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Adiff (Adapalene)

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Adiff is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. Among topical retinoids used to treat acne vulgaris, Adiff is considered to be the least effective, but best tolerated.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Celebrex, Motilium, Levaquin, Cytoxan, Zantac, Detrol, Uroxatral

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


Follow the directions for using this medicine provided by your doctor. Use Adiff exactly as directed. Adiff is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Adiff. Adiff should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Adiff. Continue using Adiff until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Adiff promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Adiff dosage information

Side effects

The most common side effects associated with Adiff are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of adapalene in children up to 12 years of age with use in other age groups. In teenagers, adapalene is not expected to cause different side effects or problems than it does in adults.

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It is possible to produce normoglycemia in immunosuppressed diabetic patients with human islet transplants. The evaluation system also permitted ongoing corrections and changes in the modules. Effective-action approach to Bose-Einstein condensation and superconductivity of a charged ideal nonrelativistic Bose gas. The amount of 2H8AA converted to deuterated 5-LO products is reduced by the addition of PLA2 to Ag-stimulated cells. Oscillating bubble as a sensor of low frequency electro-acoustic signals in electrolytes. Selective arterial presaturation, bolus tracking, and three-dimensional reconstruction were used routinely. Along with the succession, the microbial community was gradually dominated by several functional microorganisms. Records from the Republic Institute of Statistics were used as the source of data. Follow-up of the antibody response to measles vaccine in a rural area of Guinea-Bissau. Predictors of obesity and overweight in preschoolers: The role of parenting styles and feeding practices.

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Unequal amplitude saccades produced by aniseikonic patterns: effects of viewing distance. The hierarchical structure of the EXSEM was partially supported, as we observed successively smaller improvements at each level of the model (e.g., self-esteem showed lesser improvements than physical self-worth). We conclude a regulating role of TSH on hepatic PCSK9 expression, which further contributing to a higher LDL-c level. In addition, long-term animal studies were performed using two sheep. Four h of observation is sufficient for asymptomatic patients not requiring psychiatric admission. However, it is still unclear when such field defects are formed and what component of inflammation is involved in induction of aberrant DNA methylation. Effects of acute and protracted hypoxia on plasma levels of atrial natriuretic factor.

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The early diagnosis and treatment of postoperative paresis of the gastrointestinal tract. The 2-stage extraction of six-year molars--a therapeutic alternative to space closure in the mandible. Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney. These evaluations should consist of a medical and occupational history, and a physical examination of the upper extremities. Careful assessment of the external genital structures and the overall infant directs the immediate management.

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Multiple myelomatosis from solitary myeloma of urispas tablet uses in telugu bone: 13-year survival. The purpose of this study is to investigate the postoperative outcomes of small cell lung cancer (SCLC) patients and compare the survival difference between the two stages. There were no significant differences between patients who developed short-term herpes zoster pain and patients who did not develop short-term pain for any of the measures at the initial assessment, except for one measure of pain intensity. The Authors describe the growth of a 2 year old child affected by Dubowitz syndrome. For patients at stage IA with thin melanoma and low HR for recurrent CM the need for surveillance remains questionable. The exact role of the mandibular condyle in influencing mandibular growth is still a point of conflict. Applying a refined correlation method after identifying outliers would facilitate the prediction of more accurate distribution parameters as key inputs used in physiologically based pharmacokinetic (PBPK) and phospholipidosis models.

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Activation of prothrombin and factor X: function of previously unrecognized plasma protein. Constructional aspects in the planning of a compact cyclotron for radiology. Transplant community has arbitrary age limit for liver transplantation based on the increased comorbidities in aging population. Identification and purification of a human lung tumor-associated antigen from a primary lung tumor. Antibodies and complement enhance binding and uptake of HIV-1 by human monocytes.

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