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Aclene (Adapalene)

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Aclene is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Aclene belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Zyprexa, Sinequan, Lodine, Actos, Pyridium, Nimotop, Biaxin, Indocin, Desyrel, Glucotrol

Also known as: Adapalene


{name} (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

{name} is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


Follow the directions for using this medicine provided by your doctor. Use Aclene exactly as directed. Aclene is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Aclene. Aclene should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Aclene. Continue using Aclene until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Aclene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Aclene dosage information

Side effects

The most common side effects associated with Aclene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Although multiple pedicle and skin excision techniques exist for gigantomastic breast reduction, no consensus exists as to which method is most effective in providing an aesthetically pleasing breast, especially in the long-term period. Heterotopic pregnancy associated with gamete intra-fallopian transfer. When an equimolar amount of bicarbonate replaced the acetate in the calcium and magnesium-free dialysate, side effects and metabolic alkalosis were seen within three dialyses. Immunohistochemical analysis shows that the encoded protein is present in the apical meristem, the floral meristem, each whorl of organ primordia, and in ovule primordia during wild-type flower development. This epitope is formed by alpha(1,3)-galactosyltransferase, which is present in all mammals except man, apes, and Old World monkeys. This review introduces NMR spectral parameters pertinent to using phosphorus-31 NMR for investigation of structure and dynamics. faecalis opp operon abolished response at physiological concentrations of pheromone. We used an asthmatic guinea-pig model which had a high incidence of dual-phase reaction and high reproducibility. A single protein of the outer membrane protein complex, the class 2 porin protein, was purified and shown to function as a T-helper lymphocyte carrier protein. Mechanism of hydrogen peroxide-induced keratinocyte migration in a scratch-wound model.

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Although CT elevated cAMP levels in both unstimulated and concanavalin A (Con A)-stimulated monocytes, it enhanced the production of prostaglandin H synthase-2 (PGH synthase-2, PGHS-2) protein, prostaglandins, interstitial collagenase, and 92-kDa type IV collagenase/gelatinase only in Con A-stimulated monocytes. Late phase II study of MST-16 (sobuzoxane) efficacy for malignant lymphoma. Both methods and their detection systems are evaluated in the laboratory as well as in a clinical environment. The response of the disease to the luteinising hormone releasing hormone analogue goserelin is reported. A 53-year-old male being treated for a metastatic squamous cell carcinoma had fatal pulmonary toxicity as a result of bleomycin therapy. EBV-positive cell extracts caused significant migration inhibition in the group of seropositive healthy children and of IM patients. Energy band structure and linear optical properties of Si and Ge strained along the. Pathologic changes associated with injury to nerve induced by cold. Malignant neoplasm and cholesteatoma with granuloma of the middle ear in the 13-year-old boy.

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Constitutive production of alpha and beta interferons in mutant human cell lines. While overall levels of alcohol consumption in this cohort were moderate there was evidence of a minority of adolescents who consumed alcohol frequently, in large amounts or who experienced alcohol related problems. RNA and protein levels were decreased both in the testis and epididymis. Morphine, enkephalins and related drugs induced in rats and rabbits naloxone-sensitive non-convulsive hippocampal EEG epileptiform activity after systemic or central administration. The pattern of increasing P-gp expression in the series K562/P, MMF, MMG and MMB was paralleled by increasing resistance to vinblastine and daunorubicin. Follow-up of antibodies to growth hormone in 210 growth hormone-deficient children treated with different commercial preparations. Irradiated cells and blastema formation in the adult newt, Notophthalmus viridescens. A new statistical appraisal of baseline ECG features for localization of accessory pathways. Quantification of mitral regurgitant stroke volume by the proximal isovelocity surface area method. MetSigDis: a manually curated resource for the metabolic signatures of diseases.

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Determination of interleukin-2 in cerebrospinal fluid by a sensitive enzyme-linked immunosorbent assay. Many treatment modalities use predicted weights estimated from descriptors such as sex, weight and height to reduce error that is associated with using total body weight in critically ill patients. In the present study examinations with the aid of this method in several probands and different tissues are described. Prostate cancer incidence increased dramatically in Missouri in the 1990s. Clinical spectrum, therapeutic management, and follow-up of ventricular tachycardia in infants and young children. A mutation known to block in vitro oligomerization of Rev abolished both complex formation and inhibitory activity of the mutant fusion proteins. Biochemical changes following poisoning of rats by alphanaphthylthiourea.

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Serological follow-up study in patients not infected with Toxoplasma gondii. High-performance size exclusion chromatography has been used to determine the molecular size distribution of Haemophilus influenzae type b (Hib) conjugate vaccines. A critical look at recent social policy reform in Europe from a gender and family perspective. Efficient B cell responses to most polysaccharide antigens such as TNP-PAA or TNP-Ficoll require factors produced by activated T cells. The prostaglandins, their antagonists and their possible significance in ocular disease. From this time, veterinarians came to be appointed to positions formerly occupied by lay inspectors and the veterinary profession was able to take up the role of planning and executing government-led disease control programs. Differentiation of osteomyelitis and infarction in sickle hemoglobinopathy. As to postoperative complications, renal failure was most frequent. It was shown that the antibacterial and anthelminthic therapy had a favourable clinical and immunologic effect.

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Dense central projections of sensory terminals of aortic afferents have been found in the dorsolateral and medial subdivisions of the nucleus of the tractus solitarius. Cell necrosis, including classic coagulative necrosis and apoptosis, manifestations of sublethal injury, and tubular cell exfoliation are described in detail. In a chess game, players choose consecutively around 40 moves in a finite time budget. Further purification of this biological activity was achieved with preparative-scale high-voltage paper electrophoresis. AgNOR sequence could perhaps be of use to differentiate those two histological indistinguishable lesions. A programme tailored to meet the specific needs of this group can be effective in helping many to quit or reduce their tobacco use.

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The purpose of this study is to determine if there is an additive effect of combined advanced maternal and paternal age on pregnancy and live birth rates. Our sequencing of 5 isolates from recent Hendra virus outbreaks in horses found no correlation between sequences and time or geographic location of outbreaks. An unusual case of fulminant hepatitis due to primary Epstein-Barr virus infection in a 62-year-old male 18 days after a cardiosurgical operation and blood transfusions is described in the present paper. The potential of cross-term averaging is demonstrated in two- and three-pulse experiments on a single crystal and a powder sample. Learning of arbitrary stimulus-response associations is an adaptive behavior essential for species survival in an ever-changing environment. To standardize the Dermatophagoides pteronyssinus extracts used in clinical allergy practice, the relative potencies of several purified extracts were estimated by radioallergosorbent test (RAST) inhibition, histamine release, and intracutaneous titration testing, and the results were compared.

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The catalytic effect of H2O on the hydrolysis of CO32- in hydrated clusters and its implication in the humidity driven CO2 air capture. The geographical distribution of Salmonella typhi and Salmonella paratyphi A and B phage types during the period 1 January 1966 to 31 December 1969. Placental tissue, newborn umbilical cord white blood cells (UC-WBC) and umbilical vein endothelial cells were collected and DNA methylation of cytosine-guanine dinucleotides was measured by the Illumina HumanMethylation450K BeadChip. Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin. A further 40 consecutive patients admitted in Arhus with ruptured cerebral aneurysm also were studied.

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Pulpal changes in replanted and autotransplanted immature teeth of dogs. The dissection of the left renal vein was taken medially until the superior mesenteric artery. Immunogenicity of the claritin dosage kids surface of filarial larvae (Dipetalonema viteae). Difficulties encountered and adaptations necessary for developing countries are discussed within the context of international models of primary health care. Sequence analysis has revealed that at least two different groups of formamidases are classified as EC on the one hand, the derivatives of the FmdA-AmdA superfamily, which are the best studied to date, and on the other hand, the derivatives of Helicobacter pylori AmiF. The amplitude and latency of cortical SEPs were not affected by BCCA. Here, we overcame these limitations by acquiring high-resolution multidimensional nonlinear coherent spectra with frequency combs.

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The data are discussed in the light of various hypotheses about the functional organization of the CFU-S population. The acute coagulopathy of trauma is multifactorial, but generally believed to be aggravated by coexisting acidosis, hypothermia, and hemodilution. However, the incidence of LT tears and the various tear types is unknown. With human E sensitized with hIgG where can i buy sawyer permethrin as target cells, Fc gamma RI was studied selectively. Quantitative analyses of cytosolic steroid hormone receptors were performed on nine tumors from the transplantable rat prostatic adenocarcinoma R-3327H. Comparison of the fold of lipases from Geotrichum candidum and from human pancreas identified a high degree of similarity which was not expected on the basis of their amino acid sequences.

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Comparison of the rates of exchange of lead in the blood of newly born infants and their mothers with lead from their current environment. Vasculitis neuropathy treatment is fundamentally carried out at the expense of corticosteroids and immunosuppressive which may be administered individually or in combination. The absorption of these anti-sera on B lymphocytes bearing the HLA-DR antigen against which they were directed, did not remove their reactivity on alloactivated T lymphocytes. Exogenous prostaglandins, particularly prostaglandin E2 and prostaglandin F2 alpha, have been found to flagyl dosage 500 induce uterine contractions and cause regression of the corpus luteum. This review will examine specific advantages and disadvantages of different vascular imaging modalities as related to stroke diagnosis.

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Decorin is a biological ligand for the epidermal growth factor receptor. Free radicals and inflammation may be involved in the pathogenesis or in the self-propagation of the disease. Maternal Smoking in Pregnancy and Offspring Depression: a cross cohort and negative control study. The results indicated that the induction of SHBG by the synthetic estrogens was antagonized by the progestogens in a dose-dependent manner. Effect of environmental temperature on hospital admissions for cerebrovascular accidents. The Theoretical study of thermal damage processes in laser irradiated tissue provides further insight into the design of optimal coagulation procedures. Twenty-one patients with lung cancer, 12 patients with esophageal cancer, 19 patients with liver metastases, 24 patients with gastric cancer, and 26 patients with rectal cancer were recruited to the study. However, the clinical response to rIL-2 in these patients was disappointing, especially in patients treated in frank relapse. The amount of cancellous bone determined morphometrically increased significantly during treatment with both dose levels.

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Isolation of a major apolipoprotein of canine and murine pulmonary surfactant. Selenium-containing tRNAGlu from Clostridium sticklandii: correlation of aminoacylation with selenium content. The most important and frequent source of error in the diagnosis of brain death in which actually alive patients are misdiagnosed as brain death is inappropriate EEG examination. A rapid mechanism-based screen to detect potential anti-cancer agents. Furthermore, it takes less memory than the full MS method so it can be used in the near edge region without any divergence problem, even for large clusters. The possibility that the classical pathway could predate the alternate pathway is discussed. An integrative approach to predicting the functional effects of small indels in non-coding regions of the human genome. These findings suggest that the TPA signal was transduced to the tyrosine phosphorylation of cordarone tablet price in pakistan paxillin strongly associated with formation of focal adhesion, and that this in turn induced dysfunction of the cadherin system and caused spreading and disorganization of the tubular structure. Percutaneous transluminal angioplasty is the treatment of choice in the management of renal artery stenosis in transplanted kidneys. This study developed a Minnesota Multiphasic Personality Inventory-2 (MMPI-2) portrait of narcissism using the Narcissistic Personality Inventory and 5 narcissism scales derived from the MMPI-2 with a nonclinical sample of 283 subjects.

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