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Adnil (Clonazepam)

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Adnil is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Adnil works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines.

Other names for this medication:
Adnil, Anxiset, Anxrea, Calmnir, Clodep, Cloneepam, Clonix, Clonoasig, Clonotril, Clonzy, Clopam, Closis, Convaclon, Deptune, Dipwell, Ection, Eminaz, Epcon, Epicloz, Epizam, Escitapax, Escitrac, Ezinite, Klopam, Lonazep, Nazee, Norep, Nupam, Ozepam, Petril, Prasilex, Revozip, Rivotril, Sezolan, Somnolex, Somnotril, Xenotril, Zeficar, Zepam, Zicam, Zolpidox

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Xeloda, Trandate, Propecia, Tricor, Dramamine, Glyburide, Cytoxan, Cardura, Skelaxin, Avelox

Also known as: Clonazepam


{name} (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

{name} is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

{name} is also used to treat panic disorder (including agoraphobia) in adults.


Adnil is indicated for the treatment of panic disorder, with or without agoraphobia, as defined in DSM-V. Panic disorder is characterized by the occurrence of unexpected panic attacks and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks.

The efficacy of Adnil was established in two 6-to 9-week trials in panic disorder patients whose diagnoses corresponded to the DSM-IIIR category of panic disorder.

Panic disorder (DSM-V) is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes: palpitations, pounding heart or accelerated heart rate; sweating; trembling or shaking; sensations of shortness of breath or smothering; feeling of choking; chest pain or discomfort; nausea or abdominal distress; feeling dizzy, unsteady, lightheaded or faint; derealization (feelings of unreality) or depersonalization (being detached from oneself); fear of losing control; fear of dying; paresthesias (numbness or tingling sensations); chills or hot flushes.

The effectiveness of Adnil in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. The physician who elects to use Adnil for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.


Benzodiazepines like Adnil became popular prescription medications, as alternatives to another class of anti-anxiety medications called barbiturates. Barbiturates were once very popular in the treatment of anxiety; however, they were highly addictive, carried a high risk for overdose, and were frequently abused. Benzodiazepines also carry a significant risk for the development of physical dependence and abuse (see below); however, they do not appear to carry the same risk of overdose that is associated with barbiturates (although overdose on benzodiazepines can occur).

Many of the cases of overdose that include benzodiazepines also include the co-occurring use of other drugs, such as alcohol, narcotic pain medications, or antidepressants. Using these drugs and benzodiazepines like Adnil together enhances the effects of all drugs as well as increases the risk for overdose and potential fatalities due to drug interactions and drug overdose.


Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Adnil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Adnil may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic, Subsys, others), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Astramorph, Duramorph PF, Kadian), oxycodone (in Oxycet, in Percocet, in Roxicet, others), and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take Adnil with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Drinking alcohol or using street drugs during your treatment with Adnil also increases the risk that you will experience these serious, life-threatening side effects. Do not drink alcohol or use street drugs during your treatment.

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Polyphosphate:AMP phosphotransferase and polyphosphate:ADP phosphotransferase activities of Pseudomonas aeruginosa. Bamboo salt attenuates CCl4-induced hepatic damage in Sprague-Dawley rats. Our findings suggest that the variants in SLC7A9 do not influence splicing behavior. Lymph node expansion during immune responses is accompanied by rapid vascular expansion. Activation of the extracellular signal-regulated kinase (ERK-1/2), a major mediator of HER2 signalling, was measured by means of western blotting experiments and ERE activation was determined in transient reporter-gene assays. The fact that this rare occurrence happened in a couple who had been married for more than 25 years points to a common environmental exposure. In silico analysis and proteinase K accessibility data suggest that these proteins might be surface exposed. jejuni isolates of known flaA RFLP type were included in the study.

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Neurologic symptoms and signs in 347 cases of verified brain tumor. We therefore propose that AdhE acts as a H2O2 scavenger in Escherichia coli cells grown under aerobic conditions. MTS (3-(4-5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium salt) and TUNEL assays were used to detect apoptotic cell death. Adolescents affected with IAD present with more psychopathological symptoms. In particular, one male specific allergen of about 550 kDa induced strongest degranulation of RBL cells. The samples are placed in a dc magnetic field and driven by cw and pulse-modulated microwave excitations at magnetostatic mode frequencies. This study examined 1-year outcomes for individuals entering chemical dependency (CD) treatment with and without cooccurring psychiatric diagnoses targeted by California parity legislation. Although we observed significant overlap between the distributions of KIS-L, ASH1, and TRX on polytene chromosomes, KIS-L did not bind methylated histone tails in vitro, and loss of TRX or ASH1 function did not alter the association of KIS-L with chromatin. Cross-sectional survey of private households with a probabilistic sampling design was used.

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We used a genetic mouse model that dissects DNA binding-dependent vs. Changes in the specific activity of cytochrome oxidase, monoamine oxidase, acetylcholinesterase and Na,K-ATPase in the light and heavy synaptosomes and mitochondria of neurone bodies fractions in the motor cerebral cortex of rabbits were demonstrated under conditions of light (visual) deprivation. This perspective article will briefly outline the most interesting approaches recently reported for the synthesis of highly functionalized pyrimidine derivatives. In total, 763 MI-patients completed the Major Depression Inventory at discharge. Ectopic overexpression of Bcl-2 in ES cells failed to inhibit etoposide-induced apoptosis. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a specific heart muscle disease of unknown etiology characterized by fatty and fibrofatty replacement of the right ventricular myocardium. Medical interest in the AMPK system has recently increased with the demonstration that AMPK could mediate some of the effects of the fat cell-derived adiponectin and the antidiabetic drugs metformin and thiazolidinediones.

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The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. Then it was strongly expressed in the neuroepithelium of the neural tube, the developing brain and the spinal cord from E8.5 to postnatal day 7 (P7), in the cranial motor nerves from E9.5 to E11.5, and in the optic nerve from E13.5 to P7, which agrees with periods of their respective morphogenetic peaks. Analytical methods for proteomics are based on conventional tools for protein characterisation. A new method of measuring temporal resolution for computed tomography. There is a high incidence of associated syndromes when HD coexists with ARM. To explore the role of dopamine and its metabolites for change of reproductive states of workers in honeybees (Apis mellifera), brain levels of dopamine relative substances were measured and localized in both normal workers and queenless workers. Synergids and filiform apparatus in the sexual and apomictic dandelions from section Palustria (Taraxacum, Asteraceae). This study suggests that early, regular nebulized beta(2)-agonist and systemic corticosteroid therapy may reduce hospitalization and relapse rates in patients with acute severe asthma.

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We recently developed a general combinatorial approach, namely the generalized multifactor dimensionality reduction (GMDR) method, which can entertain both qualitative and quantitative phenotypes and allows for both discrete and continuous covariates to detect G x G and G x E interactions in a sample of unrelated individuals. Age alterations in the activity of several key enzymes of glucose oxidative breakdown (hexokinase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and cytochrome c oxidase) were studied in extracts from rabbit aorta. The threshold of ABR and the number of substance P-positive neurons in the cochlear nucleus were significantly increased after 1 week and 3 days of injection of gentamicin, respectively. Colostral IgA, IgG, and IgM-IgA fractions as fluorescent antibody for the detection of the coronavirus of transmissible gastroenteritis. Numerical simulations are carried out to illustrate the importance of marine reserve in fisheries management. Perception of dyspnea and tolerability was assessed 12 h after the first application of the ENDS. This study was conducted to examine the protective role of crude polysaccharide from brown seaweed Sargassum polycystum against acetaminophen-induced abnormality in blood glucose, serum albumin/globulin ratio, and liver glycogen, lactate, and pyruvate. We report the incidental operative finding of a gossypiboma 11 years after repair of Ebstein anomaly. Pubertal exposure to high fat diet causes mouse strain-dependent alterations in mammary gland development and estrogen responsiveness.

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To assess the whitening effect of salicylic acid peels in Asian patients with acne objectively by the colorimetric method. Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis. The increase in NOS2 levels is mainly due to the influx of NOS2-expressing inflammatory cells. Semipermeable membrane devices link site-specific contaminants to effects: PART II - A comparison of lingering Exxon Valdez oil with other potential sources antibiotic chloromycetin is obtained from mcq of CYP1A inducers in Prince William Sound, Alaska. The perceptual distortion of objects in the leftward parts of visual space is not sufficient to account for the occurrence of visuospatial neglect.

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