutase (MPGM) were compared by starch gel electrophoresis. In addition, the decrease in gray matter volume of the primary motor cortex showed a significant correlation with longer reaction time to target detection in a working memory task. Minute quantities of granulocyte-macrophage colony-stimulating factor prolong eosinophil survival. Our results demonstrate that anaerobic thermophilic treatment was more efficient in reducing quantities of genes associated with the spread of antibiotic resistance compared to mesophilic digestion. The importance of recording spontaneous and induced seizures for the localization of epileptogenic cortical lesions. Modern pharmacological research has demonstrated that most of the biological actions and pharmacological effects of Wuweizi can be attributed to its lignan constituents, particularly the dibenzocyclooctadiene-type lignans, which can lower the serum glutamate-pyruvate transaminase (SGPT) level, inhibit platelet aggregation, and show antioxidative, calcium antagonism, antitumor-promoting, and anti-HIV (human immunodeficiency virus) effects. We present a list of medical genetic registries in Denmark at the national level, data sources from the departments of clinical genetics and other specialized centers, and project-specific data sources.

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Diffuse axonal injury (DAI) was less common in the severely disabled cases, particularly its most severe grade. The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs. Superconductivity emerges for the A15 polymorph of the fulleride Cs3C60 upon compression to a pressure of approximately 4 kbar. There is an increasing demand for organic semiconducting materials with the emergence of organic electronic devices. The described ectofucosyltransferases are able to catalyze the transfer of fucosyl residues from GDP-fucose to the endogenous membrane acceptors but the transfer activity towards exogenous acceptors is restricted to low molecular weight compounds. In this study, we have stably transfected the PI3Kgamma-deficient human colon cancer cell line HCT8/S11 with expression vectors encoding either wild-type PI3Kgamma, its plasma membrane targeted form CAAX-PI3Kgamma, or the PI3Kgamma lipid and protein kinase-dead mutant (CAAX-K832R).

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They tended to be older with less education but reported similar health status, quality of biaxin suspension storage life, and levels of optimism. In order to reduce the noise component from reference intervals, partitioning according to relevant subgroups is a tool, and useful criteria for judging whether subgroups should be combined are reported. In 10 selected aflatoxin-resistant or aflatoxin-susceptible inbreds, Aspergillus flavus growth, which was quantified using an A. Determine if increasing annual temperature is associated with an increase in the prevalence of otolaryngologic respiratory diseases. Of 187 isolates from 120 patients, four were resistant to clarithromycin, while 183 were sensitive.

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In 1 of the 7 eyes, the fundus lesion improved as the pulsation weakened and the area of pulsation decreased. Transition-state complex of the purine-specific nucleoside hydrolase of T. More than 6,000 analytical determinations were performed on samples collected at six sampling points along the Sarno River and two points each on tributaries Solofrana and Cavaiola. In the case of hippocampal long-term potentiation (LTP), however, existing evidence is discrepant. NF-kappaB/Rel-binding activity consists of NF-kappaB1(p50) and RelA(p65). In nine paired fresh-frozen cadaver legs, an identical supination-external rotation type II ankle fracture was created. Of these, five randomised controlled trials were included after discussion between the authors. Effect of cyclin-dependent kinase (CDK) inhibition on expression, localization and activity of maturation promoting factor (MPF) and mitogen activated protein kinase (MAPK) in bovine oocytes.

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