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Acupain (Tramadol)

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Acupain is an opioid (narcotic) pain reliever. It works by binding to mu-opiate receptors in the brain and changes how you feel and respond to pain. Acupain is usually started at 25 mg per day. After slowly raising the dose over several days, a typical dose would be 50 to 100 mg by mouth every 4 to 6 hours as needed for pain.

Other names for this medication:
Acema, Anazac, Bramadol, Cemadol, Combitram, Damadol, Decotram, Ivydol, Kevtram, Madol, Mandol, Meridol, Midol, Mobiya, Nopidol, Omodol, Postadol, Ramadol, Relidol, Servodol, Simol, Stemadol, Taramol, Tolydol, Tramacip, Tramadex, Tramared, Tramazol, Trambax, Tramdop, Tramex, Tramol, Tramot, Transic, Trazac, Tridol, Tromfil, Trugesic, Trydol, Ultraspas

Similar Products:
Aceon, Strattera, Detrol, Imitrex, Mircette, Dostinex, Cenforce, Maxolon, Neoral

Also known as: Tramadol


{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Acupain ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Acupain ER.

Never share Acupain ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Acupain ER.

Acupain ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Acupain ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Acupain ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Acupain ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Acupain ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how Acupain ER will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Electrophoretic and immunological properties of the soluble root protein complement of 6 Medicago sativa L. Tracking performance was greatly improved in comparison with a standard method utilizing squared gray-level differences of the entire images. Once colonization is established, infection may be carried for life. Sucrose density gradient distribution of mitochondrial protein and enzymes from preclimacteric and climacteric pears. Assay of serum NAD-dependent malate dehydrogenase using malate as substrate.

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After a third dose of vaccine, a third blood collection followed. Female flight attendants who worked one or more long-haul international flights in the prior 3 months and 75 or more hours in the prior month were recruited from the union membership. ECT during the index hospitalization was associated with greater improvement in depressive symptoms and in most measures of QOL. Windowed Fourier-filtered and quality-guided phase-unwrapping algorithm. Observations on the treatment of nerve injuries, with an account of a new series of splints.

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Adult patients with radiologically and clinically confirmed ABS received once-daily moxifloxacin 400 mg for 10 days. Ultrastructural data relating to the ureteric lesion are illustrated. No remarkable changes were seen in urinary parameters between the 2 groups, and there was also no significant difference in water intake. By contrast, the X and third chromosomes did not show any strong segregation distortion. They are plasmalemmal invaginations, 50 to 100 nm in size, characterised by the presence of the structural protein, caveolin, which exists as three subtypes. concluded that homophones have separate word form presentations and that the absence of frequency-inheritance effects for homophones undermines an important argument in support of 2-stage models of lexical access, which assume that syntactic (lemma) representations mediate between conceptual and phonological representations. Jejunal aspirates of 50 consecutive patients with MAS were cultured for bacteria and colony counts and antibiotic sensitivity were performed. Both ectopic prostate tissue in the female genital tract and vaginal myofibroblastoma have rarely been reported in the literature. Data regarding pain and function were obtained at multiple time points over a 2-year period. Systematic review of post-treatment psychosocial and behaviour change interventions for men with cancer.


Calibration-free concentration determination of charged colloidal nanoparticles and determination of effective charges by capillary isotachophoresis. The 43 amino-terminal amino acids show extensive sequence identity with nonspecific lipid transfer proteins from other plant species. To determine any differences in oral cancer risk factor awareness and behaviour among first and second generation Gujarati muslims and to investigate the impact of a community-based health education programme on oral cancer risk factor awareness. litura with special reference to management of field evolved resistance to insecticides. The application of the P-PS/RT led to partial or complete thrombus resolution in about two thirds of the patients treated. A plan to disseminate the conclusions of the Canadian Consensus Conference on Dementia (CCCD) was developed. However, no information is available regarding their internal energy, nor on their impact angles. Single and double-blinded studies, placebo-based and comparative studies were eligible. Predictors of 2-year outcome for patients with borderline personality disorder. The results are discussed in the context of the two existing, opposite views on the homology of the dorsal ventricular ridge of sauropsids and in terms of the evolution of pallial derivatives.

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Rett syndrome (RTT) is a neurodevelopmental disorder characterized by developmental regression beginning 6-18months after birth, followed by a lifetime of intellectual disability, stereotyped behaviors, and motor deficits. Bringing together clinical embryology and basic reproduction around human cloning. At the end of the twelfth week, the hepatic stellate cells (HSCs) were isolated from the liver of one rat in model-control group using in-situ perfusion with pronase and collagenase, then density gradient centrifugation, and the other rats were killed to take the serum and liver samples. This study does not support the hypothesis that the Fe-restricted fetus is hypoxic. Analytical control of a pharmaceutical formulation of sodium picosulfate by capillary zone electrophoresis. In uterine cervical carcinomas, lymph node metastasis, recognized as a common form of metastasis, and recurrence after curative resection are critical to patient prognosis. Prospects of using marine actinobacteria as probiotics in aquaculture. Gastroesophageal reflux disease in children: efficacy of Nissen fundoplication in treating digestive and respiratory symptoms. Muscle can therefore function as an endocrine and paracrine organ. These findings reveal a previously unidentified class of PPO enzymes that do not utilize oxygen as an electron acceptor, thereby allowing gamma-proteobacteria to synthesize heme in both aerobic and anaerobic environments.

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In addition, the lowest systolic (SBP) and diastolic blood pressure (DBP) during inspiration and the highest SBP and DBP during expiration was determined breath-by-breath from segments selected from each NREM cycle. A multicentre study on the pathogenic agents in 665 adult patients with community-acquired pneumonia in cities of China. Our understanding of these processes is limited because the rates of the reactions or the existence of intermediate species is not apparent without specially designed experimental techniques and data analysis procedures. Apoptosis and the cell cycle in Xenopus: PMA and MPMA exposure of splenocytes. Three sutures specimens were treated with FGF2-soaked heparin acrylic beads to induce accelerated mineralization and premature suture closure. Heterogeneous transcription of an indoleacetic acid biosynthetic gene in Erwinia herbicola on plant surfaces. In vitro antiviral efficacy of ribavirin against feline calicivirus, feline viral rhinotracheitis virus, and canine parainfluenza virus. Vestibular toxicity is unproven as the cause of Gulf War syndrome. The purpose of this study was to evaluate our experience with an excimer laser catheter used to cross wire-refractory chronic total subclavian/innominate occlusion in 12 patients.

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Polycyclic aromatic hydrocarbon-polluted dredged peat sediments and earthworms: a mutual interference. We studied 99 eyes of 99 patients with POAG and 50 eyes of 50 patients with NTG, who underwent trabeculectomy with adjunctive mitomycin C (MMC) and were followed regularly at 1 to 3-month intervals at the Glaucoma Service of Gifu University Hospital. Penguins, and possibly other seabirds, are therefore appropriate animal models for understanding the long-term interactions between body energy reserves and fasting, breeding and feeding physiology and behaviour. The other two cell lines, infected with the MC29 strain of avian leukosis virus, liberate normal levels of infectious virus in the culture fluid. One hundred twenty patients with benign prostatic hyperplasia and urodynamically proved obstruction were randomized to undergo either TURP or HoLRP. Intrathecal baclofen therapy improves functional intelligibility of speech in cerebral palsy.

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Parainfluenza-3 (Pi3) virus infection in a group of 25 calves is described. The fluorescence emission from the QD-nanowire systems is probed spectroscopically, by microscopic imaging and decay time measurements. Our data demonstrate that AR actively represses an intrinsic NE transdifferentiation process in androgen-responsive prostate cancer cells and suggest a potential link between AR inactivation and the increased frequency of NE cells in androgen-independent tumors. Because near-infrared (NIR) light has traditionally been delivered using extracorporeal sources, most applications of plasmonic photothermal therapy have focused on isolated subcutaneous tumors. The performance of these methods depends on the weights being used.

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We show that PMQR-catalyzed reduction of CoQ0 by both NADH and NADPH is accompanied by generation of CoQ0 semiquinone radicals in a superoxide-dependent reaction. These behaviours may constitute an RS-specific profile of behaviour or behavioural phenotype. To determine whether emergency medicine (EM)-bound and non-EM-bound senior medical students on the EM subinternship have a uniform experience with respect to number and acuity of patients seen and procedures performed. Allergic reactions to henna-based temporary tattoos and their components. The results of appropriately sized randomised trials, such as the ongoing EORTC-30994 trial are needed before any definitive conclusions can be drawn. We showed here that replacement of the 4th amino acid of the 12th PPR with nonpolar or charged amino acids abolished functions (1) and (2) but not (3) of PGR3 by compromising the function of this specific PPR. Incidence of diagnosed psoriasis was calculated using the number of new psoriasis patients in 2008 and the mid-year total patient count for THIN in 2008. To study the effect of puerarin on the nitrogen monoxide (NO) concentration in rats with pre-eclampsia. Association between tumor diameter and lymphovascular space invasion among women with early-stage endometrial cancer. The results of analysis of prevalence and morbidity of epilepsy in the children population of Stavropol Kray are presented.

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Automated single-trial measurement of amplitude and latency of laser-evoked potentials (LEPs) using multiple linear regression. Coimmunoprecipitation assays indicated that these deletions also reduce the intermolecular interaction between individual delta2 receptors. Studies on the comparative pharmacology and selective toxicity of tricaine methanesulfonate: metabolism as a basis of the selective toxicity in poikilotherms. A multi-group SEM analysis indicated a good fit of the hypothesized model. Intrigued by transannular interactions occurring in stacked aromatic molecules, chemists have long endeavored to engineer discrete stacks of specific lengths and orientation. Contrary to mutagenesis, lysogenic induction produced by chemical carcinogens occurs in the majority of a population of lysogenic is zyrtec safe while breastfeeding cells. The duration of response is significantly longer with ibandronate than pamidronate. As such, c-Myc may possess the unprecedented capacity to induce expression of all ribosomal components.

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Amrubicin: potential in combination with cisplatin or carboplatin to treat small-cell lung cancer. Artisan toric lens implantation after PK was effective for reduction of refractive astigmatism and ametropia. In addition, IFNgammaR(-/-) mice exhibited an accelerated remyelination process after cuprizone was removed from the diet. The proposed method is a safe procedure, which allows correct placement of cup and stem. Priming effects were also observed for the production of interleukin-6, monocyte chemoattractant protein-1, and tumor necrosis factor-alpha. Adenohypophysial tissue from betamethasone-treated rats incubated with hypothalamic extracts from control animals showed a considerable reduction in its ability to synthesize and release ACTH. Inclusion zocor 20 mg uses of zooplankton and benthic chydorid cladocerans has provided previously unavailable information on the historical development of planktivorous fish populations, submerged macrophytes and lake production, and has been used to document exotic species introductions, rapid genetic evolution and human disturbance of lakes. An attempt has been made to produce nondefective virus by fusion of infected Ehrlich cells with permissive cells: infected and non-infected chicken fibroblasts.

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Using a temperature-sensitive transformation mutant of Rous sarcoma virus and rearing the cells at permissive temperature, we demonstrate that transformed chondroblasts stop synthesizing their cell-unique sulfated proteoglycan. Because of its widespread availability, computed tomography (CT) is usually the initial study for this indication, although endoscopic ultrasonography (EUS) is the most sensitive imaging modality for the detection of pancreatic masses. The chemotactic of cyclic AMP and AMP derivatives with substitutions in the phosphate moiety in Dictyostelium discoideum. This formula or the functions fitted to the data obtained can be used to calculate the increase in target size needed to allow for short observation times. These results indicated that NOx and IL-6 may have a pathophysiological role in convulsions. Carbon fluxes were described using (14)C labeling, radioactivity loss curves, and compartmental analysis during the second half of the photoperiod when chemical steady state was reached for soluble carbohydrates. Primary cerebral T-cell lymphoma in a sea otter (enhydra lutris). Zolpidem extended-release 12.5 mg associated with improvements in work performance in a 6-month randomized, placebo-controlled trial. Specimens of 23 cases lethal midline granulomas (LMG) were examined: (1) HE stain for immunohistochemical staining for TIA-1, CD43, CD20, CD3 epsilon, CD56 and in situ hybridization for EBV encoded small nuclear RNA(EBER1/2, Y017, DAK0). The algorithm takes an overlapping chromatogram as its input and subtracts the chromatograms of standard samples from the input by iteration of a network.

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Effect of elevated brain GABA concentrations on the actions of bicuculline and picrotoxin in mice. After examinations with slit lamp biomicroscopy and ophthalmoscope, the images of superior, inferior limbus and central cornea were acquired by laser confocal microscope. The APOE-epsilon4 allele may contribute to the unexplained weight loss in AD, especially in women. Classification of posterior fracture dislocation of the hip joint: a modification of the Thompsen Epstein classification. Pulmonary granulomatosis associated with insoluble fillers in a heroin addict. Hyaluronic acid and aspartate aminotransferase levels normalized by liver function can reflect sinusoidal impairment in chronic liver disease. The fidelity of phosphorylation of the adenovirus DNA-binding protein by an in vitro nuclear protein kinase from virus-infected cells. To study the correlation between anatomical parameters and EMG signals by means of simulations. Implementation is often so rapid that demonstration of intervention efficacy by investigators, and establishment of research and development priorities by funding bodies tend to be more reactive than proactive. Some observations on the poliomyelitis epidemic at Stanthorpe, Queensland, 1951.

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Workshop: clinical implications for clinicians treating patients with non-specific arm pain, whiplash and carpal tunnel syndrome. Study of in vitro and in vivo dissolution of theophylline from film-coated pellets. Purified IBV has a sedimentation coefficient of 320S and a buoyant density of 1.22 g/ml in sucrose-deuterium oxide equilibrium gradients. The reliability of assessments of the maturity of individual hand-wrist bones. The inhibitors of these proteases may be developed into therapeutic agents against periodontitis. Our findings suggest that some low frequency neuropathic disorders might be attributed to genetic factors. Thus, reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death. Catheterization of CAM blood vessels facilitated dynamic imaging of glucose metabolism with (18)F-FDG and demonstrated the ability to study PET tracer uptake over time in individual tumors, and CT imaging improved the accuracy of tumor volume measurements. Outcome measures included X-ray rates and identification of fracture.

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Research investigating the prevalence and correlates of Pacific peoples gambling within a New Zealand context is limited. Further, we find evidences for non-random positioning of the chromosomal rearrangement breakpoints. The results showed a significant prevalence of Porphyromonas gingivalis and Treponema denticola among HIV-negative patients compared to HIV-positive patients. The objective was to compare the effect of two litter types (wheat straw and wood shavings) and two different rearing conditions (Treated and Control) on welfare indicators, broiler performance, carcase injuries, particularly hock and foot pad dermatitis (FPD), litter characteristics and meat quality. A complex array of amino acids within the selectins engage multiple sugar residues of the branched O-glycans on PSGL-1 and provide the molecular interactions responsible for the velcro-like catch bonds that support leukocyte rolling. Mutagenesis assays showed that CDK8 kinase activity is necessary for full T3-dependent DioI activation, whereas in vitro kinase studies indicated that CDK8 may contribute to Pol II phosphorylation. The clinical phenotype of these cases includes developmental delay, brain-, heart-, and kidney defects, eye abnormalities, short neck, craniofacial malformations, hypotonia, as well as clinodactyly or syndactyly.

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Advance care planning can prevent suffering and enable patients to receive care congruent with their goals at the end of their lives. Oncology scan--low-grade gliomas: predicting and changing outcome. Pulmonary dysfunction as a major cause of inoperability among patients with non-small-cell lung cancer. Regions with lower-than-average resolution may yellow xanax bars generic be mobile components or ones with incomplete occupancy or result from multiple conformational states. The effect of altering the electron density of the terminating functional group of these compounds on their properties was also investigated. Digital holography allows one to numerically investigate a volume by refocusing the different planes of depth, allowing one to locate the objects under investigation in three dimensions. Finally we observed the effects of ADAM28 AS-ODN on HDFCs expressing extracellular matrix (ECM) proteins by immunocytochemical staining. In this study, we review our experience with plantar artery revascularization when no other bypass options are feasible. In this paper, we demonstrate the induction of autophagy in high salt and osmotic stress conditions, concomitant with the upregulation of expression of an Arabidopsis thaliana autophagy-related gene AtATG18a. To examine breast-feeding initiation and continuation among women with recent live births in 10 states.

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The magnitude of the risk disparity is disproportionately higher than the disparity in all-cause mortality. Most central nervous system D2 dopamine receptors are coupled to their effectors by Go. In mammals, a number of checkpoint and repair proteins localize to the meiotic chromosomal cores, sometimes in the context of the synaptonemal complex (SC). Comparison of the attachment and growth characteristics between human junctional epithelium and oral epithelium cells. As a result, mucosal immune cells become increasingly exposed to a vast amount of microbial stimuli. The authors report a case of idiopathic RM occurring after transnasal resection of a sincipital encephalocele. We further conclude that aberrant RAD21 expression is a strong candidate to underlie aberrant cohesion, chromosome instability and contribute to the development of the disease. The lack of correlation in the ARF group was not associated with significant differences in lag time or AUC.

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We abstracted the sensitivity and specificity of EDTU for IUP from included studies, and evaluated and summarized the evidence assessing the effect of EDTU use on time to diagnosis, time to zovirax ointment dosing treatment of ectopic pregnancy, emergency department (ED) length of stay and health care costs. The subunit composition of cytochrome c oxidase from rat liver mitochondria was studied by dodecylsulfate polyacrylamide gel electrophoresis. Other diagnoses included lymphangioma (three cases), chronic inflammation (two cases), and epidermoid cyst (one case). Tibial osteotomy is an effective surgical intervention for treating knee malalignment associated with pain or arthrosis in young and active patients. ACMSD mutation contributes to the development of FCMTE QA accumulation is likely to play an important role in the pathogenesis of FCMTE. The orphan adapter protein SLY1 as a novel anti-apoptotic protein required for thymocyte development.

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