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Aldactone (Spironolactone)

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Aldactone is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that does not improve with supplementation, early puberty in boys, acne and excessive hair growth in women.

Other names for this medication:
Aldostix, Amifru, Aquamide, Dyamide, Dytor, Fruselac, Frusis, Lactone, Lasilactone, Metolactone, Spilactone, Spiromide, Spironolactone, Spirotic, Torlactone, Tormax, Torsid, Zator

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Also known as: Spironolactone


{name} (spironolactone) is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

{name} is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood).

{name} also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome.

{name} is also used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body.


Usual Adult Dose of Aldactone for Edema:

25 to 200 mg orally per day in single or divided doses

Usual Adult Dose of Aldactone for Hypertension:

Initial dose: 50 to 100 mg orally per day in single or divided doses

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 25 mg orally once a day assuming serum potassium is less than or equal to 5 mEq/L and serum creatinine is less than or equal to 2.5 mg/dL

Usual Adult Dose for Primary Hyperaldosteronism:

Diagnostic dose:

Usual Adult Dose for Hypokalemia:

25 to 100 mg orally per day

Detailed Aldactone dosage information


If you overdose Generic Aldactone and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Aldactone overdosage: diarrhea, vomiting, nausea, red skin rash, loss of energy, slow heartbeat, weakness in legs, feeling drowsy, confusion.


Store below 25 degrees C (77 degrees F). Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aldactone are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Aldactone if you are allergic to Generic Aldactone components. Do not take Generic Aldactone if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Aldactone can harm your baby. Do not take Generic Aldactone if you are taking potassium-sparing diuretics (such as Aldactazide, amiloride (Moduretic, Midamor)), triamterene (such as Maxzide, Dyazide, Dyrenium)). Be careful using Generic Aldactone if you take inhibitors (enalapril (such as Vasotec), fosinopril (such as Monopril), captopril (such as Capoten), benazepril (such as Lotensin), lisinopril (such as Zestril, Prinivil), quinapril (such as Accupril), moexipril (such as Univasc), ramipril (such as Altace), trandolapril (such as Mavik)); oral steroids (dexamethasone (such as Decadron, Dexone), prednisone (such as Deltasone), methylprednisolone (such as Medrol)); aspirin and other nonsteroidal anti-inflammatory medicines (naproxen (such as Aleve, Naprosyn), ibuprofen (such as Advil, Motrin), indomethacin (such as Indocin)); diuretics; barbiturates, phenobarbital; digoxin (such as Digitek, Lanoxicaps, Lanoxin)); high blood pressure medicines, lithium (such as Lithobid, Eskalith); perindopril (such as Aceon).It can be dangerous to use Aldactone if you suffer from or have a history of liver disease, kidney disease, potassium high levels in your blood, problems with urination. Be careful with this drug if you are going to have a surgery. Avoid food with high level of salt. Avoid dehydration. Avoid medicines which cause lightheadedness. You should be careful when you are driving or operating machinery. Do not stop taking Generic Aldactone suddenly.

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Labeled plasma metabolites of L-methyl-hydrogen-3-methionine and L-methyl-carbon-14-methionine in the dog. Immunocytometry demonstrated the presence of the ligands sialyl Lewis X and VLA-4 on RCC, and blocking studies with monoclonal antibodies directed against tumor cell-endothelial interactions mediated by VCAM-1/VLA-4 and ELAM-1/sialyl Lewis X demonstrated marked inhibition of tumor cell adherence to cytokine-stimulated HUVEC. Inferior vena cava obstruction and diffuse hepatic uptake on lower extremity radionuclide venogram. Further characterization of the CD4 cell subset was performed using three other monoclonal antibodies, CD45RO (UCHL1), CD45RA and CD29, phenotyping memory T-cells, the inducer cells of suppressor function and helper-inducer cells, respectively. Integrated dataset of anatomical, morphological, and architectural traits for plant species in Madagascar. At present, all the patients remain alive, and one has a local recurrence.

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Influence of induced magnetic fields on Shapiro steps in Josephson-junction arrays. A review of the clinical and roentgenologic manifestations of incipient periodontal disease. Ongoing avoidance of seizure-provoking factors remains paramount to driving safety. The production of proinflammatory cytokines was significantly increased in all the studied groups compared with controls. Iso- or hypo-attenuating areas in the arterial phase on contrast-enhanced computed tomography (CE-CT) have been reported to be negative prognostic features in pancreatic neuroendocrine tumors (PNETs).

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Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. Loop fluid-inducing activity was produced by exponentially growing cells and was present in cell-free culture filtrates and associated with washed vegetative cells. To evaluate the efficiency of adenovirus-mediated gene transfer in these cells we tested the adenovirus construction containing beta-galactosidase cDNA. In addition, our integrative assessment indicated that the chronic exposure to DRCs may alter the hepatic transcript levels of genes related to oxidative stress, Fe ion homeostasis, and inflammatory responses. In total, 5157 participants from the Chilean National Health Survey 2009-10 were included in this cross-sectional study. A purified sulfated alpha-L-fucan from the sea cucumber body wall was studied, before and after almost complete desulfation, using methylation analysis and NMR spectroscopy. Structural biology of tissue factor, the initiator of thrombogenesis in vivo. Robust Weighted Sum Harvested Energy Maximization for SWIPT Cognitive Radio Networks Based on Particle Swarm Optimization. Chronic granulomatous disease (CGD), an inherited disorder of granulocyte function caused by failure of intracellular superoxide production, normally presents in the first years of life with severe recurrent bacterial and fungal infections.

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Selective appearance of Bunina bodies in amyotrophic lateral sclerosis. The diesel exhaust particulate material was aerosolized by a fluidized-bed dust generator. Like its human counterpart, the Sf CENP-B protein is related to the transposase of the pogo transposable element (TE) of D. This study was done to investigate the incidence of post-operative eye infections, their potential sources and the preparedness of the hospital to prevent such infections. To review the results of recent studies on the is allegra 180 an antibiotic use of angiotensin converting enzyme (ACE) inhibitors and calcium antagonists in patients after an acute myocardial infarction. In the course of our study we develop new switching relations using tools from convex analysis. A multitude of skin lesions have been reported in individuals with human immunodeficiency virus (HIV) infection. Histologically, peri-implant gingiva was revealed to show similar structure to that of the gingiva around natural teeth. Investigations confirmed the presence of idiopathic calcific constrictive pericarditis. Laboratory studies included routine laboratory tests, antinuclear antibodies, anti-dsDNA, antiphospholipid antibodies, and complement components C3 and C4.

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Here, we describe the development of a system that employs Drosophila S2 cells and RNA interference (RNAi) to define and characterize Cn host factors. New roles arise for a number of reasons, including a change in function or title for a preexisting role or in response to the establishment a completely new position. We find a large range of plausible epidemiological outcomes, positive and negative for public health, underscoring the need to quantify how immune pre-sensitisation modulates recovery and transmission rates in vector-borne diseases. Differences in calcium intake depended mainly on consumption of green vegetables and small fish. We have compared the long-term stability of 2 avian non-replicative retroviral vectors in an infected permanent cell line from quail fibroblasts (QT6). Badgers represent a wildlife reservoir for bovine tuberculosis in Britain, which persists in the south west despite almost 20 years of badger control. The optimal response of the clone was obtained by using B cells bearing both Mlsa and the permissive H-2 alloantigen.

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This article will discuss the conventional and newer morphologic imaging biomarkers for the assessment of tumor response to therapy. Dependence of parameter values on exposure intensity was analyzed using linear regression models. Study of the reactions occurring in the fusion of 12C and 16O with heavy nuclei at incident energies below 10 MeV/nucleon. Following reduction and alkylation of the two-chain molecule, the heavy chain and the light chain were isolated, and antisera were raised in goats against the alkylated heavy and light chains. The effectiveness of reduced graphene oxide as a solid electron mediator for water splitting in the Z-scheme photocatalysis system is demonstrated. The future is here with promising devices and the possibility to give an unprecedented precise risk estimation of adverse post-surgical events.

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Evidence-based health care: A roadmap for knowledge translation. There is a need for a deeper understanding of how community-based prevention models apply to hazardous drinking in the military. A minor peak in the red-light region also suggested the possible involvement of phytochromes. The in vivo study indicated that interactions of ASG secretions and spermatozoa were complicated by the presence of uterine secretions. Notably, heme cannot only serve as a prosthetic group for hemoglobins and enzymes, but it also is a small signaling molecule that can control the activity of diverse signaling and regulatory proteins. Nucleon-induced preequilibrium reactions in terms of the quantum molecular dynamics.

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It is suggested that this may represent an extreme expression of the foot anomalies more commonly associated with this syndrome. For these studies, we utilized the murine B-cell lymphoma CH12, which expresses both I-A and I-E class II molecules. Persistent vomiting, diarrhoea, or intolerance of feeding, are well recognised problems in children after surgical correction of intestinal malrotation. Parental hypertension and cardiac alterations in normotensive children and adolescents. Time-resolved x-ray diffraction studies of the sarcoplasmic reticulum membrane during active transport. HCM cultures were studied to investigate the effect of ET-1 on cell size and adiponectin expression. A significant increase in the total number of white blood cells from gastric cancer patients was noted in comparison to controls, but the percentage of lymphocytes was the same. Studies on Structural, Optical, Thermal and Electrical Properties of Perylene-Doped p-terphenyl Luminophors.

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