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Adefin (Nifedipine)

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Adefin is used to treat hypertension (high blood pressure) and angina (chest pain). Adefin is in a class of drugs called calcium channel blockers. Adefin relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

Other names for this medication:
Atanaal, Atenerate, Belnif, Calcianta, Cardifen, Carditas, Cardules, Cordaflex, Corotrend, Depine, Duranifin, Ficor, Glopir, Hexadilat, Jutadilat, Lemar, Macorel, Menoprizin, Nedipin, Nefelid, Nidilat, Nifatenol, Nifcal, Nifebene, Nifecardia, Nifecor, Nifedalat, Nifedigel, Nifedipress, Nifical, Nifin, Niften, Nilol, Nirena, Nycopin, Nyefax, Ospocard, Oxcord, Sepamit, Tredalat, Viscard, Xepalat

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adefin PA 20. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adefin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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The types of interaction of the microflora of the human oropharynx with the causative agent of meningococcal infection. In all known cases, the cluster acts as the sensory module, where the inherent reactivity/fragility of iron-sulfur clusters with small/redox-active molecules is exploited to effect conformational changes that modulate binding to DNA regulatory sequences. Cost efficacy analyses and quality of life assessment in ongoing and future clinical trials are essential to the development of this therapy and its diffusion into different health care systems. Proteolytic enzymes stimulate human spermatozoal motility and in vitro hamster egg penetration. The two patients with EMS reported presented with profound weakness and sensory loss and were found to have clinical, electrophysiological and pathological evidence of a chronic demyelinating polyneuropathy. She remained under our care for 4 years during which she had two successful IVF pregnancies with elective single embryo transfers on both occasions. We examined this association among participants enrolled in AIDS Clinical Trials Group (ACTG) A5322.

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Arthroscopic treatment of sports-related anterior osteophytes in the ankle. Estradiol and progesterone were injected to ovariectomized females and LH-RH levels measured in preoptic-anterior segment of the hypothalamus, arcuate nucleus, and median eminence, as well as LH and FSH concentrations in the blood in order to detect disorders in basal and cyclic gonadotropin secretion. Such immunity, in addition to reducing the overall rate of malaria transmission, would, if combined with a vaccine against the asexual (disease-causing) stages, reduce the chance of selection of parasites that are resistant to the asexual vaccine by preventing their entry into the mosquito population. This review examines the similarities and differences between these three syndromes and the other severe epilepsies of infancy and childhood, and discusses the hypothesis that the three disorders form a continuum of epileptic encephalopathies that have a predictable age-related evolution. Quantitative and qualitative verification of data quality in the childbirth registers of two rural district hospitals in Western Kenya. Incidence of MCC in WA is the highest reported in the literature.

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Employment, race and poverty in West Virginia: implications for practicing physicians. Because of the unusual combination of immunoglobulin, EGF-like and fibronectin type III domains in the extracellular portion of tie-2 which is shared by TEK and tie, these molecules may be considered members of a new family of receptor tyrosine kinases. Autoreactivity with rabbit serum albumin of rabbit antibodies against bovine or human serum albumins and autoimmune recognition of rabbit serum albumin. The presence of a graft-versus-tumor effect has been well established in leukemia but not in multiple myeloma. Following HRP injections into medullary raphe nuclei and the adjacent reticular formation double labeled cells were found in the dorsal raphe nucleus, the central superior nucleus and the ventrolateral tegmentum. We report on a 46-year-old female patient with chronic alcoholism, who presented with a severe metabolic acidosis and an increased anion gap despite repeated vomiting. If indications and activity of bone marrow transplantation depict the threshold of prioritization, then more patients with chronic liver disease should be offered liver transplantation as therapy. LCBF and LCGU were determined autoradiographically by employing the 14C-iodoantipyrine or 14C-2-deoxyglucose technique, respectively. Deceleration and acceleration in the rate of posterior neuropore klonopin overdose mg closure during neurulation in the curly tail (ct) mouse embryo.

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Development of a Social progesterone tablet uses in pregnancy Functioning Assessment using Computerized Adaptive Testing for Patients with Stroke. Kinetics of factor production after skin transplantation and genetic mapping of the H-2 region specificity. Metabolic syndrome and risks of colon and rectal cancer: the European prospective investigation into cancer and nutrition study. The initial dose recommended is 150 U heparin/kg body weight subcutaneously, followed by 125 U heparin/kg body weight subcutaneously, every 12 hours for six doses. In silico HLA-binding algorithms and in vitro T cell-based assays as predictive tools for human immunogenicity risk have made inroads in the biotherapeutic drug discovery and development process.

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Verapamil withdrawal as a possible cause of myocardial infarction in a hypertensive woman with a normal coronary angiogram. In some subjects, a smaller part of the updating error was also related to the change of visual frame orientation. Toxicity of a new dosage format, cisplatin incorporated in lactic acid oligomer microspheres, in mice. These results suggest that either germinated or ungerminated conidia could be used as inocula for in vitro susceptibility studies of A. These cells showed in vitro cytotoxicity against NK cell targets, although with lower activity than that of the peripheral blood mononuclear cells. Finally, the cystic ovary clearly contributes to the hypothalamic aberration to which it subsequently responds. Ammonia formation by metal-ligand cooperative hydrogenolysis of a nitrido ligand. The free-protein atlas of the culture is consistent with that of the stock. In this review, we present current concepts on the role of clonal evolution in lymphoid and myeloid leukemia as a driver of tumor initiation, disease progression and relapse.

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Inhibitory effect of moricizine on reperfusion induced tachyarrhythmias in rats--a comparison study with disopyramide and mexiletine. In addition, groups gave advice on statistical issues in the design of experiments. Classifications and epidemiologic considerations of epileptic seizures and epilepsy. FGH supernatant inhibited cytochrome P450-dependent APAP oxidation in microsomal incubations. HIV produces a small , dimeric aspartyl protease which specifically cleaves the polyprotein precursors encoding the structural proteins and enzymes of the virus. Differential cytostatic activity of monocyte-derived cytokines against human melanoma cells. This glycan serves as a signal for HRD ligase-mediated glycoprotein disposal. A 32-yr-old female who suffered from typical Weber-Christian disease developed hepatosplenomegaly and hepatic dysfunction. A similar localization of PI and of Uf was found in endometrial tissue from pigs at day 13 (late luteal phase) of the estrous cycle.

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